[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tooth-demineralization\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tooth-demineralization":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,52,91,134,167,197],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100598256","hydroxyapatite-based-home-treatment-for-dentin-sensitivity-in-celiac-patients-100598256",false,"NCT07069127","Hydroxyapatite-Based Home Treatment for Dentin Sensitivity in Celiac Patients","Reduction of Dentin Hypersensitivity and Enamel Demineralization in Patients With Celiac Disease: A Randomized Controlled Trial","CELIADENT","Inclusion Criteria:\n\n* Adults (≥18 years of age) with a confirmed diagnosis of celiac disease.\n* Presence of enamel defects (hypomineralization or demineralization).\n* Presence of active carious lesions.\n* Self-reported dentin hypersensitivity.\n* Willingness to comply with the study protocol and follow-up schedule.\n* Written informed consent provided.\n\nExclusion Criteria:\n\n* Age below 18 years.\n* Absence of confirmed celiac disease.\n* Poor compliance or low motivation to participate in a 6-month study.\n* Ongoing treatment with products affecting enamel mineralization.\n* Pregnancy or breastfeeding.\n* Participation in another clinical trial within the previous 30 days.","ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","This single-center, randomized controlled clinical trial aims to evaluate the effectiveness of a home-based treatment using hydroxyapatite-based oral care products in adult patients with celiac disease who exhibit enamel demineralization and dentin hypersensitivity. Forty patients will be enrolled and randomly allocated into two parallel groups. The control group will perform home oral hygiene using only a hydroxyapatite-based toothpaste (Biorepair® Total Protection) twice daily. The trial group will follow the same regimen with the toothpaste, but will also apply a hydroxyapatite mousse (Biorepair® Plus Intensive Enamel Repair) once every evening before bedtime throughout the study period.\n\nThe primary objective is to assess the reduction in dentin hypersensitivity using the Schiff Air Index. Secondary outcomes include changes in plaque accumulation (Plaque Index), gingival bleeding (Bleeding on Probing), pain perception (Visual Analogue Scale), and caries experience (DMFT and DMFS indices). Enamel demineralization will be analyzed through near-infrared transillumination (DIAGNOcam), laser fluorescence (DIAGNOdent), and digital image analysis (ImageJ software).\n\nAll clinical parameters will be evaluated at baseline and after 1 week, 1 month, 3 months, and 6 months. The study seeks to determine whether the addition of a remineralizing mousse to daily oral care provides superior benefits in reducing sensitivity and improving enamel integrity in patients with celiac disease.",[27,28,29],"Celiac Disease","Dentin Hypersensitivity","Tooth Demineralization",[27,28,31,32,33,34,35,36,37,38],"Enamel Demineralization","Hydroxyapatite","Remineralizing Agents","Biorepair","Toothpaste","Oral Mousse","Dental Sensitivity","Randomized Controlled Trial","RECRUITING","2026-04-22",{"date":42,"type":43},"2026-04-23","ACTUAL",{"date":45,"type":43},"2025-07-30",{"date":47,"type":21},"2026-09-10",{"name":49,"class":50},"University of Pavia","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":17,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":90},"100611777","effect-of-mi-paste-plus-on-streptococcus-mutans-and-white-spot-lesions-in-fixed-orthodontics-100611777","NCT07244991","Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics","Effect of MI Paste Plus™ on Streptococcus Mutans Counts and White Spot Lesions in Patients With Fixed Orthodontic Appliances: A Triple-Blind Clinical Trial","MIPASTEORTHO","Inclusion Criteria:\n\n* Age between 5 and 45 years.\n* Indication for fixed orthodontic treatment, either with fixed auxiliary appliances (including orthopedic devices) or brackets with or without auxiliary components.\n* General good health with no systemic diseases affecting oral health.\n\nExclusion Criteria:\n\n* Advanced white-spot lesions with untreated dentin involvement.\n* Presence of active untreated dental caries at baseline.\n* Antibiotic therapy within the previous two months.\n* Previous diagnosis of molar-incisor hypomineralization (MIH).\n* History of immunosuppression.\n* Iron-deficiency anemia or other clinically relevant hematological disorders.\n* Parafunctional habits such as lip sucking or finger sucking.\n* Use of any type of dental prosthesis.\n* Smoking or tobacco use.\n* Documented allergy to nickel.\n* Requirement for orthodontic treatment using removable appliances or clear aligners.",true,"5 Years","45 Years",{"count":64,"type":21},200,[24],"Background This study is part of a doctoral research project at Universidad Cardenal Herrera CEU (Spain), directed by Prof. Santiago Arias de Luxán and conducted by doctoral candidate Shirli Kelmendi within the PhD program in Translational Medicine.