[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tooth-extraction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tooth-extraction":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,20,0,[8,54,83,113,140,173,200,228,261,284,313,340,370,392,418,441,463,493,516,539],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100643193","early-phase-1-assessment-of-the-impact-of-neocement-inject-p-beta-tricalcium-phosphate-on-bone-volume-in-alveolar-ridge-preservation-after-tooth-extraction-100643193",false,"NCT07638319","Assessment of the Impact of Neocement Inject P® (Beta-Tricalcium Phosphate) on Bone Volume in Alveolar Ridge Preservation After Tooth Extraction","Assessment of Safety and Performance of Neobone®: A Prospective Observational Study in the Field of Dentistry","BTCPARPBV","Inclusion Criteria:\n\n* 18 years or older\n* Acceptance of informed consent\n* Type 1 or 2 extraction sockets (Elian et al. 2007)\n\nExclusion Criteria:\n\n* Presence of active infection or severe inflammation in the intervention zone\n* Relevant medical history that contraindicates implant surgery\n* Patients with poor oral hygiene (full-mouth plaque score and full-mouth bleeding score \\>15%) and lack of motivation\n* Uncontrolled diabetes (reported levels of glycated haemoglobin exceeding 7%)\n* Uncontrolled and \u002For untreated periodontal disease\n* Heavy smokers (more than 10 cigarettes per day)\n* Immunosuppression",true,"ALL","18 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","The goal of this randomized clinical trial is to assess whether β-TCP (Beta-Tricalcium Phosphate) improves alveolar ridge preservation (ARP) in patients who need tooth extraction. The main question it aims to answer is whether using β-TCP for alveolar ridge preservation has a positive effect on bone volume compared with natural healing.\n\nThe main questions it aims to answer are:\n\nDoes β-TCP improve ridge preservation compared with natural healing?\n\nResearchers will compare β-TCP grafted sockets to natural healing sockets to see if β-TCP better preserves ridge volume.\n\nParticipants will:\n\nHave a tooth indicated for extraction.\n\nBe assigned to either β-TCP or natural healing.\n\nUndergo CBCT (Cone Beam Computed Tomography) and intra-oral scanning after extraction and after six months of healing to measure horizontal and vertical resorption and bone density.",[28,29,30,31],"Tooth Extraction","Tooth Extraction Site Healing","Alveolar Bone Grafting","Alveolar Bone Loss",[33,34,35,36,37,38,39,40],"Beta-tricalcium phosphate","Alveolar ridge preservation","Bone volume","Implant site development","Socket preservation","Ridge augmentation","Tooth extraction","Volumetric Changes","RECRUITING","2026-06-09",{"date":44,"type":45},"2026-06-11","ACTUAL",{"date":47,"type":45},"2025-12-01",{"date":49,"type":22},"2028-12",{"name":51,"class":52},"Egas Moniz - Cooperativa de Ensino Superior, CRL","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":53},"100640921","effect-of-collagen-membrane-on-ridge-preservation-100640921","NCT07580495","Effect of Collagen Membrane on Ridge Preservation","Effect of Collagen Membrane on Ridge Preservation for Delayed Implant Placement in Sites With Absent Buccal Bone Wall: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18-80\n* Indicated for extraction of a single-rooted maxillary tooth\n* ≥ 50% buccal bone dehiscence confirmed by CBCT reconstructions\n* Presence of both adjacent teeth\n* No interproximal bone loss\n* ASA I-II health status\n* Ability to comply with required procedures, including attending required number of clinic visits\n\nExclusion Criteria:\n\n* Patients diagnosed with periodontitis adjacent to the area to be treated\n* History of allergic reactions to local anesthetics or bone graft material (self-reported);\n* Current heavy smokers (≥ 10 cigarettes\u002Fday) or those who quit smoking recently (self-reported; last 6 months);\n* Diagnosis of diabetes mellitus, liver or kidney failure (self-reported);\n* Presence of active infectious diseases of any kind;\n* History of chemotherapy or radiation therapy to the head or neck within the past 5 years (self-reported);\n* Severe hematologic disorders (risk for hemorrhage)(self-reported);\n* Assumption of corticosteroids, IV bisphosphonates or immunosuppressive drugs;\n* Any history of alcohol or drug abuse (self-reported);\n* Pregnancy or plans to become pregnant within 4 months of study enrollment (self-reported);","80 Years",{"count":21,"type":22},[64],"NA","This study will evaluate whether adding a resorbable collagen membrane to an anorganic bone-collagen composite (ABCC) graft improves ridge preservation after tooth extraction. Ridge preservation is a procedure used to maintain the shape and volume of the jawbone following tooth removal, which is important for future dental implant placement.\n\nParticipants will be randomly assigned to receive either ABCC alone or ABCC combined with a collagen membrane. Healing outcomes will be assessed after approximately 4 months using three-dimensional cone beam computed tomography (CBCT) scans.\n\nThe primary outcome is the change in horizontal ridge dimension (width). Secondary outcomes include vertical and contour changes in ridge dimensions, changes in soft tissue contour assessed with digital scans, postoperative healing and complications (such as wound dehiscence, swelling, or infection), and patient-reported outcomes, including pain and satisfaction. In a subset of participants, bone healing will also be evaluated using laboratory and imaging analyses of bone samples obtained at the time of implant placement. The study will additionally assess whether the treatment allows implant placement in the ideal position without the need for further bone grafting.",[67,28,31],"Dehiscence",[69,70,71,72,73],"Ridge preservation","Collagen membrane","Socket grafting","Buccal bone loss","Delayed implant placement","2026-06-02",{"date":76,"type":45},"2026-06-04",{"date":78,"type":45},"2026-05-26",{"date":80,"type":22},"2027-10-31",{"name":82,"class":52},"Debora Dias",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":18,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100638907","injectable-alloplastic-bone-graft-for-socket-preservation-clinical-radiographic-and-histological-evaluation-100638907","NCT07595445","Injectable Alloplastic Bone Graft for Socket Preservation: Clinical, Radiographic, and Histological Evaluation","Clinical, Radiographic, and Histological Evaluation of Injectable Alloplastic Bone Graft in Extraction Socket Preservation","Inclusion Criteria:\n\n* Patient aged between 40 and 60 years.\n* General good health.\n* Presence of a hopeless mandibular posterior tooth that requires extraction.\n* Volunteer subjects have to voluntarily sign an informed consent.\n* Patient Indicated for implant.\n\nExclusion Criteria:\n\n* Patient with systemic disease affection bone metabolism.\n* Large periapical radiographic changes related to the tooth to be Extracted, in the form of abscess, granuloma, or cyst.\n* Teeth need trans-alveolar extraction.\n* Patients with contraindication to surgical treatment.\n* Patients suffering from a psychological disorder.