[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tmd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tmd":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,48,74,109,137,158,184,213,238,265,284],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100588957","exploration-of-the-utility-of-dental-dedicated-mri-for-dentistry-100588957",false,"NCT06948162","Exploration of the Utility of Dental-dedicated MRI for Dentistry","Inclusion Criteria:\n\n1. Patient Age: 18 years old or older\n2. Receiving imaging for routine dental care\n3. Does not have a serious medical condition\n4. Is not pregnant or is not potentially pregnant\n5. Is willing and able to give consent in English\n6. Has the ability to manage their own calendar and schedule appointments\n7. Willing to have a separate 2-hour appointment to have an MRI\n\nExclusion Criteria:\n\n1. Unable to consent to participant in English\n2. Serious health condition, which includes but not limited to renal failure\u002Fon dialysis, unstable heart disease (uncontrolled arrhythmia, cardiomyopathy and\u002For unable to lay flat, within 1 month of cardiac catheterization or myocardial infarction), unstable cerebral vascular disease (within 1 month of stroke and\u002For stent placement), diabetes (type I or II) not controlled by medication or diet, uncontrolled seizures, uncontrolled hyperthyroidism, non-allergic bronchospasm (chronic obstructive pulmonary disease and emphysema), uncontrolled movement disorder, and liver failure\n3. Pregnant and\u002For intending to become pregnant,\n4. Prisoner and\u002For not able to manage their own scheduling\n5. Screen positive on MR safety questionnaire, specifically including people that have worked with or otherwise been exposure to metal particles and have the potential for such particles to be embed within them.",true,"ALL","18 Years",{"count":19,"type":20},300,"ESTIMATED","OBSERVATIONAL","This description observational research is comparative in design, that is comparing existing standard clinical dental images, not obtained in this study, to test (i.e., ddMRI) images. The standard clinical dental images consist of radiographs, such as bitewings, periapical, panoramic, cone-beam CT, and medical CT, as well medical MRIs of the temporomandibular joints (TMJ).The conceptualization of research questions, study designing, and interpretation of imaging data has and will involve content expertise in all ddMRI research.",[24,25,26,27,28,29,30,31],"Dental Crowding","Dental Occlusion, Traumatic","Dental Pain","TMD\u002FOrofacial Pain","TMD","Orthodontics","Endodontic Disease","Orthodontic Treatment",[33,34],"Diagnosis","Magnetic resounance imaging","RECRUITING","2026-05-18",{"date":38,"type":39},"2026-05-20","ACTUAL",{"date":41,"type":39},"2025-03-14",{"date":43,"type":20},"2027-12-31",{"name":45,"class":46},"University of Minnesota","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":68,"completionDateStruct":69,"leadSponsor":71,"locationsCount":47},"100637183","a-double-blind-placebo-controlled-evaluation-of-the-effect-of-the-erchonia-evrl-on-chronic-jaw-pain-arising-from-tmj-100637183","NCT07600203","A Double-blind, Placebo-controlled Evaluation of the Effect of the Erchonia® EVRL on Chronic Jaw Pain Arising From TMJ","A Double-blind, Placebo-controlled, Randomized Evaluation of the Effect of the Erchonia® EVRL on Chronic Jaw Pain Arising From TMJ Clinical Study Protocol","Inclusion Criteria:\n\n* Able to understand and voluntarily sign the IRB-approved informed consent form.\n* Adults 22 to 75 years of age.\n* Subject's self-reported rating for jaw pain on the 0-100 VAS pain scale is 50 or greater (≥ 50).\n* Constant jaw pain on-going over at least the past 3 months.\n* Subjects score ≥3 points on the validated TMD Pain Screener (long version).\n* Subject has a primary diagnosis of TMJ-related nociceptive musculoskeletal pain made by a suitably qualified healthcare professional, confirmed using the Diagnostic Criteria for Temporomandibular Disorders (DC\u002FTMD) Axis I, with at least one of the following pain-related diagnoses: myalgia (including local myalgia, myofascial pain, myofascial pain with spreading, myofascial pain with referral) and\u002For arthralgia.\n* Subject is willing and able to refrain from consuming any OTC and\u002For prescription medications including muscle relaxants and\u002For herbal supplements and\u002For recreational and medical drugs including cannabis intended for the relief of pain and\u002For inflammation throughout the course of study participation, except for the study-specific pain relief medication of OTC Tylenol.