[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tomography-optical-coherence\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tomography-optical-coherence":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,41,64,96,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100580538","structural-and-microbiological-characterization-of-arterial-catheter-biofilm-in-icus-patients-using-optical-coherence-tomography-100580538",false,"NCT06838598","Structural and Microbiological Characterization of Arterial Catheter Biofilm in ICU's Patients Using Optical Coherence Tomography","OCT-BIO-KTA","Inclusion Criteria:\n\n* Patient or relative informed of the study and having declared their non-objection\n* Patient over 18 years old\n* Patient hospitalized in ICU with an arterial catheter\n\nExclusion Criteria:\n\n* Patient unable to express consent\n* Patient whose collection of the arterial catheter is impossible or for whom storage at 4°C is impossible\n* Patient with arterial catheter removed outside the usual procedure of the ICU\n* Patient admitted in ICU with an arterial catheter already in place","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","OBSERVATIONAL","29.3% of bacteremias in intensive care units (ICU) are linked to vascular devices, including 7.7% to arterial catheters, with an influence on both morbility and mortality.\n\nIt is now accepted that biofilm as a role on bacterial development on inner surface of vascular devices but there is yet a lack of clinical relevant data documenting a causal relation between biofilm formation and bacteremias.\n\nThe investigators assume that a better structural and microbiological characterization of arterial catheter biofilm in ICU patients could help preventing bacteremias or have a more specific treatment when it appears.",[24,25,26,27],"Biofilms","Arterial Catheterization, Peripheral","Bacteremia","Tomography, Optical Coherence","RECRUITING","2026-03-16",{"date":31,"type":32},"2026-03-18","ACTUAL",{"date":34,"type":32},"2024-06-03",{"date":36,"type":20},"2027-12",{"name":38,"class":39},"Centre Hospitalier William Morey - Chalon sur Saône","OTHER",2,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":51,"conditions":52,"keywords":55,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":57,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":63},"100495210","histopathological-analysis-of-renal-biopsies-with-dynamic-full-field-optical-coherence-tomography-a-comparison-to-conventional-histopathological-findings-for-the-diagnosis-of-either-acute-kidney-injury-or-chronic-kidney-disease-in-routine-practices-nephroct-100495210","NCT05728216","Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings for the Diagnosis of Either Acute Kidney Injury or Chronic Kidney Disease in Routine Practices (NEPHROCT)","Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings for the Diagnosis of Either Acute Kidney Injury or Chronic Kidney Disease in Routine Practices","NEPHROCT","Inclusion Criteria:\n\n* patients \\> 18 years of age with suspected acute kidney injury requiring biopsy in the nephrology department\n* patients \\> 18 years of age with suspected chronic kidney disease requiring biopsy in the nephrology department\n\nExclusion Criteria:\n\n* inability to perform dynamic full-field optical coherence tomography observation at the moment of kidney biopsy",{"count":50,"type":20},50,"Kidney biopsy play a key role for the investigation of either acute kidney injury or chronic kidney disease. Despite possible complications due to the invasive nature of the biopsy, such procedure is still essential in a number of clinical situations to improve the diagnosis specificity of kidney disease, better inform about its prognosis and guide the management of a future treatment. Pursuing the idea to improve both performance and rapidity associated with the histopathological analysis of kidney biopsy, with a possible recourse to artificial intelligence-based renal pathology, the present study intends to assess the impact of direct histopathological examination of kidney biopsy with dynamic full-field optical coherence tomography in routine practices for the diagnosis of either acute kidney injury or chronic kidney