[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tooth-eruption-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tooth-eruption-disorder":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100639713","risk-factors-for-tooth-eruption-diseases-100639713",false,"NCT07587567","Risk Factors for Tooth Eruption Diseases","Determination of Risk Factors for Eruption Disorders in the Primary and Permanent Dentition","Inclusion Criteria:\n\n* Partial or complete failure of one or more deciduous and\u002For permanent molar teeth to erupt\n* Diagnostic records (medical history, orthopantomography, clinical photographs)\n* Age between 5 and 80 years\n* Ability to understand and sign consent forms from patients, if adults, or their parents\u002Fguardians\n\nExclusion Criteria:\n\n* Malformative syndromes and\u002For systemic diseases\n* Lack of diagnostic records\n* Failure of eruption due to traumatic causes","ALL","5 Years","80 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","Failure of eruption of primary and\u002For permanent teeth is a rare condition caused by four possible causes. The first is ankylosis of the tooth roots, which, in the absence, even partial, of the alveolar ligament, join the surrounding bone. The second possible cause is failure of eruption due to mechanical impediment, in the presence of a cyst or lack of resorption of the bone overlying the developing tooth, or due to severe lack of space or an abnormal inclination of the tooth's eruption path. The third cause, called Primary Failure of Eruption (PFE), is genetic in nature due to insufficient production of the factors that determine tooth eruption. In this case, molars are the most affected teeth, and pathogenic variants of the PTH1R gene are often observed. The fourth possibility is delayed tooth eruption. In cases of ankylosis and PFE, orthodontic treatments to help recover the teeth in the arch may fail.\n\nThis interventional study, comprising a retrospective cohort, aims to evaluate the clinical signs of dental eruption disorders to identify criteria to facilitate clinical diagnosis. Furthermore, in cases where PFE is suspected, diagnostic testing for the PTH1R gene will be performed.\n\nThe study will be conducted at the Fondazione Policlinico Universitario \"A. Gemelli\" IRCCS in Rome and will enroll 50 consecutive patients with dental eruption disorders of deciduous and\u002For permanent molars. The primary outcome will be to strengthen the differential diagnostic hypothesis. The study will also examine the phenotype\u002Fgenotype correlation in patients tested for PTH1R gene variants. The characteristics of the sample will be compared with those of the sample enrolled in the previous study (C.E. UCSC ID 565-11\u002F2015), which will be examined retrospectively. Extending the analysis to the patient cohort enrolled since 2015 is particularly valuable given the rarity of the diseases under study and the resulting small number of cases available for research.\n\nThe study results will provide new data on pathogenic variants of PTH1R and on the phenotype\u002Fgenotype correlation of the various diseases characterized by tooth eruption disorder. They will also help identify more sustainable and effective clinical strategies.",[27],"Tooth Eruption Disorder",[29,30,31,32],"primary failure of dental eruption","Dental ankylosis","mechanical failure of dental eruption","PTH1R gene","NOT_YET_RECRUITING","2026-05-08",{"date":36,"type":37},"2026-05-14","ACTUAL",{"date":39,"type":21},"2026-06-08",{"date":41,"type":21},"2030-12-31",{"name":43,"class":44},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":64,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100618255","graphene-reinforced-cadcam-restorations-for-mih-affected-molars-in-adolescents-a-prospective-clinical-study-100618255","NCT07329244","Graphene-Reinforced CAD\u002FCAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study","Clinical Evaluation of Graphene-Reinforced CAD\u002FCAM Indirect Restorations in Molars Affected by Molar-Incisor Hypomineralization (MIH) in Adolescents: A Clinical Study","Inclusion Criteria:\n\n* Adolescents aged 10-16 years.\n* Permanent molars with moderate or severe MIH (EAPD criteria).\n* Vital and restorable teeth.\n* Ability to attend follow-up visits.\n* Informed consent from guardian + assent from the minor.\n\nExclusion Criteria:\n\n* Fluorosis, amelogenesis imperfecta, or other enamel defects.\n* Severe bruxism not controlled.\n* Active extensive caries or irreversible pulpitis.\n* Systemic conditions affecting enamel or healing.\n* Hypersensitivity\u002Fallergy to materials\u002Fadhesives.\n* Use of analgesics\u002FAINEs \\\u003C24 h before baseline VAS.\n\n  * Orthodontic bands on the study molar.","10 Years","16 Years",{"count":55,"type":21},30,[24],"This study evaluates the clinical performance, marginal integrity, surface wear, color stability, and postoperative sensitivity of graphene-reinforced CAD\u002FCAM indirect restorations (inlays, onlays, overlays) in molars affected by moderate to severe Molar-Incisor Hypomineralization (MIH) in adolescents. A total of 30 patients aged 10-16 years will receive minimally invasive indirect restorations fabricated from a nano-reinforced graphene polymer (G-CAM®). Clinical outcomes will be assessed using FDI criteria, VAS sensitivity scores, patient satisfaction, and digital 3D scans over a 12-month follow-up. The study aims to determine clinical acceptability and safety compared with historical outcomes reported for composite and lithium-disilicate indirect restorations.",[59,60,61,62,27,63],"Tooth Demineralization","Tooth Sensitivity","Enamel Mineralization Disorders","Tooth Sensitivity After Composite Restorations","Indirect Restoration",[65,66,67,68,69,70],"molar-incisor hypomineralization","MIH","enamel defects","indirect restorations","minimally invasive dentistry","adhesive dentistry","2025-12-28",{"date":73,"type":37},"2026-01-09",{"date":75,"type":21},"2026-01-10",{"date":77,"type":21},"2027-01-11",{"name":79,"class":44},"Universitat Internacional de Catalunya",1]