[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tobacco-related-carcinoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tobacco-related-carcinoma":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,42,66,86,111,134,157,184,204,224,244,264,283],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100637303","phase-1-comparative-evaluation-of-nicotine-analogs-100637303",false,"NCT07585006","Comparative Evaluation of Nicotine Analogs","CENA","Inclusion Criteria:\n\n* Aged 21 years or older\n* Current adult EC user for at least the past 3 months (confirmed by cotinine testing strip)\n* Willing and able to provide informed consent\n* Willing to abstain from using any nicotine, tobacco, or marijuana products for 12 or more hours prior to the three lab visits\n* Able to read, write, and speak English\n\nExclusion Criteria:\n\n* Currently attempting to quit nicotine or tobacco products\n* Use of other tobacco or nicotine products \\> 10 days in the past month\n* Have had a recent cardiac event or distress (defined as occurring within the previous 3 months)\n* Have had a recent serious lung disease or infection (e.g., tuberculosis, cystic fibrosis, asthma, or lung cancer) (defined as occurring in the previous 30 days)\n* Currently pregnant, planning to become pregnant, or breastfeeding (verified with urine pregnancy test)",true,"ALL","21 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","This phase I trial compares electronic cigarette (EC) user preferences and smoking behaviors of nicotine analogs to nicotine to improve the understanding of nicotine analog addictiveness. Over the last ten years, EC use has become a major concern due to its increased use among adolescents and young adults. Though progress has been made in regulating nicotine containing products, some companies have shifted toward producing products containing nicotine analogs. ECs are battery-powered electronic devices designed to atomize a nicotine (the poisonous chemical found in tobacco)-containing liquid solution for inhalation in a manner that simulates smoking a tobacco cigarette. When nicotine enters the body, it causes an increased heart rate and use of oxygen by the heart, and a sense of well-being and relaxation. Nicotine analogs are compounds that are similar to nicotine in their chemical structure. Some nicotine analogs have been shown to have nicotine-like effects; however, more research is needed to prove they function similarly to nicotine and\u002For have similar effects. Comparing EC user preferences and smoking behaviors of nicotine analogs to nicotine may help improve the understanding of nicotine analog addictiveness.\n\nAdditionally, combustible cigarette smoking is well-known to have deleterious effects on cardiovascular health. High blood pressure is one of the major health consequences of cigarette smoking and can increase the risk of hypertension, heart attack, and stroke. Although ECs have been marketed as a less harmful alternative to cigarette smoking, clinical trials have shown that vaping ECs can also lead to acute increases in blood pressure and heart rate. Nicotine can alter vascular reactivity by promoting the release of vasoconstrictors and suppressing the production of vasodilators. No research has examined how the synthetic nicotine in ECs affects hemodynamics, vascular health, and endothelial function. Assessing acute cardiovascular responses to nicotine analogs is therefore critical to enhancing our understanding of the potential cardiovascular risks associated with vaping ECs containing synthetic nicotine.",[27,28],"Tobacco-Related Carcinoma","Addiction","RECRUITING","2026-06-23",{"date":32,"type":33},"2026-06-26","ACTUAL",{"date":35,"type":33},"2026-05-29",{"date":37,"type":21},"2026-12-31",{"name":39,"class":40},"Ohio State University Comprehensive Cancer Center","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":16,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":65},"100636848","a-novel-mobile-health-intervention-for-improving-tobacco-cessation-among-young-adults-100636848","NCT07571018","A Novel Mobile Health Intervention for Improving Tobacco Cessation Among Young Adults","Development and Pilot Evaluation of a Novel Mobile Health Intervention for Young Adult Tobacco Cessation","Inclusion Criteria:\n\n* USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-identify being between 18 and 30 years of age\n* USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must be a United States (US) resident, with a US mailing address\n* USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report use of any (non-therapeutic) nicotine or tobacco product at least once per week in the 30 days prior to screening\n* USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must own a smartphone\n* USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report having internet access for the interviews\n* USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report that they are interested in participating in the study for themselves (versus \\[vs\\] someone else)\n* USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report that they have not participated in one of our prior tobacco cessation studies\n* USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report that they understand and agree to the conditions of compensation\n* USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report that they are not currently incarcerated\n* USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must be willing and able to complete study procedures in English\n* PILOT TRIAL: Participants must self-identify being between 18 and 30 years of age\n* PILOT TRIAL: Participants must currently reside in the US and anticipate continued residence for the duration of the study (3 months)\n* PILOT TRIAL: Participants must self-report use of any (non-therapeutic) nicotine or tobacco product at least once per week in the 30 days prior to screening\n* PILOT TRIAL: Participants must own an Android (running version 12 or higher) or iPhone (running iOS version 17 or higher, iPhone 11 or more recent)\n* PILOT TRIAL: Participants must self-report having at least weekly internet access for the next three months\n* PILOT TRIAL: Participants must be willing and able to download an app to their phone and receive text messages\n* PILOT TRIAL: Participants must self-report current use of a personal email account\n* PILOT TRIAL: Participants must self-report current use of text messaging\n* PILOT TRIAL: Participants must self-report that they are interested in participating in the study for themselves (vs someone else)\n* PILOT TRIAL: Participants must self-report that they have not participated in one of our prior tobacco cessation studies\n* PILOT TRIAL: Participants must self-report that they understand and agree to the conditions of compensation\n* PILOT TRIAL: Participants must self-report that they are not currently incarcerated\n* PILOT TRIAL: Participants must be willing to use the assigned intervention program, complete the study assessments, and complete an online consent form in English\n* POST PILOT TRIAL DIARY STUDY: Participants must self-identify being between 18 and 30 years of age\n* POST PILOT TRIAL DIARY STUDY: Participants must currently reside in the US\n* POST PILOT TRIAL DIARY STUDY: Participants must self-report use of any (non-therapeutic) nicotine or tobacco product at least once per week in the 30 days prior to screening\n* POST PILOT TRIAL DIARY STUDY: Participants must own an Android (running version 12 or higher) or iPhone (running iOS version 17 or higher, iPhone 11 or more recent)\n* POST PILOT TRIAL DIARY STUDY: Participants must self-report having at least internet access for the duration of the diary study\n* POST PILOT TRIAL DIARY STUDY: Participants must be willing and able to download an app to their phone and receive text messages\n* POST PILOT TRIAL DIARY STUDY: Participants must self-report current use of a personal email account\n* POST PILOT TRIAL DIARY STUDY: Participants must self-report current use of text messaging\n* POST PILOT TRIAL DIARY STUDY: Participants must self-report that they are interested in participating in the study for themselves (vs someone else)\n* POST PILOT TRIAL DIARY STUDY: Participants must self-report that they have not participated in one of our prior tobacco cessation studies\n* POST PILOT TRIAL DIARY STUDY: Participants must self-report that they understand and agree to the conditions of compensation\n* POST PILOT TRIAL DIARY STUDY: Participants must self-report that they are not currently incarcerated\n* POST PILOT TRIAL DIARY STUDY: Participants must be willing to use the intervention program, complete the study assessments, and complete an online consent form in English\n\nExclusion Criteria:\n\n* USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Individuals must not be \\\u003C 18 or \\> 30 years of age\n* USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Individuals must not have a Google voice number as their sole phone number\n* USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Individuals who are non-English speaking cannot participate, as this would prevent their participation in the interviews, which will be conducted in English\n* PILOT TRIAL: Participants must not be \\\u003C 18 or \\> 30 years of age\n* PILOT TRIAL: Participants must not be currently using other tobacco cessation treatments at the time of screening, including pharmacotherapy or behavioral support (but initiating these treatments during the study is allowed)\n* PILOT TRIAL: Participants must not be a member of the same household as another research participant\n* PILOT TRIAL: Participants must not have a Google voice number as their sole phone number\n* PILOT TRIAL: Participants must not be identified as fraudulent per our fraud prevention protocol\n* PILOT TRIAL: Participants must not be pregnant or plan on becoming pregnant over the next 3 months\n* POST PILOT TRIAL DIARY STUDY: Individuals must not be \\\u003C 18 or \\> 30 years of age\n* POST PILOT TRIAL DIARY STUDY: Participants must not have a Google voice number as their sole phone number\n* POST PILOT TRIAL DIARY STUDY: Individuals who are non-English speaking cannot participate, as this would prevent their participation in the interviews, which will be conducted in English","18 Years","30 Years",{"count":52,"type":21},140,[54],"NA","Tobacco use is the leading cause of preventable cancer deaths. Among young adults, approximately 1 in 5 use commercial nicotine and tobacco products, putting them at risk of developing nicotine addiction and long-term health effects from exposure to toxicants. Innovative approaches are needed to engage young adults in treatment, as they are less engaged in traditional treatment.