\n* Subject agrees to refrain from taking a dosage of the study rescue pain medication of over-the-counter Regular Strength Tylenol® tablets for at least 6 hours before a scheduled VAS jaw pain rating is to be recorded. The subject understands that he may take a dosage of the over-the-counter Regular Strength Tylenol® tablets right after the VAS rating has been recorded, if needed to manage jaw pain.\n* Subject is willing and able to refrain from engaging in any non-study procedure therapies for the management of his or her jaw pain throughout the course of study participation, including conventional therapies such as physical therapy, occupational therapy and hot or cold packs, as well as alternative therapies such as chiropractic care and acupuncture\n* Subject is able to communicate fluently in English with the investigator and is able to read and write English sufficiently to comply with the study procedures.\n\nExclusion Criteria:\n\n* Pain that is undiagnosed or determined by a qualified medical\u002Fdental professional to be primarily attributable to causes other than TMJ-related nociceptive musculoskeletal pain.\n* Diagnosis using the Diagnostic Criteria for Temporomandibular Disorders (DC\u002FTMD) Axis I does not include at least one of the following pain-related diagnoses: myalgia (including local myalgia, myofascial pain, myofascial pain with spreading, myofascial pain with referral) and\u002For arthralgia OR includes one or more of the following pain-related diagnoses: disc displacement disorder with reduction, disc replacement disorder with reduction with intermittent locking, disc displacement disorder without reduction with limited opening, disc displacement disorder without reduction without limited opening, degenerative joint disease, headache attributed to RMD, and subluxation.\n* History of surgical intervention involving the temporomandibular joint within the past 12 months, or any history of total joint replacement or major reconstructive surgery of the TMJ.\n* Intra-articular TMJ interventions, including corticosteroid injections, botulinum toxin injections, or prolotherapy, within 3 months prior to enrollment.\n* Neurologic, neuromuscular, or neuropathic conditions affecting the craniofacial region that could confound TMJ pain assessment, including:\n\n  1. Diagnosed conditions: trigeminal neuralgia, Parkinson's disease, or other neuropathic facial pain disorders\n  2. Pain primarily characterized by neuropathic descriptors (burning, shooting, electric-like, sharp\u002Fstabbing pain, paresthesias, numbness, or tingling).\n* TMJ ankylosis or severe structural deformity requiring surgical intervention.\n* Degenerative disc disease or internal derangement of the temporomandibular joint associated with significant structural degeneration, disc perforation, or requiring surgical intervention.\n* Diagnosed systemic inflammatory or autoimmune conditions that could confound pain assessment (e.g., active rheumatoid arthritis, lupus) unless stable and well controlled.\n* Active cancer or treatment for cancer in the past 6 months.\n* Active infection, wound, or other external trauma to the areas to be treated with the laser.\n* Medical, physical, or other contraindications for, or sensitivity to, light therapy.\n* Pregnant, breast feeding, or planning pregnancy prior to the end of study participation.\n* Serious mental health illness such as dementia or schizophrenia; psychiatric hospitalization in past two years.\n* Developmental disability or cognitive impairment that in the opinion of the investigator would preclude adequate comprehension of the informed consent form and\u002For ability to record the necessary study measurements.\n* Any condition or other variable that in the opinion of the investigator may confound or interfere with the evaluation of the effectiveness of the investigational treatment or otherwise render the subject unable to comply with the requirements of the study protocol.","22 Years","75 Years",{"count":58,"type":20},64,"INTERVENTIONAL",[61],"NA","The purpose of this clinical study is to determine the effectiveness of the Erchonia EVRL, manufactured by Erchonia Corporation (the Company), in providing temporary relief of nociceptive musculoskeletal chronic jaw pain arising from temporomandibular joint (TMJ).",[64,65,28],"TMJ","TMJ Pain","2026-05-14",{"date":38,"type":39},{"date":66,"type":39},{"date":70,"type":20},"2027-12-22",{"name":72,"class":73},"Erchonia Corporation","INDUSTRY",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":59,"phases":85,"briefSummary":86,"conditions":87,"keywords":92,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":105,"leadSponsor":107,"locationsCount":4},"100638786","efficacy-and-safety-of-ha35-gel-nighttime-occlusive-application-for-tmd-pain-100638786","NCT07584642","Efficacy and Safety of HA35 Gel Nighttime Occlusive Application for TMD Pain","A Prospective, Single-Arm, Open-Label Pilot Clinical Study to Evaluate Efficacy and Safety of Nighttime Occlusive 10% 35 kDa Hyaluronan (HA35) Gel for Temporomandibular Joint Disorder (TMD) Pain and Muscle Over-Tension","HA35-TMJ","Inclusion Criteria:\n\n* Age 18-60 years, male or female\n* Clinically diagnosed with TMD with TMJ pain and\u002For muscle over-tension\n* Baseline TMJ pain NRS score ≥3\n* History of bruxism or jaw clenching\n* Ability to complete NRS assessments independently\n* Signed written informed consent\n\nExclusion Criteria:\n\n* TMJ treatment (medication, physical therapy, injection) within 2 weeks\n* Topical analgesic\u002Fanti-inflammatory use within 24 hours\n* Skin damage, allergy, or infection in the TMJ application area\n* Severe systemic disease (cardiovascular, diabetes, autoimmune)\n* Known hypersensitivity to hyaluronan or gel components\n* Pregnant or lactating women","60 Years",{"count":84,"type":20},30,[61],"This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of nighttime occlusive application of 10% high-concentration 35 kDa hyaluronan (HA35) gel in subjects with temporomandibular joint disorder (TMD). Eligible participants will apply HA35 gel to the TMJ area nightly under occlusive conditions for 8-12 hours. The primary objectives are to assess rapid pain relief and muscle over-tension reduction at 60 seconds and 12 hours after application. Safety and local tolerability will be evaluated throughout the study period. This is a minimal-risk, non-pharmacological, non-invasive intervention.",[88,28,89,90,91],"Temporomandibular Joint Disorders","Temporomandibular Joint Pain","Jaw Muscle Over-Tension","Bruxism",[93,94,95,64,28,89,96,97,98,99],"Hyaluronan","35 kDa Hyaluronan","Nighttime Occlusive","Muscle Over-Tension","Analgesia","Non-invasive Treatment","Pilot Clinical Study","NOT_YET_RECRUITING","2026-05-07",{"date":103,"type":39},"2026-05-13",{"date":38,"type":20},{"date":106,"type":20},"2026-07-20",{"name":108,"class":73},"Nakhia Impex LLC",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":116,"minAge":17,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":59,"phases":120,"briefSummary":121,"conditions":122,"keywords":124,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":4},"100615115","effects-of-vagus-nerve-stimulation-on-temporomandibular-disorders-100615115","NCT07288411","Effects of Vagus Nerve Stimulation on Temporomandibular Disorders.","Pilot Study of the Effects of Transcutaneous Non-Invasive Vagus Nerve Stimulation (nVNS) on Symptoms and Brain Mechanisms in Premenopausal Women With Temporomandibular Disorders (TMD)","Inclusion Criteria:\n\n* Ages 18-50\n* Premenopausal menstruating women\\*\n* Participants report or present with at least 1 of 3 cardinal signs of TMD: jaw pain, limited mouth opening, or TMJ noise.\n* Specific screening reveals clinical findings that require standard of care medically-indicated intra-articular procedure for management of symptoms including TMJ pain, intra-articular joint disorder leading to joint locking or limited mouth opening or displacement, and severe degenerative joint disease.\n* Must have a negative urine test for pregnancy\n* Ability to speak the English language fluently due to the standardized assessments involved\n* Right-handed (participants are limited to right-handed individuals to reduce variability in brain lateralization and ensure more consistent, interpretable data).\n\n  * Only premenopausal women are included to control for hormonal variability that may influence the results. Participants will be scheduled during their follicular phase based on self-reported last menstrual period to further reduce hormonal confounds.\n\nExclusion Criteria:\n\n* Medical condition, laboratory finding, or physical exam finding that precludes participation, such as systemic arthritides, juvenile idiopathic arthritis, idiopathic condylar resorption, connective tissue disorders, mandibular osteonecrosis, mandibular and condylar fractures, salivary gland disorders (incl. history of stones or swelling), neoplasms, neurologic\u002Fneuropathic, endocrine, or immune\u002Fautoimmune diseases and congenital or developmental disorders.