[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tooth-extraction-site-healing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tooth-extraction-site-healing":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,51,71,99,124,142,173],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100643380","early-phase-1-assessment-of-the-impact-of-neobone-biphasic-calcium-phosphate-on-bone-volume-in-alveolar-ridge-preservation-after-tooth-extraction-100643380",false,"NCT07638358","Assessment of the Impact of Neobone® (Biphasic Calcium Phosphate) on Bone Volume in Alveolar Ridge Preservation After Tooth Extraction","Assessment of Safety and Performance of Neobone®: A Prospective Observational Study in the Field of Dentistry","BCPARPBV","Inclusion Criteria:\n\n* 18 years or older\n* Acceptance of informed consent\n* Type 1 or 2 extraction sockets (Elian et al. 2007)\n\nExclusion Criteria:\n\n* Presence of active infection or severe inflammation in the intervention zone\n* Relevant medical history that contraindicates implant surgery\n* Patients with poor oral hygiene (full-mouth plaque score and full-mouth bleeding score \\>15%) and lack of motivation\n* Uncontrolled diabetes (reported levels of glycated haemoglobin exceeding 7%)\n* Uncontrolled and \u002For untreated periodontal disease\n* Heavy smokers (more than 10 cigarettes per day)\n* Immunosuppression",true,"ALL","18 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","The goal of this randomized clinical trial is to assess whether BCP (Biphasic Calcium Phosphate) improves alveolar ridge preservation (ARP) in patients who need tooth extraction. The main question it aims to answer is whether using BCP for alveolar ridge preservation has a positive effect on bone volume compared with natural healing.\n\nThe main questions it aims to answer are:\n\nDoes BCP improve ridge preservation compared with natural healing?\n\nResearchers will compare BCP grafted sockets to natural healing sockets to see if BCP better preserves ridge volume.\n\nParticipants will:\n\nHave a tooth indicated for extraction.\n\nBe assigned to either BCP or natural healing.\n\nUndergo CBCT (Cone Beam Computed Tomography) and intra-oral scanning after extraction and after six months of healing to measure horizontal and vertical resorption and bone density.",[28,29],"Tooth Extraction Site Healing","Alveolar Ridge Preservation",[29,31,32,33,34,35,36,37],"Biphasic Calcium Phosphate","Tooth Extraction","Volumetric Changes","Implant site development","Bone volume","Socket preservation","Ridge augmentation","RECRUITING","2026-06-09",{"date":41,"type":42},"2026-06-11","ACTUAL",{"date":44,"type":42},"2025-12-01",{"date":46,"type":22},"2028-12",{"name":48,"class":49},"Egas Moniz - Cooperativa de Ensino Superior, CRL","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":14,"acronym":56,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":67,"startDateStruct":68,"completionDateStruct":69,"leadSponsor":70,"locationsCount":50},"100643193","early-phase-1-assessment-of-the-impact-of-neocement-inject-p-beta-tricalcium-phosphate-on-bone-volume-in-alveolar-ridge-preservation-after-tooth-extraction-100643193","NCT07638319","Assessment of the Impact of Neocement Inject P® (Beta-Tricalcium Phosphate) on Bone Volume in Alveolar Ridge Preservation After Tooth Extraction","BTCPARPBV",{"count":21,"type":22},[25],"The goal of this randomized clinical trial is to assess whether β-TCP (Beta-Tricalcium Phosphate) improves alveolar ridge preservation (ARP) in patients who need tooth extraction. The main question it aims to answer is whether using β-TCP for alveolar ridge preservation has a positive effect on bone volume compared with natural healing.\n\nThe main questions it aims to answer are:\n\nDoes β-TCP improve ridge preservation compared with natural healing?\n\nResearchers will compare β-TCP grafted sockets to natural healing sockets to see if β-TCP better preserves ridge volume.\n\nParticipants will:\n\nHave a tooth indicated for extraction.\n\nBe assigned to either β-TCP or natural healing.\n\nUndergo CBCT (Cone Beam Computed Tomography) and intra-oral scanning after extraction and after six months of healing to measure horizontal and vertical resorption and bone density.",[32,28,61,62],"Alveolar Bone Grafting","Alveolar Bone Loss",[64,65,35,34,36,37,66,33],"Beta-tricalcium phosphate","Alveolar ridge preservation","Tooth extraction",{"date":41,"type":42},{"date":44,"type":42},{"date":46,"type":22},{"name":48,"class":49},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":23,"phases":82,"briefSummary":84,"conditions":85,"keywords":86,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":50},"100640509","socket-preservation-using-autogenous-dentin-100640509","NCT07608289","Socket Preservation Using Autogenous Dentin","Socket Preservation