\n\nThis clinical trial compares two versions of a mobile health intervention called Living Free from Tobacco (LiFT), designed to support nicotine and tobacco cessation among young adults. Both versions of the app are designed to motivate and support young adults to stop using nicotine and tobacco, regardless of current readiness to quit. Version A of the LiFT app (LiFT A) focuses on increasing psychological flexibility to support cessation, while Version B (LiFT B) provides educational content and resources related to tobacco use and cessation. Both versions of the program are delivered through a smartphone application and include accompanying text messages.",[27],"2026-06-18",{"date":30,"type":33},{"date":60,"type":33},"2026-06-07",{"date":62,"type":21},"2028-04-01",{"name":64,"class":40},"Fred Hutchinson Cancer Center",2,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":16,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":41},"100585986","a-digital-intervention-act-on-vaping-app-for-vaping-cessation-in-young-adult-e-cigarette-users-100585986","NCT06909500","A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users","ACT on Vaping: Digital Therapeutic for Young Adult Vaping Cessation","Inclusion Criteria:\n\n* Age 18-30\n* Current weekly user of e-cigarette product(s) for the last 30 days\n* Has a smartphone; either an Android (running version 12 or higher) or iPhone (running iOS version 17 or higher, iPhone 11 or more recent)\n* Experience downloading and using one or more apps on their smartphone\n* Have a mobile data plan and\u002For access to WiFi to support the use of the ACT on Vaping app\n* Has access to text messaging\n* Has an email address\n* United States (US) resident, with a US mailing address\n* Willing to complete all study procedures\n* Comfortable reading and writing in English\n\nExclusion Criteria:\n\n* Currently using other tobacco cessation treatments at the time of screening, including pharmacotherapy or behavioral support (note: use of these treatment is allowable during trial participation)\n* Member of the same household as another research participant\n* Currently in prison\n* Google voice number as sole phone number, due to its association with fraudulent study entry attempts\n* Is ineligible per fraud prevention protocol\n* Employees\u002Ffamily of investigator or study center",{"count":74,"type":21},1178,[54],"This clinical trial evaluates a smartphone application (app) called Acceptance and Commitment Therapy (ACT) on Vaping for helping young adults quit using electronic cigarettes (e-cigarettes). E-cigarettes pose numerous risks, particularly to youth and young adults. Addressing the high prevalence of e-cigarette use by young adults requires effective and accessible treatments to support current users to quit. Research shows this group prefers and benefits from newer methods of treatment delivery such as digital interventions. ACT on Vaping is a digital therapeutic intended to deliver behavioral therapy to young adults who vape to motivate and support abstinence from all nicotine and tobacco products. The app contains sessions that promote awareness of cues that trigger tobacco use and teach skills for responding to these triggers in a way that is tailored for the participant's readiness to quit. Receiving access to the ACT on Vaping app may be effective in helping young adults quit vaping.",[78,27],"Nicotine Dependence",{"date":80,"type":33},"2026-06-22",{"date":82,"type":21},"2026-07-15",{"date":84,"type":21},"2027-11-15",{"name":64,"class":40},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":22,"phases":96,"briefSummary":97,"conditions":98,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":110},"100435381","impact-of-behavior-modification-interventions-and-lung-cancer-screening-on-smoking-cessation-in-people-living-with-hiv-a-feasibility-study-100435381","NCT04949464","Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study","Inclusion Criteria:\n\n* Able to understand and willing to sign a written informed consent document\n* HIV positive. Documentation of HIV-1 infection by means of any one of the following:\n\n  * Documentation of HIV diagnosis in the medical record by a licensed health care provider;\n  * Documentation of receipt of antiretroviral therapy (ART) (at least two different medications that do not constitute a prescription for pre-exposure prophylaxis \\[PrEP\\] or post-exposure prophylaxis \\[PEP\\]) by a licensed health care provider. Documentation may be a record of an ART prescription in the participant's medical record, a written prescription in the name of the participant for ART, or pill bottles for ART with a label showing the participant's name;\n  * HIV-1 ribonucleic acid (RNA) detection by a licensed HIV-1 RNA assay demonstrating \\> 1000 RNA copies\u002FmL;\n  * Any licensed HIV screening antibody and\u002For HIV antibody\u002Fantigen combination assay confirmed by a second licensed HIV assay such as a HIV-1 Western blot confirmation or HIV rapid multispot antibody differentiation assay.\n\nNote: The term \"licensed\" refers to a kit that has been certified or licensed by an oversight body within the participating country and validated internally (e.g., U.S. Food and Drug Administration \\[FDA\\]).\n\nWHO (World Health Organization) and CDC (Centers for Disease Control and Prevention) guidelines mandate that confirmation of the initial test result must use a test that is different from the one used for the initial assessment. A reactive initial rapid test should be confirmed by either another type of rapid assay or an E\u002FCIA that is based on a different antigen preparation and\u002For different test principle (e.g., indirect versus competitive), or a Western blot or a plasma HIV-1 RNA viral load\n\n* Receiving antiretroviral therapy and CD4 count at least 200 cells\u002FuL within 6 months of registration (due to increased risk of LDCT false positivity with CD4 count \\\u003C 200cells\u002FuL)\n* Age 45-80 years. This age restriction reflects lung cancer risk and appropriateness for lung cancer screening; in epidemiologic studies lung cancer emerges 5-10 years earlier in PLWH, and therefore this is an appropriate risk group for screening. Although younger persons are likely to benefit more from smoking cessation as a lung cancer prevention measure, the risk\u002Fbenefit ratio associated with lung cancer screening is unlikely to be optimal at ages \\\u003C 45 years for PLWH\n* Biochemically confirmed current smoker (exhaled carbon monoxide \\[CO\\] \\>= 7 parts per million)\n* Meets United States Preventive Services