[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tka\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tka":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,42,70,105,131,165],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100641479","eras-in-total-knee-arthroplasty-a-randomized-controlled-trial-100641479",false,"NCT07655921","ERAS in Total Knee Arthroplasty: a Randomized Controlled Trial","Effectiveness of Enhanced Recovery After Surgery (ERAS) Protocols in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Tria","ERAS","Inclusion Criteria:\n\n* ASA grade of 1-3 BMI was restricted to less than 30 kg\u002Fm²\n\nExclusion Criteria:\n\n* ASA grade of IV or higher uncontrolled comorbidities not consenting to the protocol","ALL","50 Years","70 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"NA","Total knee arthroplasty(TKA) is the most commonly performed procedure for advanced knee osteoarthritis. Enhanced recovery after surgery (ERAS) protocols are primarily implemented to reduce perioperative stress and improve surgical and functional outcomes. Evidence of the implementation of ERAS protocols in low to middle-income countries like Pakistan is limited. This study aims to evaluate the effectiveness of ERAS protocols in TKA patients.\n\nA prospective randomized controlled trial study was conducted within our institute from July 2025 to January 2026, in which a total of 239 patients who underwent primary bilateral TKA, of which 121 patients received conventional treatment and protocols, and a study group with 120 participants were managed according to the ERAS protocol. Patients were in the 50-70 years age bracket, and had an American Society of Anesthesiologists grade I-III. The protocol included preoperative physiotherapy, reduced fasting time, multimodal anesthesia, perioperative tranexamic acid, early ambulation and early oral intake. Postoperative outcomes included time to oral intake, postoperative nausea and vomiting, time to mobilization, length of hospital stay, range of motion and Hospital for Special Surgery score.",[15,28],"TKA","RECRUITING","2026-06-12",{"date":32,"type":33},"2026-06-18","ACTUAL",{"date":35,"type":33},"2025-05-13",{"date":37,"type":22},"2026-07-01",{"name":39,"class":40},"Liaquat National Hospital & Medical College","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":28,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":41},"100637173","effect-of-bupivacaine-liposome-injection-on-muscle-strength-after-total-knee-arthroplasty-100637173","NCT07616102","Effect of Bupivacaine Liposome Injection on Muscle Strength After Total Knee Arthroplasty","Effect of Bupivacaine Liposome Adductor Canal Block on Muscle Strength After Total Knee Arthroplasty.","Inclusion Criteria:\n\n1. Patients aged 60-75 years scheduled for elective TKA;\n2. ASA physical status classification II-III;\n3. BMI 18-30 kg\u002Fm²;\n4. Agreement to participate in this study and provision of signed informed consent.\n\nExclusion Criteria:\n\n1. Individuals with communication barriers such as language or hearing impairments;\n2. Patients with contraindications to nerve blocks;\n3. Severe systemic diseases, such as severe renal disease (estimated glomerular filtration rate below 50 mL\u002Fmin), cardiac disease (congestive heart failure New York Heart Association Class III to IV), or severe hepatic disease defined as a current or past diagnosis of acute\u002Fsubacute hepatic necrosis, acute liver failure, chronic liver disease, liver abscess, hepatic coma, or hepatorenal syndrome;\n4. History of long-term opioid use (defined as daily or nearly daily opioid use within the past 3 months).","60 Years","75 Years",{"count":52,"type":22},80,[25],"This study employs a randomized controlled trial to investigate whether bupivacaine liposome injection for adductor canal block can effectively improve lower limb muscle strength after total knee arthroplasty.",[28,56],"Muscle Strength",[58,59,28,56],"Bupivacaine Liposome","Adductor Canal Block","NOT_YET_RECRUITING","2026-05-26",{"date":63,"type":33},"2026-05-29",{"date":65,"type":22},"2026-06-10",{"date":67,"type":22},"2026-11-03",{"name":69,"class":40},"General Hospital of Ningxia Medical University",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":23,"phases":81,"briefSummary":82,"conditions":83,"keywords":92,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":41},"100626579","binaural-beats-for-postoperative-pain-and-anxiety-reduction-100626579","NCT07437469","Binaural Beats for Postoperative Pain and Anxiety Reduction","Binaural Beats vs Music of Choice for Early Postoperative Pain After Ambulatory Total Knee and Total Hip Arthroplasty: A Randomized Controlled Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists Physical Status Classification System (ASA) 1-3\n* Spinal anesthesia\n* Patients receiving nerve-block in Post-Anesthesia Care Unit (PACU)\n* Primary total hip or total knee arthroplasty\n\nExclusion