[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tooth-crown-fracture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tooth-crown-fracture":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100641017","platelet-rich-fibrin-prf-vs-bone-graft-with-membrane-for-ridge-preservation-after-tooth-extraction-100641017",false,"NCT07595198","Platelet-Rich Fibrin (PRF) vs Bone Graft With Membrane for Ridge Preservation After Tooth Extraction","Application of Platelet-Rich Fibrin Consolidated Bone Substitutes in Alveolar Ridge Preservation: A Randomized Controlled Study","Inclusion Criteria:\n\n1. Patients of age between 18-80.\n2. Non-smokers or former smokers with at least a 5-year successful cessation history.\n3. Patients with normal systemic health (ASA-I) or well-controlled\u002Fstable systemic conditions (ASA-II), such as diabetes with HbA1c \\\u003C 7.0%, no recent acute myocardial infarction and cerebrovascular accidents within 6 months, or any contraindication for periodontal or implant surgery.\n4. Patients treatment planned for extraction and ridge preservation for at least 2 non-adjacent single-rooted teeth.\n\nExclusion Criteria:\n\n1. Current smokers, smokers who have quit \\\u003C5 years prior to study entry.\n2. Pregnant or lactating women\n3. Patients with substance or alcohol abuse\n4. Patients with a history of antiresorptive therapy, head and neck radiotherapy, and chemotherapy for malignant tumors\n5. Other systemic conditions or medications affecting wound healing.\n6. Poor plaque control with plaque score \\> 20%\n7. Active\u002Funtreated odontogenic and periodontal infections",true,"ALL","18 Years","80 Years",{"count":21,"type":22},14,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study uses a natural material called Platelet-Rich Fibrin (PRF) to help improve healing after tooth removal. PRF is made from your own blood. A small amount of blood is taken from your arm and spun in a machine to make a thick, sticky layer full of platelets. These platelets help your body heal. PRF acts like a \"natural bandage\" and may help your gums and bone heal faster. Because it comes from your own body, it is safe and lowers the chance of infection or problems.\n\nThe goal of this research is to see if adding PRF to a bone graft (used to fill the tooth socket after extraction) can help the area heal faster and grow more new bone.\n\nIf you join this study, it will last about 4 months. You will have two teeth removed, and each socket will get a different treatment:\n\n1. One socket (test side) will get PRF + bone graft (this combination is also called \"sticky bone\").\n2. The other socket (control side) will get a bone graft + a covering called a barrier membrane (made of collagen).\n\nWe will compare how well the two sides heal by looking at:\n\n1. How the gums close over the area\n2. How much pain you feel\n3. How much the bone changes\n4. How much new bone grows You will come to the clinic for about 9 visits in total. These visits are part of your regular treatment, along with a few extra steps for the study.\n\nOne possible risk is bruising or soreness from the blood draw. If we cannot collect enough blood (about 60-80 ml) because your veins are too small or hard to find, you will not continue in the study, and both sockets will be treated using the control method (bone graft + membrane).",[28,29,30,31],"Extraction, Tooth","Tooth Fracture","Tooth Crown Fracture","Root; Fracture",[33,34],"Platelet Rich Fibrin","Extraction, tooth","NOT_YET_RECRUITING","2026-05-12",{"date":38,"type":39},"2026-05-19","ACTUAL",{"date":41,"type":22},"2026-06-01",{"date":43,"type":22},"2027-06-01",{"name":45,"class":46},"Ohio State University","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":17,"minAge":55,"maxAge":19,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100621477","therapeutic-wavelength-nanotechnology-devices-in-alveolar-preservation-100621477","NCT07371130","Therapeutic Wavelength Nanotechnology Devices in Alveolar Preservation","Evaluation of Low-Intensity Therapeutic Wavelength Nanotechnology Devices in Alveolar Preservation: A Clinical Trial","APnanotecnolog","Inclusion Criteria:\n\n* Adults in good general health\n* Indication for tooth extraction in sites planned for delayed implant placement\n* Inability to place immediate post-extraction implants due to insufficient residual bone to ensure primary stability\n* Extraction sockets presenting absence of the buccal (vestibular) bone wall\n* Signed informed consent\n\nExclusion Criteria:\n\n* Systemic conditions affecting bone healing\n* Uncontrolled periodontal disease\n* Smoking \\>10 cigarettes\u002Fday\n* Pregnancy or lactation\n* Use of medications interfering with bone metabolism","21 Years",{"count":57,"type":22},20,[25],"After tooth extraction, a progressive alveolar bone resorption is observed. Alveolar ridge preservation consists of placing a biomaterial within the extraction socket and covering it with a membrane.\n\nThis procedure helps limit physiological bone resorption, making the soft and hard tissue profile of the edentulous site more prosthetically favorable.",[61,30],"Tooth Avulsion",[63,64,65,66],"alveolar ridge preservation","alveolar preservation","bone loss","bone preservation","2026-02-04",{"date":69,"type":39},"2026-02-05",{"date":71,"type":22},"2026-02-15",{"date":73,"type":22},"2026-05-01",{"name":75,"class":46},"University of Bari Aldo Moro"]