Task Force (USPSTF) criteria for LDCT (age 50-80 and \\>= 20 pack-years smoking) or high-risk but not meeting USPSTF (age 45-49 and \\>= 20 pack-years smoking)\n* Possession of a smartphone that can support Positively Smoke Free Mobile (PSF-M) (\\> 95% of subjects had eligible phones in prior trials although researchers will include specific study screening questions assessing for adequate smartphone for the intervention)\n* Sufficient literacy; \\>= 4 on the Rapid Estimate of Adult Literacy in Medicine-Short Form (REALM-R) literacy scale\n\nExclusion Criteria:\n\n* Receiving any other smoking cessation interventions currently or within the prior 30 days\n* Contraindication to nicotine replacement therapy\n* Pneumonia or serious lung infection in prior 12 weeks\n* Uncontrolled intercurrent illness including, but not limited to, ongoing or active major infection, malignant tumors (unless these tumors were: (a) completely resected basal cell or squamous cell skin carcinomas or (b) in-situ squamous cell carcinoma of the cervix or anus), or any other major uncontrolled comorbid condition that would limit life expectancy or psychiatric illness\u002Fsocial situations that would limit compliance with study requirements\n* History of lung cancer\n* Pregnant women are excluded from this study because computed tomography introduces radiation exposure and may have teratogenic effects\n* Women who are breastfeeding (the safety of nicotine replacement therapy has not been established with breastfeeding)\n* Received a chest computed tomography scan in the previous twelve months","45 Years","80 Years",{"count":95,"type":21},100,[54],"This clinical trial evaluates the usefulness of using a smartphone-based HIV-specific smoking cessation intervention at the time of lung cancer screening in helping people living with HIV quit smoking. Positively Smoke Free - Mobile may help patients with HIV quit smoking.",[99,27],"HIV Infection","2026-06-04",{"date":102,"type":33},"2026-06-05",{"date":104,"type":33},"2023-03-22",{"date":106,"type":21},"2027-08-31",{"name":108,"class":109},"AIDS Malignancy Consortium","NETWORK",11,{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":16,"sex":17,"minAge":49,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":22,"phases":120,"briefSummary":121,"conditions":122,"keywords":124,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":41},"100596767","healthy-family-project-tobacco-use-and-smoke-exposure-in-asian-american-communities-100596767","NCT07049757","Healthy Family Project: Tobacco Use and Smoke Exposure in Asian American Communities","Healthy Family Project: Ending Tobacco Use and Smoke Exposure in Asian American Communities","Inclusion Criteria:\n\nAll Participants (Lay Health Workers, Smokers, Family Participants, and Post-Trial Household Member Group Interview Participants):\n\n1. Must be 18 years of age or older.\n2. Must self-identify as Chinese or of Chinese descent (ethnic or cultural identification, not national origin).\n3. Must be able to understand in spoken Chinese (Cantonese and\u002For Mandarin) or English.\n4. Able to attend educational sessions in person or via video conferencing.\n5. Ability to understand and the willingness to sign a written informed consent document.\n6. Have a mobile phone that can receive Short Message Service (SMS) text messages, or an email address and a phone number where they can be reached by the study team.\n\nLay Health Workers:\n\n1. Must have experience or interest in community outreach and education.\n2. Must demonstrate proficiency in language (Cantonese and\u002For Mandarin or English) sufficient to deliver study materials and interact with participants.\n3. Must be affiliated with the Chinese Community Health Resource Center (CCHRC) or recruited through community networks.\n4. Must agree to participate in training and intervention delivery activities as outlined in the study protocol.\n\nSmokers (Participants who are current smokers):\n\n1. Must have smoked within the past 30 days, either daily or occasionally.\n2. Must have a non-smoking household member.\n\nFamily Participants (Non-smoking family\u002Fhousehold members):\n\n1. Must live in the same household as the smoker participant.\n2. Must not have used any tobacco products in the past 30 days.\n\nPost-Trial Household Member Group Interview Participants:\n\n1\\. Living in the same household with the smoker-household member dyad participant being interviewed or considered as a household member.\n\nExclusion Criteria:\n\nLay Health Workers, Smokers (Participants who are current smokers) and Family Participants (Non-smoking Family\u002Fhousehold members):\n\n1. Currently participating in another smoking cessation program.\n2. Non-residents of California.\n3. Participants unwilling to provide follow-up contact for assessments at 6 and 12 months.\n\nLay Health Workers:\n\n1. Lack of willingness or ability to complete training or deliver intervention sessions as required by the study protocol.\n2. Inability to maintain confidentiality and professionalism during interactions with study participants.