\n\nFixed orthodontic appliances complicate oral hygiene by creating retention areas that favor bacterial colonization and alter microbial balance. These conditions increase plaque accumulation and Streptococcus mutans (S. mutans) proliferation in saliva and plaque. The frequent low-pH environment favors aciduric bacteria such as S. mutans and lactobacilli, promoting enamel demineralization and formation of white spot lesions (WSLs) or cavitations. WSLs appear as opaque white areas due to subsurface mineral loss, mainly in the gingival third of the crown. They may develop as early as one month after bracket placement, while in patients without appliances, progression occurs after at least six months. Increased S. mutans levels have been reported as early as six weeks after treatment start. Risk factors include poor brushing, lack of floss or rinse use, time since last cleaning, and presence of caries or lesions.\n\nIntervention MI Paste Plus (GC, Japan) is a remineralizing cream with 0.20% sodium fluoride (900 ppm) and 10% CPP-ACP (RECALDENT™), providing calcium and phosphate stabilized by casein phosphopeptides. It has antibacterial and remineralizing effects, suitable during or after orthodontic treatment to prevent or reduce WSLs.\n\nObjective To evaluate whether MI Paste Plus during fixed orthodontic treatment reduces S. mutans counts in saliva and\u002For WSL incidence.\n\nStudy Design A prospective, triple-blind, randomized clinical trial, approved by the Ethics Committee of the Ministry of Health of Albania and the Ethics Committee for Human Research of Universidad Cardenal Herrera CEU, Spain.\n\nThe study will include 200 patients (100 per group) from two orthodontic clinics in Tirana, Albania. Participants will be stratified by age, risk level, and appliance type, then randomized by third parties.\n\nOutcome Measures Primary variables: S. mutans counts in saliva and number of WSLs after 3 months.\n\nStandardized saliva collection, culturing, and bacterial quantification ensure consistency. Clinical assessments will be performed at 1 and 3 months using QRay Cam Pro (Inspektor Systems, Netherlands) for quantitative fluorescence and ICDAS for visual inspection.\n\nData will be analyzed using SPSS\u002FR Commander software.",[68,69,29,70],"Dental Caries","Streptococcus Mutans","Orthodontic Appliances, Fixed",[72,73,74,75,76,77,38,78,79,80],"MI Paste Plus","Remineralization","Streptococcus mutans","White Spot Lesions","Fixed Orthodontic Appliances","Quantitative Light-Induced Fluorescence","Triple-Blind Study","Albania","CEU Cardenal Herrera University","2026-03-24",{"date":83,"type":43},"2026-03-27",{"date":85,"type":43},"2026-01-04",{"date":87,"type":21},"2027-11",{"name":89,"class":50},"Cardenal Herrera University",2,{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":17,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":4,"studyType":22,"phases":103,"briefSummary":104,"conditions":105,"keywords":110,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":51},"100620261","comparison-of-a-3-step-bonding-system-transbond-xt-and-a-2-step-system-gc-ortho-connect-on-demineralization-around-maxillary-orthodontic-brackets-100620261","NCT07355322","Comparison of a 3-step Bonding System (Transbond™ XT) and a 2-step System (GC Ortho Connect™) on Demineralization Around Maxillary Orthodontic Brackets","Comparison of a 3-step Bonding System (TRANSBOND™ XT) Versus a 2-step System (GC ORTHO CONNECT™) on Demineralization Around Maxillary Orthodontic Brackets: a Randomized Split-mouth Clinical Trial.","ORTHOCOLLAGE","Inclusion Criteria:\n\n* Patient aged 10 to 16 years included,\n* Patient attending their first dentofacial orthopedics consultation at the Montpellier Dental Care Center, in adolescent or young adult dentition (according to Démogé classification),\n* Patient requiring the placement of a bimaxillary multi-bracket treatment and opting for a metallic vestibular technique.\n\nExclusion Criteria:\n\n* Syndromic patient (all syndromes included, e.g., cleft lip) or with a severe long-term condition (ALD),\n* Patient previously treated with a multi-bracket orthodontic treatment using a mixed, lingual, or vestibular technique,\n* Any medical condition deemed incompatible with bracket placement by the investigator,\n* Patient with severe MIH (molar-incisor hypomineralization) and\u002For severe demineralization on one or more teeth (including severe amelogenesis imperfecta or dentinogenesis imperfecta),\n* Patient with restorations such as metal crowns, ceramic crowns, porcelain-fused-to-metal crowns, inlays, onlays, or amalgam on one or more vestibular surfaces,\n* Patient with oral hygiene incompatible