disease.",[53,54,27],"Acute Kidney Injury","Chronic Kidney Diseases",[27,54,53,56],"Kidney Biopsy",{"date":31,"type":32},{"date":59,"type":32},"2022-11-01",{"date":61,"type":20},"2028-11-30",{"name":38,"class":39},1,{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":63},"100593454","chopxe---analysis-of-choriocapillaris-flow-deficits-in-patients-with-pseudoxanthoma-elasticum-100593454","NCT07006649","CHOPXE - Analysis of Choriocapillaris Flow Deficits in Patients With Pseudoxanthoma Elasticum","CHOPXE","Inclusion Criteria:\n\n* Participant not afflicted by the disease under investigation and without ophthalmological pathology\n* Person matched in age (+\u002F- 5 years) and gender to a case (patient with PXE in pre-atrophic stages included in the PXE cohort)\n* Signature of informed consent for participation in the protocol\n* Adult at time of inclusion Criteria for non-inclusion of research subjects\n* Known ophthalmological diseases (maculopathy, glaucoma, optic neuropathy, retinopathy whatever the aetiology)\n* Known severe myopia, defined by a sphere \\> - 6 dioptres\n* Diabetic subject\n* Unable to carry out the ophthalmological examinations of the study\n* Pregnant, breast-feeding or parturient woman\n* Person undergoing psychiatric care under constraint\n* Person subject to a legal protection measure\n* Person not affiliated or not benefiting from a social security scheme\n\nExclusion Criteria:\n\n* Ophthalmic pathology (maculopathy, glaucoma, optic neuropathy, retinopathy, whatever the etiology) discovered during the ophthalmic workup\n* AngioOCT examination inexploitable (artifact and\u002For image quality less than 50\u002F100 even after pupillary dilation)\n* Severe myopia (sphere \\> - 6 dioptres) discovered during the ophthalmic workup.\n\nCase inclusion critera :\n\n* Patient diagnosed with pseudoxanthoma elasticum, defined according to Plomp's criteria: two out of three features related to PXE: (1) two pathogenic mutations in the ABCC6 gene, and\u002For (2) disease-specific dermatological changes and\u002For (3) disease-specific ocular changes;\n* Included in the PXE cohort ;\n* With pre-atrophic damage, i.e. at least one eye without choroidal neovessels on OCT-A, without previous intravitreal injection of anti-VEGF, and without major retinal atrophy (less than 2 papillary diameters);\n* who have had an angiographic OCT (performed during follow-up consultations) with usable results (no artifacts and image quality of 50\u002F100 or better) ;\n* patient's non-objection to participation in a study\n\nCase criteria for non-inclusion :\n\n* Other known ophthalmological pathology (maculopathy, glaucoma, optic neuropathy, retinopathy of any etiology)\n* Severe myopia, defined by a sphere \\> - 6 dioptres\n* Diabetic subject",true,{"count":19,"type":20},"INTERVENTIONAL",[75],"NA","This observational study sets out to compare choriocapillaris flow deficits between healthy control subjects and patients with pseudoxanthoma elasticum. Pseudoxanthoma elasticum (PXE) is a rare, incurable hereditary disease caused by genetic mutations. The condition is characterised by excessive tissue mineralisation, which can result in a range of dermatological, vascular, and ophthalmological complications. Among these complications is the potential for visual impairment. The management of this condition is focused on the treatment of its complications. Degeneration of the retina and the choroid (the layer responsible for ensuring its vascularisation) occurs in the eye, resulting in premature degeneration. We would like to study the premature alteration of these structures, which could subsequently be used as an objective marker of the evolution of pseudoxanthoma elasticum.",[78,27,79],"Pseudoxanthoma Elasticum","Retinal Disease",[81,82,83,84,85],"comparative studies","observational study","adult","cross-sectional studies","healthy volunteers","2025-12-01",{"date":88,"type":32},"2025-12-08",{"date":90,"type":32},"2025-11-28",{"date":92,"type":20},"2026-11",{"name":94,"class":95},"University Hospital, Angers","OTHER_GOV",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":63},"100581025","vessel-imaging-using-optical-coherence-tomography-for-plaque-morphology-and-vessel-fractional-flow-reserve-100581025","NCT06844942","Vessel