\n3. Active participation in conflicting research studies or programs.",{"count":119,"type":21},760,[54],"This study evaluates whether the Smokefree Family Living (SFL) intervention improves quit rates (smoking cessation) and exposure to tobacco contamination that stays in items such as, carpets, walls, and furniture, even after the smoke has cleared (third-hand smoke (THS)) among Chinese American smokers and their non-smoking household members. Smoking remains high among Chinese American males with limited ability to speak English. This causes the non-smoking household members to be exposed to THS, which contains many of the same harmful components as smoking and becomes more toxic as it ages. SFL is tailored for Chinese Americans and combines the contents of the Quit Smoking for a Healthy Family (QS) intervention with additional THS education and cleaning strategies. QS focuses on smoking cessation through educational sessions and support. THS education and cleaning strategies provide information on THS and how to clean the home for THS. SFL may help Chinese American smokers and their non-smoking household members learn about the importance of quitting and the dangers of THS, this may improve smoking cessation and reduce THS exposure",[27,123],"Smoking Cessation",[125],"Third-hand Smoke","2026-06-02",{"date":100,"type":33},{"date":129,"type":33},"2026-03-23",{"date":131,"type":21},"2028-09-30",{"name":133,"class":40},"University of California, San Francisco",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":16,"sex":17,"minAge":141,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":22,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":41},"100491455","support-and-outreach-to-increase-screening-for-lung-cancer-in-patients-with-a-history-of-smoking-100491455","NCT05679349","Support and Outreach to Increase Screening for Lung Cancer in Patients With a History of Smoking","Provider Support and Patient Outreach in Lung Cancer Screening","Inclusion Criteria:\n\n* PRACTICE LEVEL:\n* Primary care practice (family medicine, geriatrics, internal medicine) in one of the 4 participating health systems\n* Practice using the main electronic medical record (EMR) of each system, in order to run appropriate patient recruitment reports\n* Practice with at least 50% of practice providers (physicians and advanced care providers) consenting to participate\n* PATIENT LEVEL:\n* Have an office or telemedicine established patient visit scheduled with a primary care provider in one of the participating practices within next 14 to 25 days\n* 50 to 77 years of age\n* Have at least a 20-pack-year smoking history (based on self-report at baseline eligibility assessment)\n* Currently smoke or have quit smoking within the past 15 years (based on self-report at baseline eligibility assessment)\n* Able to communicate in English or Spanish (determined at baseline eligibility assessment)\n\nExclusion Criteria:\n\n* PATIENT OUTREACH:\n* Any lung computed tomography (CT) or low-dose computed tomography (LDCT) scan in the past 11 months, current procedural terminology (CPT) Codes are as follows\n\n  * G0297 - LDCT screening\n  * 71250 - CT w\u002Fo contrast\n  * 71260 - CT w\u002F contrast\n  * 71270 - CT with and w\u002Fo contrast\n  * 71275 - CT angiography chest\n  * 78815 - Positron emission tomography computed tomography (PET CT) skull base to mid-thigh\n  * 78816 - PET CT whole body\n* Prior history of lung cancer (The patient's problem list includes a problem with an international classification of diseases (ICD10) code of \"Z85.118\" or one beginning with \"C34.\", or by self-report at baseline eligibility assessment)\n* Recent hospitalization (Admission date within the last 60 days listed in electronic health record (EHR), or by self-report at baseline eligibility assessment)\n* Dementia (diagnosis codes F03.90 or F03.91) in EHR","50 Years","77 Years",{"count":144,"type":21},822,[54],"This clinical trial tests how well providing education improves screening for lung cancer in patients with a history of smoking. Screenings may help doctors find lung cancer sooner when it may be easier to treat. Education and counseling may be an effective method to help providers and patients learn about lung cancer screening. Providing education and decision counseling to providers and patients may increase lung cancer screening.",[148,27],"Lung Carcinoma","2026-05-26",{"date":35,"type":33},{"date":152,"type":33},"2024-04-01",{"date":154,"type":21},"2027-02-26",{"name":156,"class":40},"Ronald Myers",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":22,"phases":167,"briefSummary":169,"conditions":170,"keywords":171,"overallStatus":176,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":41},"100631687","phase-4-thrive-study-understanding-how-oral-nicotine-pouches-affect-public-health-100631687","NCT07503925","THRIVE Study: Understanding How Oral Nicotine Pouches Affect Public Health","THRIVE Study: Informing Oral Nicotine Pouch Regulations to Promote Public Health","THRIVE","Inclusion Criteria:\n\n* Age 21 or older\n* Able to read and speak English\n* Willing to abstain from tobacco, nicotine, and marijuana for at least 12 hours prior to study visits\n* Exclusive use of ONPs (other product use \\\u003C10x\u002Fmo).\n* Exhaled CO reading \\\u003C10 ppm\n* Owns a smartphone and can receive SMS text messages with embedded survey links\n* Negative pregnancy test at V1 and V2 (if applicable)\n* Uses ≥1.5 cans of ONPs\u002Fweek\n* Daily use of ONPs for the past 3 months\n* At least half of ONPs used are 6mg nicotine concentration.\n\nExclusion Criteria:\n\n* Non-English speaker\n* Individuals currently pregnant, planning to become pregnant, or breastfeeding are excluded due to potential risks associated with nicotine exposure and study procedures (e.g., blood draws).\n* Individuals with unstable or significant psychiatric conditions are excluded to minimize risk and ensure reliable participation.\n* Individuals actively attempting to quit nicotine use are excluded to avoid ethical concerns and ensure that study participation does not interfere with cessation efforts\n* Non-nicotine users and regular tobacco users are excluded from the clinical trial component to ensure that participants have established use patterns appropriate for assessing ONP use behaviors.",{"count":166,"type":21},15,[168],"PHASE4","Although nicotine pouches have been gaining popularity over the last few years, little known about how nicotine pouch users actually use these products.