[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tomography\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tomography":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100607732","shift-hours-impact-on-fatigue-and-tracking-of-eye-dynamics-100607732",false,"NCT07192380","Shift Hours' Impact on Fatigue and Tracking of Eye Dynamics","SHIFTED","Inclusion Criteria:\n\nAssociate radiologists at IMADIS Group\n\n* In their current position for at least one year\n* Working at one of the IMADIS Group on-call centers\n* Performing night shifts during the study period\n* Able to wear an actimeter watch during the study period (it may be removed during certain procedures, but must be put back on afterwards)\n* Having given their free and informed consent to participate in the study\n\nNon- inclusion criteria:\n\n* Leave during the study period\n* Pregnant women, women in labor, or breastfeeding women\n* Subjects wearing glasses or contact lenses\n\nExclusion Criteria:\n\n\\- Having slept more than 6 hours during the night shift",true,"ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn how night shift-induced sleep debt affects oculomotor patterns, attentional state, and diagnostic performance in emergency radiologists.\n\nThe main questions it aims to answer are:\n\n* Does sleep debt from a night shift alter oculomotor parameters, as eyes movements (speed and amplitude), fixation duration, pupil size?\n* Does a night shift impact radiologists' diagnostic accuracy, attentional state, and perceived fatigue? Researchers will compare radiologists after a night shift (sleep-deprived) with the same radiologists after a night of rest (control) to see if fatigue-related changes affect both visual exploration strategies and diagnostic performance.\n\nParticipants will:\n\n* Perform a guided saccade task assessed by eye tracking (primary endpoint),\n* Read thoracic CT scans (with and without pulmonary embolism cases) to assess diagnostic performance and visual exploration patterns,\n* Undergo EEG recording to measure attentional state,\n* Complete self-report questionnaires on sleepiness and fatigue.",[27,28,29,30,31,32],"Sleep Deprivation","Sleepiness","Eye-Tracking Technology","Radiologists","Tomography","Electroencephalography",[34,35,36,37,38,39],"Night-Shift","Radiology","performance","Eye-tracking","Fatigue","Eye strain","NOT_YET_RECRUITING","2025-09-17",{"date":43,"type":44},"2025-09-25","ACTUAL",{"date":46,"type":21},"2025-09-15",{"date":48,"type":21},"2026-05-15",{"name":50,"class":51},"IMADIS Technologies et Services","INDUSTRY",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":52},"100596226","evaluation-of-the-performance-of-glomerular-filtration-rate-measurement-using-ct-urography-in-patients-with-a-gfr-below-60-mlmin173-m-100596226","NCT07042698","Evaluation of the Performance of Glomerular Filtration Rate Measurement Using CT Urography in Patients With a GFR Below 60 mL\u002FMin\u002F1.73 m²","Evaluation of the Performance of Glomerular Filtration Rate Measurement Using CT Urography in Patients With Chronic Kidney Disease","DUSIR","Inclusion Criteria:\n\n* Patients older than 18 years of age\n* Having given written consent to participate in the study\n* Patient referred to the medical imaging department of the Henri Mondor University Hospital for a 3-phase or 4-phase abdominal CT scan\n* With an estimated GFR according to CKD-EPIcreat2009 \\\u003C 60 ml\u002Fmin\u002F1.73m²\n* Hospitalized or outpatient\n* Affiliated with French national health insurance\n\nExclusion Criteria:\n\n* Patients with hip implants, due to artifacts that make quantification of the contrast agent in the bladder unreliable\n* Lack of health insurance\n* Patients under legal protection.",{"count":62,"type":21},70,[24],"Glomerular filtration rate (GFR), which is the main biomarker used in clinical practice to assess kidney function, is usually estimated from the serum concentration of endogenous markers such as creatinine and\u002For cystatin C. GFR estimation equations all share the disadvantage of imperfect accuracy due to non-GFR-related determinants of creatinine and cystatin C. When knowing the exact GFR value is necessary for clinical decision-making, measurement by clearance of an exogenous tracer is required. Various tracers are available, some of which are radioactive tracers (99mTc-DTPA and 51Cr-EDTA), while others are iodinated contrast agents (iohexol, iothalamate). GFR measurement procedures are time-consuming and require significant human resources (4 to 5 hours, or even 24 hours for plasma clearances at very low GFR values).Urinary clearance methods may be inaccurate in cases of inadequate voiding. Plasma clearance results may be inaccurate in cases of increased (overestimation) or decreased (underestimation) extracellular