After Tooth Extraction Using Autogenous Dentin in Comparison With Other Techniques","SPAD","Inclusion Criteria:\n\n* 18-70 years\n* no active periodontitis\n* signed informed consent with participation in the study\n* need for extraction of teeth other than third molars\n* patients requesting only standard\u002Freimbursed care\n\nExclusion Criteria:\n\n* drug or alcohol abuse\n* ongoing chemotherapy\n* ongoing radiotherapy\n* pregnancy\n* ongoing treatment of osteoporosis or other biological treatment with MRONJ risk\n* low compliance\n* patients asking for premium care","70 Years",{"count":81,"type":22},80,[83],"NA","Tooth extraction leads to a substantial reduction in alveolar bone volume, with up to 25% loss within the first year and up to 40-60% within three years. This prospective randomized clinical study aims to compare four commonly used methods of alveolar ridge preservation, evaluating their effectiveness in maintaining bone volume for later prosthetic or implant rehabilitation. Alveolar dimensions will be measured using calibrated CBCT imaging pre-extraction and at six months post-extraction.",[28],[36,87,88,89],"autogenous dentin","tooth extraction","alveolar ridge augmentation","2026-05-20",{"date":92,"type":42},"2026-05-27",{"date":94,"type":42},"2025-01-01",{"date":96,"type":22},"2028-12-31",{"name":98,"class":49},"University of Ostrava",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":108,"phases":4,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":50},"100621558","wound-healing-following-extraction-and-ridge-preservation-in-smokers-and-non-smokers-100621558","NCT07372183","Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers","Inclusion Criteria:\n\n* Adult patients (18-75 years)\n* Good general health (controlled conditions)\n* Smokers (≥10 cigarettes\u002Fday for ≥5 years) and never smokers. Confirmation of smoking status will be done via use of a smokerlyzer. The cut-off point for distinguishing smokers from non-smokers is 8 carbon monoxide parts per million (ppm).\n* Periodontal status: periodontal health, gingivitis on intact or reduced periodontium, treated periodontitis\n* Intact post-extraction bony walls or less than 50% bone dehiscence\n* Distance at least 8 mm of vertical bone height between bone crest and anatomical structures (i.e. sinus floor, inferior alveolar nerve (IAN) canal, mental foramen)\n* Extracted tooth root in the same three-dimensional position as the future implant placement so that the bone core biopsy can be taken from a site totally within the confines of the former tooth socket without inclusion of surrounding native alveolar bone\n* Scheduled for single tooth extraction with bone graft placement and membrane\n\nExclusion Criteria:\n\n* Uncontrolled periodontal disease\n* Uncontrolled systemic disease\n* Pregnancy\n* Use of therapy and\u002For medication that impairs wound healing (e.g., bisphosphonates, steroids, chemotherapy, radiotherapy etc.)","75 Years",{"count":107,"type":22},12,"OBSERVATIONAL","The goal of this study is to evaluate bone wound healing following extraction and alveolar ridge preservation (bone graft and membrane) clinically, histologically and in relation to gene expression in smokers and non-smokers. Data from a small group of participants will be analyzed after age-matched subjects undergo extraction and alveolar ridge preservation prior to implant placement. The data obtained in this pilot study will be used to plan a full-fledged study involving a larger number of smoking and non-smoking participants to compare the two groups.",[111,61,112,113,28],"Smoking, Cigarette","Wound Healing","Bone Healing","NOT_YET_RECRUITING","2026-01-20",{"date":117,"type":42},"2026-01-28",{"date":119,"type":22},"2026-01-25",{"date":121,"type":22},"2028-10-01",{"name":123,"class":49},"Marquette University",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":105,"enrollmentInfo":130,"targetDuration":4,"studyType":108,"phases":4,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":50},"100564116","determinants-of-bone-dimensional-changes-after-extraction-and-alveolar-ridge-preservation-100564116","NCT06624982","Determinants of Bone Dimensional Changes After Extraction and Alveolar Ridge Preservation","Inclusion Criteria:\n\n* Adult patients (18-75 years)\n* Good general health (controlled conditions)\n* Controlled periodontal disease\n* Scheduled for single tooth extraction with bone graft placement and resorbable membrane\n* Tooth to be extracted must have adjacent teeth\n* Socket wall integrity\n\nExclusion Criteria:\n\n* Smoking\n* Pregnancy\n* Active periodontal disease\n* Systemic conditions that affect healing\n* Lack of socket wall integrity (bone loss ≥50 %) prior to extraction, teeth with severe infection requiring pre-extraction antibiotic treatment to control infection), and