[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tongue-cancer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tongue-cancer":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,68,94,165],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":44},"100602515","normative-ranges-of-lingual-strength-and-endurance-and-the-impact-of-the-iopi-lingual-strength-trainer-on-quantitative-functional-outcomes-and-patient-reported-outcomes-after-partial-glossectomy-or-hemiglossectomy-for-oral-tongue-cancer-an-unblinded-randomized-pilot-study-100602515",false,"NCT07124520","Normative Ranges of Lingual Strength and Endurance and the Impact of the IOPI Lingual Strength Trainer on Quantitative Functional Outcomes and Patient-Reported Outcomes After Partial Glossectomy or Hemiglossectomy for Oral Tongue Cancer, An Unblinded: Randomized Pilot Study","Inclusion Criteria:\n\n* Age ≥18 years old\n* Scheduled to undergo primary surgery for oral tongue cancer (glossectomy types 1 to 3) using any type of closure or reconstruction\n\nExclusion Criteria:\n\n* Previous radiation therapy to the oral cavity or head and neck\n* Previous surgery for oral cavity cancer\n* Recurrent oral cavity cancer\n* Surgical requirement of extension to involve bone (mandible resection)\n* Subtotal or total glossectomy\n* Feeding tube dependance prior to surgery","ALL","18 Years",{"count":18,"type":19},60,"ESTIMATED","INTERVENTIONAL",[22],"NA","The purpose of this study is to learn more about tongue strength and endurance by using the Iowa Oral Performance Instrument (IOPI). The IOPI is a device that measures tongue pressure.",[25],"Tongue Cancer",[25,27,28,29,30,31,32],"Oral Tongue Cancer","IOPI Lingual Strength Trainer","Iowa Oral Performance Instrument","Iowa Oral Performance Instrument Tongue Strength Trainer","Memorial Sloan Kettering Cancer Center","25-162","RECRUITING","2026-06-26",{"date":36,"type":37},"2026-06-30","ACTUAL",{"date":39,"type":37},"2025-08-07",{"date":41,"type":19},"2028-08-07",{"name":31,"class":43},"OTHER",7,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":20,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":44},"100608619","surgeon-performed-ultrasound-for-real-time-guidance-in-oral-cancer-surgeries---a-multicenter-randomized-controlled-trial-100608619","NCT07203911","Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial","SURGIO","Inclusion criteria\n\n• Patients scheduled for surgical treatment of biopsy-proven T1-T3 oral squamous cell carcinoma.\n\nExclusion criteria\n\n* Age \\\u003C 18 years.\n* Oral cancer with suspected bone involvement.\n* Unable to understand verbal or written information.\n* Prior radiotherapy treatment of oral cavity cancer.\n* Tumor not visible on ultrasound.",{"count":53,"type":19},150,[22],"The goal of this clinical trial is to improve the surgical treatment of patients with oral cancer. We will explore whether the use of surgeon performed ultrasound during these surgeries result in better tumor removal. We hypothesize that using intraoperative ultrasound to assist the resection results in more frequent clear surgical margins in oral cancer surgeries compared to standard methods. This improvement is associated with a reduced need for post-operative adjuvant therapies such as radiotherapy and reoperation, lower mortality rates, lower cancer recurrence, and enhanced quality of life for patients undergoing surgery for oral cancer.\n\nParticipants will be randomized to either the control or intervention group:\n\n* Control group will receive standard treatment for oral cancer.\n* Intervention group will in addition to the standard treatment have surgery performed using ultrasound to guide the resection and evaluate resection margins intraoperatively.\n\nOutcomes:\n\n* Number of free surgical margins between control and intervention group.\n* Intraoperative surgeon assessed surgical margins compared to final histology report.\n* Dysphagia and quality of life questionnaires.\n* Recurrence rates.\n* Mortality rates.