\n\nThis study will be comprised of adults who use nicotine pouches. If eligible, participants will be asked to complete three study visits and participate in two switching periods where participants use study-provided nicotine pouches.",[27],[172,173,174,175],"Tobacco","Oral Nicotine Pouches","Particle Size","Tobacco Regulation","NOT_YET_RECRUITING","2026-05-21",{"date":149,"type":33},{"date":180,"type":21},"2026-07-01",{"date":182,"type":21},"2027-12-31",{"name":39,"class":40},{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":188,"acronym":4,"eligibilityCriteria":189,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":190,"enrollmentInfo":191,"targetDuration":4,"studyType":22,"phases":193,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":41},"100550536","manipulating-e-cigarette-nicotine-to-promote-public-health-100550536","NCT06448351","Manipulating E-Cigarette Nicotine to Promote Public Health","Inclusion Criteria:\n\n* Current exclusive young adult EC user for at least the past 3 months (confirmed by cotinine testing strip) between 21-24 years old with no\u002Fminimal history of smoking cigarettes (≤ 10 cigarettes in entire life)\n* Current older adult smoker (daily use, ≥ 100 cigarettes in entire life) aged 25-65 with interest in trying an EC\n* Willing to abstain from all nicotine, tobacco products, and marijuana for at least 12 hours for Study 1 and 2 hours for Study 2 before study visits\n* Read, write, and speak English\n\nExclusion Criteria:\n\n* Currently attempting to quit nicotine or tobacco products\n* Currently pregnant (will be verified with urine pregnancy test), planning to become pregnant, or breastfeeding\n* If age 21-24 years old AND use of any tobacco products other than ECs (use of \\>10 cigarettes in entire life; use of \\>10 traditional cigars, cigarillos, or filtered cigars in entire life; use of smokeless tobacco products \\>10 times in entire life; or hookah in the last 30 days).\n* Self-reported diagnosis of lung disease including asthma, cystic fibrosis, or chronic obstructive pulmonary disease\n* New or unstable cardiovascular disease diagnosed within the past 3 months\n* Use of medications that are inducers of CYP2A6 enzyme such as rifampicin, dexamethasone, phenobarbital, and other anti-convulsion drugs","65 Years",{"count":192,"type":21},375,[54],"This clinical trial explores the manipulation of e-cigarette (EC) nicotine to promote public health. Researchers are trying to understand and gather information about how the strength, form, and structure of nicotine in products play a significant role in their potential for addiction and how they might affect health risks. The information gained from this study may allow researchers to understand how these aspects of nicotine influence the potential for addiction, how people puff on ECs, how the body processes nicotine, and any potential harmful effects it might have on health. Exploring these specific characteristics of nicotine may also determine if an EC product standard could help identify optimal nicotine levels for users.",[27],"2026-05-08",{"date":198,"type":33},"2026-05-13",{"date":200,"type":33},"2024-05-20",{"date":202,"type":21},"2027-05-20",{"name":39,"class":40},{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":16,"sex":17,"minAge":211,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":22,"phases":214,"briefSummary":215,"conditions":216,"keywords":4,"overallStatus":176,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":223,"locationsCount":41},"100638732","studying-the-impacts-of-higher-taxes-and-bans-on-electronic-cigarettes-to-improve-public-health-100638732","NCT07581041","Studying the Impacts of Higher Taxes and Bans on Electronic Cigarettes to Improve Public Health","Design Tiered Tax Rates for Electronic Cigarettes (ECs) Based on Their Appeals to Youth and Young Adults","Inclusion Criteria:\n\n* AYAs aged 15-24 who are daily or nondaily users of ECs and are not smoking in the past 30 days\n* AYA tobacco nonusers aged 15-24 who are susceptible to EC or tobacco use (i.e., curiosity about the product, intention to try it in the near future, and likely response if a best friend were to offer them the product)\n* Adults aged 18+ who are daily or nondaily users of ECs and combustible tobacco in the past 30 days\n* Adults aged 18+ who are daily or nondaily users of combustible tobacco in the past 30 days, not currently using ECs but are open to trying ECs","15 Years",{"count":213,"type":21},3400,[54],"This clinical trial studies whether imposing higher taxes and bans on electronic cigarettes (EC) with appealing features impacts tobacco use among current and susceptible adolescents and young adults (AYA) EC users and adults who use EC or are open to EC use. ECs are currently the most popular form of nicotine or tobacco product in the United States. Compared to burned cigarette products, ECs generally pose fewer short-term harms, making them a promising tool for lowering users' exposure to toxins and cancer-causing chemicals from smoking, promoting better public health outcomes. However, evidence shows that EC marketing has increased overall initiation into nicotine use among AYAs, and that EC users are at a higher risk of becoming smokers, which could have negative public health outcomes. Therefore, understanding the public health impact of EC use and regulation remains a major goal in tobacco control research. This trial studies different scenarios which impose higher taxes or bans on ECs with appealing features. Researchers hope that by studying participant responses to the different scenarios they may be able to identify which ones best discourage EC use among AYAs while promoting adult EC users to quit smoking, which may improve public