\n* Pathologic processes found on imaging including neoplasm (Exception: disc displacements and osseous pathology including osteoarthritis\u002Fosteoarthrosis).\n* Radiation treatment to head and neck\n* Prior jaw or open TMJ (including contralateral joint) surgery including plication, chondroplasty, joint replacement, disectomy, and discoplasty.\n* Intra-articular therapies of TMJ being sampled that include arthrocentesis, visco-supplementation, and steroid, platelet-rich plasma\u002Fplatelet-rich fibrin administration within the last 6mo\n* Recent febrile illness within the past 8 weeks that precludes or delays participation by more than 90 days\n* Trauma to jaw in the last 2mo\n* Presence of non-TMD orofacial pain disorders excluding comorbidity of interest (fibromyalgia).\n* Pregnancy or lactation\n* Undergoing or previously undergone bone anabolic or other hormonal therapies for medical needs\n* Unable to participate due to language barrier or mental\u002Fintellectual incompetence\n* Use of antidepressant drugs unless the participants have been on a stable dose for 60 days.\n* Drug and\u002For alcohol abuse in the past year\n* Ongoing dental treatments requiring invasive procedures (e.g. implant placement, tooth extractions, etc.)\n* Recent dental treatments within past two weeks that required sustained mouth opening for more than 20 minutes.\n* Wearing removable or implant supported dentures or fixed orthodontic appliances\n* Unable or unwilling to give informed consent\n* Participation in another clinical study that interferes with participation in this study\n* Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.\n* Presence of non-TMD orofacial pain disorders such as that from periodontal disease and carious lesions.\n* Presence of major psychiatric diagnosis such as schizophrenia, bipolar disorder, post-traumatic stress disorder, obsessive compulsive disorder, or current history of drug or alcohol abuse.\n* Individuals with current regular use of narcotics and\u002For opioids. Use of centrally acting medications that will interfere with neuroimaging testing, such as systemic steroids, opiate analgesics.\n* Smokes\u002FVapes tobacco more than 1\u002F3 pack per day","FEMALE","50 Years",{"count":119,"type":20},10,[61],"The study aims to examine the effects of transcutaneous non-invasive vagus nerve stimulation (nVNS) on symptoms and brain mechanisms in premenopausal women with temporomandibular disorders (TMD). Non-invasive vagus nerve stimulation (nVNS) is the most well researched and possibly the most effective non-invasive neuromodulation treatment for chronic pain conditions that targets the brain-gut-microbiome (BGM) axis.\n\nParticipants will be asked to come in for 2 in-clinic visits, at baseline and post treatment. Participants will also be asked to come in 2x\u002Fweek for 8 consecutive weeks to receive the nVNS treatment. The in-clinic visits will include physical measures, blood draw, saliva sample, and brain MRI. Participants will be asked to collect a stool sample at home and answer online questionnaires regarding, mood, pain, and health behaviors at home, prior to the in-clinic appointments.",[28,123],"Temporomandibular Disorders (TMDs)",[28,125,126,127],"Temporomandibular Disorders","non-invasive vagus nerve stimulation","nVNS","2026-03-13",{"date":130,"type":39},"2026-03-17",{"date":132,"type":20},"2026-06-01",{"date":134,"type":20},"2026-12-31",{"name":136,"class":46},"Arpana Church",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":59,"phases":147,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":156,"locationsCount":47},"100619991","two-treatment-modalities-for-myogenous-temporomandibular-disorders-100619991","NCT07351812","Two Treatment Modalities for Myogenous Temporomandibular Disorders","Evaluation of Two Treatment Modalities for Myogenous Temporomandibular Disorders: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Participants presenting with pain score grading at least 4 out of 10 on NRS.\n* Participants with fully dentate type I occlusion.\n* Patients experiencing no neurological disorders.\n\nExclusion Criteria:\n\n* Patients with arthrogenous TMJ will be excluded by Magnetic Resonance Imagining (MRI)\n* Patients who have clicking or crepitation.\n* Previous history of TMD treatment.\n* History of recent trauma.