[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tmj-disc-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tmj-disc-disorder":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,75,98,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100638314","arthroscopic-lysis-and-lavage-with-and-without-intra-articular-injection-of-hyaluronic-acid-in-patients-with-ddwor-in-tmj-100638314",false,"NCT07614932","Arthroscopic Lysis and Lavage With and Without Intra-articular Injection of Hyaluronic Acid in Patients With DDwoR in TMJ","Assessment of Arthroscopic Lysis and Lavage With And Without Intra-Articular Injection of Hyaluronic Acid in the Management of Patients With Disc Displacement Without Reduction: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Adults above 18 years old.\n2. Diagnosis of Disc Displacement Without Reduction (DDWOR) with limited mouth : eitherunilateral or bilateral based on the DC\u002FTMD and confirmed with MRI\n3. History of unsuccessful conservative treatment such as physical therapy, occlusal splints,or medications (e.g., NSAIDs, muscle relaxants) for at least 3 months.\n4. Patients must sign the informed consent, understand the study procedures and potential risks, accept to volunteer in the study and be available to attend the follow-up visits.\n\nExclusion Criteria:\n\n1. Degenerative Temporomandibular Joint Disorders (e.g., osteoarthritis, rheumatoid arthritis).\n2. History of prior TMJ surgery (e.g., joint replacement, previous arthroscopy).\n3. Severe Systemic Conditions (e.g., cardiovascular disease, autoimmune disorders, uncontrolled diabetes).\n4. Active joint infection, acute inflammation, or presence of any condition that may increase the risk of complications from arthroscopic surgery or injections (e.g., local infection, uncontrolled bleeding disorders).\n5. Pregnancy or Breastfeeding.\n6. Patients with severe Psychological Conditions (e.g., severe depression, psychosis, myofascial pain disorder) or dental related pain will be identified at the initial assessment and referred for appropriate psychological, behavioural, or dental management prior to inclusion in the study.","ALL","18 Years",{"count":19,"type":20},52,"ESTIMATED","INTERVENTIONAL",[23],"NA","The study aims to assess the outcomes of arthroscopic lysis and lavage procedure with and without single intra-articular injection of hyaluronic acid in managing patients with anterior disc displacement without reduction.\n\nThe research question that this study will answer is:\n\nDoes arthroscopic lysis and lavage combined with hyaluronic acid provide better outcomes in terms of pain intensity and maximum mouth opening compared to arthroscopic lysis and lavage alone?",[26,27,28,29,30],"TMJ Disc Disorder","Temporomandibular Joint Disc Displacement, Without Reduction","TMD\u002FOrofacial Pain","Temporomandibular Disorder","TMJ Closed Lock",[32,33,34],"TMJ arthroscopy","TMJ arthroscopic lysis and lavage","Anterior Disc Displacement without reduction","NOT_YET_RECRUITING","2026-05-22",{"date":38,"type":39},"2026-05-29","ACTUAL",{"date":41,"type":20},"2026-05",{"date":43,"type":20},"2027-01",{"name":45,"class":46},"Cairo University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100602912","a-comparison-of-the-outcomes-following-intra-articular-dextrose-5-injection-versus-arthrocentesis-in-patients-with-anterior-disc-displacement-with-reduction-of-the-tomporomandibular-joint-100602912","NCT07129681","a Comparison of the Outcomes Following Intra-articular Dextrose 5% Injection Versus Arthrocentesis in Patients With Anterior Disc Displacement With Reduction of the Tomporomandibular Joint","A Comparison of the Outcomes Following Intra-articular Dextrose 5% Injection Versus Arthrocentesis in Patients With Anterior Disc Displacement With Reduction of the Temporomandibular Joint.","Inclusion Criteria:\n\nInclusion Criteria\n\n-Patients diagnosed with anterior disc displacement with reduction of TMJ with pain,limited mouth opening and\n\npainful clicking who underwent conservative therapy with physiotherapy but failed to receive any relief after 3\n\nmonths of conservative therapy.\n\n* Age ranges from 18 to 50 years.