[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tooth-abnormalities\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tooth-abnormalities":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,61,97,123],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":37,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":60},"100644109","morphology-in-oral-rare-syndromes--artificial-intelligence-for-clinical-diagnosis-100644109",false,"NCT07666269","Morphology in Oral Rare Syndromes & Artificial Intelligence for Clinical Diagnosis","Geometric Morphometric Characterization of Oro-Dental Anomalies in Rare Bone and Cartilage Diseases From 3D Digital Data (MOSAIC)","MOSAIC","Inclusion Criteria:\n\n* For cases: Diagnosis of a rare bone and cartilage disorder confirmed by the Rare Disease Competence Center for Constitutional Bone Disorders (MOC) or Calcium and Phosphate Metabolism Disorders (CaP), genetically and\u002For clinically.\n* Ability to undergo a 3D intra-oral scan;\n* Ability of the participant to understand the information notice provided regarding the use of their medical data and 3D digital models for research purposes, and to express informed non-objection to participation in the research.\n* For controls: healthy adults recruited in the Dental Medicine Department.\n\nExclusion Criteria:\n\n* History of major orthodontic\u002Forthognathic treatment;\n* Craniofacial conditions unrelated to the studied diseases (e.g., cleft palate, non-target craniofacial syndromes);\n* Impossibility to obtain a 3D optical impression;\n* Refusal or inability of the participant to understand the information notice and\u002For to express informed non-objection to participation in the research.",true,"ALL","18 Years",{"count":21,"type":22},240,"ESTIMATED","INTERVENTIONAL",[25],"NA","MOSAIC aims to determine whether oro-dental morphological anomalies, particularly palatal morphology, associated with rare bone and cartilage diseases can be precisely characterized using 3D digital models analysed through geometric morphometrics. The study will also evaluate whether these morphological signatures can train an artificial intelligence (AI) algorithm to classify syndromes. A prospective monocentric case-control cohort will be constituted, including 3D intra-oral scans and associated clinical data. The final goal is to improve diagnostic accuracy and reduce diagnostic delay in rare bone disorders.",[28,29,30,31,32,33,34,35,36],"Osteogenesis Imperfecta","Rare Bone Disorders","Hypophosphatemia","X-Linked","Mucopolysaccharidoses","Tooth Abnormalities","Palate; Deformity","Artificial Intelligence (AI)","Machine Learning",[38,39,40,41,42,43,44,45,46,47],"Rare bone diseases","palatal morphology","geometric morphometrics","3D intra-oral scan","machine learning","artificial intelligence","diagnostic classification","osteogenesis imperfecta","X-linked hypophosphatemia","mucopolysaccharidosis","NOT_YET_RECRUITING","2026-06-18",{"date":51,"type":52},"2026-06-24","ACTUAL",{"date":54,"type":22},"2026-09-01",{"date":56,"type":22},"2028-03-01",{"name":58,"class":59},"University Hospital, Bordeaux","OTHER",1,{"id":62,"slug":63,"hasResults":11,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":68,"targetDuration":4,"studyType":70,"phases":4,"briefSummary":71,"conditions":72,"keywords":82,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":60},"100629572","oral-health-dento-facial-condition-and-ohrqol-in-subjects-with-mowat-wilson-syndrome-an-epidemiologic-study-100629572","NCT07476417","Oral Health, Dento-facial Condition and OHRQoL in Subjects With Mowat-Wilson Syndrome: an Epidemiologic Study.","ORALMOWAT26","Inclusion Criteria:\n\n* individuals affected by MWS with confirmed molecularly diagnosis of ZEB2 gene variation.\n* written informed consent statement signed by parents\u002Flegal guardians for participation in the study\n\nExclusion Criteria:\n\n* individuals not affected by MWS\n* refusal of parents\u002Flegal guardians to participate in the study",{"count":69,"type":22},25,"OBSERVATIONAL","Mowat-Wilson Syndrome (MWS) is a rare syndrome characterized by the presence of facial gestalt and delayed psychomotor development, variably associated with intellectual disability, epilepsy, Hirschsprung's disease (HSCR) and multiple congenital malformations.\n\nAlthough there is evidence of the presence of dental and craniofacial anomalies in MWS, little epidemiological data is available to date.\n\nThe goal of this observational study is to assess oral health and dento-facial phenotype of people affected by Mowat-Wilson Syndrome (MWS). In addition, the Oral Health Related Quality of Life (OHRQoL) will be investigated.",[73,74,75,76,77,78,33,79,80,81],"Mowat-Wilson Syndrome","Dental Caries","Periodontal Diseases","Sleep Related Breathing Disorder","Tooth Diseases","Malocclusion","Oral Health Related Quality of Life (OHRQoL)","Craniofacial Abnormalities","Oral Mucosal Disease",[83,84,85,86,87,80],"Mowat-Wilson syndrome","dental caries","periodontal diseases","malocclusion","oral health","2026-03-19",{"date":90,"type":52},"2026-03-24",{"date":92,"type":22},"2026-04-01",{"date":94,"type":22},"2026-08-30",{"name":96,"class":59},"University of