\n* The presence of systemic diseases (i.e., rheumatoid arthritis, osteoarthritis myologic or arthrological disease).\n* Vascular disease (migraine and hypertension).\n* Participants with uncontrolled systemic disease (diabetes), hematologic or neurologic disorders or inflammatory diseases.\n* Patients who: Underwent trigger point myofascial injection, intramuscular stimulation, or dry needling in the last six months or Underwent neck and\u002For shoulder surgery in the last year.","45 Years",{"count":146,"type":20},32,[61],"Temporomandibular disorder (TMD) is a common condition with multifactorial etiology, including trauma, emotional stress, parafunctional habits, and occlusal discrepancies. TMD may be classified as myogenous, involving the masticatory and cervical muscles, or arthrogenous, affecting the temporomandibular joint structures. Management approaches range from noninvasive to invasive methods. The intraoral stabilization appliance (SA) is a widely used noninvasive treatment, while the ear stent (ES) has recently been introduced for managing myogenous TMD.\n\nAim: This randomized clinical trial aims to compare the effectiveness of SA and ES in the management of myogenous TMD.",[28],"2026-01-12",{"date":152,"type":39},"2026-01-20",{"date":154,"type":39},"2025-01-01",{"date":132,"type":20},{"name":157,"class":46},"Alexandria University",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":59,"phases":168,"briefSummary":169,"conditions":170,"keywords":171,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":47},"100616357","effects-exercises-in-temporomandibular-joint-disorders-on-pain-joint-and-tongue-functions-100616357","NCT07304557","Effects Exercises in Temporomandibular Joint Disorders on Pain, Joint and Tongue Functions","COMPARISON OF THE EFFECTS OF OROFACIAL AND TONGUE EXERCISES APPLIED AS AN ADDITION TO MYOFUNCTIONAL TREATMENT IN TEMPOROMANDIBULAR JOINT DISORDERS ON PAIN, JOINT AND TONGUE FUNCTIONS: A RANDOMIZED CONTROLLED TRIAL","Inclusion Criteria:\n\n* 18 - 65 aged people\n* Not having received physical therapy for the neck or jaw within the past three months.\n* No history of surgical or oncological treatment related to the neck or jaw.\n* Having a diagnosis of temporomandibular disorder according to the RDC\u002FTMD criteria, specifically Group Ia, Group Ib, or Group IIa under Axis I.\n\nExclusion Criteria:\n\n* Individuals who are pregnant or suspected to be pregnant.\n* Individuals with rheumatologic diseases affecting the temporomandibular joint.\n* Individuals with a diagnosed psychiatric disorder.","65 Years",{"count":167,"type":20},48,[61],"The goal of this clinical trial is to learn if orofacial exercises works to treat temporomandibular disorders in adults. It will also learn about the safety of orofacial exercises on temporomandibular disorders. The main questions it aims to answer are:\n\nDoes orofacial exercises improve function of temporomandibular disorders ? Does orofacial exercises decrease pain in temporomandibular disorders?\n\nResearchers will compare orofacial exercises and manual therapy to manual therapy.\n\nParticipants will:\n\nTake manual therapy and orofacial exercises or manual therapy two days in every week for 6 weeks Assessment once every 2 weeks for tests",[28,27],[172,28,173,174],"Orofacial Pain","Tongue Strength","OMES","2025-12-12",{"date":177,"type":39},"2025-12-26",{"date":179,"type":39},"2025-06-19",{"date":181,"type":20},"2026-11-15",{"name":183,"class":46},"Tayfun ISIK",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":59,"phases":194,"briefSummary":195,"conditions":196,"keywords":200,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":47},"100610355","effects-of-core-strengthening-exercises-for-treating-tmd-100610355","NCT07226505","Effects of Core Strengthening Exercises for Treating TMD","A Randomized Trial Analyzing the Effects of Core Strengthening Exercises in Physical Therapy for Treating Temporomandibular Joint Dysfunction","Who Can Participate (Inclusion Criteria):\n\nAdults between 18 and 70 years old.\n\nHave had jaw pain or problems with the jaw joint (TMD) in the last 30 days.\n\nAble and willing to attend at least six physical therapy sessions over three months.\n\nSpeak English or have access to a qualified interpreter.\n\nAble to safely do physical exercises.\n\nWho Cannot Participate (Exclusion Criteria):\n\nRecently had surgery on the jaw, teeth, or spine (within the last 3 months).