[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tonsillectomy-with-or-without-adenoidectomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tonsillectomy-with-or-without-adenoidectomy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100628580","preoperative-high-dose-oral-paracetamol-for-postoperative-analgesia-in-children-undergoing-tonsillectomy-100628580",false,"NCT07463482","Preoperative High-Dose Oral Paracetamol for Postoperative Analgesia in Children Undergoing Tonsillectomy\"","Effect of Preoperative Oral Paracetamol Loading Dose Versus Standard Dose on Postoperative Opioid Consumption in Pediatric Tonsillectomy With Multimodal Analgesia: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Children aged 3 to 15 years\n2. ASA physical status I-III\n3. Scheduled for elective tonsillectomy with or without adenoidectomy\n\nExclusion Criteria:\n\n1. Known allergy or contraindication to paracetamol or any agents in the study protocol\n2. Chronic opioid use","ALL","3 Years","15 Years",{"count":20,"type":21},54,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized clinical trial compares two different preoperative doses of oral paracetamol (acetaminophen) in children undergoing elective tonsillectomy. The aim is to determine whether a higher loading dose (30 mg\u002Fkg) decreases the need for opioid rescue medication after surgery compared with the standard dose (15 mg\u002Fkg), when used as part of a multimodal pain management approach. Children aged 3 to 15 years will be randomly assigned to receive either 30 mg\u002Fkg or 15 mg\u002Fkg of oral paracetamol before surgery. All participants will receive the same standard anesthesia and postoperative pain management. The primary outcome is the total amount of rescue opioid (fentanyl) required during the first 12 hours after surgery. Secondary outcomes include postoperative pain scores and the occurrence of side effects such as nausea and vomiting. This study seeks to determine whether a higher initial dose of paracetamol offers additional clinical benefits in pediatric tonsillectomy with multimodal analgesia.",[27,28],"Post Operative Analgesia","Tonsillectomy With or Without Adenoidectomy",[30,31,32,33,34,35],"paracetamol","acetaminophen","tonsillectomy","postoperative analgesia","pediatric anesthesia","multimodal analgesia","NOT_YET_RECRUITING","2026-03-05",{"date":39,"type":40},"2026-03-11","ACTUAL",{"date":42,"type":21},"2026-03",{"date":44,"type":21},"2026-11",{"name":46,"class":47},"Thammasat University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":48},"100602059","phase-4-effects-of-remimazolam-and-ciprofol-tiva-on-prae-in-pediatric-tonsillectomy-and-adenoidectomy-100602059","NCT07118579","Effects of Remimazolam and Ciprofol TIVA on PRAE in Pediatric Tonsillectomy and Adenoidectomy","Effects of Remimazolam and Ciprofol Total Intravenous Anesthesia on Perioperative Respiratory Adverse Events in Pediatric Tonsillectomy and Adenoidectomy: A Randomized Controlled Study","Inclusion Criteria:\n\n* Aged 2-12 years\n* ASA physical status I-II\n* Body mass index (BMI): 14-28 kg\u002Fm²\n* Scheduled for elective tonsillectomy with or without adenoidectomy\n* Signed informed consent by legal guardian(s) and assent by children (≥8 years old)\n\nExclusion Criteria:\n\n* History of severe pulmonary diseases (e.g., asthma, bronchiectasis, severe OSA)\n* Previous episodes of significant PRAEs\n* Documented drug allergies (e.g., to remimazolam, propofol, or ciprofol)\n* Comorbidities including: Uncorrected congenital heart disease, neuromuscular disorders, Developmental delay, Abnormal hepatic\u002Frenal function\n* Preoperative moderate-to-severe respiratory infections requiring surgery postponement\n* Recent participation in other clinical trials","2 Years","12 Years",{"count":59,"type":21},114,[61],"PHASE4","To observe the effects of remimazolam versus ciprofol TIVA on PRAE in pediatric tonsillectomy and adenoidectomy.",[28],[65,66,67,68],"Remimazolam","Ciprofol","TIVA","PRAE","RECRUITING","2025-11-17",{"date":72,"type":40},"2025-11-21",{"date":74,"type":40},"2025-09-23",{"date":76,"type":21},"2026-08",{"name":78,"class":47},"Tongji Hospital",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":16,"minAge":56,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":48},"100575085","effect-of-neck-hyperextension-on-endotracheal-tube-cuff-pressure-in-children-100575085","NCT06767696","Effect of Neck Hyperextension on Endotracheal Tube Cuff Pressure in Children","The Effect of Neck Hyperextension on