health.",[27],"2026-05-06",{"date":219,"type":33},"2026-05-12",{"date":221,"type":21},"2026-08-01",{"date":182,"type":21},{"name":39,"class":40},{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":22,"phases":232,"briefSummary":234,"conditions":235,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":41},"100540364","phase-2-informing-oral-nicotine-pouch-regulations-to-promote-public-health-100540364","NCT06315881","Informing Oral Nicotine Pouch Regulations to Promote Public Health","Inclusion Criteria:\n\n* Read and speak English\n* At least 21 years old\n* Willing to provide informed consent and abstain from all tobacco, nicotine, and marijuana use for at least 12 hours prior to Phase 1 study visits\n* Willing to attend all study visits and use study ONPs\n* Owns a smartphone and able to receive short messaging service (SMS) text messages with embedded survey link (for daily diary reports of ONP and other tobacco use)\n* Negative pregnancy test produced during Phase 1 visits 1-5 and Phase 2 visit 1 if capable of becoming pregnant\n* Exhaled carbon monoxide (CO) reading \\\u003C 10 (Phase 1)\n* CIGARETTE SMOKERS ONLY: Established cigarette smoker (has smoked at least 100 cigarettes, has smoked daily for at least the past 3 months, now smokes at least 5 cigarettes per day)\n* ST USERS ONLY: Established moist snuff user (has used moist snuff daily for at least the past 3 months, uses at least 1.5 cans\u002Fweek (as in Pickworth et al., 2014)\n\nExclusion Criteria:\n\n* Unstable or significant psychiatric conditions (past and stable conditions will be allowed)\n* History of cardiac event or distress within the past 3 months\n* Currently pregnant, planning to become pregnant, or breastfeeding (will be verified with urine pregnancy test before each Phase 1 study visit \\[acute use of usual product and study ONPs\\] and Phase 2 study visit 1 \\[distribution of study ONPs for outpatient ad libitum use\\])\n* Currently engaging in tobacco quit attempt, interested in quitting all tobacco, or planning on quitting all tobacco in the next 3 months\n* Oral or systemic health issues that affect oral microbiome or epithelium, including having fewer than 21 teeth, diabetes mellitus, or autoimmune disease (e.g., rheumatoid arthritis, lupus)\n* CIGARETTE SMOKERS ONLY: Use of non-cigarette tobacco products ≥ 10 of the past 30 days\n* CIGARETTE SMOKERS ONLY: Self-reported diagnosis of lung disease including asthma (if uncontrolled or worse than usual), cystic fibrosis, or chronic obstructive pulmonary disease\n* CIGARETTE SMOKERS ONLY: Roll-your-own cigarette smokers\n* ST USERS ONLY: Use of non-moist-snuff tobacco products ≥ 10 of the past 30 days",{"count":231,"type":21},160,[233],"PHASE2","This clinical trial evaluates the characteristics of oral nicotine pouches (ONPs) to determine if they are a comparable substitute to cigarette or smokeless tobacco (ST) products. ONPs contain nicotine but no tobacco and are used primarily by adult tobacco uses in the United States (US). ONPs are recognized by the Food and Drug Administration as having lower risk than combustible cigarettes and are approved as a modified risk tobacco product. While ONPs have lower toxic risk than other tobacco products, acute and longer term harm related to their use has not been studied. Information gathered from this study may identify product characteristics of ONPs that improve successful switching from high-risk cigarettes or ST to lower risk ONPs.",[27],"2026-04-22",{"date":238,"type":33},"2026-04-27",{"date":240,"type":33},"2025-01-13",{"date":242,"type":21},"2028-08-31",{"name":39,"class":40},{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":251,"targetDuration":4,"studyType":22,"phases":253,"briefSummary":254,"conditions":255,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":41},"100619551","studying-the-health-perceptions-and-social-behaviors-of-graduate-students-at-the-ohio-state-university-for-the-development-of-effective-oral-nicotine-pouch-addictive-risk-communication-100619551","NCT07346092","Studying the Health Perceptions and Social Behaviors of Graduate Students at the Ohio State University for the Development of Effective Oral Nicotine Pouch Addictive Risk Communication","Health Perceptions and Social Behaviors in Young Adults","Inclusion Criteria:\n\n* AIM 1: OSU graduate students aged 21 years or older\n* AIM 2 AND 3: Students identified in Aim 1 as susceptible to ONPs, having experimented with ONPs, or currently using ONPs-those considered at high risk for nicotine dependence-will be invited to participate in Aim 2 or Aim 3\n* AIM 3: Participants in Aim 2 will not be invited to participate in Aim 3, as they will have already been exposed to the experimental stimuli",{"count":252,"type":21},2000,[54],"This clinical trial studies the health perceptions and social behaviors of Ohio State University (OSU) graduate students to develop an interactive, social norms-based approach that is effective in communicating the addictive risks of oral nicotine pouches (ONPs). The use of ONPs is rising rapidly among young adults (YA). Various factors contribute to the growing popularity of ONPs, including their affordability, accessibility both online and in physical stores, discreet use, and heavy internet advertising. However, for those who are experimenting, have tried ONPs in the past, or have never used them but are surrounded by others who do, factors like affordability and availability may not be the only reasons for initiating or continuing use. Social norms are also a significant factor influencing YA tobacco use. Peer influence on college campuses and in other social environments may encourage YA to conform to behaviors they perceive as popular or acceptable. Being surrounded by peers who use ONPs may create pressure to try them, especially as