\n\nRecently had head or neck injuries or certain neurological problems (such as dizziness, double vision, trouble swallowing, or sudden falls).\n\nAre pregnant or become pregnant during the study.\n\nCurrently doing physical therapy for other movement problems that could affect the study.\n\nHave had lower back or pelvic health issues in the last 3 months.\n\nCurrently receiving chemotherapy or radiation for cancer in the head, neck, pelvis, spine, or hip.\n\nWear dentures or cannot safely perform exercises.","80 Years",{"count":193,"type":20},50,[61],"Temporomandibular disorders (TMD) are commonly managed with non-invasive interventions such as manual therapy, therapeutic exercise, relaxation techniques, and patient education. Core strengthening (also known as abdominal strengthening) is a fundamental element of physical therapy that engages deep and superficial trunk musculature to enhance postural control and functional performance. Protocols such as the Shirley Sahrmann progression have demonstrated increased activation of key core stabilizing muscles. Emerging evidence suggests a potential relationship between core stability training and reductions in TMD-related pain, though improvements in functional outcomes remain inconclusive. Biomechanical links between the pelvic floor, spine, and temporomandibular joint further support the rationale for core-focused interventions. Nevertheless, few studies have isolated the effects of core strengthening on TMD symptomatology. This study seeks to determine whether the integration of core stability exercises into TMD management can reduce pain, improve function, and enhance quality of life.",[197,28,198,199],"Temporomandibular Joint Dysfunction","TMJ Internal Derangement","Myofascial Pain",[201,202,203],"Core strengthening","physical therapy","RCT","2025-11-07",{"date":206,"type":39},"2025-11-10",{"date":208,"type":20},"2025-11-01",{"date":210,"type":20},"2027-01-31",{"name":212,"class":46},"Loyola University",{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":4,"eligibilityCriteria":219,"healthyVolunteers":15,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":220,"targetDuration":4,"studyType":59,"phases":222,"briefSummary":223,"conditions":224,"keywords":227,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":4},"100601845","ars-vs-ars-with-arthrocentesis-and-prp-injection-in-ddwr-100601845","NCT07115797","ARS vs ARS With Arthrocentesis and PRP Injection in DDWR","Anterior Repositioning Splint With or Without Arthrocentesis and Platelet-rich Plasma Injection In TMD Patients With Anterior Disc Displacement With Reduction: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients suffering from internal derangement anterior disc displacement\n* Mouth Opening: Limited range of motion or difficulty with full mouth opening\n* Symptoms: Patients who report typical symptoms of TMJ dysfunction, such as pain, discomfort, or clicking sounds in the joint, especially when opening or closing the mouth.\n* Clicking: Audible clicking.\n* Pain: Pain or tenderness around the TMJ, often radiating to the ear, temple, or neck.\n\nExclusion Criteria:\n\n* Blood dyscrasias and Uncontrolled systemic diseases.\n* Rheumatoid Arthritis.\n* Infection in the pre-auricular area.",{"count":221,"type":20},20,[61],"This study will be conducted to assess the effect of anterior repositioning splint and arthrocentesis with platelet-rich plasma injection compared to anterior repositioning splint only, in TMD patients with anterior disc displacement with reduction",[225,28,226],"TMJ Disc Displacement With Reduction","PRP Injection",[228],"ARS-PRP-Arthrocentsis","2025-08-04",{"date":231,"type":39},"2025-08-11",{"date":233,"type":20},"2025-09",{"date":235,"type":20},"2026-10",{"name":237,"class":46},"Cairo University",{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":245,"enrollmentInfo":246,"targetDuration":4,"studyType":59,"phases":247,"briefSummary":248,"conditions":249,"keywords":251,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":4},"100576132","digital-occlusal-analysis-and-enamel-wear-assessment-in-temporomandibular-disorder-patients-treated-with-fully-digital-versus-conventional-stabilization-splints-100576132","NCT06781320","Digital Occlusal Analysis and Enamel Wear Assessment in Temporomandibular Disorder Patients Treated with Fully Digital Versus Conventional Stabilization Splints","Digital Occlusal Analysis and Enamel Wear Assessment in Temporomandibular Disorder Patients Treated with Fully Digital Versus Conventional Stabilization Splints: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. 