[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tooth-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tooth-diseases":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,74,98,132,158],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":4,"leadSponsor":41,"locationsCount":44},"100194349","oral-specimen-and-data-acquisition-study-of-subjects-requiring-third-molar-removal-100194349",false,"NCT01805869","Oral Specimen and Data Acquisition Study of Subjects Requiring Third Molar Removal","* INCLUSION CRITERIA:\n* Ages greater than or equal to 16-50 years\n* Clinical evidence of need for third molar extraction as determined by medical, dental, and radiographic evaluation by a NIDCR oral surgeon\n* Willing to allow for the collection of extracted waste tissue (e.g., teeth, alveolar bone, excessive gingival tissue) to be used for research\n* In good general health as defined by the American Society of Anesthesiologists (ASA) status I or II\n* Able to understand and sign an informed consent\n\nEXCLUSION CRITERIA:\n\n* Pregnant or nursing women\n* Unable to have third molar extraction as determined by NIDCR surgeon\u002Fdentist, due to medical conditions (beyond ASA I or II), complexity of the surgery, or history that precludes safe outpatient conscious sedation. These clinical decisions will be based on the risks and benefits related to the surgery.",true,"ALL","16 Years","50 Years",{"count":20,"type":21},3000,"ESTIMATED","OBSERVATIONAL","Background:\n\n\\- The third molars (wisdom teeth) normally grow in during late adolescence or early adulthood. Many people need or choose to have these teeth removed with oral surgery. Normally, the removed teeth and tissue are thrown away as medical waste. However, oral health researchers want to collect the teeth and tissue for research. They also want to encourage dentists at the National Institutes of Health to improve their skills in oral surgery. This study will collect the teeth and tissue of people who need to have oral surgery to remove their wisdom teeth.\n\nObjectives:\n\n* To provide continued dental skills training for dentists at the National Institutes of Health.\n* To collect teeth and tissue samples following wisdom tooth removal surgery.\n\nEligibility:\n\n\\- Individuals between 16 and 50 who need to have their wisdom teeth removed.\n\nDesign:\n\n* This study will involve a minimum of three visits. There will be a screening visit, a surgery visit, and at least one follow-up visit.\n* Participants will be screened with a physical exam and medical history. A full dental exam with x-rays will be given to evaluate the need for surgery.\n* At the second visit, participants will have oral surgery to remove their wisdom teeth. The teeth and tissue removed during the surgery will be collected for study.\n* Participants will receive drugs to control the pain after surgery. They will also be able to contact a dentist if there are any problems.\n* Between 7 and 21 days after surgery, participants will have a followup visit to check the healing. If they are having no problems, this will be the last visit. If there are any postsurgery issues, they will be scheduled for additional visits as needed.",[25,26,27,28,29],"Stomatognatic","Tooth Diseases","Diseases","Tooth","Tooth Impaction",[31,32,33],"Third Molar","Specimen Acquisition","Natural History","RECRUITING","2026-06-27",{"date":37,"type":38},"2026-06-30","ACTUAL",{"date":40,"type":38},"2013-06-19",{"name":42,"class":43},"National Institute of Dental and Craniofacial Research (NIDCR)","NIH",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":44},"100584942","accuracy-of-immediate-implant-placement-using-robotic-system-versus-dynamic-navigation-system-in-anterior-maxillae-a-random-controlled-clinical-trial-100584942","NCT06895915","Accuracy of Immediate Implant Placement Using Robotic System Versus Dynamic Navigation System in Anterior Maxillae: A Random Controlled Clinical Trial","Inclusion Criteria:\n\n* a. ≥18 years old and in good health; b. One or more maxillary incisors that cannot be retained due to non-periodontitis; c. The buccal bone plate is intact; d. No acute infection; e. The extraction socket have at least 3-5 mm apical bone.