\n* Patients with uncontrolled medical conditions.","40 Years","60 Years",{"count":5,"type":22},[64],"This study will evaluate the clinical efficacy of injectable alloplastic bone grafts in terms of radiography and histology in order to preserve tooth sockets following extraction. Methodology: Twenty new extraction sockets from twenty surgically extracted non-restorable mandibular molar teeth will be used in this clinical investigation.",[28,96],"Socket Preservation",[98,96,99,100,101,102],"Injectable Alloplastic Bone Graft","Bone Regeneration","Clinical Evaluation","Radiographic Evaluation","Histological Evaluation","NOT_YET_RECRUITING","2026-05-14",{"date":106,"type":45},"2026-05-19",{"date":108,"type":22},"2026-08",{"date":110,"type":22},"2026-11",{"name":112,"class":52},"Suez Canal University",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":23,"phases":123,"briefSummary":124,"conditions":125,"keywords":126,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":53},"100630208","reduced-time-interval-for-implant-placement-after-extraction-socket-preservation-using-the-vega-plus-implants-100630208","NCT07484685","Reduced Time Interval for Implant Placement After Extraction Socket Preservation Using the Vega Plus Implants","Effect of Reducing the Time Interval for Implant Placement After Extraction Socket Preservation Using the Vega Plus Implant System (Klockner): A Randomized Controlled Clinical Trial","RIP-VEGA","Inclusion Criteria:\n\n* Age: ≥ 18 years.\n* Good general health.\n* Need of extraction of incisors, canines or premolars due to carious lesion, endodontic complication, root fracture or prosthetic reason.\n* Presence of three intact socket walls after tooth extraction with a defect of 50% or more of the buccal wall.\n* Need of single-tooth implant treatment, with presence of adjacent teeth and opposing occluding teeth (for measurement stent indexing).\n* Enough available bone assessed on CBCT to place implants with 3.6 mm diameter and 10 mm in length.\n* Periodontal health in intact or reduced periodontium.\n* Full-mouth plaque and bleeding scores \\\u003C 20%.\n* Able and willing to follow study procedures and instructions.\n\nExclusion Criteria:\n\n* \\\u003C 18 years.\n* Compromised health. Existence of any systemic condition such as uncontrolled diabetes mellitus, cancer, HIV, disorders that compromise wound healing, chronic high dose steroid therapy, intravenous and oral bisphosphonate therapy, bone metabolic diseases, history of irradiation of the head and neck area, or any other immunosuppressive therapy that would contraindicate oral surgical treatment.\n* Absence of any adjacent teeth or the opposing occluding teeth.\n* The hopeless tooth is a molar.",{"count":122,"type":22},40,[64],"This randomized controlled clinical trial aims to evaluate whether reducing the healing interval for implant placement after extraction socket preservation improves clinical and radiographic outcomes compared with the conventional waiting period. Participants requiring single-tooth extraction and implant therapy will be randomly assigned to implant placement either 4 months or 6 months after ridge preservation using the Vega Plus implant system (Klockner).\n\nClinical and radiographic assessments will be performed at baseline and during follow-up visits. The primary outcome will be the mean change in horizontal alveolar ridge width measured using cone-beam computed tomography (CBCT). Secondary outcomes will include vertical bone height changes measured on CBCT, implant stability measured using resonance frequency analysis (ISQ values), marginal bone level changes assessed on standardized periapical radiographs, and postoperative pain assessed using the Visual Analog Scale (VAS).\n\nThe results of this study may contribute to optimizing treatment timing and improving efficiency in implant dentistry while maintaining favorable clinical outcomes.",[31,28],[127,39,34,128,129,130],"Dental implant","Guided Bone Regeneration","Bone regeneration","Dental Implant Placement","2026-04-27",{"date":133,"type":45},"2026-05-01",{"date":135,"type":45},"2026-02-28",{"date":137,"type":22},"2027-02-27",{"name":139,"class":52},"Universidad Catolica Santiago de Guayaquil",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":18,"minAge":147,"maxAge":148,"enrollmentInfo":149,"targetDuration":4,"studyType":23,"phases":151,"briefSummary":152,"conditions":153,"keywords":157,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":4},"100635146","comparison-of-needle-free-injection-and-conventional-syringe-for-tooth-extractions-in-children-100635146","NCT07548892","Comparison of Needle-Free Injection and Conventional Syringe for Tooth Extractions in Children","Comparison of Needle-Free Injection and Conventional Syringe in Tooth Extractions in Children: Effects on Pain, Anxiety, and Vital Signs","Inclusion Criteria:\n\n* Being between 6-12 years of age\n* Having a primary tooth to be extracted with buccal and lingual anesthesia\n* Being in category 2, 3, or 4 according to the Frankl Behavior Scale\n* Being systemically healthy\n* No known history of allergy to local anesthetics\n* No antibiotic use in the last month and no analgesic use in the last 12 hours\n* Not having acute dental pain\n* Having sufficient cognitive ability to understand the anxiety assessment scales\n* Voluntary participation with written parental consent\n\nExclusion Criteria:\n\n* Being under 6 years of age or over 12 years of age\n* Displaying category 1 behavior according to the Frankl scale\n* Presence of severe acute dental infection or a condition requiring emergency intervention\n* Presence of a requirement for surgical extraction in the tooth indicated for extraction\n* Incomplete root development of the underlying permanent tooth\n* History of systemic disease (for example heart disease, uncontrolled asthma, epilepsy, diabetes)\n* Inability to use pain\u002Fanxiety scales due to neurological or developmental disorder\n* History of allergic reaction to local anesthetics or other drugs used\n* Presence of hypersensitivity to odors or inhalation intolerance\n* Refusal of participation by the child or parent","6 Years","12 Years",{"count":150,"type":22},60,[64],"The goal of this clinical trial is to learn whether a needle-free injection system can make tooth extraction less stressful for children than a conventional dental syringe. The study will include healthy children 6 to 12 years old who need a primary tooth extraction with buccal and lingual local anesthesia. The main questions are whether the needle-free method can lower anxiety, lower pain, and reduce changes in vital signs compared with the conventional syringe.\n\nResearchers will randomly assign participants to 1 of 2 groups. One group will receive local anesthesia with a needle-free jet injection system. The other group will receive local anesthesia with a conventional syringe and a 27-gauge dental needle. In both groups, a topical lidocaine spray will be used before the injection, and the same anesthetic solution will be given. All tooth extractions will be performed by the same clinician using standard clinical procedures.\n\nParticipants' anxiety, pain, and vital signs will be checked before the procedure, after anesthesia, and after tooth extraction. Anxiety will be measured with the Face Image Scale (FIS). Pain will be measured with the Face, Legs, Activity, Cry, Consolability (FLACC) scale and the Wong-Baker Faces Pain Rating Scale (WBS). Vital signs will include systolic and diastolic blood pressure, heart rate, and oxygen saturation. No blood, saliva, or tissue samples will be collected, and no audio or video recording will be made.",[28,154,155,156],"Dental Anxiety","Procedural Pain","Anesthesia, Dental",[158,159,28,160,161,154,162,163],"Needle-Free Injection","Conventional Syringe","Pediatric Dentistry","Local Anesthesia","Pain Perception","Vital Signs","2026-04-23",{"date":166,"type":45},"2026-04-29",{"date":168,"type":22},"2026-04-15",{"date":170,"type":22},"2026-12-31",{"name":172,"class":52},"Ondokuz Mayıs University",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":17,"sex":18,"minAge":147,"maxAge":148,"enrollmentInfo":180,"targetDuration":4,"studyType":23,"phases":182,"briefSummary":183,"conditions":184,"keywords":186,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":53},"100635029","effectiveness-of-aromatherapy-and-digital-anesthesia-in-managing-dental-anxiety-and-pain-in-children-100635029","NCT07547371","Effectiveness of Aromatherapy and Digital Anesthesia in Managing Dental Anxiety and Pain in Children","Assessing the Effectiveness of Aromatherapy and Digital Anesthesia Techniques for the Management of Tooth-Extraction-Related Dental Anxiety and Pain in Children","Inclusion Criteria:\n\nParticipants will be recruited from the Department of Pediatric Dentistry at Istanbul University Faculty of Dentistry who meet the following criteria:\n\nChildren aged 6-12 years,\n\nIndicated for extraction of a mandibular primary molar without acute infection or abscess,\n\nNo use of analgesic or sedative medications within the previous 24 hours,\n\nAbsence of any systemic disease,\n\nBehavior rated as Category 2, 3, or 4 on the Frankl Behavior Rating Scale,\n\nVoluntary agreement to participate in the study.