\n* Patients with adequate follow up duration for outcome assessment.\n\nExclusion Criteria:\n\n* Patients having pain or reduced mouth opening due to fracture of the condyle.\n* patients having any degenerative changes in the TMJ.\n* patients having other systemic diseases such as polyarthritis.\n* patients having any neurological disorders.\n* Pregnant and lactating women.",true,"50 Years",{"count":58,"type":20},42,[23],"The Aim of this study is to evaluate the efficacy of intra-articular Dextrose injection with\n\nconcentration 5% in superior joint space of TMJ in comparison to arthrocentesis in patients with\n\nanterior disc displacement with reduction of TMJ who did not respond favorably to conservative\n\ntreatment and to compare and infer which among the two procedures is more satisfactory,\n\nwhether dextrose 5% injection or Arthrocentesis.",[26],[63,64,65,66],"TMJ","Disc displacement with reduction","Dextrose 5%","Arthrocentesis","2025-08-15",{"date":69,"type":39},"2025-08-19",{"date":71,"type":20},"2025-10-01",{"date":73,"type":20},"2026-12-01",{"name":45,"class":46},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":4},"100601200","phase-2-therapeutic-effect-of-microfragmented-adipose-tissue-lipogems-injection-on-maximum-interincisal-opening-versus-injectable-platelet-rich-plasma-prp-for-the-treatment-of-anterior-disc-displacement-with-reduction--a-randomized-clinical-trial-100601200","NCT07107399","Therapeutic Effect of Microfragmented Adipose Tissue (Lipogems) Injection on Maximum Interincisal Opening Versus Injectable Platelet-rich Plasma (PRP) for the Treatment of Anterior Disc Displacement With Reduction : A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients should have one or more signs and symptoms of these\n\n  * Disc displacement assessed by clinical examination and MRI\n  * Symptoms: Patients who report typical symptoms of TMJ dysfunction, such as pain, discomfort, or clicking sounds in the joint, especially when opening or closing the mouth.\n  * Mouth Opening: Limited range of motion or difficulty with full mouth opening .\n  * Clicking: Audible clicking.\n  * Pain: Pain or tenderness around the TMJ, often radiating to the ear, temple, or neck.\n\nExclusion Criteria:\n\n* Previously diagnosed hematological and neurological conditions;\n\n  * Previous malignant head and neck neoplasms;\n  * Contraindication to fat harvesting.\n  * Uncooperative patients.\n  * connective tissue disorders.\n  * a pacemaker or any other metal prosthesis in the body.",{"count":82,"type":20},16,[84,85],"PHASE2","PHASE3","this procedure is to remove inflammatory mediators, reduce friction, stimulate the production of new synovial fluid, eliminate suction-cup effect.\n\nThe purpose of this study was to evaluate the hypothesis that TMJ arthrocentesis with injection of autologous micro fragmented adipose tissue leads to better clinical outcomes in terms of reducing pain and improving function compared with arthrocentesis and injection of platelets rich plasma (prp)in patients with TMJ internal derangement and osteoarthritis.\n\nPreliminary results of this clinical trial show that the injection of micro fragmented adipose tissue can significantly improve outcomes of pain and function compared with the standard treatment and encourage to pursue research on this topic.\n\nFurther studies with a longer follow-up time are needed to evaluate the clinical stability of the achieved improvement in pain and function.\n\nFor this reason, this protocol has been designed with the aim to investigate whether injection in the TMJ of micro fragmented fat tissue can achieve the same improvements of pain and function, compare this technique with prp injection.",[26],[89],"lipogem","2025-07-30",{"date":92,"type":39},"2025-08-06",{"date":94,"type":20},"2025-08-05",{"date":96,"type":20},"2025-12-01",{"name":45,"class":46},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":21,"phases":106,"briefSummary":107,"conditions":108,"keywords":109,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":4},"100582109","phase-2-therapeutic-effect-of-proliferative-therapy-prolotherapy-on-pain-using-injectable-hypertonic-dextrose-25-versus-injectable-dextrose-10-in-retrodiscal-tissues-in-patients-with-anterior-disc-displacement-with-reduction-a-randomized-clinical-trial--100582109","NCT06859034","Therapeutic Effect of Proliferative Therapy (Prolotherapy) on Pain Using Injectable Hypertonic Dextrose 25% Versus Injectable Dextrose 10% in Retrodiscal Tissues in Patients With Anterior Disc Displacement With Reduction: A Randomized Clinical Trial .","Exclusion criteria:\n\n* The clinical or radiographic signs of disc displacement without reduction .