[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tooth-loss\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tooth-loss":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,24,0,[8,52,79,104,133,155,189,220,241,269,292,317,340,383,412,436,467,489,510,531,555,585,605,630],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100642394","pmcf-study-on-the-performance-and-safety-of-on-dent-pmma-discsblocks-and-resin-products-for-temporary-restorations-100642394",false,"NCT07632443","PMCF Study on The Performance and Safety of ON DENT® PMMA Discs\u002FBlocks and Resin Products for Temporary Restorations","Post-Market Clinical Follow-Up (PMCF) Study Evaluating the Performance and Safety of ON DENT™ PMMA Disc\u002FBlock and Resin Products Used in Temporary Restoration Fabrication","Inclusion Criteria:\n\n* Aged 18 years or older\n* Male or female\n* Requires 1\u002F2\u002F3-unit prosthetic restoration with temporary crown or bridge\n* No active periodontal disease\n* No general health condition contraindicated to treatment\n* Not legally restricted (no military conscription, incarceration, or other legal restriction)\n* Provision of signed informed consent form\n\nExclusion Criteria:\n\n* Suspected or confirmed pregnancy,\n* Temporomandibular joint disorder or limited mouth opening\n* Deep subgingival margins (\\>0.5 mm)\n* Non-restorable teeth\n* Non-functional teeth (no opposing counterpart \u002Fantagonist)\n* Probing depth \\>3 mm\n* Pathological tooth mobility\n* Unfavorable occlusal relationship or parafunction (bruxism, etc.)\n* Active systemic infection or condition\u002Ftreatment that may impede treatment (radiotherapy, bisphosphonate use, etc.)\n* Inadequate oral hygiene or cognitive\u002Fphysical disorders impairing daily self-care maintenance.\n* Uncontrolled alcohol, tobacco, or nicotine product use\n* History of allergy or hypersensitivity to PMMA or resin components\n* Concurrent participation in another interventional clinical study","ALL","18 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"NA","This prospective, single-center, interventional post-market clinical follow-up (PMCF) study aims to evaluate the clinical performance and safety of temporary crown and bridge restorations fabricated using CE-marked ON DENT™ restorative materials throughout their functional intraoral clinical duration. A total of 120 adult patients requiring fixed prosthodontic treatments will be randomly assigned to four independent parallel groups (30 patients per group) based on the specific type of temporary material utilized: Tempo-CAD Monocolor PMMA, Tempo-CAD Monocolor SHT PMMA, Tempo-CAD Multicolor SHT PMMA, or Print On Cyclone Perma liquid resin. Patients will be monitored closely across 5 clinical visits up to a maximum duration of 6 months to assess prosthodontic survival, success rates, biological adaptations, and patient-reported quality of life outcomes.",[26,27,28],"Tooth Loss","Dentin Caries","Tooth Fractures",[30,31,32,33,34,35,36,37,38],"Post-Market Clinical Follow-Up (PMCF)","Temporary Dental Restoration","Dental Prosthetics","Temporary Crown","Temporary Bridge","PMMA","Dental Resin","CAD\u002FCAM Dentistry","Revised FDI Criteria","RECRUITING","2026-06-07",{"date":42,"type":43},"2026-06-10","ACTUAL",{"date":45,"type":43},"2025-12-05",{"date":47,"type":20},"2027-07-04",{"name":49,"class":50},"On Dent Tibbi Malzeme Dis Protez Ith. ve Ihr. San. Ltd. Sti.","INDUSTRY",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":51},"100643148","pmcf-study-on-the-effectiveness-and-safety-of-biodentoss-and-dwc-dental-implants-and-superstructures-100643148","NCT07633665","PMCF Study on the Effectiveness and Safety of BIODENTOSS® and DWC® Dental Implants and Superstructures","Post-Market Clinical Follow-Up (PMCF) Study on the Effectiveness and Safety of BIODENTOSS® and DWC® Dental Implants and Superstructures","Inclusion Criteria:\n\n* 18 years of age or older,\n* Male or female,\n* Subjects with missing tooth who require dental implant treatment,\n* At least 2 months elapsed since tooth extraction,\n* General health status suitable for implantation,\n* Not legally restricted (e.g., soldier, convict),\n* Provision of signed Informed Consent Form (ICF)\n\nExclusion Criteria:\n\n* Suspected or confirmed pregnancy or breastfeeding,\n* Disorders preventing adequate daily oral hygiene,\n* Hypersensitivity\u002Fallergy to titanium or implant components,\n* Inappropriate interarch relationship or parafunction (e.g., bruxism),\n* Bone\u002Fsoft tissue deficiency requiring augmentation,\n* Active periodontal infection or untreated oral pathologies,\n* Unstable systemic diseases affecting wound healing (e.g., diabetes),\n* Use of