\n\nExclusion Criteria:\n\nChildren with a history of systemic disease or those taking medications on a regular basis,\n\nKnown allergy to local anesthetic agents or essential oils,\n\nUse of analgesic or sedative medications within the previous 24 hours,\n\nChildren with asthma, chronic obstructive pulmonary disease (COPD), upper respiratory tract infections, or any respiratory condition that may increase sensitivity to inhalational therapies,\n\nChildren rated as Category 1 on the Frankl Behavior Rating Scale, indicating an inability to cooperate,\n\nTeeth indicated for extraction due to acute infection or abscess,\n\nPatients with teeth presenting mobility, ankylosis, or root resorption exceeding one-third of the root length.",{"count":181,"type":22},132,[64],"The goal of this clinical study is to learn whether aromatherapy and digital anesthesia are effective in reducing dental anxiety and pain during tooth extraction in children. The study also aims to understand how these methods influence children's comfort and cooperation during treatment.\n\nThe main questions this study aims to answer are:\n\nDo aromatherapy (lavender and orange essential oils) and digital anesthesia reduce dental anxiety and pain during tooth extraction in children?\n\nAre these methods more comfortable and less stressful for pediatric patients compared to traditional anesthesia techniques?\n\nDoes digital anesthesia improve cooperation and ease of management during dental treatment?\n\nResearchers will compare aromatherapy and digital anesthesia with conventional anesthesia methods to determine whether these techniques make the extraction process easier and more comfortable for children.\n\nParticipants will:\n\nReceive either aromatherapy, digital anesthesia, conventional anesthesia, or a combination depending on the study group\n\nUndergo tooth extraction under controlled clinical conditions\n\nBe evaluated before, during, and after treatment using standardized pain and anxiety scales\n\nProvide post-treatment feedback along with their parents regarding comfort and anxiety levels\n\nThis study may help identify gentler and more child-friendly approaches to managing anxiety and pain during pediatric dental procedures.",[185,154,28],"Pain",[187,188,189,190,191],"Dental anxiety","Dental pain","Primary molar extraction","Aromatherapy","Computer-controlled anesthesia","2026-04-16",{"date":164,"type":45},{"date":195,"type":45},"2025-12-11",{"date":197,"type":22},"2026-07-04",{"name":199,"class":52},"Arzu Pınar Erdem",{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":208,"targetDuration":4,"studyType":23,"phases":210,"briefSummary":212,"conditions":213,"keywords":217,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":4},"100614129","phase-4-antibiotic-prophylaxis-after-simple-tooth-extraction-in-immunosuppressed-patients-with-autoimmune-rheumatic-diseases-100614129","NCT07275580","Antibiotic Prophylaxis After Simple Tooth Extraction in Immunosuppressed Patients With Autoimmune Rheumatic Diseases","Effectiveness of Short-Course Antibiotic Prophylaxis After Simple Tooth Extraction in Immunosuppressed Patients With Autoimmune Rheumatic Diseases","PRO-EXOD","Inclusion Criteria:\n\n* Age ≥18 years\n* Confirmed diagnosis of an ARD: SLE, RA, JIA, AS, PsA, IIM, systemic vasculitis, primary Sjögren's syndrome, or SSc\n* Under immunosuppressive or biologic therapy ≥3 months\n* Indication for simple extraction of tooth with chronic odontogenic focus\n* Provided informed consent\n\nExclusion Criteria:\n\n* Individuals who do not agree to participate in the study will be excluded.\n* Patients who require more technically complex extractions, such as impacted or impacted third molars.\n* Patients with local and systemic changes that require more extensive antibiotic coverage, such as cases with clinical signs of acute infections, anticoagulated patients, heart patients, patients who have undergone radiotherapy or are undergoing treatment for neoplasms.\n* Patients allergic to amoxicillin.",{"count":209,"type":22},352,[211],"PHASE4","This randomized, double-blind, placebo-controlled clinical trial aims to evaluate whether single-dose amoxicillin prophylaxis administered prior to simple tooth extraction reduces postoperative infection rates in immunosuppressed patients with autoimmune rheumatic diseases (ARDs).\n\nAlthough antibiotic prophylaxis is not recommended for healthy individuals undergoing simple extractions, immunosuppressed ARD patients frequently receive antibiotics despite limited evidence supporting this practice.\n\nSecondary objectives include assessing infection severity, postoperative complications, and the impact of ARD diagnosis and immunosuppressive treatment on infection risk.",[214,28,215,216],"Autoimmune Rheumatic Diseases","Infection Prevention","Antibiotic Prophylaxis",[214,28,215,218,219],"Amoxicillin","Antibiotic Stewardship","2026-04-14",{"date":168,"type":45},{"date":223,"type":22},"2026-06-01",{"date":225,"type":22},"2029-12-30",{"name":227,"class":52},"University of Sao Paulo General Hospital",{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":17,"sex":18,"minAge":236,"maxAge":237,"enrollmentInfo":238,"targetDuration":4,"studyType":23,"phases":239,"briefSummary":242,"conditions":243,"keywords":244,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":53},"100632003","phase-1-evaluation-of-stem-cell-exosomes-versus-platelet-rich-fibrin-in-tooth-extraction-socket-healing-100632003","NCT07508033","Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing","Evaluation of Mesenchymal Stem Cell-Derived Exosomes Versus Platelet-Rich Fibrin (PRF) in Post-Extraction Socket Healing: A Randomized Controlled Clinical Trial.","MSC-EXO vs PRF","Inclusion Criteria:\n\n* Patients aged between 20 and 45 years.\n* Patients requiring a single tooth extraction of a non-infected tooth in the aesthetic zone (incisors, canines) or premolar area.\n* Presence of adjacent teeth to the extraction site.\n* Adequate oral hygiene (Plaque Index \\\u003C 20%).\n* Patients willing and able to comply with the follow-up schedule and 3-month CBCT scan.\n* Signed informed consent provided by the participant.\n\nExclusion Criteria:\n\n* Patients with systemic diseases that contraindicate oral surgery or interfere with bone healing (e.g., uncontrolled diabetes, osteoporosis, hyperparathyroidism).\n* History of head and neck radiation therapy or bisphosphonate medication use.\n* Active infection or acute abscess at the extraction site.\n* Heavy smokers (more than 10 cigarettes per day).\n* Pregnant or lactating women.\n* Patients with poor oral hygiene or active periodontal disease in the rest of the mouth.\n* Use of any medications known to affect bone metabolism (e.g., long-term corticosteroids).","20 Years","45 Years",{"count":122,"type":22},[240,241],"PHASE1","PHASE2","This study evaluates two different treatments used to help the jawbone heal after a tooth is removed. When a tooth is extracted, the surrounding bone often shrinks, which can make it difficult to place dental implants later. Currently, doctors often use Platelet-Rich Fibrin (PRF), which is made from the patient's own blood, to help the area heal.