18-40 years old\n2. complete dentition\n3. intact tooth\n4. no occlusal disorder\n5. stable jaw relation\n6. No ongoing dental therapy, such as orthodontic or prosthodontics treatment.\n\nExclusion Criteria:\n\n1. pregnant\u002Flactating women\n2. temporomandibular joint lesions found on clinical palpation or medical imaging examination\n3. dentoalveolar pathology or ongoing treatment related to TMD\n4. jaw opening less than 3 fingers\n5. patients with occlusal dysfunctions\n6. Patients with severe or moderate periodontitis.\n7. Unable to undergo examination or treatment due to the presence of a psychological or mental disorder.\n8. Severe jaw functional limitations.\n9. Removable dentures or partially dentate patients\n10. Trauma of recent date towards face, head or neck","40 Years",{"count":221,"type":20},[61],"This randomized controlled research aimed to analyse the occlusion and assist the enamel wear before and after using of the stabilization splints produced by the conventional methods with the fully digitally fabricated stabilization splints.\n\nResearch question: Will the fully digital stabilization splint offer significantly better occlusal equilibration and enamel wear compared to the conventional stabilization splint? the primary outcome will be Digital occlusal analysis, and secondary outcome will be enamel wear assessment",[28,250],"Temporomandibular Disorders (TMD)",[252,253,254,255],"temporomandibular disorder, TMD,","Digital occlusal analysis","enamel wear assessment","stabilization splints","2025-01-15",{"date":258,"type":39},"2025-01-17",{"date":260,"type":20},"2025-01-26",{"date":262,"type":20},"2026-07-17",{"name":264,"class":46},"Minia University",{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":245,"enrollmentInfo":272,"targetDuration":4,"studyType":59,"phases":274,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":281,"leadSponsor":283,"locationsCount":4},"100573893","amount-of-intraoral-occlusal-adjustments-in-occlusal-splints-fabricated-using-fully-digital-versus-combined-digital-workflow-in-tmd-patients-100573893","NCT06752200","AMOUNT OF INTRAORAL OCCLUSAL ADJUSTMENTS IN OCCLUSAL SPLINTS FABRICATED USING FULLY DIGITAL VERSUS COMBINED DIGITAL WORKFLOW IN TMD PATIENTS","AMOUNT OF INTRAORAL OCCLUSAL ADJUSTMENTS IN OCCLUSAL SPLINTS FABRICATED USING FULLY DIGITAL VERSUS COMBINED DIGITAL WORKFLOW IN TMD PATIENTS (RANDOMIZED CONTROLLED TRIAL)","Inclusion Criteria:\n\n* (1) 18-40 years old\n\n  (2) Complete dentition.\n\n  (3) Normal jaw opening.\n\n  (4) Intact teeth.\n\n  (5) No occlusal disorder; stable jaw relation.\n\n  (6) No ongoing dental therapy, such as orthodontic or prosthodontic treatment.\n\n  (7) TMD patients with more than one of following symptoms or signs: myofascial pain and \u002For pain in the TMJ, myofascial pain and\u002For pain in the TMJ on palpation, muscles tenderness, headache or earache.\n\n  (8) Patients who had unsuccessfully undergone splint therapy or other TMD treatments in the past were not excluded.\n\nExclusion Criteria:\n\n* (1) Patients with an unstable occlusion\n\n  (2) Patients with systemic diseases and comorbidities\n\n  (3) Temporomandibular joint lesions found on clinical palpation or medical imaging examination\n\n  (4) Jaw opening less than 3 fingers\n\n  (5) Patients with occlusal dysfunctions\n\n  (6) Patients with severe or moderate periodontitis\n\n  (7) Unable to undergo examination or treatment due to the presence of a psychological or mental disorder.",{"count":273,"type":20},26,[61],"Each eligible patient will be randomly into one of two groups:\n\ngroup A: Occlusal splints fabricated using a fully digital workflow including the use of a jaw tracking device.\n\ngroup B: Occlusal splints fabricated using a combined digital workflow using a conventional bite technique.\n\nThe intervention involves the fabrication of 3D printing of occlusal splint with fully digitalization technique by the aid of Jaw Tracing Device (Zebis JMA, Germany). The acquisition and scanning of the patients are done by using an intra oral scanner (Medit i700, South Korea) and designing them using a designing software (Exocad, USA). This device will be printed with a 3D printer (Anycubic, China) utilizing printable resin material with codes for which the outcome assessor is kept totally unaware.\n\nFor the comparator group, upper and lower arches will be scanned intraorally. The bite will be registered at centric by using rubber base bite registration material after patient deprogramming with Lucia jig. Then the bite will be scanned.