Endotracheal Tube Cuff Pressure in Children","Inclusion Criteria:\n\n* Patients aged 2-18 years\n* undergoing adenoidectomy, tonsillectomy or adenotonsillectomy surgery\n\nExclusion Criteria:\n\n* Patients with restricted head and neck mobility,\n* patients with intraoperative complications,\n* patients with previous neck surgery,\n* patients with BMI \\> 35 kg\u002Fm2",true,"18 Years",{"count":89,"type":21},120,"OBSERVATIONAL","Introduction: Patients undergoing surgery under general anaesthesia are frequently intubated with an endotracheal tube (ETT). The safety margin of ETT cuff pressure is between 20-30 cmH2O. Inadequately inflated cuff (\\\u003C20 cmH2O) may cause secretions in the mouth, foreign bodies, bleeding due to surgery to escape into the trachea and\u002For air leakage. As a result of air leakage, the effect of mechanical ventilation decreases, end-tidal CO2 measurement cannot be performed accurately, and inhalation anaesthetics leak into the operating room. An overinflated cuff (\\>30 cmH2O) may affect tracheal mucosa blood flow. This may result in tracheal stenosis, tracheoesophageal fistula or tracheal rupture. There may be significant changes in cuff pressure during endotracheal intubation because cuff pressure can be affected by changes in head and neck position. Due to all these situations, controlling ETT cuff pressure is very important for patient health and safety.\n\nFor ETT cuff pressure control; manual palpation of the pilot balloon, listening for the disappearance of an audible air leak, inflating the cuff with minimal occlusive pressure to a peak inflation pressure of 20-22 cmH2O during positive pressure ventilation, inflating the cuff until the airway is closed by maintaining a continuous positive airway pressure of 20 cmH2O, or cuff manometers are commonly used applications. Although cuff manometers can be used to guide the monitoring of cuff pressure, their use and availability is not mandatory in many institutions around the world (due to the large number of anaesthetic areas, it is not possible to have a manometer everywhere). Therefore, in anaesthetic practice, cuff pressure is monitored manually or using a manometer at regular intervals during the operation.\n\nAim\u002FHypothesis:\n\nH0: Endotracheal tube cuff pressure does not change with hyperextension position given to the neck during adenoidectomy, tonsillectomy or adenotonsillectomy surgery.\n\nH1: Endotracheal tube cuff pressure changes with hyperextension position given to the neck during adenoidectomy, tonsillectomy or adenotonsillectomy surgery.\n\nMaterial-Methods: The study will include patients between the ages of 2-18 years who will undergo adenoidectomy, tonsillectomy or adenotonsillectomy after obtaining informed consent from their parents. Routine practice will be followed for induction and maintenance of anaesthesia. Patients monitored in the operating room according to the standard American Society of Anesthesiologists (ASA) protocol will be orotracheally intubated with an ETT of appropriate internal diameter after induction of anaesthesia by the anaesthesiologist responsible for the patient. After the tube placement of the intubated patients is confirmed by the responsible anaesthesiologist, the ETT cuff will be measured and recorded by the responsible investigator with a cuff manometer (VBM Medizintechnik, GmbH, Germany) while the head and neck are in the neutral position (T0). When the patients are given the head-neck hyperextension position in which the surgery will be performed by the surgical team responsible for the patient's surgery, the pressure measurements will be repeated by the responsible investigator (T1). At the end of the operation, when the head and neck are returned to the neutral position, the tubular cuff pressure will be measured by the responsible investigator for the last time (T2).\n\nPatients between 2-18 years of age who underwent adenoidectomy, tonsillectomy or adenotonsillectomy surgery will be included in the study. Patients with head and neck mobility restriction, patients who have had neck surgery before, and patients with body mass index (BMI) \\> 35 kg\u002Fm2 will be excluded from the study.",[93,94,95,96],"Endotracheal Cuff","Adenoidectomy Surgery","Tonsillectomy with or Without Adenoidectomy","Position Differences","2025-02-05",{"date":99,"type":40},"2025-02-07",{"date":101,"type":40},"2025-01-06",{"date":103,"type":21},"2025-12-31",{"name":105,"class":106},"Ankara Ataturk Sanatorium Training and Research Hospital","OTHER_GOV"]