Criteria:\n\n* Moderate-severe hearing impairment or use of hearing aids\n* History of significant tinnitus, active delirium, chronic high-dose opioid therapy (\\>60 MME\u002Fday baseline)\n* Major psychiatric pathology\n* General anesthesia","18 Years","99 Years",{"count":80,"type":22},50,[25],"To deliver a 30-minute binaural beats audio intervention in PACU and collect pain and anxiety outcomes immediately following surgery, and 4 hours following surgery completion in adults undergoing ambulatory total knee arthroplasty and total hip arthroplasty (TKA and THA).",[28,84,85,86,87,88,89,90,91],"THA","Anxiety","Binaural Beats","Music Exposure","Total Hip Arthroplasty (THA)","Total Knee Arthroplasty","Total Knee Replacement","Total Hip Replacement",[84,28,93,94,85,95,86,87],"Total hip arthroplasty","Total knee arthroplasty","Pain","2026-04-29",{"date":98,"type":33},"2026-04-30",{"date":100,"type":33},"2026-03-09",{"date":102,"type":22},"2026-08-30",{"name":104,"class":40},"University of Miami",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":23,"phases":115,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":4},"100595253","comparing-articular-noise-and-its-perception-between-two-different-types-of-individualized-total-knee-arthroplasty-100595253","NCT07030049","Comparing Articular Noise and Its Perception Between Two Different Types of Individualized Total Knee Arthroplasty","Monocentric, Randomized Study, Comparing Articular Noise and Its Perception Between Two Different Types of Individualized Total Knee Arthroplasty","ANIKA","Inclusion Criteria:\n\nAdult patients:\n\n* receiving elective primary TKA as a treatment for osteoarthritis\n* with an intact and functional posterior cruciate ligament\n* with no previous knee surgery, on the ipsi- or contra-lateral knee\n* who signed the informed consent and are willing to comply with the protocol requirements based on the investigator's judgment.\n* affiliated with a social security scheme\n* with an ability to answer questionnaires and to communicate freely in French.\n\nExclusion Criteria:\n\nPatients:\n\n* that underwent previous knee surgery, except arthroscopic surgery, on their ipsilateral knee\n* with coronal deformities \\>20°\n* that are pregnant\n* any contraindication mentioned in the instructions for use of the medical devices under investigation\n* with protected status under articles L1121-6, LL121-8 and L1122-2 of the French Public Health Code\n* with other significant disease or disorder which, in the opinion of the investigating surgeon, may put the participant at risk because of participation in the study, or may influence the result of the study\n* who cannot comply with the protocol requirements based on the investigator's judgment.",{"count":114,"type":22},210,[25],"Knee osteoarthritis is a degenerative joint disorder leading to pain and limited movement. Total knee arthroplasty (TKA) has transformed the treatment of knee osteoarthritis, resulting in long-term outcomes that enhance the quality of life for patients. Some individuals report experiencing noise after undergoing TKA. However, there are few randomized controlled trials that assess postoperative noise following the procedure. Additionally, no research has been conducted on individualized TKA, which involves custom-made prostheses tailored to a patient's knee shape. This study aimed to compare the incidence of noise reported by patients who undergo a primary individualized TKA using either cruciate-retaining or posterior-stabilized designs.",[118,28],"Osteoarthritis",[120,28,121],"osteoarthritis","articular noise","2025-06-23",{"date":124,"type":33},"2025-06-26",{"date":126,"type":22},"2025-09-30",{"date":128,"type":22},"2028-09-30",{"name":130,"class":40},"Clinique Trenel",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":140,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":164},"100580309","comparison-of-functional-recovery-between-restricted-inverse-kinematic-alignment-and-adjusted-mechanical-alignment-with-robotic-assisted-unilateral-total-knee-arthroplasty-100580309","NCT06835621","Comparison of Functional Recovery Between Restricted Inverse Kinematic Alignment and Adjusted Mechanical Alignment With Robotic-assisted Unilateral Total Knee Arthroplasty.","Comparison of Functional Recovery Between Restricted Inverse Kinematic Alignment and Adjusted Mechanical Alignment With Robotic-assisted Unilateral Total Knee Arthroplasty. A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Age 50 - 80 years old\n* Diagnosed with primary OA knee and indicated for unilateral total knee arthroplasty with MAKO robotic-assisted knee replacement system\n* ASA classification I-II\n\nExclusion Criteria:\n\n* Valgus deformity\n* KL grading \\> 3 on contralateral knee\n* Unable or difficulty for walking due to comorbidities\n* BMI \\> 40 kg\u002Fm2\n* Previous knee surgery\n* Infection around the knee","80 Years",{"count":52,"type":22},[25],"The goal of this clinical trial