[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tobacco-cessation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tobacco-cessation":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,40,66,90,121,146,169],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100428916","adaptation-and-evaluation-of-a-tobacco-cessation-program-an-integrated-mhealth-approach-100428916",false,"NCT04865276","Adaptation and Evaluation of a Tobacco Cessation Program: An Integrated mHealth Approach","Inclusion Criteria:\n\n* 18 years of age\n* Current tobacco use\n* Willingness to quit tobacco use\n* resident in the town assigned to intervention or control\n\nExclusion Criteria:\n\n* None",true,"FEMALE","18 Years",{"count":19,"type":20},431,"ESTIMATED","INTERVENTIONAL",[23],"NA","We developed and established the efficacy of a theory-based, culturally- and gender-relevant Community Health Worker (CHW) intervention for low-income Brazilian women that augments the tobacco cessation program offered through the public health system. This study seeks to adapt this CHW-delivered tobacco cessation program to be integrated with mHealth support through mobile devices (App). During phase I we will make the adaptations and determine feasibility of a CHW-delivered intervention that is integrated with a mHealth tobacco cessation application (interactive App for participants and tracking system for CHWs) through formative assessments among all involved stakeholders, pretesting, and pilot testing of the intervention. In phase II we will assess the effectiveness of the integrated CHW-mHealth tobacco cessation intervention through a group randomized trial with towns as the unit of randomization (8 towns, N=344). The comparison group will consist of a home visit by a CHW during which the participant is scheduled to attend the tobacco cessation program at the neighborhood public health clinic). We hypothesize that at 6-months, women smokers who receive the integrated CHW-mHealth intervention will have significantly higher 7-day point prevalence abstinence (defined as no cigarettes in the past 7 days) than women smokers in the control condition. If shown to be effective, this approach could be utilized as a model for a population-based intervention in low-resource settings, including rural and disadvantaged women in the U.S.",[26],"Tobacco Cessation","RECRUITING","2026-06-16",{"date":30,"type":31},"2026-06-18","ACTUAL",{"date":33,"type":31},"2022-09-01",{"date":35,"type":20},"2027-08-31",{"name":37,"class":38},"University of Alabama at Birmingham","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":46,"minAge":17,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":65},"100562915","phase-2-neural-mechanisms-connecting-deficient-sleep-and-smoking-relapse-100562915","NCT06609369","Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse","Inclusion Criteria:\n\n* English literate\n* report heavy tobacco use (including nicotine e-cigarettes) for \\>6 months\n* meet biochemical cut off for recent cigarette smoking or e-cigarette use\n* optimal body mass index\n\nExclusion Criteria:\n\n* currently enrolled in other treatments\n* neuropsychiatric exclusions that could interfere with study participation, increase risk of adverse events, and\u002For induce deficient sleep\n* medical contraindications for fMRI, varenicline, and\u002For behavioral treatment\n* factors that cause deficient sleep and for which behavioral treatment has less benefit\n* women who are pregnant or nursing","ALL","65 Years",{"count":49,"type":20},114,[51],"PHASE2","The study aims to investigate whether behavioral interventions promote cessation in adult smokers by ameliorating negative emotions and improving self-control and identify the neural markers of these effects.",[54,26,55],"Tobacco Use","Insomnia","2026-06-04",{"date":58,"type":31},"2026-06-05",{"date":60,"type":31},"2025-04-21",{"date":62,"type":20},"2029-06",{"name":64,"class":38},"Yale University",2,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":15,"sex":46,"minAge":17,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":21,"phases":74,"briefSummary":75,"conditions":76,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":4},"100640657","community-gateway-to-health-study-100640657","NCT07592793","Community Gateway to Health Study","Study participants include community health center and community partner staff participating in surveys and interviews about the implementation of the intervention.