\n\nExclusion Criteria:\n\n* a. General contraindications of oral implant surgery (such as immunodeficiency, long-term use of corticosteroids); b. Treatments or diseases that may affect bone tissue metabolism (for example, taking bisphosphonates or receiving local radiotherapy); c. Periodontitis history or uncontrolled periodontitis. Bleeding of probing (BOP) positive site ≥ 10%, or probing depth (PD) ≥ 4mm; d. Heavy smokers or previous heavy smoking history (quit smoking time \\\u003C5 years or\\> 20 cigarettes per day); e. Refuse to participate in this trial.","18 Years",{"count":53,"type":21},24,"INTERVENTIONAL",[56],"NA","Prosthetic-driven immediate implant placement for optimal aesthetic restoration has been increasing in demand during the last decades but requires higher accuracy. Dynamic navigation has been reported better implant positioning in immediate implant placement compared to free hand procedure. On the basis of dynamic navigation, robotic system uses the robotic arm to replace the manual process of implant bed preparation and implant placement, therefore improving the accuracy of implant placement theoretically. The goal of this randomized controlled trial is to compare the positional implant accuracy, the surgical time, and patient satisfaction between dynamic navigation and robotic assisted immediate implant placement in maxillae. Subjects will be randomized to either group based on the allocation. The accuracy of placement will be assessed evaluating the difference between the planned and the actual position using a follow-up CBCT scan taken at the end of the surgery. Subjects will be followed up for one year to assess both patient reported and professional outcomes.",[26],[60,61,62],"immediate implant placement","dynamic navigation","robotic surgery","NOT_YET_RECRUITING","2026-05-19",{"date":66,"type":38},"2026-05-22",{"date":68,"type":21},"2026-06-01",{"date":70,"type":21},"2027-09-01",{"name":72,"class":73},"Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University","OTHER",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":15,"sex":16,"minAge":51,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":54,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":44},"100595392","comparison-of-clinical-performance-of-partial-restorations-fabricated-with-three-dimensional-printer-and-cad-cam-100595392","NCT07031856","Comparison of Clinical Performance of Partial Restorations Fabricated With Three-Dimensional Printer and CAD-CAM","Comparison of Clinical Performance of Partial Restorations Fabricated With Three-Dimensional Printer and CAD-CAM: A Split-Mouth Randomized Clinical Trial","İncluiding:\n\n\\-- Patients with periodontally stable and appropriate oral hygiene habits without serious systemic diseases that preclude restoration. - Male and female patients with hard tissue loss in their mouth or with 2 teeth in need of restoration replacement (eligibility for split-mouth design). - People who can comply with the treatment and volunteer for follow-up for 2 years-\n\nExclusion Criteria:\n\nPatients with systemic conditions that may affect the study process (e.g. diabetes, autoimmune diseases).\n\n* Patients with excessive bruxism or parafunctional habits.\n* Pregnant or lactating women.\n* Patients with gum disease or severe bone loss.\n* Patients with a history of allergic reactions.","65 Years",{"count":83,"type":21},12,[56],"The aim of this clinical study is to compare CAD-CAM and 3D restorations in individuals with two hard tissue losses or restorations in their mouths. The main question it aims to answer is: Is there a difference between CAD-CAM and 3D restorations according to FDI criteria? Researchers will compare participants to see if there is a difference between the two restorations according to FDI criteria. In this split-mouth study, participants will be randomized to receive a CAD-CAM partial restoration on one tooth and a 3D partial restoration on the other tooth.",[87,88,26],"Dental Caries","Dental Restoration, Permanent","2026-03-27",{"date":91,"type":38},"2026-04-02",{"date":93,"type":38},"2025-07-01",{"date":95,"type":21},"2026-11",{"name":97,"class":73},"Cukurova University",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":107,"conditions":108,"keywords":117,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":44},"100629572","oral-health-dento-facial-condition-and-ohrqol-in-subjects-with-mowat-wilson-syndrome-an-epidemiologic-study-100629572","NCT07476417","Oral Health, Dento-facial Condition and OHRQoL in Subjects With Mowat-Wilson Syndrome: an Epidemiologic Study.","ORALMOWAT26","Inclusion Criteria:\n\n* individuals affected by MWS with confirmed molecularly diagnosis of ZEB2 gene variation.\n* written informed consent statement signed by parents\u002Flegal guardians for participation in the study\n\nExclusion Criteria:\n\n* individuals not affected by MWS\n* refusal of parents\u002Flegal guardians to participate in the study",{"count":106,"type":21},25,"Mowat-Wilson Syndrome (MWS) is a rare syndrome characterized by the presence of facial gestalt and delayed psychomotor development, variably associated with intellectual disability, epilepsy, Hirschsprung's disease (HSCR) and multiple congenital malformations.