\n\nThis research compares PRF to a newer treatment using \"exosomes\" derived from stem cells. Exosomes are tiny particles that carry signals to tell the body to repair tissue and grow new bone. The goal of this study is to see if these exosomes work better than PRF at keeping the bone strong and thick after an extraction. Researchers will use specialized X-rays (CBCT) to measure the bone three months after the procedure to see which treatment provided better results.",[31,28,99],[245,246,247,248,249,250,251],"MSC-derived Exosomes","Platelet-Rich Fibrin (PRF)","Alveolar Ridge Preservation","Socket Grafting","Cone-Beam Computed Tomography (CBCT)","Stem Cell Secretome","Bone Density","2026-03-27",{"date":254,"type":45},"2026-04-02",{"date":256,"type":45},"2026-01-15",{"date":258,"type":22},"2026-08-01",{"name":260,"class":52},"Al Salam University",{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":4,"eligibilityCriteria":267,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":268,"targetDuration":4,"studyType":23,"phases":270,"briefSummary":271,"conditions":272,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":4},"100631112","is-cross-linked-hyaluronic-acid-a-biologic-alternative-for-alveolar-ridge-preservation-100631112","NCT07496437","Is Cross-linked Hyaluronic Acid a Biologic Alternative for Alveolar Ridge Preservation?","Is Cross-linked Hyaluronic Acid a Biologic Alternative for Alveolar Ridge Preservation? A Single-blind, Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n(1) Patients elder than 18 years in need of (2) maxillary non-molar tooth extraction, and (3) later rehabilitation with delayed implant installation.\n\nExclusion Criteria:\n\n(1) Patients with chronic diseases (e.g., uncontrolled diabetes mellitus, etc.) and\u002For (2) taking any medication, influencing hard or soft-tissue healing; (3) acute pain\u002Finfection or (4) presence of a fistula at the extraction site; (5) untreated periodontal disease; (6) \\>25% of the buccal bone plate missing after tooth extraction; (7) pregnancy; (8) history of hypersensitivity or allergy to xHyA or xenogenic bone substitute material; and (9) inability to attend the follow-up appointments.",{"count":269,"type":22},48,[64],"Even after atraumatic tooth removal and\u002For immediate implant placement, some reduction of the alveolar ridge dimension is expected. To counteract (or limit) this reduction, alveolar ridge preservation technique (ARP) was developed. However, standard ARP techniques, such as grafting with bone substitutes, have some concerns, such as a long healing time prior to implant installation, residual graft particles, and often the need of re-grafting at implant installation. To overcome some of these limitations biologics have been discussed as an alternative approach, such as cross-linked hyaluronic acid (xHyA). However, whether the use of biologics only can achieve comparable results to the standard techniques, has yet to be answered.\n\nThe aim of the present single-blind, randomized controlled clinical trial is to test non-inferiority in terms of mid-buccal alveolar ridge height resorption 4 months after ARP between 1) control\u002Fstandard treatment (i.e., grafting with bone substitutes and socket seal) and 2) test treatment (i.e., xHyA applied with a collagen sponge and socket seal) at maxillary non-molar teeth.\n\nForty-eight patients will be included and randomly assigned to one of the following 2 groups: 1) control group: standard ARP with deproteinized bovine bone material and covering of the socket with a free gingival graft (FGG) (n=24), 2) test group: application of xHyA soaked in a collagen sponge and covered by a FGG (n=24). The primary outcome parameter is the extent of mid-buccal alveolar ridge height resorption after 4 months, i.e., prior to implant installation, and the sample size calculation is based on a non-inferiority limit of 0.6 mm. The secondary outcome parameters are frequency of additional grafting at implant installation due to 1) a bony dehiscence or fenestration, 2) a thin buccal bone (\\\u003C 1.5 mm), or 3) contour improvement, cervical alveolar ridge width, alveolar ridge volume, histomorphometric assessment of alveolar ridge healing, feasibility of implant installation, aesthetic outcome parameters, patient reported outcome measures, changes in keratinized mucosa width, soft tissue healing, and assessment of postoperative complications. Patients will be followed up to 1 year after prosthetic restoration.",[273,274,28,275],"Alveolar Bone Resorption","Alveolar Ridge Enlargement","Hyaluronic Acid","2026-03-22",{"date":252,"type":45},{"date":279,"type":22},"2026-04-01",{"date":281,"type":22},"2028-12-31",{"name":283,"class":52},"Medical University of Vienna",{"id":285,"slug":286,"hasResults":11,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":4,"eligibilityCriteria":290,"healthyVolunteers":17,"sex":18,"minAge":291,"maxAge":4,"enrollmentInfo":292,"targetDuration":294,"studyType":295,"phases":4,"briefSummary":296,"conditions":297,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":304,"lastUpdatePostDateStruct":305,"startDateStruct":307,"completionDateStruct":308,"leadSponsor":310,"locationsCount":312},"100628414","surgeons-prediction-of-dental-surgery-complications-and-the-influence-of-patient-characteristics-development-of-an-ai-model-100628414","NCT07461324","Surgeons' Prediction of Dental Surgery Complications and the Influence of Patient Characteristics: Development of an AI Model","Systematic Risk Assessment Prior to Oral Surgery","Inclusion Criteria:\n\n* Patients reffered from a general dentist practicioner for the following surgeries: third molar removal, apicoectomy, dental implant placement.\n* Patients \\>15 years of age\n* A valid diagnosis prior to the surgery\n* Cases with fully completed questionnaires.\n\nExclusion Criteria\n\n* Pathological condition requiring hospital refferal\n* Complications following re-surgery\n* Re-assesment of the diagnosis from the general dentist practicioner\n\nSpecific for apical surgery:\n\n* Root fracture present.\n* Buccal bone height \\\u003C3mm.\n\nSpecific for third molar removal:\n\n\\- if coronectomy is conducted instead of total root removal.\n\nSpecific for dental implant:\n\n* if an implant has been placed before in the same region of interest.\n* Health conditions were dental implants are contraindicated.","15 Years",{"count":293,"type":22},3000,"1 Year","OBSERVATIONAL","The goal of this observational study is to learn how to better predict and prevent intra- and postoperative complications in oral surgery in adult patients referred for oral surgical procedures. The study aims to understand how accurately surgeons can foresee complications and which patient, tooth, and surgery related factors influence the outcomes.\n\nThe research questions are:\n\n* What is the incidence of intra and postoperative complications in oral surgery?\n* Which factors predict these complications, and how accurately can surgeons anticipate them?\n* Can the development of an AI tool reduce postoperative complications?\n\nParticipants will:\n\n* Receive standard oral surgery treatment at a private referral clinic (Specialtandlægerne Sjælland).\n* Have clinical information collected about their procedure, medical history, and personal characteristics (including anxiety level).\n* Conduct a short questionnaire, the STAI-6 and the I-PANAS-SF.\n* Have the surgeon record their prediction of whether complications are expected.