\n* A history of allergic reactions to any components of the injectable solution.\n* Blood dyscrasias and systemtic diseases .\n* Previous surgery of the affected joint.\n* Infection in pre-auricular area\n\nInclusion criteria:\n\nPatients should have one or more signs and symptoms of these\n\n* Symptoms: Patients who report typical symptoms of TMJ dysfunction, such as pain, discomfort, or clicking sounds in the joint, especially when opening or closing the mouth.\n* Mouth Opening: Limited range of motion or difficulty with full mouth opening .\n* Clicking: Audible clicking.\n* Pain: Pain or tenderness around the TMJ, often radiating to the ear, temple, or neck",{"count":105,"type":20},24,[84,85],"prolotherapy is an injection-based treatment method used to alleviate pain, particularly musculoskeletal pain associated with chronic ligament and tendon injuries. The process involves the injection of a solution, typically containing dextrose (a sugar), saline, or other irritants, into the affected tissues. Prolotherapy is believed to stimulate healing by causing a mild inflammatory response that promotes the regeneration of ligaments, tendons, and other connective tissues. This review explores the existing literature on the therapeutic effects of prolotherapy for pain management.",[26],[110],"retrodiscal tissues","2025-03-02",{"date":113,"type":39},"2025-03-05",{"date":115,"type":20},"2025-03-03",{"date":117,"type":20},"2025-10",{"name":45,"class":46},{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":21,"phases":129,"briefSummary":130,"conditions":131,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":47},"100553571","evaluation-of-temporomandibular-joint-condition-post-longstanding-mouth-opening-by-rubber-dam-100553571","NCT06487819","Evaluation of Temporomandibular Joint Condition Post Longstanding Mouth Opening by Rubber Dam","Evaluation of Temporomandibular Joint Condition Post Longstanding Mouth Opening by Rubber Dam (A Clinical and Radiographic Study)","Inclusion Criteria:\n\n1. Patients aged from 18 - 40 years old of both sexes.\n2. No evidence of bad habits that affect occlusion like bruxism or clenching.\n3. Patient with normal occlusion.\n4. Patient free of any signs and symptoms of TMD and myofascial pain.\n5. Normal range of TMJ movements.\n6. Normal biting force.\n\nExclusion Criteria:\n\n1. Patient with systemic or local diseases that can affect TMJ like osteoarthritis, rheumatoid arthritis, or systemic lupus erythema.\n2. Patient with trismus.\n3. Patient with Recurrent dislocation of TMJ.\n4. Swelling affects mouth opening.\n5. Patient came with TMJ ankylosis.","40 Years",{"count":128,"type":20},300,[23],"This Clinical and radiographic study will be designed to evaluate the temporomandibular joint condition post longstanding mouth opening during dental procedure using rubber dam. primary outcome : preoperative and postoperative assessment of interincisal distance , occlusal biting force , visual analogue scale , lateral excursion movement and Magnetic resonance imaging (MRI).\n\nSecondary outcome: investigator will try to answer the question of what is the best duration of time could the dentist use rubber dam isolation in dental procedures without harmful effect on TMJ and its supporting structures?",[132,26,133,134],"Temporomandibular Joint Condition Post Longstanding Mouth Opening During Dental Procedure Using Rubber Dam","Osteoarthritis","Myofacial Pain","2025-02-14",{"date":137,"type":39},"2025-02-18",{"date":139,"type":20},"2025-08-10",{"date":141,"type":20},"2026-07-01",{"name":143,"class":46},"Al-Azhar University"]