contraindications for tooth extraction.",{"count":131,"type":22},160,"The main purpose of the study is to measure and localize immediate post extraction changes i.e. socket expansion versus no width change along the socket wall and identify whether the immediate post-extraction ridge width condition (expansion or no change) is a determinant of buccolingual ridge width and height changes 4 months following extraction and ridge preservation.",[61,113,28,112],"2025-11-13",{"date":136,"type":42},"2025-11-17",{"date":138,"type":42},"2025-10-08",{"date":140,"type":22},"2027-10-01",{"name":123,"class":49},{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":23,"phases":151,"briefSummary":152,"conditions":153,"keywords":158,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":50},"100600289","impact-of-ndyag-laser-photobiostimulation-on-healing-of-gingiva-100600289","NCT07095556","Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva","Impact of Nd: YAG Laser Photobiostimulation on Healing of Gingiva Following Tooth Extraction and Alveolar Ridge Preservation","Inclusion Criteria:\n\n* Participants who are ≥ 18 years old,\n* Patients who are scheduled for the treatment of tooth extraction and alveolar ridge preservation (ARP)\n* No contraindications for tooth extraction and alveolar ridge preservation based on electronic health records.\n* Participants who can express the level of pain\n* Participants who self-report \"not pregnant\"\n\nExclusion Criteria:\n\n* Untreated periodontal disease\n* Acute infection of the teeth\n* Use of antibiotics within the last three months.\n* Pregnant or lactating women\n* Use of bisphosphonates based on EHR\n* Alveolar bone defects occurred or were detected during tooth extraction",{"count":150,"type":22},39,[83],"The intervention in this study is to determine whether multiple applications of photobiostimulation with Nd-YAG laser improve wound healing following tooth extraction and alveolar ridge preservation. Investigators plan to assess the impact of laser treatment on wound healing by measuring salivary biomarkers, gingival wound size and surveying for the use of pain reduction and patient satisfaction. The intervention group will receive extraction and alveolar ridge preservation with Nd-YAG laser photobiostimulation on days 1, 3, and 7 following extraction and socket preservation, while the control group will receive the standard of care extraction and alveolar ridge preservation without the laser",[154,155,156,157,28],"Wound Healing and Prevention","Oral Inflammation","Photobiomodulation","Post-operative Pain Management",[159,160,161,162,163],"Inflammation","Periodontal Disease","low-level laser therapy","gingival healing","Post-operative pain","2025-11-07",{"date":166,"type":42},"2025-11-12",{"date":168,"type":42},"2025-11-05",{"date":170,"type":22},"2027-04-30",{"name":172,"class":49},"Medical University of South Carolina",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":17,"sex":18,"minAge":181,"maxAge":182,"enrollmentInfo":183,"targetDuration":4,"studyType":23,"phases":185,"briefSummary":186,"conditions":187,"keywords":194,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":201,"leadSponsor":203,"locationsCount":50},"100608752","improving-healing-in-children-after-tooth-extraction-using-laser-therapy-or-hyaluronic-acid-100608752","NCT07205640","Improving Healing in Children After Tooth Extraction Using Laser Therapy or Hyaluronic Acid","Effect of Low-Level Laser Therapy Versus Hyaluronic Acid on Wound Healing After First Permanent Molar Extraction in Children.","LLLT vs HA","Inclusion Criteria:\n\n1. Children aged from six to ten years.\n2. Children of both genders.\n3. Children with badly decayed first permanent molar beyond repair and indicated for extraction.\n4. Parents acceptance to participate in the study.\n\nExclusion Criteria:\n\n1. Medically compromised children.\n2. Uncooperative children.\n3. Children who will not attend the follow up visits","6 Years","10 Years",{"count":184,"type":22},36,[83],"Tooth extraction may be an unpleasant and painful experience for children, Post-extraction wound healing. Low-level laser therapy (LLLT) is a widely used adjuvant treatment for wound healing, resulting in both an increase in cell number and an increase in cell metabolism. HA it is an important component of the extracellular matrix and a constituent of the neural, connective, and epithelial tissues.",[188,189,190,191,192,193,28],"Mesh","Healthy Volunteer","Low Level Laser Therapy","Hyaluronic Acid Gel for Preservation the Extraction Socket","Extraction Socket Healing","Badly Decayed Molars",[195,196,88],"hyaluronic acid","low level laser therapy","2025-09-25",{"date":199,"type":42},"2025-10-03",{"date":44,"type":22},{"date":202,"type":22},"2026-12-01",{"name":204,"class":49},"Cairo University"]