with orthodontic treatment,\n* Agenesis of lateral incisors,\n* Subject already participating in another interventional clinical trial that could interfere with this study,\n* Uncontrolled psychiatric disorder,\n* Lack of written informed consent from a legal representative after a reflection period,\n* Lack of cooperation or difficulty in communication\u002Fcomprehension, or refusal of participation by the minor,\n* Subject with a dependency or employment relationship with the sponsor or investigator,\n* Subject participating in another research study with an ongoing exclusion period,\n* Subject not affiliated with the French social security system or not a beneficiary of such a system,\n* Protected populations according to the French Public Health Code:\n\nPregnant or breastfeeding women Subjects deprived of liberty (by judicial, administrative decision, or involuntary hospitalization) Subjects under guardianship or curatorship","10 Years","16 Years",{"count":102,"type":21},34,[24],"White spot lesions (WSLs) are one of the most common adverse effects of fixed orthodontic treatments, affecting up to 97% of patients treated with labial appliances. These early enamel demineralizations, caused by microleakage between enamel and adhesive, can appear as early as the fourth week of treatment. They not only pose aesthetic concerns but also increase the risk of bracket failure.\n\nThis randomized split-mouth clinical trial compares two bonding systems : the traditional three-step system (Transbond™ XT) and the simplified two-step system (GC Ortho Connect™) to assess their impact on enamel demineralization around orthodontic brackets. The degree of demineralization will be measured using the Enamel Decalcification Index (EDI) based on intraoral photographs and confirmed with a fluorescence camera (C50 Acteon).\n\nThe aim of the study is to determine whether the simplified bonding protocol can reduce clinical time and saliva contamination risk without increasing enamel demineralization, thus offering a potentially more efficient and conservative approach for orthodontic bonding procedures.",[29,106,107,108,109],"White Spot Lesion","Demineralization","Orthodontic Appliance Complication","Dental Braces Complication",[111,112,113,114,115,116,117,76,118,119,120,121,122,123],"White spot lesions","Orthodontic bonding","Enamel demineralization","Transbond XT","GC Ortho Connect","Split-mouth trial","Orthodontic Brackets","Adolescents","Oral Hygiene","Dental Plaque","Orthodontic Adhesives","Bracket detachment","Bracket debonding","NOT_YET_RECRUITING","2026-01-12",{"date":127,"type":43},"2026-01-21",{"date":129,"type":21},"2026-01",{"date":131,"type":21},"2028-04",{"name":133,"class":50},"University Hospital, Montpellier",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":17,"minAge":99,"maxAge":100,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":143,"briefSummary":144,"conditions":145,"keywords":151,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":51},"100618255","graphene-reinforced-cadcam-restorations-for-mih-affected-molars-in-adolescents-a-prospective-clinical-study-100618255","NCT07329244","Graphene-Reinforced CAD\u002FCAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study","Clinical Evaluation of Graphene-Reinforced CAD\u002FCAM Indirect Restorations in Molars Affected by Molar-Incisor Hypomineralization (MIH) in Adolescents: A Clinical Study","Inclusion Criteria:\n\n* Adolescents aged 10-16 years.\n* Permanent molars with moderate or severe MIH (EAPD criteria).\n* Vital and restorable teeth.\n* Ability to attend follow-up visits.\n* Informed consent from guardian + assent from the minor.\n\nExclusion Criteria:\n\n* Fluorosis, amelogenesis imperfecta, or other enamel defects.\n* Severe bruxism not controlled.\n* Active extensive caries or irreversible pulpitis.\n* Systemic conditions affecting enamel or healing.\n* Hypersensitivity\u002Fallergy to materials\u002Fadhesives.\n* Use of analgesics\u002FAINEs \\\u003C24 h before baseline VAS.\n\n  * Orthodontic bands on the study molar.",{"count":142,"type":21},30,[24],"This study evaluates the clinical performance, marginal integrity, surface wear, color stability, and postoperative sensitivity of graphene-reinforced CAD\u002FCAM indirect restorations (inlays, onlays, overlays) in molars affected by moderate to severe Molar-Incisor Hypomineralization (MIH) in adolescents. A total of 30 patients aged 10-16 years will receive minimally invasive indirect restorations fabricated from a nano-reinforced graphene polymer (G-CAM®). Clinical outcomes will be assessed using FDI criteria, VAS sensitivity scores, patient satisfaction, and digital 3D scans over a 12-month follow-up. The study aims to determine clinical acceptability and safety compared with historical outcomes reported for composite and lithium-disilicate