\n\nAlthough there is evidence of the presence of dental and craniofacial anomalies in MWS, little epidemiological data is available to date.\n\nThe goal of this observational study is to assess oral health and dento-facial phenotype of people affected by Mowat-Wilson Syndrome (MWS). In addition, the Oral Health Related Quality of Life (OHRQoL) will be investigated.",[109,87,110,111,26,112,113,114,115,116],"Mowat-Wilson Syndrome","Periodontal Diseases","Sleep Related Breathing Disorder","Malocclusion","Tooth Abnormalities","Oral Health Related Quality of Life (OHRQoL)","Craniofacial Abnormalities","Oral Mucosal Disease",[118,119,120,121,122,115],"Mowat-Wilson syndrome","dental caries","periodontal diseases","malocclusion","oral health","2026-03-19",{"date":125,"type":38},"2026-03-24",{"date":127,"type":21},"2026-04-01",{"date":129,"type":21},"2026-08-30",{"name":131,"class":73},"University of Milan",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":15,"sex":16,"minAge":140,"maxAge":141,"enrollmentInfo":142,"targetDuration":4,"studyType":54,"phases":144,"briefSummary":145,"conditions":146,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":44},"100623235","autogenous-tooth-transplantation-with-instrumentally-simulated-open-apex-and-platelet-rich-fibrin-100623235","NCT07393997","Autogenous Tooth Transplantation With Instrumentally Simulated Open Apex and Platelet-Rich Fibrin","Clinical Evaluation of Autogenous Tooth Transplantation With Instrumentally Simulated Open Apex and Autologous Platelet-Rich Fibrin (PRF) Support in Teeth With Complete Root Formation","OpenApexT","Inclusion Criteria:\n\nAutotransplantation will be performed in selected cases with favorable biological and functional prognosis, including:\n\n* Early loss of permanent teeth due to trauma, extensive caries, or agenesis.\n* Dental agenesis, particularly involving premolars or incisors, when a suitable donor tooth is available.\n* Replacement of non-restorable teeth (fractures or destructive caries).\n* Preservation of alveolar bone in growing patients where implant therapy is contraindicated.\n* Functional and aesthetic rehabilitation of anterior teeth in pediatric and adolescent patients.\n* Post-traumatic oral rehabilitation in young patients.\n* Good general and oral health.\n* Presence of a vital and intact periodontal ligament on the donor tooth.\n* Adequate recipient site dimensions and morphology, or surgically adaptable.\n* Absence of active infection at the recipient site. Donor Tooth Selection Criteria\n* Tooth extracted for orthodontic purposes.\n* Impacted or erupting third molars with compatible morphology.\n* Suitable supernumerary teeth.\n\nExclusion Criteria:\n\n* Poor patient compliance.\n* Active infection at the recipient site.\n* Smoking of more than 15 cigarettes a day\n\n  •. Untreated periodontal disease\n* Pregnancy or breastfeeding at date of inclusion\n* Acute infections","10 Years","80 Years",{"count":143,"type":21},5,[56],"Autogenous tooth transplantation (autotransplantation) represents a biologically valid alternative to implant therapy, particularly in young patients where implant placement is contraindicated due to ongoing skeletal growth. This approach preserves alveolar bone volume, maintains periodontal proprioception, and allows physiological adaptation over time.",[147,26,148],"Tooth Loss","Reimplant; Complications","2026-01-30",{"date":151,"type":38},"2026-02-06",{"date":153,"type":38},"2026-01-01",{"date":155,"type":21},"2026-09-01",{"name":157,"class":73},"University of Bari Aldo Moro",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":15,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":167,"conditions":168,"keywords":171,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":4},"100500127","kap-of-dental-practitioners-regarding-cra-100500127","NCT05792215","KAP of Dental Practitioners Regarding CRA","Dental Practitioners' Knowledge, Attitude, and Practice (KAP) in Cairo and Riyadh Regarding Caries Risk Assessment and Management: A Cross-Sectional Study","Inclusion Criteria:\n\n* Licensed Egyptian and Saudi general dentists.\n\nExclusion Criteria:\n\n* Undergraduate dental students\n* Dental specialists\n* Dentists who refused to participate",{"count":166,"type":21},174,"The aim of the study is to evaluate the knowledge, attitude, and practice of a group of dental practitioners from Cairo and Riyadh regarding caries risk assessment and management.",[169,170,26],"Caries,Dental","Tooth Decay",[172,173,174],"Caries Risk Assessment","Caries Prevention","General Practitioners","2024-08-01",{"date":177,"type":38},"2024-08-02",{"date":179,"type":21},"2024-09-01",{"date":181,"type":21},"2024-10-30",{"name":183,"class":73},"Cairo University"]