immunosuppressive drug therapy due to systemic disorders, organ transplantation, or any other medical conditions,\n* Hematological disorders or current use of anticoagulants (such as Warfarin, dabigatran or related therapies),\n* Presence of osteoporosis and\u002For any disease condition affecting bone metabolism,\n* Presence of an active systemic infection, or any health condition or ongoing treatment (e.g., radiotherapy, bisphosphonate therapy) that contraindicates elective surgery,\n* Recent myocardial infarction or cerebrovascular event,\n* Individuals who consume high doses of alcohol, cigarettes, or tobacco products and are unable to control their usage,\n* Participation in another interventional clinical study.",{"count":60,"type":20},80,[23],"This prospective, single-center, interventional post-market clinical follow-up (PMCF) study aims to evaluate the early-term (24 months post-implantation) safety and efficacy of CE-marked BIODENTOSS® and DWC ® Dental Implants and Superstructures in patients requiring dental restoration for tooth loss.",[26,64],"Edentulism",[30,66,67,68,69],"Dental Implants","Osseointegration","Implant Stability","Marginal Bone Loss (MBL)","2026-06-04",{"date":72,"type":43},"2026-06-08",{"date":74,"type":43},"2024-12-11",{"date":76,"type":20},"2028-07-31",{"name":78,"class":50},"Değirmenci Otomotiv ve Metal Endüstri A.Ş.",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100560028","a-clinical-study-of-the-tsx-dental-implant-system-xpresso-100560028","NCT06571812","A Clinical Study of the TSX Dental Implant System (Xpresso)","A Prospective, Observational Clinical Study of the Safety, Effectiveness and Clinical Performance of the TSX Dental Implant System","Xpresso","Inclusion Criteria:\n\n1. Patients at least 18 years of age\n2. Patients for whom a decision has already been made to use a dental implant in an edentulous or immediately removed tooth site to be fully restored in the mandible or maxilla.\n3. Site planned for immediate extraction and immediate restoration should have intact bony walls- Type I (as described in Special Procedures section) sockets as verified by CBCT and during surgery; Type II may be considered at the discretion of the treating clinician\n4. Previously extracted sites (healed at least 3-4 months)\n5. For all sites, presence of opposing dentition (antagonist may be natural teeth or implant supported prosthesis) that will allow for functional occlusion is essential.\n6. The site intended for implant placement should have at least 10mm of alveolar bone height and sufficient restorative space for a restoration; without the need for augmentation except for minor dehiscence, which can be augmented with autogenous bone chips and\u002For allograft (i.e.: Puros) to improve soft tissue attachment.\n7. Patients must be physically able to tolerate conventional surgical and restorative procedures (IV sedation protocols may be used at the discretion of the treating clinician).\n8. Patients who provide a signed informed consent.\n9. Patients who agree to be evaluated for each study visit.\n\nExclusion Criteria:\n\n1. Patients with known systemic diseases such as diabetes, endocrine disease, heart disease, immuno-compromised, or mental disorders that are uncontrolled at the time of enrollment.\n2. Patients with current use of bisphosphonates.\n3. Patients with active infection or severe inflammation in the areas intended for treatment.\n4. Patients with more than10 cigarette per day smoking habit.\n5. Patients with a history of therapeutic radiation to the head or jaw.\n6. Patients who are known to be pregnant at the screening visit or planning to become pregnant within 6 months of study enrollment.\n7. Patients with evidence of untreated severe parafunctional habits such as bruxing or clenching.\n8. Patients who have previously failed dental implants at the site intended for study implant placement\n9. Patients with HIV or active Hepatitis infection.\n10. Patients with a history of untreated generalized severe periodontitis.",{"count":88,"type":20},62,"OBSERVATIONAL","A prospective, observational, multicenter study where 62 patients needing implants in the maxilla or mandible will be enrolled. The patients will be restored with a final prosthesis no later than 4 months following implant placement surgery. The patients will come back for follow-up evaluations yearly for 2 years.",[26],[93],"dental implant","2026-04-29",{"date":96,"type":43},"2026-05-06",{"date":98,"type":43},"2024-04-24",{"date":100,"type":20},"2028-04-30",{"name":102,"class":50},"ZimVie",2,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":112,"conditions":113,"keywords":117,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":103},"100636635","changes-in-oral-health-related-quality-of-life-ohrqol-during-full-arch-implant-treatment-a-prospective-study-100636635","NCT07568249","Changes in Oral Health-related Quality of Life (OHRQoL) During Full Arch Implant Treatment: A Prospective Study","Inclusion Criteria:\n\n* Systemically good health and absence of contraindications for implant therapy, with indication to be rehabilitated with at least one FASISR - maxilla or mandible.