\n* Be followed in the postoperative lapse to document whether complications occur after surgery.",[298,299,300,301,302,28,303],"Postoperative Infections","Mandibular Nerve Injuries","Alveolar Osteitis","Complication","Dental Implantation","Apical Surgery","2026-03-04",{"date":306,"type":45},"2026-03-10",{"date":279,"type":22},{"date":309,"type":22},"2030-06-01",{"name":311,"class":52},"University of Copenhagen",2,{"id":314,"slug":315,"hasResults":11,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":4,"eligibilityCriteria":319,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":320,"enrollmentInfo":321,"targetDuration":4,"studyType":23,"phases":323,"briefSummary":324,"conditions":325,"keywords":326,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":53},"100604836","wound-healing-following-tooth-extraction-and-ridge-preservation-using-osteogen-100604836","NCT07154693","Wound Healing Following Tooth Extraction and Ridge Preservation Using OsteoGen®","Wound Healing Following Tooth Extraction and Ridge Preservation Using Resorbable Non-ceramic Calcium Apatite Granules in Type I Bovine Collagen Plugs (OsteoGen®)","Inclusion Criteria:\n\n* Male or female patient aged 18 to 89\n* One tooth, excluding molars, that has been identified by dental faculty as requiring a single tooth extraction\n* A dental implant is indicated and treatment planned to replace the missing tooth\n* Site has adequate restorative space for a dental implant-retained restoration\n* Site has at least 10mm of alveolar bone height, without impinging on the maxillary sinus or inferior alveolar canal.\n* Site has a dehiscence of the buccal or lingual bony plate of the tooth socket extending no more than 50% of the total depth of the socket.\n* Female patients who have undergone a hysterectomy, tubal ligation, or menopause, and nonpregnant women of child-bearing potential.\n* Patients are nonsmokers or former smokers. Current smokers may be included if they smoke \\\u003C10 cigarettes per day (less than or equal to 10 cigarettes per day)\n\nExclusion Criteria:\n\n* Patient allergic to bovine-derived collagen products, Bacitracin, Gentamicin, Polymyxin\n* Patients who will not cooperate with the follow-up schedule.\n* Patients will not be entered who are mentally incompetent, prisoners, or pregnant.\n* Pregnant women or women intending to become pregnant during the study period (as confirmed verbally; an over-the-counter pregnancy test will be provided if pregnancy status is unknown or suspected).\n\n  * Patients who become pregnant during the study will be withdrawn and standard care will be delivered.\n* Smokers who smoke \\>10 cigarettes per day (more than 10 cigarettes per day)","89 Years",{"count":322,"type":22},44,[64],"After the removal of a tooth, a bone graft is often placed in the socket to try to keep the volume of bone that was there when the tooth was present so that the bone does not \"shrink\". The bone graft is sometimes kept in place with a small piece of material over the top of the tooth socket and with stitches. This procedure is called \"Ridge Preservation\". Many different materials are used for ridge preservation including bone allografts (bone grafts derived from a human tissue donor), bone xenografts (bone grafts derived from species other than humans, such as cows and pigs), and synthetic materials that are similar in structure to bone (such as calcium apatite). The bone allograft and the calcium apatite product used in this study are Food and Drug Administration (FDA) approved.\n\nThis study will compare the two methods used to see how much new bone formation there is inside the tooth socket at about 16 weeks of healing after ridge preservation with a calcium apatite\u002Fcollagen sponge versus an allograft.",[28],[327,328,329,330,69],"Wound healing","Vital bone","Mineralized freeze-dried bone allograft (FDBA)","Demineralized freeze-dried bone allograft (DFDBA)","2026-01-02",{"date":333,"type":45},"2026-01-06",{"date":335,"type":45},"2025-11-19",{"date":337,"type":22},"2027-12-31",{"name":339,"class":52},"The University of Texas Health Science Center at San Antonio",{"id":341,"slug":342,"hasResults":11,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":347,"targetDuration":4,"studyType":23,"phases":349,"briefSummary":350,"conditions":351,"keywords":355,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":312},"100616205","efficacy-and-safety-evaluation-study-of-implants-with-periodontal-ligament-100616205","NCT07302581","Efficacy and Safety Evaluation Study of Implants With Periodontal Ligament","Evaluation of the Efficacy and Safety of Periodontal Ligament Integrated Implants Via Residual Periodontal Ligament Tissue in Extraction Sockets","Inclusion Criteria:\n\n* Patients who have only one single-rooted tooth, from the upper or lower incisors to the premolars, which require extraction due to caries or a fracture, and who have healthy periodontal tissue remaining around the root of the tooth to be extracted.\n* The teeth adjacent to the tooth to be extracted are natural teeth with healthy periodontal tissues, and no abnormalities are found in dental X-rays, CT scans, periodontal pocket examinations, or physiological mobility tests. Also, patients should be able to achieve proper occlusion with opposing teeth.\n* Patients aged 18 years or older at the time of consent.\n* Patients who have provided written consent to participate in this clinical study and are able to comply with study visits and procedures.\n\nExclusion Criteria:\n\n* Patients whose jawbone is still growing.\n* Patients undergoing orthodontic treatment or wearing retainers after orthodontic treatment.\n* Patients with multiple missing teeth or an edentulous jaw where multiple occlusal support areas of the remaining teeth are missing.\n* Patients who have periodontal pockets of 4mm or more around the root of the tooth to be extracted or the teeth adjacent to the tooth to be extracted.\n* Patients with bacterial infection or acute inflammation such as periodontitis in the tooth to be extracted.\n* Patients with apical periodontitis in the tooth to be extracted.\n* Patients who will have two or more consecutive missing teeth or free-end edentulous space due to the extraction of the target teeth.\n* Patients who have already had the target tooth extracted.\n* Patients for whom extraction of the target tooth is expected to be difficult.\n* Patients who are not healthy enough to undergo the tooth extractions and surgical procedures required for implant treatment using this product.\n* Patients with abnormal root morphology or position (curved, tilted, etc.) of the tooth to be extracted.\n* Patients in whom this product cannot be implanted due to the root size of the tooth to be extracted (root length less than 10 mm, root diameter at the cervical part less than 5.4 mm in long diameter, less than 3.4 mm in short diameter) or malocclusion.\n* Patients with open bite.\n* Patients with a history of hypersensitivity to the components of this product or similar products.\n* Patients with alveolar bone resorption in the area where the implant is to be placed.\n* Patients with bleeding disorders. (There is a risk of abnormal bleeding and poor healing of the surgical site).\n* Patients with uncontrolled diabetes. (There is a risk of poor healing of the surgical site and increased susceptibility to infection.)\n* Patients for whom general oral surgery is contraindicated. (There is a risk that the invasive procedure may worsen the disease, cause recurrence of preexisting conditions, or result in poor healing of the surgical site postoperatively.)\n* Patients who undergo radiation therapy or chemotherapy due to malignant tumors, etc. (There is a risk that the surgical site may not heal properly.)\n* Patients receiving bisphosphonate therapy.\n* Patients who currently smoke.\n* Patients who do not understand or cooperate with the treatment.\n* Pregnant patients or patients who may be pregnant.\n* Any other patient deemed unsuitable for participation in this study by the principal investigator (or co-investigator).",{"count":348,"type":22},6,[64],"The goal of this clinical trial is to evaluate the efficacy and safety of periodontal ligament-integrated implants placed via residual periodontal ligament tissue in extraction sockets in adult patients (aged 18 and older) requiring extraction of a single-rooted tooth.