\n\nAll participant will be followed-up at 3 months and 12 months with:\n\n* MDADI dysphagia questionnaire\n* EORTC head and neck cancer quality of life questionnaire\n* Follow-up on recurrrence and mortality.",[25,57,58],"Oral Cancer","Squamous Cell Carcinoma of the Oral Cavity or Oropharynx","2026-05-10",{"date":61,"type":37},"2026-05-13",{"date":63,"type":37},"2025-09-15",{"date":65,"type":19},"2031-08",{"name":67,"class":43},"Tobias Todsen",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":20,"phases":78,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":93},"100253924","prosthesis-guided-speech-rehabilitation-of-t1t2-cancers-of-the-tongue-100253924","NCT02584270","Prosthesis Guided Speech Rehabilitation of T1\u002FT2 Cancers of the Tongue","Prosthesis Guided Speech Rehabilitation of T1\u002FT2 Cancers of the Tongue (PGSRT): a Randomized Clinical Trial","PGSRT","Inclusion Criteria:\n\n* Patients with a new diagnosis of a T1\u002FT2 tongue cancer\n\nExclusion Criteria:\n\n* Patients with recurrent disease\n* Patients with a history of prior head and neck radiation therapy\n* Patients who lack adequate maxillary dentition to support a palatal augmentation prosthesis",{"count":77,"type":19},40,[22],"This study will fill a scientific gap in the current knowledge providing data for evaluation of the palatal augmentation prosthesis (PAP) as a therapeutic modality post-surgery. This is a robust scientific randomized prospective clinical trial.\n\nPositive outcomes from this study have the potential to dramatically alter the most common issues of oral cancer therapy, namely speech and swallowing functions. Patients will have been diagnosed with a cancer lesion of the tongue requiring surgery and removal of part of the tongue. Smaller cancers of the tongue are sized as T1 or T2. For patients with smaller lesions, a PAP, which can aid in speaking and swallowing, is not routinely provided.",[81,25,57],"Tongue Neoplasms",[83],"palatal drop prosthesis","2026-05-05",{"date":86,"type":37},"2026-05-08",{"date":88,"type":37},"2018-01-02",{"date":90,"type":19},"2028-06",{"name":92,"class":43},"University of Michigan",1,{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":20,"phases":103,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":93},"100169023","transoral-robotic-surgery-in-treating-patients-with-benign-or-malignant-tumors-of-the-head-and-neck-100169023","NCT01473784","Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck","A Pilot Study Assessing Transoral Robotic Surgery (TORS) for Oral and Laryngopharyngeal Benign and Malignant Lesions Using the Da Vinci Robotic Surgical System","Inclusion Criteria:\n\n* Patient must present with indications for diagnostic or therapeutic approaches for benign and\u002For malignant diseases of the oral cavity or laryngopharynx (including the neoplastic lesions of the tongue, tongue base, retromolar trigone, tonsils, palate, posterior and lateral pharynx, glottic, supraglottic and subglottic larynx)\n* Patients must have adequate transoral exposure of the oral cavity and laryngopharynx for TORS instrumentation\n* Written informed consent and\u002For Consent waiver by institutional review board (IRB)\n\nExclusion Criteria:\n\n* Unexplained fever and\u002For untreated, active infection\n* Patient pregnancy\n* Previous head and neck surgery that would preclude transoral\u002Frobotic procedures. This is at the investigator's discretion. This is not an exclusion criterion for the non-surgical arm.\n* The presence of medical conditions contraindicating general anesthesia or transoral surgical approaches\n* Inability to grant informed consent\n* INTRAOPERATIVE EXCLUSION CRITERIA:\n* Inability to adequately visualize anatomy to perform the diagnostic or therapeutic surgical approach transorally",{"count":102,"type":19},600,[22],"This pilot clinical trial studies transoral robotic surgery (TORS) in treating patients with benign or malignant tumors of the head and neck. TORS is a less invasive type of surgery for head and neck cancer and may have fewer side effects and improve recovery",[106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,25],"Recurrent Adenoid Cystic Carcinoma of the Oral Cavity","Recurrent Mucoepidermoid Carcinoma of the Oral Cavity","Recurrent Squamous Cell Carcinoma of the Hypopharynx","Recurrent Squamous Cell Carcinoma of the Larynx","Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity","Recurrent Verrucous Carcinoma of the Larynx","Recurrent Verrucous Carcinoma of the Oral Cavity","Stage 0 Hypopharyngeal Cancer","Stage 0 Laryngeal Cancer","Stage 0 Lip and Oral Cavity Cancer","Stage I Adenoid Cystic Carcinoma of the Oral Cavity","Stage I Mucoepidermoid Carcinoma of the Oral Cavity","Stage I Squamous Cell