indirect restorations.",[29,146,147,148,149,150],"Tooth Sensitivity","Enamel Mineralization Disorders","Tooth Sensitivity After Composite Restorations","Tooth Eruption Disorder","Indirect Restoration",[152,153,154,155,156,157],"molar-incisor hypomineralization","MIH","enamel defects","indirect restorations","minimally invasive dentistry","adhesive dentistry","2025-12-28",{"date":160,"type":43},"2026-01-09",{"date":162,"type":21},"2026-01-10",{"date":164,"type":21},"2027-01-11",{"name":166,"class":50},"Universitat Internacional de Catalunya",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":60,"sex":17,"minAge":174,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":178,"briefSummary":179,"conditions":180,"keywords":182,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":51},"100514538","effectiveness-of-two-health-education-interventions-in-the-prevention-of-caries-and-gingivitis-in-orthodontic-patients-100514538","NCT05979805","Effectiveness of Two Health Education Interventions in the Prevention of Caries and Gingivitis in Orthodontic Patients","Effectiveness of Motivational Interviewing and Conventional Oral Health Education (OHEc) Versus OHEc in the Prevention and Control of Dental Caries and Gingivitis in Subjects With Fixed Orthodontic Appliances. A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients enrolled in the different orthodontic postgraduate clinics of the National University of Colombia who requires treatment with fixed orthodontic appliances\n* 13 years old up to 28 years of age.\n* Willingness to participate in the study and signature of the informed consent form.\n\nExclusion Criteria:\n\n* Patients with untreated caries lesions\n* Patients with periodontal diseases or experience\n* Previous orthodontics treatments\n* Severe fluorosis or enamel abnormalities.\n* Medical compromise or treatments generating hyposalivation or gingival enlargement\n* Craniomaxillary anomalies\n* Cognitive or motor disability\n* Pregnancy.\n* Dependence to alcohol, nicotine or psychoactive substances","13 Years","28 Years",{"count":177,"type":21},94,[24],"Dental caries and gingivitis are classified by the World Health Organization (WHO) as an important public health problem due to their high prevalence and incidence worldwide despite the development of public policies to combat them. They are chronic diseases that have a severe impact in terms of pain and suffering, impairment of function and effect on quality of life. During orthodontic treatments, the most common adverse event is the appearance of dental caries lesions and gingivitis due to increased retention and change of dental biofilm composition or difficulty of removal with conventional oral hygiene techniques. Efforts to implement various conventional preventive interventions of self-care and education have not decreased their incidence, so it is necessary to implement motivational interventions to help adolescents and young adults to make positive changes in their oral health habits, which are constant and lasting and prevent and control gingivitis and caries.",[68,29,181],"Gingivitis",[183,184,185,186,187],"Adolescent,Teenagers,Young Adult,Adult",""Motivational Interviewing"[Mesh]",""Health Education, Dental"[Mesh]",""Orthodontic Appliances"[Mesh]",""Orthodontic Appliances, Fixed"[Mesh]","2025-03-15",{"date":190,"type":43},"2025-03-19",{"date":192,"type":43},"2024-04-15",{"date":194,"type":21},"2026-04-20",{"name":196,"class":50},"Universidad Nacional de Colombia",{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":17,"minAge":203,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":22,"phases":206,"briefSummary":207,"conditions":208,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":51},"100343562","evaluation-of-optical-coherence-tomography-in-dentistry-100343562","NCT03753256","Evaluation of Optical Coherence Tomography in Dentistry","Inclusion Criteria:\n\n* Orthodontic treatment need\n* Informed consent from all patients and their parents or legal guardians after explaining of the study\n\nExclusion Criteria:\n\n• withdrawn consent","6 Years",{"count":205,"type":21},20,[24],"Optical coherence tomography (OCT) is a medical diagnostic tool, providing non-invasive, non-radiative and high resolution imaging. OCT has been established since many years in ophthalmology. In dentistry the diagnostic potential of OCT is currently increasingly being noticed. This clinical study includes two individual trials: (i) Longitudinal assessment of surface sealant thickness using optical coherence tomography and (ii) comparison of crevicular fluid levels of inflammatory cytokines after the application of surface sealants.",[68,29],"2018-11-26",{"date":211,"type":43},"2018-11-28",{"date":213,"type":43},"2017-12-04",{"date":215,"type":21},"2027-12",{"name":217,"class":50},"University of Heidelberg Medical Center"]