\n\nThe main questions it aims to answer are:\n\n* Does the periodontal ligament-integrated implant achieve stable integration with the jawbone at 24 weeks after placement?\n* Can this implant reproduce physiological tooth mobility and sensory function similar to natural teeth while maintaining periodontal health?\n\nThis is a multicenter, single-arm, exploratory study with approximately six participants.\n\nParticipants will:\n\n* Undergo tooth extraction of one single-rooted tooth that meets eligibility criteria.\n* Receive immediate placement of a periodontal ligament-integrated implant into the extraction socket.\n* Attend scheduled follow-up visits over 48 weeks for assessments including:\n\n  * Dental X-rays and clinical examinations to evaluate bone healing, periodontal ligament formation, and implant stability.\n  * Measurements of tooth mobility, pocket depth, and pain levels.\n  * Quality of life assessments using a standardized oral health questionnaire.\n\nResearchers will monitor participants for implant integration, safety outcomes, and physiological function restoration over the study period.",[28,352,353,354],"Tooth Fractures","Dental Caries","Tooth Dislocation",[356,357,358,359,360],"Root Fracture","Crown Fracture","Tooth Mobility","Carious Tooth","Extraction site healing",{"date":362,"type":45},"2025-12-24",{"date":364,"type":45},"2025-06-20",{"date":366,"type":22},"2027-07",{"name":368,"class":369},"OrganTech, Inc.","INDUSTRY",{"id":371,"slug":372,"hasResults":11,"nctId":373,"briefTitle":374,"officialTitle":374,"acronym":4,"eligibilityCriteria":375,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":376,"targetDuration":4,"studyType":23,"phases":378,"briefSummary":379,"conditions":380,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":383,"lastUpdatePostDateStruct":384,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":390,"locationsCount":4},"100597496","phase-4-periodontal-regeneration-at-the-distal-site-of-second-molars-after-the-extraction-of-lower-included-third-molars-100597496","NCT07059247","Periodontal Regeneration at the Distal Site of Second Molars After the Extraction of Lower Included Third Molars","Inclusion Criteria:\n\n* Adult (\\\u003C 18 years old) patients with impacted or semi-impacted lower third molars and with indication of extraction\n* Systemically healthy patients\n* Non-smokers or less than 10 cigarettes per day\n\nExclusion Criteria:\n\n* Patients with uncontrolled systemic diseases (ASA III-IV)\n* Medication that potentially affects bone metabolism\n* Absence of adjacent lower second molar\n* Presence of crowns, distal caries or distal fillings of the adjacent second molar",{"count":377,"type":22},24,[211],"From an exclusively periodontal point of view, the extraction of third molars (3M) or wisdom teeth is relatively frequently recommended, either because they show reduced bone support or to avoid periodontal damage to the supporting bone of the adjacent second molar (2M). There are anatomical conditions that make plaque control difficult for the patient, and it is common to find periodontal pockets with significantly increased depths on the distal side of second molars that are or have been closely associated with an impacted third molar.\n\nAmong the periodontal considerations regarding impacted third molars, two aspects have traditionally been included: 1)The periodontal damage that certain impactions can cause to the periodontal health of the second molar, and 2) the periodontal sequelae or complications that the extraction of a wisdom tooth may leave on the distal surface of that second molar.\n\nVarious therapeutic approaches have been described in the literature to prevent periodontal damage following the surgical intervention involved in the extraction of a fully or partially impacted wisdom tooth. These include scaling of the distal surface of the 2M after extraction, modifications in the surgical technique - such as flap design or suturing method - and various regenerative techniques.\n\nWithin this context, the clinical research in which we invite the patients to participate will be developed. We will study the changes in bone levels on the posterior part of the second molar that is in contact with or close to the third molar, as well as the health of the soft tissues, after performing a conventional extraction protocol of the impacted lower third molar. This protocol includes the placement of a regenerative material of porcine origin (test procedure; enamel matrix derivatives) and will be compared to extraction without such material - and therefore without any attempt at periodontal regeneration (standard procedure). The patients will be closely followed up to one year after the surgical performance. This follow-up will be performed clinically and radiographically.",[28,381,382],"Wisdom Tooth Removal","Periodontal Regeneration","2025-07-01",{"date":385,"type":45},"2025-07-10",{"date":387,"type":22},"2025-07",{"date":389,"type":22},"2026-09",{"name":391,"class":52},"Universidad Complutense de Madrid",{"id":393,"slug":394,"hasResults":11,"nctId":395,"briefTitle":396,"officialTitle":397,"acronym":4,"eligibilityCriteria":398,"healthyVolunteers":17,"sex":18,"minAge":399,"maxAge":90,"enrollmentInfo":400,"targetDuration":401,"studyType":295,"phases":4,"briefSummary":402,"conditions":403,"keywords":405,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":410,"lastUpdatePostDateStruct":411,"startDateStruct":413,"completionDateStruct":415,"leadSponsor":416,"locationsCount":53},"100578049","effects-of-tranexamic-acid-irrigation-on-impacted-third-molar-surgery-100578049","NCT06806241","Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery","Investigation of the Effects of Tranexamic Acid Solution Irrigation on Bleeding, Surgical Field Visibility, and Postoperative Edema in the Extraction of Horizontally Impacted Third Molars","Inclusion Criteria:\n\n1. Indicated for the Extraction of Bilaterally Impacted Third Molars with Bone Retention.\n2. Systemically healthy patients aged 14-40 years with no bleeding disorders.\n\nExclusion Criteria:\n\n1. Patients with systemic diseases affecting general health.\n2. Patients diagnosed with any bleeding disorder.\n3. Patients with advanced infection or cysts associated with the impacted tooth.","14 Years",{"count":5,"type":22},"3 Days","Tranexamic acid (TXA) is an effective hemostatic agent used to reduce blood loss and the need for transfusion. It is a relatively safe drug with minimal significant side effects. The most commonly reported complications include nausea, diarrhea, and occasional orthostatic reactions. The increased risk of thromboembolic events associated with the drug is the most serious complication; however, this has not been reported in most clinical studies and remains uncertain. Based on experience from other types of surgeries, tranexamic acid appears to be safe for use without an increased risk of venous thrombosis. To mitigate systemic absorption and minimize undesirable side effects, TXA can be applied topically rather than intravenously, reducing the risk of venous thromboembolism.",[404,28],"Bleeding",[406,407,408,409],"bleeding","tranexamic acid","wisdom teeth removal","edema","2025-06-23",{"date":412,"type":45},"2025-06-24",{"date":414,"type":45},"2025-01-01",{"date":306,"type":22},{"name":417,"class":52},"Bezmialem Vakif University",{"id":419,"slug":420,"hasResults":11,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":4,"eligibilityCriteria":424,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":90,"enrollmentInfo":425,"targetDuration":4,"studyType":23,"phases":427,"briefSummary":428,"conditions":429,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":53},"100596395","diode-laser-photocoagulation-with-immediate-implant-placement-100596395","NCT07044895","Diode Laser Photocoagulation With Immediate Implant Placement","Evaluation of Diode Laser Photocoagulation With Immediate Implant Placement in the Maxillary Esthetic Zone","Inclusion Criteria:\n\n* Patients with non-restorable maxillary teeth in the aesthetic zone are indicated for extraction and subsequent immediate implant placement, including those with:\n* A severely carious tooth that cannot be restored.