\n\nInclusion Criteria:\n\n* Community health center staff or community partners\n* Age 18 or older\n\nExclusion Criteria:\n\n* Under 18\n\nPatients will not be individually recruited for the study because the intervention is being offered as part of routine care.",{"count":73,"type":20},100,[23],"The goal of this study is to evaluate the impact of a multi-level intervention on cancer prevention and social determinants of health outcomes. This partnership between academic and community-based researchers aims to link community health centers and communities in ways that maximize both civic engagement and participation in cancer control care. The system-level intervention consists of two components: (1) provision of community health center systems-level tools for cancer screening (breast, cervical, colorectal) and tobacco cessation treatment gaps; and (2) digital access screening and navigation. These interventions will be delivered via usual care.",[77,78,79,26],"Breast Cancer Screening","Cervical Cancer Screening","Colon Cancer Screening","NOT_YET_RECRUITING","2026-05-11",{"date":83,"type":31},"2026-05-18",{"date":85,"type":20},"2026-06",{"date":87,"type":20},"2029-07",{"name":89,"class":38},"Harvard School of Public Health (HSPH)",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":46,"minAge":17,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":21,"phases":100,"briefSummary":101,"conditions":102,"keywords":106,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":39},"100600482","health-warnings-and-counseling-for-smoking-cessation-100600482","NCT07098065","Health Warnings and Counseling for Smoking Cessation","Health Warnings and Counseling at Primary Health Care Centers for Smoking Cessation and NCD Prevention: A Randomized Controlled Trial in Bangladesh and Pakistan","Inclusion Criteria:\n\n* Adults aged 18 and older\n* Adults (≥18 years) who are current smokers (daily or occasional) and regular visitors to participating pharmacies.\n* Permanent resident of the study area,\n* Access to mobile phone\n* Able to operate smartphone or tablet.\n\nExclusion Criteria:\n\n* Without pregnancy and lactation\n* Without cognitive or psychiatric conditions,\n* Without severe medical conditions,\n* Participation in other studies, and inability to consent.","90 Years",{"count":99,"type":20},3400,[23],"Tobacco use remains persistently high across South Asia, despite numerous public health efforts, and continues to significantly contribute to the burden of non-communicable diseases (NCDs) such as cardiovascular disease, hypertension, diabetes, and stroke. Community pharmacists-widely accessible and trusted within their communities-are an underutilized resource for delivering public health interventions. Graphic health warnings (GHWs), recommended by the World Health Organization (WHO), have been shown to promote smoking cessation, but are rarely paired with personalized counseling by healthcare providers.\n\nThis study aims to evaluate both the effectiveness and cost-effectiveness of integrating GHWs with pharmacist-led personalized counseling at primary healthcare pharmacies in Bangladesh and Pakistan. A cluster randomized controlled trial (RCT) will be conducted, enrolling 3,240 adult participants in Bangladesh and \\~160 participants in Pakistan (for feasibility study) from community pharmacies. Participants will be randomly assigned to one of three groups: (1) GHW only (distribution of printed booklets); (2) GHW + counseling (pharmacist-led counselling sessions based on booklets at baseline and six months, with monthly SMS reminders); or (3) standard care (usual pharmacy services with no additional materials).\n\nThe intervention includes twice-yearly counseling sessions-delivered both in-person and digitally-supported by educational booklets and leaflets. The primary outcome is self-reported 7-day point prevalence abstinence at 12 months (validated where feasible). Secondary outcomes include reduction in cigarettes per day, quit attempts, readiness to quit, awareness of tobacco harms, diet and physical activity scores, quality of life, blood pressure control among hypertensive participants, and cost-effectiveness. Feasibility outcomes in Pakistan include recruitment rate, participant retention, intervention fidelity and acceptability. Bayesian statistical models will be used to assess efficacy, and economic evaluations will determine the cost-effectiveness of the