Imaging Using Optical Coherence Tomography for Plaque Morphology and Vessel Fractional Flow Reserve","VISION-FFR","Inclusion Criteria:\n\n* 18 years or older\n* Chronic coronary syndrome defined as presence of chest pain ranked 2-3 in the Canadian Cardiovascular Society classification or positive ischemia test (exercise test, single photon emission tomography (SPECT)\n* Intermediate grade coronary stenosis of 40-80% assessed visually in coronary angiography and OCT examination The patient is willing to participate in the study and has provided a written informed consent\n\nExclusion Criteria:\n\n* Acute coronary syndrome\n* Proximal left main lesion\n* Ostial right coronary artery lesion\n* Bypass of the assessed vessel\n* Contraindications for adenosine administration\n* Hemodynamic instability\n* Heart insufficiency in New York Heart Association (NYHA) class IV scale\n* Acute renal insufficiency\n* Pregnancy",{"count":104,"type":20},200,"The aim of this prospective, investigator-initiated study is to evaluate the diagnostic accuracy and correlations between mopphometric indices: luminal and qualitative parameters assessed by optical coherence tomography (OCT) including minimal lumen area, plaque type, presence of thin cap fibroatheroma and a functional index - angiography based vessel fractional flow reserve (vFFR) among patients with chronic coronary syndrome identified with intermediate grade coronary stenosis.",[107,108,27,109],"Coronary Artery Disease","Coronary Artery Stenosis","3D-angio-based FFR","2025-02-19",{"date":112,"type":32},"2025-02-25",{"date":114,"type":32},"2020-09-20",{"date":116,"type":20},"2029-01-31",{"name":118,"class":39},"Medical University of Warsaw",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":127,"enrollmentInfo":128,"targetDuration":130,"studyType":21,"phases":4,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":63},"100550998","histopathological-analysis-versus-full-field-optical-coherence-tomography-of-minor-salivary-gland-biopsy-in-suspect-sjogren-syndrome-100550998","NCT06454370","Histopathological Analysis Versus Full-field Optical Coherence Tomography of Minor Salivary Gland Biopsy in Suspect Sjogren Syndrome","Histopathological Analysis of Minor Salivary Gland Biopsy Following Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings in Patients Suspect Sjogren Syndrome.","TOCOSS","Inclusion Criteria:\n\n* Patient \\> 18 years of age with suspected Sjogren Syndrome received minor gland salivary biopsy\n\nExclusion Criteria:\n\n* Inability to perform dynamic full-field optical coherence tomography observation at the moment of temporal artery biopsy","99 Years",{"count":129,"type":20},30,"1 Month","Primary Sjögren syndrome (pSS) is a systemic autoimmune disease that mainly affects the exocrine glands leading to severe dryness of mucosal surfaces, principally in the mouth and eyes. The other clinical manifestations are fatigue and musculoskeletal pain. Diagnosis of pSS associates clinical abnormalities with specific antibodies (Ro\u002FSSA and La\u002FSSB antibodies) or histopathological criteria of a minor salivary gland biopsy (the presence and number of lymphocytic focus, as well as chronicity findings like acinar atrophy, ductal dilatation or fibrosis). Apart from its variable sensitivity, one of the weaknesses of minor salivary gland biopsy is the delay in obtaining the result due to the time required to prepare the sample for histological analysis.\n\nOur group recently demonstrated the use of full-field optical coherence tomography (FF-OCT) to visualize structural changes associated with the inflammatory processes in Giant Cell Arteritis (temporal artery biopsy examination). It may suggests a further use of dynamic FF-OCT of minor salivary gland biopsy to visualize structural changes associated with the lymhocytic focus to ensure rapid on-site diagnosis of pSS.",[133,134],"Sjogren's Syndrome","Tomography Optical Coherence",[136,27],"Minor Salivary gland biopsy","2024-06-11",{"date":139,"type":32},"2024-06-12",{"date":141,"type":32},"2024-06-07",{"date":143,"type":20},"2024-12-07",{"name":145,"class":39},"Centre Hospitalier de Mâcon"]