\n\nExclusion Criteria:\n\n\\-",{"count":111,"type":20},100,"Full arch implant-supported fixed dental prosthesis is widely accepted as a treatment modality for edentulous patients, presenting high long-term implant survival rates, although further research is necessary to evaluate patient satisfaction on a longer term and the psycho-social impact of this treatment on the daily life and functioning of patients. Patient-related outcome measures evaluated through oral health-related quality of life (OHRQol) parameters, patient satisfaction and patient preference allows to evaluate the impact of the prosthodontic needs.",[114,115,26,116],"Edentulous Mouth","Quality of Life","Oral Health Quality of Life (OHQoL) Was Assessed",[93,118,119,120,121,122],"oral health","outcome studies","oral quality of life","OHIP-14","Implant-supported prosthesis","2026-04-28",{"date":125,"type":43},"2026-05-05",{"date":127,"type":43},"2025-11-01",{"date":129,"type":20},"2028-10-01",{"name":131,"class":132},"Implantology Institute","OTHER",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":16,"minAge":140,"maxAge":141,"enrollmentInfo":142,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":51},"100634040","digitally-assisted-immediate-implants-in-geriatric-patients-100634040","NCT07534514","Digitally Assisted Immediate Implants in Geriatric Patients","Digitally Assisted Immediate Implant Placement and Loading in Geriatric Patients","Inclusion Criteria:\n\n* Patients aged ≥65 years\n* Indication for tooth extraction with immediate implant placement\n* Sufficient residual bone volume to achieve primary implant stability\n* Ability to achieve insertion torque ≥35 Ncm and\u002For implant stability quotient (ISQ) ≥60\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Adequate oral hygiene and patient compliance\n\nExclusion Criteria:\n\n* Uncontrolled systemic diseases (e.g., uncontrolled diabetes mellitus)\n* History of head and neck radiotherapy\n* Active untreated periodontal disease\n* Heavy smoking (\\>10 cigarettes\u002Fday)\n* Current or previous bisphosphonate therapy\n* Parafunctional habits (e.g., severe bruxism)","60 Years","80 Years",{"count":143,"type":20},40,"This prospective clinical study aims to evaluate the clinical performance of digitally assisted immediate implant placement and immediate loading in geriatric patients. The study will assess biological outcomes, including implant survival and marginal bone level changes, as well as mechanical complications and primary stability progression. Additionally, patient-reported outcomes such as pain, functional improvement, and esthetic satisfaction will be evaluated using visual analog scales. A fully digital workflow incorporating CBCT, intraoral scanning, and guided surgery will be utilized to enhance treatment accuracy and efficiency. Patients will be followed for 12 months to determine the predictability and effectiveness of this treatment approach in the elderly population.",[26],"2026-04-09",{"date":148,"type":43},"2026-04-16",{"date":150,"type":43},"2025-01-01",{"date":152,"type":20},"2026-10-01",{"name":154,"class":132},"Menoufia University",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":21,"phases":165,"briefSummary":166,"conditions":167,"keywords":170,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":188},"100632817","clinical-safety-and-effectiveness-of-the-straumann-dynamic-navigation-system-falcon-100632817","NCT07518615","Clinical Safety and Effectiveness of the Straumann Dynamic Navigation System Falcon","Clinical Safety and Effectiveness of Straumann Dynamic Navigation System (Falcon): a Prospective Multicenter and Multinational Clinical Investigation","Falcon","Inclusion Criteria:\n\n* Patients of either sex, ≥ 18 years old.\n* Partially edentulous patients requiring at least one dental implant.\n* Suitable clinical situation as judged by the investigator (e.g., satisfactory soft and hard tissue conditions and occlusion).\n* Ability to understand and sign the informed consent form.\n* Willingness and ability to participate in the planned study program.\n\nExclusion Criteria:\n\n* Fully edentulous patients.