\n\nThe splint will be designed and printed in the same workflow as the intervention group.\n\nThe amount of intraoral occlusal adjustments (represented by the 3-dimension volumetric changes) will be measured by Medit link by millimeters before the splint insertion.",[28],"2024-12-21",{"date":279,"type":39},"2024-12-30",{"date":154,"type":20},{"date":282,"type":20},"2025-07",{"name":237,"class":46},{"id":285,"slug":286,"hasResults":11,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":4,"eligibilityCriteria":290,"healthyVolunteers":15,"sex":116,"minAge":291,"maxAge":245,"enrollmentInfo":292,"targetDuration":4,"studyType":59,"phases":294,"briefSummary":295,"conditions":296,"keywords":4,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":4},"100559317","impact-of-breather-device-on-ventilatory-effort-in-patient-with-mtmd-100559317","NCT06562556","Impact of Breather Device on Ventilatory Effort in Patient With MTMD","Impact of Breather Device on Ventilatory Effort in Patient With Myogenic Temporomandibular Joint Disorders","Inclusion Criteria:\n\n* Inclusion criteria:\n\n  1. Sixty female patients who fulfilled the RDC\u002FTMD criteria of myofascial pain and the presence of parafunctional habits, such as bruxism, teeth grinding, mouth breathing, and lip biting.\n  2. The Patient's ages will range from 20 to 40 years.\n\n  4- Patients with a waist-height ratio measuring less than 0.5. 5- Patients with a craniocervical angle measuring from 30 to 50° (Bo-Been et al., 2016).\n\n  6- the patients have points from 20-65 on the Fonseca Anamnestic Index (FAI) 7- the patients have the willingness to participate in this study. 8- All patients will sign a consent form before starting the study.\n\nExclusion Criteria:\n\nPatients will meet one of the following criteria will be excluded from the study:\n\n1. patients undergo surgery or trauma in the orofacial region; systemic or degenerative odontologic disease.\n2. The patient has Surgery or trauma in the spine and upper limb.\n3. Patients suffering from rheumatic diseases and other severe comorbidities.\n4. Patients suffering from any respiratory diseases (restrictive, obstructive, suppurative diseases).\n5. Patients suffering from neurological disorders affecting respiratory muscles or any muscular dystrophies","20 Years",{"count":293,"type":20},60,[61],"PURPOSE:\n\nThe purpose of the study is to investigate the effect of the breather device on ventilatory effort and in patients with myogenic temporomandibular joint disorders To investigate the effect of the breather device on craniocervical angle and oral Health quality in patients with myogenic temporomandibular joint disorders\n\nBACKGROUND:\n\nTMDs affect between 5% and 12% of the population which is presented by symptoms such as pain in the masticatory muscles with a decrease in the mandible's movement. Other symptoms include ear pain, headache, joint sounds with mandible movement, and\u002For functional limitations in the jaw like swallowing difficulties commonly found. (Hatice ., et al 2023) Increased prevalence of TMDs has been linked to physical, psychological, and hormonal changes throughout pubertal development. The age predisposes to the development of masticatory system problems in students since symptoms peak between the ages of 20 and 40 years. Women of breeding age are the majority of TMD sufferers. The prevalence of TMD increases globally throughout adolescence and may vary from 7% to 30% of the population (Loster ., et al2017). Alterations of body posture, upper thoracic breathing pattern, and mouth breathing constitute causal factors for the overuse of the accessory inspiratory musculature, which generates hyperactivity and consequently, alteration of head position, and mandibular traction. (Kim., et al 2017)\n\nHYPOTHESES:\n\nThere will be no significant effect of the breather device on ventilatory effort in patients with myogenic temporomandibular joint disorders.\n\nThere will be no significant effect of the breather device on a craniocervical angle and oral Health quality in patients with myogenic temporomandibular joint disorders RESEARCH QUESTION: Does the breather device can improve ventilatory effort in patients with myogenic temporomandibular joint disorders?.",[28],"2024-08-21",{"date":299,"type":39},"2024-08-23",{"date":301,"type":20},"2024-09",{"date":303,"type":20},"2025-05",{"name":237,"class":46}]