interventions. The findings aim to inform scalable public health strategies for tobacco control and NCD prevention in resource-limited settings.",[26,103,104,105],"Health Warning Label","Hypertension","Non Communicable Chronic Diseases",[107,108,109,110,111],"Tobacco cessation","Graphic health warnings (GHWs)","Non-communicable diseases (NCDs)","Cluster randomized controlled trial (RCT)","Pharmacist-led counseling","2026-04-13",{"date":114,"type":31},"2026-04-14",{"date":116,"type":31},"2026-02-01",{"date":118,"type":20},"2027-04-30",{"name":120,"class":38},"Hitotsubashi University",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":15,"sex":46,"minAge":17,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":21,"phases":130,"briefSummary":131,"conditions":132,"keywords":133,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":4},"100626129","a-web-based-text-messaging-for-tobacco-cessation-in-rural-mississippi-100626129","NCT07431619","A Web-Based Text Messaging for Tobacco Cessation in Rural Mississippi","A Randomized Trial of a Web-Based Text Messaging for Tobacco Cessation in Rural Mississippi","Inclusion Criteria:\n\n* ≥18 years-old\n* resident of rural Mississippi (verified by a ZIP code)\n* not planning to move out of Mississippi during the next 6 months\n* own a personal cellphone with an unlimited texting plan\n* having the intention to quit tobacco and having made at least 1 quit attempt in the past 6 months\n* smokes ≥5 cigarettes per day during the past 6 months (for the cigarette smoking condition)\n* uses SLT ≥3 times per day during the past 6 months (for the SLT condition)\n* concurrent use of cigarettes and SLT on ≥15 days monthly during the past 6 months (for the dual use condition).\n\nExclusion Criteria:\n\n* a self-report of being diagnosed with or taking medications for severe mental illness\n* refusal to provide informed consent\n* having no intention to quit tobacco\n* currently using electronic cigarettes or pharmacological medications for tobacco cessation\n* currently participating in another RCT.",{"count":129,"type":20},150,[23],"Cigarette smoking prevalence has decreased to \\~12% in 2022; however, over 40 million U.S. adults were current cigarette smokers in the same year. Rural-urban disparities in tobacco use are persistent, with higher tobacco use and lower cessation in rural areas. Less research has been dedicated to addressing rural-urban tobacco use disparities, perhaps due to logistics, difficulty recruiting and following participants from rural areas, and challenges with conducting clinic-based interventions. Mississippi is one of the states with higher rurality, as 79% of Mississippi counties are classified as rural. Additionally, Mississippi has a higher prevalence of tobacco use and lower cessation rates compared with the national average. Moreover, Mississippi is one of the few states that did not expand Medicaid, which covers comprehensive tobacco cessation services. This may add to the persistent disparity in tobacco use and cessation between rural and urban Mississippians. To overcome these challenges, the investigators propose a randomized clinical trial to test the effectiveness of theory-driven text messaging for tobacco cessation in rural Mississippi among users of cigarettes, smokeless tobacco (SLT), and dual users of cigarettes and SLT. Specifically, this proposal has the following specific aims: (1) To conduct a two-arm, randomized, clinical trial (RCT) of a web-based, text messaging approach for tobacco cessation among cigarette smokers, SLT users and dual users from rural Mississippi; (2) To assess the effectiveness of a web-based, text messaging intervention on tobacco cessation among cigarette smokers, SLT users and dual users; and (3) To identify barriers to and facilitators of tobacco cessation using ecological momentary assessment (EMA). To achieve these aims, a sample of 150 tobacco users (50 cigarette smokers, 50 SLT users, 50 dual users) who intend to quit and have made ≥1 quit attempt in the past 6 months will be recruited via a web-based, crowdsourcing platform (ResearchMatch.org). ResearchMatch.org is a large crowdsourcing platform that facilitates recruitment of a desired research sample from an online panel. Eligible participants will be randomized to intervention and control arms and will be asked to set up a quit date within the first 4 weeks post-intervention. Participants in the intervention arm will receive