Milan",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":18,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":23,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":122},"100589146","associations-between-dental-anomalies-and-ocular-cutaneous-and-skin-appendages-features-100589146","NCT06950619","Associations Between Dental Anomalies and Ocular, Cutaneous and Skin Appendages Features","A Clinical Investigation Into the Co-occurrence of Dental Anomalies With Ocular and Cutaneous Features","Inclusion Criteria:\n\n* Supernumerary teeth\n* oligodontia\n* screw driver sharped incisors\n* Hutchinson's teeth\n* mulberry molars\n* tooth agenesis\n* congenital cataract, keratitis, keratoconus, corneal dystrophies, ectopia lentis, glaucoma, retinitis pigmentosa, coloboma and aniridia in probands or relatives\n* skin appendages anomalies in probands or relatives\n\nExclusion Criteria:\n\n* Previous orthodontic, restorative, endodontic, prosthetic and surgical treatment that could alter tooth morphology and position","12 Years","70 Years",{"count":107,"type":22},5,[25],"Considering recent literature, it is possible to hypothesise a link between dental anomalies and ocular and\u002For cutaneous findings, given the existence of shared genetic and developmental mechanisms between these two anatomical areas. Both the eye and teeth develop from ectodermal and mesenchymal tissues, involving common molecular signalling pathways such as Wnt, BMP and PAX. Genetic variants affecting these pathways can therefore determine combined phenotypes, such as congenital cataracts associated with dental agenesis or enamel malformations. Some rare genetic syndromes, such as Nance-Horan syndrome and oculofacio-cardio-dental (OFCD) syndrome, support the hypothesis of a systemic correlation between odontogenesis and ocular development. In a previous study on congenital cataracts, nearly 10% of probands with variants in the BCOR, CWC27, IFIH1, NHS, and PAX6 genes had various dental abnormalities. Therefore, exploring the possible connection between eye and dental diseases may not only facilitate early and multidisciplinary diagnosis, but also open up new perspectives in genetic research and the development of personalised therapeutic approaches, for which whole genome sequencing (WGS) appears to be the first choice for investigating non-syndromic forms. Therefore, the current clinical study aims to identify variants in genes common to eye diseases and dental anomalies (agenesis, supernumerary teeth, Hutchinson's teeth, mulberry molars) in orthodontic patients over the age of 12 with dental anomalies who are about to begin orthodontic treatment or who are attending routine check-ups at the Orthodontics and Paediatric Dentistry Unit, Department of Clinical, Surgical, Diagnostic and Paediatrics Sciences at the University of Pavia who have a family history of ocular and cutaneous manifestations or presenting at the same time dental, ocular and\u002For cutaneous anomalies. Patients who are eligible will be invited to participate in the study. After signing the informed consent form, the Case Report Form will be completed to collect the data of interest for the study; previous medical reports will be asked to patients or parents\u002Flegal guardians in case of minors to ascertain ocular and cutaneous pathologies; a buccal swab will be taken to collect a DNA sample that will be analysed with Next Generation Sequencing. In addition, cephalometric evaluations will be performed if lateral teleradiographs will be available, if already performed in accordance with Good Clinical Practice for the purposes of orthodontic assessment of patients.",[111,33,112],"Congenital Cataract","Ocular Pathologies","2025-11-14",{"date":115,"type":52},"2025-11-19",{"date":117,"type":22},"2026-02",{"date":119,"type":22},"2027-04",{"name":121,"class":59},"University of Pavia",2,{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":70,"phases":4,"briefSummary":132,"conditions":133,"keywords":138,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":60},"100606085","analysis-of-tooth-root-number-100606085","NCT07170956","Analysis of Tooth Root Number","Variability in Tooth Root Number: A Cross-Sectional Study","Inclusion Criteria:\n\n* CBCT scans obtained following a written referral from a dentist,\n* clear and complete visibility of the assessed structure,\n* completed development of assessed roots.\n\nExclusion Criteria:\n\n* incomplete root development in teeth other than third molars within the dentition,\n* CBCT scans with significant artefacts.",{"count":131,"type":22},4000,"The aim of this cross-sectional study is to assess the number of roots in permanent teeth. For this reason, researchers will conduct an analysis of CBCT scans. The collected data will be used for epidemiological analysis, including an examination of differences in outcomes between male and female patients.",[33,134,135,136,137],"Tooth Abnormality","Tooth Anatomy","Tooth Development Disorder","Tooth Disorder",[139,140,141],"Tooth root","Tooth abnormalities","Tooth anatomy","2025-09-04",{"date":144,"type":52},"2025-09-12",{"date":146,"type":22},"2025-09",{"date":148,"type":22},"2025-12",{"name":150,"class":59},"Hospital of the Ministry of Interior, Kielce, Poland"]