\n* Patients without at least 3 adjacent teeth for accurate positioning of the digital tray, and another tooth for accuracy check (minimum 30 mm distance from marker position).\n* Contraindications for dental implant treatment as per the implant Instructions for Use.\n* Contraindications listed in the Instructions for Use of the Straumann Falcon system.\n* Pregnant women or women planning pregnancy during study participation.",{"count":164,"type":20},75,[23],"The Falcon Study is a prospective, multicenter, multinational clinical investigation evaluating the Straumann® Dynamic Navigation System (Falcon) for dental implant placement. The Falcon system is a real-time dynamic navigation device that helps clinicians visualize the position of dental instruments during surgery.\n\nThe purpose of the study is to assess whether Falcon enables safe and precise implant placement in partially edentulous patients compared to benchmarks from the literature for freehand implant placement. The study will enroll approximately 75 adult patients across four European centers (Switzerland, Italy, the Netherlands, and Belgium). Each patient will undergo preoperative planning, implant surgery with the Falcon system, and a postoperative cone beam computed tomography (CBCT) scan to measure implant placement accuracy.\n\nThe main outcomes are (1) angular deviation between planned and actual implant position, and (2) safety as measured by adverse device effects. Results will provide clinical evidence to support regulatory clearance and the safe adoption of the Falcon system in routine practice.",[168,26,169],"Partially Edentulous Jaw","Dental Implant",[169,171,172,173,174,175,176,177,178],"Dynamic Navigation","Computer-Assisted Surgery","Falcon System","Straumann","CBCT (Cone Beam Computed Tomography)","Partially Edentulous Patients","Accuracy of Implant Placement","Post-Market Clinical Investigation","2026-04-02",{"date":181,"type":43},"2026-04-08",{"date":183,"type":43},"2026-01-22",{"date":185,"type":20},"2027-04",{"name":187,"class":50},"Institut Straumann AG",4,{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":11,"sex":16,"minAge":196,"maxAge":140,"enrollmentInfo":197,"targetDuration":4,"studyType":21,"phases":199,"briefSummary":200,"conditions":201,"keywords":202,"overallStatus":210,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":4},"100629421","mandibular-biological-drilling-at-different-speeds-for-dental-implant-placement-100629421","NCT07474454","Mandibular Biological Drilling at Different Speeds for Dental Implant Placement","Radiographic Assessment of Mandibular Biological Drilling at Different Drilling Speeds: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult patients aged 20-60 years.\n* Partially edentulous patients requiring a single dental implant in the mandible.\n* Adequate bone height and width at the implant site to accommodate the planned implant dimensions without the need for advanced grafting.\n* Good oral hygiene (full-mouth plaque and bleeding scores within acceptable limits).\n* Patients willing to participate, available for 12-month follow-up, and able to sign informed consent.\n\nExclusion Criteria:\n\n* Systemic diseases or conditions that may compromise bone healing (e.g. uncontrolled diabetes, immunosuppression, recent radiotherapy in head and neck region).\n* Smoking more than 10 cigarettes\u002Fday or heavy vaping.\n* Pregnant or lactating women.\n* History of bisphosphonate or other anti-resorptive therapy affecting bone metabolism.\n* Active periodontal disease or poor oral hygiene.\n* Acute infection or pathology at the planned implant site.\n* Need for simultaneous major bone grafting at the same site.\n* Bruxism or severe parafunctional habits.","20 Years",{"count":198,"type":20},39,[23],"This randomized controlled clinical trial aims to evaluate the effect of different biological drilling speeds (50, 150, and 300 rpm) during implant osteotomy preparation in the mandible on marginal bone level changes and implant stability. Thirty-nine patients requiring a single dental implant in the mandible will be randomly allocated into three groups according to drilling speed. All implants will be placed using a biological drilling protocol without irrigation. Implant stability will be measured using resonance frequency analysis at implant placement and follow-up visits. Marginal bone levels will be evaluated radiographically using standardized periapical radiographs during the follow-up period up to 12 months. The study aims to determine whether different low-speed drilling protocols influence peri-implant bone remodeling and implant stability.",[64,26],[203,204,205,206,207,208,209],"dental implants","biological drilling","low speed drilling","marginal bone loss","implant stability","mandible","randomized