\n* Pulpal necrosis or irreversible pulpitis that is not amenable to endodontics.\n* Periodontally involved teeth with grade 2 mobility or above.\n* Teeth with root caries that can't be restored.\n* Patients with an extraction socket Type I.\n* A good standard of oral hygiene.\n\nExclusion Criteria:\n\n* Patients with extraction socket Type II or III, with buccal plate defects.\n* Absence of at least 2 mm of bone apical to the extraction socket\n* tooth ankylosis.\n* Patients with deciduous teeth.\n* Heavy smokers.\n* Systemic conditions\n* History of oral or intravenous bisphosphonate therapy or any treatments with other medications that may interfere with bone metabolism within the past 12 months",{"count":426,"type":22},8,[64],"Placement of an immediate implant is becoming popular because of its potential in minimizing the treatment time and enhancing the patient comfort and esthetic outcomes. It is crucial to maintain adequate thickness of labial bone with the establishment of a stable and healthy gingival seal around the implant abutment to prevent the invasion of bacteria and peri-implant inflammation. Diode lasers have been developed as a promising tool in dentistry, providing a precise manipulation and photocoagulation effect that may have a positive influence on both bone remodeling and soft tissue healing. This study aims to evaluate the effectiveness of the utilization of diode laser photocoagulation with immediate implant placement and customized healing abutment in the maxillary esthetic zone.",[28,430,431,432],"Immediate Dental Implant","Photocoagulation","Maxillary Esthetic Zone","2025-06-22",{"date":383,"type":45},{"date":436,"type":22},"2025-06-30",{"date":438,"type":22},"2026-02-25",{"name":440,"class":52},"Hams Hamed Abdelrahman",{"id":442,"slug":443,"hasResults":11,"nctId":444,"briefTitle":445,"officialTitle":445,"acronym":4,"eligibilityCriteria":446,"healthyVolunteers":17,"sex":18,"minAge":447,"maxAge":4,"enrollmentInfo":448,"targetDuration":4,"studyType":23,"phases":449,"briefSummary":450,"conditions":451,"keywords":452,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":461,"locationsCount":312},"100558578","combination-therapy-effect-of-laser-on-wound-healing-and-bone-regeneration-of-dental-sockets-100558578","NCT06552936","Combination Therapy Effect of Laser on Wound Healing and Bone Regeneration of Dental Sockets","Inclusion Criteria:\n\n* At least 21 years old, regardless of gender\n* Non-traumatic tooth extraction of the lower jaw is indicated\n* Willing for dental implant surgery\n* Dental appointments are available at the study place\n* Absence of active infection at the extraction site\n* Signed informed permission is provided.\n\nExclusion Criteria:\n\n* Pregnant, lactating, and menopausal women\n* Smokers\n* Those having head and neck radiotherapy\n* Those with any sort of acute infection (e.g., periodontal abscess), immune deficiency, or metabolic conditions such as diabetes mellitus and osteoporosis\n* Patients will also be eliminated if they have a complication during surgery, such as bleeding or operational difficulties, or if the procedure takes longer than 90 minutes.","21 Years",{"count":322,"type":22},[64],"The goal of this clinical trial is to learn if the laser works to improve wound healing and bone regeneration after tooth extraction. The main question it aims to answer is:\n\nDoes laser therapy improve wound healing and bone regeneration after tooth extraction?\n\nResearchers will compare a laser to sham laser therapy to see if the laser enhances wound healing and bone regeneration.\n\nParticipants will:\n\nHave exposure to laser or sham laser therapy immediately after tooth extraction Record their pain intensity on days 2, 4, 6 and 14 Visit the clinic after 10 days for follow-up Again, visit the clinic after 4 months for evaluation",[28],[453],"Tooth socket, Laser, wound healing, bone regeneration, pain","2025-05-13",{"date":456,"type":45},"2025-05-16",{"date":458,"type":45},"2024-12-15",{"date":460,"type":22},"2025-12",{"name":462,"class":52},"Sharif Medical Research Center",{"id":464,"slug":465,"hasResults":11,"nctId":466,"briefTitle":467,"officialTitle":468,"acronym":469,"eligibilityCriteria":470,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":471,"enrollmentInfo":472,"targetDuration":4,"studyType":23,"phases":474,"briefSummary":475,"conditions":476,"keywords":478,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":485,"startDateStruct":487,"completionDateStruct":489,"leadSponsor":491,"locationsCount":53},"100571786","phase-4-comparison-of-two-collagen-membranes-for-bone-augmentation-around-dental-implants-restored-with-monolithic-zirconia-single-crowns-100571786","NCT06724783","Comparison of Two Collagen Membranes for Bone Augmentation Around Dental Implants Restored with Monolithic Zirconia Single Crowns","A Randomized Controlled Clinical Trial to Compare Two Collagen Membranes for Guided Bone Regeneration (GBR) Around Dental Implants Restored with Monolithic Zirconia Single Crowns Using Three Different Veneering Designs","BioGide-Compr","Inclusion Criteria:\n\n* Informed Consent signed by the subject\n* ≥18 years of age\n* No active periodontal disease\n* Full-mouth plaque score and full-mouth bleeding score \\\u003C25%.\n* Patients in need of an implant-supported crown at a single-tooth gap in the aesthetic region: 11-15, 21-25, 31-35, 41-45 (FDI)\n* Patients in need of GBR during implant placement (1-stage procedure)\n* Presence of mesial and distal natural teeth or implant\n* Implant placement at least 6 weeks after tooth extraction\n* No need for soft tissue grafting\n\nExclusion Criteria:\n\n* Any conditions or circumstances which would interfere with the requirements for oral surgery\n* Patients with large bone defects, in need of a primary bone augmentation (two-stage procedure)\n* Allergy to any implant metallic component\n* Allergy to collagen\n* Previous oral-maxillo-facial radiotherapy\n* Any disorders in the planned implant area such as previous tumors, chronic bone\n* disease (such as rheumatoid disease)\n* Any ongoing application of interfering medication (steroid therapy, bisphosphonate, etc.)\n* Alcohol or drug abuse\n* No need for soft tissue grafting\n* Patients with inadequate oral hygiene or persistent oral infection\n* Clinically significant concomitant diseases (e.g. renal failure, hepatic disfunction, cardiovascular diseases)\n* Heavy smokers (\\>10 cigarettes\u002Fday)\n* Uncontrolled diabetes\n* Severe bruxism or other destructive habits\n* Pregnant or lactating women","90 Years",{"count":473,"type":22},68,[211],"The goal of this randomized controlled clinical trial is to compare the use of two covering collagen membranes in a bone augmentation procedure around single implants and to assess three different veneering approaches on crowns in patients lacking a single tooth in the esthetic zone.\n\nThe main aims include:\n\n1. Bone stability, i.e. the difference in the bone defect depth 4 months after bone augmentation\n2. The occurrence of ceramic restoration chipping at the inserted single crowns after 5 years.\n\nParticipants will receive an implant with simultaneous bone augmentation using the bone particles and a covering collagen membrane. After the healing period, they will receive a crown restoration on the implant.\n\nIn the surgical part, researchers will compare the commonly used collagen membrane with the compressed (stronger) version of the same collagen membrane in an otherwise identical procedure to evaluate if the compressed membrane offers the same or better bone stability.