[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tooth-discoloration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tooth-discoloration":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,54,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100628634","effectiveness-of-dental-bleaching-using-different-designs-of-3d-printed-and-conventional-customized-nightguards-100628634",false,"NCT07464197","Effectiveness of Dental Bleaching Using Different Designs of 3D-Printed and Conventional Customized Nightguards","Evaluation of the Effectiveness in Dental Bleaching by Different Designs of 3D-Printed Digital Customized Nightguards","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Good general and oral health\n* No current medical treatment (self-reported)\n* No need for surgical, endodontic, periodontal, or restorative dental treatment\n* At least six upper and six lower anterior teeth free of caries and restorations\n* Maxillary central incisors with baseline shade A2 or darker\n* Willingness to follow the study protocol and use the study-provided oral hygiene products\u002Finstructions\n\nExclusion Criteria:\n\n* Previous tooth bleaching treatment\n* Orthodontic appliances or prostheses that interfere with treatment\n* Severe intrinsic discoloration (e.g., tetracycline staining, fluorosis, or endodontically treated teeth with discoloration)\n* Pregnancy or lactation\n* Bruxism\n* Gingival recession, dentin exposure, visible enamel cracks, or other conditions associated with increased sensitivity\n* Use of anti-inflammatory or analgesic medication during the study period (according to protocol)",true,"ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized, double-blind, split-mouth clinical trial evaluates the effectiveness of at-home dental bleaching using customized nightguards fabricated by digital (3D-printed CAD-CAM) and conventional methods, with and without reservoirs. Adult participants with good general and oral health and a baseline tooth shade of A2 or darker undergo bleaching with 10% carbamide peroxide. Outcomes include tooth color change (subjective and spectrophotometric measures), tooth sensitivity, gingival irritation, patient comfort, and patient satisfaction over time.",[27,28],"Tooth Discoloration","Tooth Staining",[30,31,32,33,34,35,36,37,38,39,40],"dental bleaching","custom tray","3D-printed tray","CAD-CAM","Carbamide peroxide","Nightguard vital bleaching","Tooth sensitivity","Gingival irritation","Spectrophotometer","Split-mouth trial","tooth whitening","RECRUITING","2026-03-11",{"date":44,"type":45},"2026-03-16","ACTUAL",{"date":47,"type":45},"2022-05-01",{"date":49,"type":21},"2026-07",{"name":51,"class":52},"Universitat Internacional de Catalunya","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":53},"100577770","efficacy-and-safety-assessment-of-experimental-bleaching-agents-100577770","NCT06802614","Efficacy and Safety Assessment of Experimental Bleaching Agents","A Randomized Controlled Clinical Trial Comparing the Efficacy of Two Experimental Bleaching Gels With and Without Nanoparticles and Light Irradiation Versus Whiteness HP 35% and Whiteness HP AutoMixx 6% in Patients With A2-C4 Tooth Discolorations","Inclusion Criteria:\n\n* Age: 18-65 years old.\n* Healthy periodontal tissues.\n* Willingness to participate and follow the post-treatment protocols.\n* Ability to provide informed consent.\n* Teeth having baseline colors ranging from shade A2 to C4\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women.\n* Teeth with restorations.\n* History of dentin hypersensitivity.\n* Active caries, periodontal disease or endodontically treated teeth.\n* Use of substances that could affect tooth color during the trial, such as smoking and vaping.","65 Years",{"count":63,"type":21},240,[24],"Tooth bleaching is widely used to treat the colors of teeth. This study compares the efficiency of two experimental bleaching gels, with and without nanoparticles, and with and without light activation versus two commercial bleaching products of low and high concentrations. The objective is to evaluate tooth color change, sensitivity, and patient satisfaction in patients with moderate yellowing of their teeth. Methods: This is a randomized controlled trial that will include 120 participants aged 18-65 years. Participants will be randomly assigned to one of 12 treatment groups: Gel A (with or without nanoparticles, with or without light), Gel B (with or without nanoparticles, with or without light), Whiteness HP 35% (with or without light) and Whiteness Automixx 6% (with or without light). The primary outcome is tooth color change, measured using a commercially-available equipment. Secondary outcomes will include tooth sensitivity and patient satisfaction. Randomization will be computer-generated. Results: The study is expected to show differences in color change between the experimental and commercial gels. Tooth sensitivity and patient satisfaction will be evaluated to determine the overall effectiveness and safety of the treatments. Conclusions: This trial will provide information into the whitening efficacy of two experimental gels compared to two widely used commercial products.",[27,67,68],"Dentin Sensitivity","Patient Satisfaction",[70,71,72,73],"Tooth Whitenining","Dental Bleaching","Hydrogen Peroxide","Titanium Dioxide Nanoparticles","NOT_YET_RECRUITING","2025-01-24",{"date":77,"type":45},"2025-01-31",{"date":79,"type":21},"2025-03-01",{"date":81,"type":21},"2025-09-30",{"name":83,"class":52},"University of Oklahoma",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":95,"conditions":96,"keywords":97,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":53},"100557008","effects-of-bio-active-desensitizer-on-reduction-of-tooth-sensitivity-caused-by-in-office-bleaching-100557008","NCT06532526","Effects of Bio-active Desensitizer on Reduction of Tooth Sensitivity Caused by In-office Bleaching.","Assessment of the Effects of Bio-active Desensitizing Materials on the Bleaching Efficacy and Reduction of Tooth Sensitivity Caused by Vital In-office Bleaching: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* At least eight maxillary anterior teeth present.\n* Age between 18 and 30 years Smokers\n* The selected teeth has a mean shade of C2 or darker (Vitapan Classical, Vita-Zahnfabrik, Sa¨ckingen, Germany)\n* Good general and oral health (no visible plaque or gingivitis)\n* No restorations or carious lesions on the buccal surfaces of the anterior teeth to be whitened\n* No history of tooth sensitivity\n* No use of a desensitizing agent or desensitizing toothpaste in the past six months\n\nExclusion Criteria:\n\n* Active caries and\u002For periodontal diseases (gingivitis and recession) or wasting diseases\n* Smokers\n* Pregnant\u002Flactating women\n* Patients who have bleached their teeth previously\n* No schedule availability","35 Years",{"count":93,"type":21},51,[24],"The main aim of this randomized controlled clinical trial is to evaluate the efficacy of a bioactive glass desensitizer in reducing tooth sensitivity associated with in-office vital tooth bleaching. In addition, this study aims to compare the effectiveness of the bioactive glass desensitizer with that of a fluoride gel and a gel without desensitizing agent with regard to incidence, intensity, and duration of tooth sensitivity and, finally, to investigate how these agents affect tooth-shade following in-office bleaching. The hypothesis of the study is: There will be no difference in the effect of a bio-active glass desensitizer on tooth sensitivity associated with vital in-office tooth bleaching compared to a fluoride gel and the bio-active glass desensitizer has no effect on the bleaching efficacy.",[27],[98,99,100],"Sensitivity","Bio-active desensitizer","in-office bleaching","2024-07-29",{"date":103,"type":45},"2024-08-01",{"date":105,"type":45},"2024-07-01",{"date":107,"type":21},"2025-04-01",{"name":109,"class":52},"King Abdullah University Hospital"]