up to 3 motivational text messages daily during the first 4 weeks, and up to 2 daily during the last 2 weeks. The same frequency will be followed for the control group, but they will receive non-specific text messages. Participants will also receive a daily, midday text message during weeks 1-10 post-intervention to document the barriers and facilitators of tobacco cessation using EMA approach. After week 10 and to the end of 6 months post-intervention, the frequency of EMA texts will be reduced to once per week. Two-way text messaging will be facilitated via a web-based service called Mosio. The investigators will assess prolonged and 7-day point prevalence abstinence at 6 weeks, 3 months, and 6 months post-intervention. This project represents an attempt to test a simple and innovative approach to reducing rural-urban tobacco use disparities and overall tobacco-related morbidity and mortality. The findings can facilitate applying for extramural funding for a larger trial.",[26],[134,135,136],"Rural","Text messaging","Smokeless tobacco","2026-02-18",{"date":139,"type":31},"2026-02-24",{"date":141,"type":20},"2026-12-01",{"date":143,"type":20},"2027-11-30",{"name":145,"class":38},"University of Mississippi Medical Center",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":46,"minAge":17,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":21,"phases":153,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":39},"100604339","phase-4-extended-intervention-for-tobacco-use-exit-for-people-experiencing-homelessness-100604339","NCT07148232","Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness","Inclusion Criteria:\n\n1. Age 18 years or older\n2. Able to understand study procedures and to comply with them for the entire length of the study.\n3. Ability of individual to understand a written informed consent document, and the willingness to sign it.\n4. Staying at the recruitment site and meeting criteria for homelessness as defined by the Homeless Emergency and Rapid Transition to Housing Act.\n5. Current smoking (smoking at least 5 cigarettes per day (cpd), verified via expired carbon monoxide (CO) \\>= 8 ppm using Micro+pro Smokerlyzer).\n6. Having an intention to quit smoking within the next six months.\n7. English speaking.\n\nExclusion Criteria:\n\n1. Contraindication to any study-related procedure or assessment.\n2. Reasons that preclude the use of nicotine replacement therapy (NRT) (e.g., pregnancy or myocardial infarction in the past two weeks).",{"count":129,"type":20},[154],"PHASE4","This study is investigating tobacco use and providing tobacco treatment among people experiencing homelessness in California, in San Francisco and Los Angeles.",[26,157,54,158,159],"Tobacco Abstinence","Tobacco Use Cessation","Tobacco Dependence","2025-11-19",{"date":162,"type":31},"2025-11-21",{"date":164,"type":31},"2025-11-14",{"date":166,"type":20},"2027-06-30",{"name":168,"class":38},"University of California, San Francisco",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":15,"sex":46,"minAge":17,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":21,"phases":178,"briefSummary":180,"conditions":181,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":39},"100400959","phase-2-a-stepped-care-approach-to-treating-tobacco-use-in-rural-veterans-100400959","NCT04501016","A Stepped Care Approach to Treating Tobacco Use in Rural Veterans","Stepped Care","Inclusion Criteria:\n\n* Use tobacco (cigarettes, smokeless tobacco, pipes, cigars, hookah) on a daily basis\n* Be willing to make a quit attempt in the next 30 days\n* Able to provide informed consent\n* Have access to a telephone\n* Have a stable residence,\n\nExclusion Criteria:\n\n* Planning to move within the next 6 months\n* Terminal illness\n* Unstable psychiatric disorder (e.g., acute psychosis)","99 Years",{"count":73,"type":20},[51,179],"PHASE3","Tobacco use remains prevalent among Veterans. Although effective smoking cessation interventions exist, long-term term quit rates remain sub-optimal. The project will investigate the feasibility of a stepped care approach to treating tobacco use that includes enhancements based on initial response to treatment to augment the investigators' existing tailored tobacco treatment intervention.",[26],"2020-08-02",{"date":184,"type":31},"2020-08-06",{"date":186,"type":20},"2020-09",{"date":188,"type":20},"2023-09",{"name":190,"class":191},"Iowa City Veterans Affairs Medical Center","FED"]