YA seek to fit in within their social circles. Studying the health perceptions and social behaviors of OSU graduate students may help researchers develop an interactive, social norms-based approach that is effective in communicating the addictive risks of ONPs.",[27],"2026-03-03",{"date":258,"type":33},"2026-03-05",{"date":260,"type":33},"2025-03-20",{"date":262,"type":21},"2027-03-20",{"name":39,"class":40},{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":270,"targetDuration":4,"studyType":22,"phases":272,"briefSummary":273,"conditions":274,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":65},"100535296","effects-of-tobacco-cut-and-nicotine-form-on-the-abuse-liability-of-moist-snuff-100535296","NCT06249984","Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff","Inclusion Criteria:\n\n* AIM 1 (Adults Tobacco User Adult Cohort \\[TUAC\\]): Exclusive adult smokers who smoked \\>100 cigarettes or other combustible tobacco products in their lifetime and reported being current, every day, or some days\u002Fweek smokers at time of enrollment\n* AIM 1 (TUAC): Exclusive SLT user reporting every day or some days use per week at time of enrollment\n* AIM 1 (TUAC): Or dual users who met criteria for both aims at time of enrollment who resided in participating Appalachian and urban counties\n* AIM 1 (Buckeye Teen Health Study \\[BTHS\\]): Male youth ages 12-15 in Appalachian and urban regions of Ohio with parental consent and participant assent given\n* AIM 2: As derived from Aim 1, commercially available SLT products used by TUAC and BTHS participants will be purchased from retailers in nearby Appalachian counties, as composition of SLT products can vary regionally\n* AIM 3: Adults aged 21 and older who reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification and use SLT daily for at least 3 months and using 1.5 cans\u002Fweek will be considered for this project\n* Established moist snuff user (has used moist snuff daily for at least the past 3 months, uses at least 1.5 cans\u002Fweek.\n* Age 21 years or older\n* Reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification\n* Willing to complete 5 study visits and provide informed consent study procedures, including abstaining from all tobacco, nicotine, and marijuana for 12 hours before clinic visits\n* Willing to abstain from nicotine and tobacco products 12-hours before study visit\n* Ability to read and speak English\n\nExclusion Criteria:\n\n* Pregnant, planning to become pregnant, or breastfeeding (will be verified with a urine pregnancy test at the first session visit)\n* Unstable or significant psychiatric conditions (past and stable conditions will be allowed)\n* History of cardiac event or distress, including but not limited to uncontrolled high blood pressure, chest pain, and shortness of breath, within the past 3 months\n* Working with a cessation counselor, using cessation devices such as Chantix or Wellbutrin, or planning to quit within the next 3 months\n* Severe periodontal or oral lesions",{"count":271,"type":21},80,[54],"This clinical trial tests the effects of tobacco cut and nicotine form on the abuse liability in participants who use moist snuff (smokeless tobacco \\[SLT\\]). Two features of moist snuff that are key targets of manipulation from the tobacco industry and drivers of its addiction potential are length of tobacco cut (long versus fine) and nicotine form (low versus high levels of nicotine in the free-base form). Finer tobacco cuts and higher levels of free-base nicotine (FBN) result in faster, greater nicotine delivery. Researchers want to gain information on how certain characteristics of moist snuff affect how long people use it, how it delivers nicotine, or how much people like it. This clinical trial may provide justifications for local, state, or federal regulations aimed at reducing the appeal and addictiveness of moist snuff.",[27],"2025-12-18",{"date":277,"type":33},"2025-12-22",{"date":279,"type":33},"2024-12-20",{"date":281,"type":21},"2028-01-31",{"name":39,"class":40},{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":16,"sex":17,"minAge":49,"maxAge":4,"enrollmentInfo":290,"targetDuration":4,"studyType":22,"phases":292,"briefSummary":293,"conditions":294,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":298,"completionDateStruct":300,"leadSponsor":302,"locationsCount":41},"100560899","a-smoke-free-home-intervention-in-tribal-communities-100560899","NCT06583148","A Smoke-Free Home Intervention in Tribal Communities","Assessing the Effectiveness of a Smoke-Free Home Program in Tribal Communities","Inclusion Criteria:\n\n* 18 years of age and older\n* Self-report as being a smoker or living with a smoker\n* Indicate that they do not reside in a smoke-free home\n* Identify as living in an American Indian household\n\nExclusion Criteria:\n\n* Children under the age of 18 will not be included",{"count":291,"type":21},575,[54],"This clinical trial evaluates a smoke-free home intervention for reducing exposure to secondhand smoke from commercial tobacco in homes of participants who live in rural tribal communities. Smoke-free homes are an innovative and relatively untapped strategy for cancer prevention in rural tribal communities. Smoke-free policies, including those that target homes, can reduce exposure to secondhand smoke and support smoking cessation. Rural and racial\u002Fethnic inequities intersect to increase tobacco-related harms among Indigenous populations. A smoke-free home program may improve the health of the household as well as impact smoking behavior among the family unit by reducing secondhand smoke exposure.",[27],"2025-12-05",{"date":297,"type":33},"2025-12-08",{"date":299,"type":33},"2024-11-15",{"date":301,"type":21},"2029-01-31",{"name":303,"class":40},"Emory University"]