clinical trial","NOT_YET_RECRUITING","2026-03-11",{"date":213,"type":43},"2026-03-16",{"date":215,"type":20},"2026-03-15",{"date":217,"type":20},"2027-04-01",{"name":219,"class":132},"Cairo University",{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":16,"minAge":196,"maxAge":140,"enrollmentInfo":227,"targetDuration":4,"studyType":21,"phases":229,"briefSummary":230,"conditions":231,"keywords":232,"overallStatus":210,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":237,"startDateStruct":238,"completionDateStruct":239,"leadSponsor":240,"locationsCount":4},"100629495","effect-of-mandibular-drilling-speed-on-implant-stability-and-osteogenic-potential-a-randomized-clinical-trial-100629495","NCT07475416","Effect of Mandibular Drilling Speed on Implant Stability and Osteogenic Potential: A Randomized Clinical Trial","Impact of Mandibular Biological Drilling Speeds on Implant Stability and Osteogenic Potential of Autogenous Bone Particles: A Randomized Clinical Trial","Inclusion Criteria:\n\nAdult patients requiring single dental implant placement in the mandible\n\nAdequate bone volume for implant placement without need for bone grafting\n\nGood general health\n\nAbility to provide informed consent\n\nExclusion Criteria:\n\nSystemic diseases affecting bone metabolism or healing\n\nHistory of radiotherapy in the head and neck region\n\nUncontrolled diabetes mellitus\n\nActive periodontal disease\n\nHeavy smoking\n\nPregnancy or lactation",{"count":228,"type":20},36,[23],"This randomized clinical trial aims to evaluate the effect of different low-speed biological drilling protocols on implant stability and the osteogenic potential of autogenous bone particles collected during implant osteotomy. Patients requiring single dental implant placement in the mandible will be randomly assigned to different drilling speed protocols without irrigation. Implant stability will be measured clinically, while collected bone particles will be analyzed for osteogenic markers. The study aims to determine whether biological drilling improves implant stability and preserves the regenerative potential of autogenous bone.",[64,26],[204,205,203,207,233,234,235,236],"autogenous bone particals","BMP-2","VEGF","mandibular implants",{"date":213,"type":43},{"date":215,"type":20},{"date":217,"type":20},{"name":219,"class":132},{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":248,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":21,"phases":251,"briefSummary":252,"conditions":253,"keywords":255,"overallStatus":210,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":51},"100628984","influence-of-implant-insertion-depth-on-peri-implant-bone-changes-around-short-implants-100628984","NCT07468747","Influence of Implant Insertion Depth on Peri-implant Bone Changes Around Short Implants","\"Influence Of Crestal Versus Subcrestal Implant Placement Levels On Peri-Implant Health And Radiographic Bone Changes Around Short Implants: A Randomized Controlled Clinical Trial.\"","Inclusion Criteria:\n\n1. Adults aged 18 years or older requiring dental implant therapy for replacement of a missing tooth in the posterior maxilla or mandible.\n2. Presence of sufficient bone volume to receive a short dental implant without the need for bone augmentation procedures.\n3. Patients in good general health or with controlled systemic conditions that do not contraindicate implant surgery.\n4. oral hygiene, defined as a plaque score ≤25%.\n5. Presence of healthy or treated periodontal tissues prior to implant placement.\n6. Patients willing and able to return for follow-up visits at 3, 6, and 12 months.\n7. Patients who provide written informed consent to participate in the study.\n\nExclusion Criteria:\n\n1. Patients with uncontrolled systemic diseases (e.g., uncontrolled diabetes mellitus, immunosuppressive disorders).\n2. History of radiotherapy in the head and neck region.\n3. Patients currently receiving bisphosphonate therapy or other medications affecting bone metabolism.\n4. Active periodontal disease or untreated oral infections.\n5. Heavy smokers (≥10 cigarettes per day).\n6. Presence of parafunctional habits such as severe bruxism or clenching.\n7. Patients requiring simultaneous bone grafting or sinus augmentation at the implant site.\n8. Pregnant or lactating women.\n9. Patients unable or unwilling to comply with the study protocol or follow-up schedule.",true,{"count":250,"type":20},58,[23],"Dental implants are widely used to replace missing teeth and restore oral function and aesthetics. One of the key factors affecting the long-term success of dental implants is the stability of the bone surrounding the implant, particularly the crestal bone around the implant neck. Implant insertion depth relative to the alveolar crest may influence peri-implant tissue health and marginal bone remodeling.