Carcinoma of the Hypopharynx","Stage I Squamous Cell Carcinoma of the Larynx","Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity","Stage I Verrucous Carcinoma of the Larynx","Stage I Verrucous Carcinoma of the Oral Cavity","Stage II Adenoid Cystic Carcinoma of the Oral Cavity","Stage II Mucoepidermoid Carcinoma of the Oral Cavity","Stage II Squamous Cell Carcinoma of the Hypopharynx","Stage II Squamous Cell Carcinoma of the Larynx","Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity","Stage II Verrucous Carcinoma of the Larynx","Stage II Verrucous Carcinoma of the Oral Cavity","Stage III Adenoid Cystic Carcinoma of the Oral Cavity","Stage III Mucoepidermoid Carcinoma of the Oral Cavity","Stage III Squamous Cell Carcinoma of the Hypopharynx","Stage III Squamous Cell Carcinoma of the Larynx","Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity","Stage III Verrucous Carcinoma of the Larynx","Stage III Verrucous Carcinoma of the Oral Cavity","Stage IV Squamous Cell Carcinoma of the Hypopharynx","Stage IVA Adenoid Cystic Carcinoma of the Oral Cavity","Stage IVA Mucoepidermoid Carcinoma of the Oral Cavity","Stage IVA Squamous Cell Carcinoma of the Larynx","Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity","Stage IVA Verrucous Carcinoma of the Larynx","Stage IVA Verrucous Carcinoma of the Oral Cavity","Stage IVB Adenoid Cystic Carcinoma of the Oral Cavity","Stage IVB Mucoepidermoid Carcinoma of the Oral Cavity","Stage IVB Squamous Cell Carcinoma of the Larynx","Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity","Stage IVB Verrucous Carcinoma of the Larynx","Stage IVB Verrucous Carcinoma of the Oral Cavity","Stage IVC Adenoid Cystic Carcinoma of the Oral Cavity","Stage IVC Mucoepidermoid Carcinoma of the Oral Cavity","Stage IVC Squamous Cell Carcinoma of the Larynx","Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity","Stage IVC Verrucous Carcinoma of the Larynx","Stage IVC Verrucous Carcinoma of the Oral Cavity","2026-02-06",{"date":158,"type":37},"2026-02-10",{"date":160,"type":37},"2007-12-03",{"date":162,"type":19},"2026-12-31",{"name":164,"class":43},"Ohio State University Comprehensive Cancer Center",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":173,"targetDuration":175,"studyType":176,"phases":4,"briefSummary":177,"conditions":178,"keywords":185,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":93},"100567034","arabic-pro-measures-for-head-and-neck-cancer-radiotherapy-100567034","NCT06662929","Arabic PRO Measures for Head and Neck Cancer Radiotherapy.","Arabic Patient-reported Outcome Measures During Radiotherapy for Head and Neck Cancer: a Validation Study","PROMs","Inclusion Criteria:\n\n* Adults aged 18 or above and who is planned for receiving and who is currently receiving and who had already received radiotherapy for the HNC at King Saud University Medical City.\n\nExclusion Criteria:\n\n* Individuals who are less than 18 years, presence of debilitating disease (e.g. heart failure) or who lack the capacity to read, understand and sign the informed consent and those.",{"count":174,"type":19},125,"2 Weeks","OBSERVATIONAL","The goal of Arabic patient-reported outcome measures during radiotherapy for head and neck cancer is to test the patient-reported outcome measure (PROM) tools. PROM tools are not validated cross-culturally in Arabic-speaking patient populations, which limits their use in our clinical setting. Validation of these PROM tools will allow clinicians to identify the concerns related to our patient population and measure the outcome of our interventions. Main objectives are:\n\n* To further validate (cross-culture) the PROM instruments related to head and neck cancer (HNC) in Arabic patients.\n* To investigate the prevalence and severity of the patient-reported concerns and their relevance with demographics and clinical characteristics.\n\nThe participants will be given tasks to complete 6 tools survey before, during, and after radiotherapy.",[179,180,181,182,183,57,25,184],"Head and Neck Cancer","Head and Neck Neoplasms","Head and Neck Squamous Cell Carcinoma","Oropharynx Cancer","Nasopharyngeal Cancer","Oral Neoplasm",[171,179,186,187,188],"Radiotherapy","COSMIN","Cancer","2024-10-26",{"date":191,"type":37},"2024-10-29",{"date":193,"type":37},"2023-05-01",{"date":195,"type":19},"2025-10-01",{"name":197,"class":43},"King Saud University"]