is to learn if restricted inverse kinematic alignment total knee arthroplasty (restricted iKA TKA) improves functional recovery compared to adjusted mechanical alignment total knee arthroplasty (aMA TKA) in patients undergoing unilateral robotic-assisted total knee arthroplasty by comparing performance-based outcome, 2-minute walk test (2MWT) as a primary outcome. This trial will also assess other outcomes including satisfaction, patient-reported functional outcomes, range of motion, visual analog scale for pain and complication of both techniques. The main question aims to answer is:\n\nIn unilateral robotic-assisted total knee arthroplasty, dose Restricted iKA technique provide better postoperative performance-based outcome compared to aMA technique?\n\nResearchers will compare restricted iKA and aMA technique to determine which technique offers better acceleration in functional recovery and patient satisfaction.\n\nParticipants will:\n\nAfter randomization, participants will allocate to either restricted iKA or aMA technique for unilateral robotic-assisted total knee arthroplasty.\n\nAttend follow-up visits for assessments of 2-minute walk test (Primary outcome), Time up and go test (TUG), VAS for pain, ROM and complete patient-reported functional outcome questionnaires regarding knee function and satisfaction at regular intervals.",[143,28],"OA Knee",[145,146,147,148,149,150,151,152,153,154],"Osteoarthritis (OA) of the Knee","OA knee","MAKO","Kinematic alignment","Mechanical alignment","Restricted Kinematic alignment","Inversed Kinematic alignment","Inversed Restricted Kinematic alignment","Robotic assist Total Knee Arthroplasty","Adjusted mechanical alignment","2025-02-14",{"date":157,"type":33},"2025-02-19",{"date":159,"type":22},"2025-03",{"date":161,"type":22},"2028-08",{"name":163,"class":40},"Thammasat University",2,{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":172,"sex":17,"minAge":77,"maxAge":138,"enrollmentInfo":173,"targetDuration":175,"studyType":176,"phases":4,"briefSummary":177,"conditions":178,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":41},"100556655","a-randomized-study-on-sagittal-angle-differences-in-lower-limbs-between-normal-individuals-and-osteoarthritis-patients-100556655","NCT06527924","A Randomized Study on Sagittal Angle Differences in Lower Limbs Between Normal Individuals and Osteoarthritis Patients","A Randomized Controlled Trial of the Difference in Sagittal Angle of the Lower Limbs Between Healthy Individuals and Patients With Osteoarthritis","Inclusion Criteria:\n\n1. The age ranged from 18 to 80 years old;\n2. Non OA examinees of lower limb sagittal EOS in the General Hospital of Chinese PLA;\n3. OA patients with sagittal EOS were photographed in the Department of joint surgery, General Hospital of Chinese PLA;\n4. Patients are willing to participate in the study and sign written informed consent.\n\nExclusion Criteria:\n\n1. People unable to conduct EOS inspection;\n2. Combined with knee meniscus injury, anterior cruciate ligament injury and other diseases that may affect the sagittal force line of the knee joint\n3. Combined with other diseases that may affect the study\n4. Patients refused to use their imaging data and knee score for this study",true,{"count":174,"type":22},400,"3 Years","OBSERVATIONAL","With China gradually entering an aging society, the proportion of the elderly population is gradually increasing, and the number of patients with knee disease is also increasing year by year. Total knee arthroplasty is one of the effective methods for the treatment of joint disease, which can effectively relieve knee pain, restore function and improve the quality of life. The goal of total knee arthroplasty is to relieve pain, restore function and obtain a long service life. Whether total knee arthroplasty can obtain good alignment is very important for the postoperative recovery of patients. The alignment of lower limb sagittal position is of great significance for evaluating whether the crowd is straightened or not, and can also evaluate and guide the TKA in sagittal position. At present, there are few studies on the sagittal position of the lower limb, and there is no clear definition of whether the lower limb is extended in the sagittal position. At the same time, there is no clear method to evaluate whether the lower limb is extended in the sagittal position in normal people and patients with OA. Therefore, it is urgent to develop a classification standard for the sagittal extension of the lower limb, which can be used in clinical evaluation and TKA operation evaluation. This study will be carried out in the first medical center of the Chinese PLA General Hospital, and a total of about 400 people are expected to be enrolled.",[179,28,180],"OA","EOS","2024-08-04",{"date":183,"type":33},"2024-08-06",{"date":185,"type":22},"2024-09-01",{"date":187,"type":22},"2026-09-01",{"name":189,"class":40},"Chinese PLA General Hospital"]