volume, low GFR (unless late sampling is performed), or glomerular hyperfiltration. Measuring tracers requires either warm labs for measuring radioactive markers or labs with HPLC (High Performance Liquid Chromatography) chains for iohexol, which are part of an external quality assurance program. The complexity and\u002For length of GFR measurement procedures, their cost, and laboratory constraints explain why measured GFR is underused in routine clinical practice. There is a critical need to develop GFR measurement methods that are simpler to implement, reliable across the entire GFR spectrum, and widely available. We have demonstrated that it is possible to measure GFR using 4-phase CT urography performed as part of the care of living kidney donor candidates (healthy individuals with normal GFR). The examination takes 10 minutes, requires no biological sampling, and is not subject to potential inaccuracies due to sodium overload or poor bladder emptying.",[66,31,67],"Kidney Diseases","X-Ray Computed",[69,31,67],"Glomerular Filtration Rate","2025-06-25",{"date":72,"type":44},"2025-06-29",{"date":74,"type":21},"2025-07-15",{"date":76,"type":21},"2027-07-15",{"name":78,"class":79},"Assistance Publique - Hôpitaux de Paris","OTHER",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":52},"100591158","creation-of-a-database-of-healthy-subjects-with-18fdg-pet-brain-imaging-as-part-of-the-mobile-project-multimodal-whole-brain-imaging-in-epilepsy-100591158","NCT06976788","Creation of a Database of Healthy Subjects With 18FDG PET Brain Imaging as Part of the MOBILE Project (Multimodal Whole-Brain Imaging in Epilepsy)","MOBILE-PET","Inclusion Criteria:\n\n* \\- Female or male, over 18 and under 65 years of age.\n* Subject free of any general illness, psychiatric disorders or infectious, inflammatory, tumoral, vascular, degenerative or traumatic pathology of the central nervous system, as determined on examination,\n* Subject not receiving chronic treatment, particularly psychotropic,\n* Subject with no history of alcoholism or drug addiction,\n* Subject with no contraindications to PET scintigraphic exploration (pregnancy and breast-feeding),\n* Subject with social security coverage,\n* Subject having read, understood and signed an informed consent form.\n\nExclusion Criteria:\n\n* \\- Minors,\n* Pregnant or breast-feeding women,\n* Women of childbearing age without contraception,\n* Subjects presenting a contraindication to PET scintigraphic exploration,\n* adult subject to a legal protection measure, as provided for in L.1121-6 to L.1121-8 of the French Public Health Code.","65 Years",{"count":89,"type":21},30,[24],"The MOBILE project is part of the dynamic European collaboration of the Human Brain Project (HBP). The overall aim of the project is to characterize brain structure and function in healthy subjects and patients with epilepsy, using a quantitative multimodal approach involving both neuroimaging (MRI, PET) and electrophysiology (EEG\u002FMEG). The project is funded by the European HBP consortium, and the data acquired will ultimately be made available to the scientific community formed by this international collaboration. Several aspects of the project have already been initiated on the basis of extensions to previous authorizations, or as part of care activities. As part of this overall project, the present MOBILE-PET application concerns exclusively the performance of 18F-FDG PET (Positron Emission Tomography) imaging in the 30 healthy adult subjects in the protocol (aged 18 to 65, with inclusion parity for gender). This cerebral examination, performed at rest on a 45-minute 3D volume acquisition, enables quantitative measurement of the metabolic consumption of glucose underlying global synaptic activity, and to determine the associated connectivity. Around 1,500 examinations of this type are carried out each year in our department as part of care for patients with brain pathology, and over 10,000 for patients with cancer. This examination requires intravenous injection of a weakly radioactive tracer corresponding to a radiopharmaceutical which has been approved for marketing for over 20 years. We also carried out and finalized a similar project in 2007 on 60 healthy subjects, using a previous-generation PET camera (NCT00484523). The Nuclear Medicine Department holds clinical research authorizations for imaging in patients and healthy subjects (including early phase and first-in-man, although the present project does not fall into this research categarogy).",[93,31,94],"Healthy","Brain Development","RECRUITING","2025-05-15",{"date":98,"type":44},"2025-05-16",{"date":100,"type":44},"2024-09-26",{"date":102,"type":21},"2026-09-25",{"name":104,"class":79},"Assistance Publique Hopitaux De Marseille"]