\n\nIn the restorative part, researchers will compare three types of crown finishes: non-veneered, conventionally veneered and window-veneered (test group)\n\nParticipants will be asked to come to follow-up appointments over a period of 7 years. Depending on the follow-up time in the study, different dental measurements will be taken to assess the stability of the implants and restorations.",[28,477],"Tooth Replacement",[479,480,481,482,483],"guided bone regeneration (GBR)","collagen membrane","dental implants","zirconia","monolithic ceramic fixed dental prosthesis (singe crowns)","2024-12-04",{"date":486,"type":45},"2024-12-09",{"date":488,"type":45},"2023-06-30",{"date":490,"type":22},"2030-09-30",{"name":492,"class":52},"Dr. med. dent. Malin Strasding",{"id":494,"slug":495,"hasResults":11,"nctId":496,"briefTitle":497,"officialTitle":498,"acronym":499,"eligibilityCriteria":500,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":501,"targetDuration":4,"studyType":23,"phases":503,"briefSummary":504,"conditions":505,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":510,"completionDateStruct":512,"leadSponsor":514,"locationsCount":53},"100563170","a-new-syndesmotomy-technique-for-tooth-extractions-to-preserve-the-alveolar-bone-100563170","NCT06612684","A New Syndesmotomy Technique for Tooth Extractions to Preserve the Alveolar Bone","A New Syndesmotomy Technique for Tooth Extractions: Preserving the Integrity of the Alveolar Bone","SINDESM-EXt","Inclusion Criteria:\n\n* Age ≥ 18 years old\n* Single-rooted tooth to extract that:\n* has mobility grade 0 or 1\n* is considered hopeless or needs to be extracted due to orthodontic indication\n* Sign of informed consent\n\nExclusion Criteria:\n\n* Age lower than 18 years old\n* Pregnancy\n* Heavy smokers (more than 10 cigarettes a day)\n* Uncompensated systemic diseases\n* Drugs that influence wound healing (radiotherapy in the last year, bisphosphonates)\n* Low compliance due to psychiatric diseases\n* Mobility grade 2 or 3\n* Refusal of informed consent",{"count":502,"type":22},80,[64],"In both surgical and nor surgical tooth extractions, the first phase is done by syndesmotomy. This procedure allows to interrupt the fibers of the periodontal ligament. Traditionally, syndesmotomy is done by manual instruments. Usually, the manual approach leads to the loss of the vestibular cortical plate due to the size of those instruments.\n\nThe piezoelectric surgery device provides an alternative to manual instruments. Its advantages are: selectivity for hard tissues; better cut control; protection of soft tissue, vessels and nerves; post-op pain and discomfort reduction.\n\nThe aim of this study is to evaluate a piezosurgery driven syndesmotomy technique during tooth extraction.",[28,506],"Piezoelectric Technique","2024-09-23",{"date":509,"type":45},"2024-09-25",{"date":511,"type":22},"2024-10",{"date":513,"type":22},"2025-10",{"name":515,"class":52},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":517,"slug":518,"hasResults":11,"nctId":519,"briefTitle":520,"officialTitle":521,"acronym":4,"eligibilityCriteria":522,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":523,"enrollmentInfo":524,"targetDuration":4,"studyType":23,"phases":526,"briefSummary":527,"conditions":528,"keywords":529,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":531,"lastUpdatePostDateStruct":532,"startDateStruct":534,"completionDateStruct":535,"leadSponsor":537,"locationsCount":53},"100554684","evaluation-of-antibiotic-administration-following-tooth-extraction-100554684","NCT06502288","Evaluation of Antibiotic Administration Following Tooth Extraction","Evaluation of Necessity of Antibiotic Administration Following Tooth Extraction: A Randomized Control Trial","Inclusion Criteria:\n\n1. Patient indicated extraction of teeth\n2. Provide informed written consent\n3. Patients aged between 18 to 50 years\n\nExclusion Criteria:\n\n1. The tooth with abscess, infected cyst and tumors that require extensive surgery including impacted teeth\n2. Patients who have taken antibiotics before 5 days for any reason will be excluded\n3. Patients who are medically compromised such as DM, Congenital cyanotic heart disease, chronic kidney disease (CKD), Patients with chemotherapy or radiotherapy, Chronic Liver Disease (CLD), etc.\n4. Female patients who are pregnant or lactating\n5. Those women during the menstruation period (disturbed fibrinolytic activity),\n6. Participants who are known hypersensitive to the given drugs used in this study\n7. Participants who have known resistance to intervention drugs","50 Years",{"count":525,"type":22},152,[64],"The trial aims to evaluate the effects of prescribing antibiotics after tooth extraction. 152 dental patients aged 18 to 50 will be randomly assigned. The study will assess infection rates, healing times, pain, and adverse effects in patients who receive antibiotics versus those who do not. The trial will be conducted at the Oral and Maxillofacial Surgery Department, Dental Unit, Chittagong Medical College. Data analysis will involve the use of the χ²-test, t-tests, and logistic regression, with a significance level of 5%. Ethical considerations include obtaining informed consent from all participants, and safety will be monitored by an independent expert team.",[28],[530],"Antibiotic, tooth extraction, RCT","2024-07-13",{"date":533,"type":45},"2024-07-16",{"date":414,"type":22},{"date":536,"type":22},"2025-10-15",{"name":538,"class":52},"Chittagong Medical College",{"id":540,"slug":541,"hasResults":11,"nctId":542,"briefTitle":543,"officialTitle":544,"acronym":4,"eligibilityCriteria":545,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":546,"enrollmentInfo":547,"targetDuration":4,"studyType":295,"phases":4,"briefSummary":549,"conditions":550,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":551,"lastUpdatePostDateStruct":552,"startDateStruct":554,"completionDateStruct":556,"leadSponsor":558,"locationsCount":53},"100552502","assessing-levels-of-fear-and-anxiety-and-monitoring-wound-healing-among-patients-who-are-about-to-undergo-wisdom-tooth-extraction-surgery-or-jaw-implant-surgery-under-local-anesthesia-versus-general-anesthesia-100552502","NCT06473922","Assessing Levels of Fear and Anxiety and Monitoring Wound Healing Among Patients Who Are About to Undergo Wisdom Tooth Extraction Surgery or Jaw Implant Surgery Under Local Anesthesia Versus General Anesthesia","Assessing Levels of Fear and Anxiety and Monitoring Wound Healing Among Patients Who Are About to Undergo Wisdom Tooth Extraction or Jaw Implant Surgery Under Local Anesthesia Versus General Anesthesia","Inclusion Criteria:\n\nAge - from ≥ 18 years, ASA 1- or 2, Signing a written informed consent before starting all procedures related to the research, Ability to cooperate with the researcher and meet the research requirements.\n\nExclusion Criteria:","85 Years",{"count":548,"type":22},46,"Tooth extraction is one of the most common surgical procedures in dentistry. Up to 15% of the world's adult population suffers from high anxiety about dental treatments. The stress resulting from this anxiety may cause a delay in the healing and fusion of the surgical wound. Therefore, it is possible to perform this surgical tooth extraction procedure under general anesthesia.\n\nThe purpose of the present study is to assess the level of anxiety\u002Ffear and to monitor the wound healing process among patients who are about to undergo surgery to remove wisdom teeth or no more than 3 jaw implants under local anesthesia in the dental clinic compared to patients who are about to undergo the same surgery under general anesthesia.",[28],"2024-06-19",{"date":553,"type":45},"2024-06-25",{"date":555,"type":22},"2024-07-01",{"date":557,"type":22},"2026-08-30",{"name":559,"class":560},"Assaf-Harofeh Medical Center","OTHER_GOV"]