\n\nThis randomized controlled clinical trial aims to evaluate the influence of implant placement depth on peri-implant health and radiographic bone changes around short dental implants placed using guided surgical protocol. All implants will be placed using the Bicon Implant System following computer-guided implant planning and surgical guide fabrication to ensure precise implant positioning.\n\nParticipants requiring implant therapy will be randomly allocated into two groups. In the test group, implants will be placed 2 mm below the crestal bone level (subcrestal placement). In the control group, implants will be placed at the crestal bone level (crestal placement). Implant placement will be performed using guided implant surgery to standardize surgical positioning and minimize variability in implant angulation and depth.\n\nClinical parameters related to peri-implant health, including Modified Plaque Index, Implant Mucosal Index, Peri-implant Mucosal Tissue Index and Probing Depth during follow-up visits at 3, 6 and 12 months. In addition, standardized radiographic examinations will be performed to measure peri-implant Crestal bone level changes at 12 months.\n\nThe primary objective of this study is to determine whether subcrestal implant placement (2 mm below the bone crest) results in improved preservation of peri-implant crestal bone compared with crestal implant placement. Secondary outcomes will include assessment of peri-implant soft tissue health and overall implant stability.\n\nThe findings of this study may help clarify the optimal implant insertion depth for short implants placed using guided surgery and may contribute to improving long-term implant success and peri-implant tissue stability.",[26,64,254],"Peri-implant Bone Loss",[66,256,257,258,259],"Short Implants","Subcrestal Implant Placement","Peri-Implant Health","Radiographic Bone Changes","2026-03-09",{"date":262,"type":43},"2026-03-13",{"date":264,"type":20},"2026-03-30",{"date":266,"type":20},"2027-05-30",{"name":268,"class":132},"Gulf Medical University",{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":273,"acronym":4,"eligibilityCriteria":274,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":275,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":277,"conditions":278,"keywords":280,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":284,"lastUpdatePostDateStruct":285,"startDateStruct":287,"completionDateStruct":288,"leadSponsor":290,"locationsCount":51},"100576307","peri-implant-mucosal-changes-over-time-following-implant-provisional-removal-in-the-esthetic-zone-100576307","NCT06783595","Peri-implant Mucosal Changes Over Time Following Implant Provisional Removal in the Esthetic Zone","Inclusion Criteria:\n\n* Patient must have a maxillary anterior immediate implant and provisionalization treatment completed.\n* The adjacent tooth next to the implant should be a natural tooth\n* The temporary crown must have been in place for a minimum of 4 months\n* The patient needs to be of general good health, with no significant medical history or social habits that might directly affect the hard and soft tissue\n* Patient must have generally good oral hygiene without any history of gum disease or gum recession of other teeth around the region of interest\n\nExclusion Criteria:\n\n* Patient with an implant crown that has no teeth next to the implant crown\n* Patients who have an active gum disease",{"count":276,"type":20},34,"The study will examine the temporary volumetric change that happens in the gums around an implant crown when the crown is removed. The main question of the study is \"how much time has to pass to see a significant change, especially when there could be a need to make a mold of the surrounding gum to make a new crown?\"\n\nThe area of the implant crown will be scanned with an intra-oral scanner over a period of 15 minutes.",[26,279],"Implant Site Reaction",[281,282,283],"immediate implant placement","provisional","impression","2026-02-18",{"date":286,"type":43},"2026-02-20",{"date":98,"type":43},{"date":289,"type":20},"2026-12",{"name":291,"class":132},"Loma Linda University",{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":298,"eligibilityCriteria":299,"healthyVolunteers":248,"sex":16,"minAge":300,"maxAge":141,"enrollmentInfo":301,"targetDuration":4,"studyType":21,"phases":303,"briefSummary":304,"conditions":305,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":51},"100623235","autogenous-tooth-transplantation-with-instrumentally-simulated-open-apex-and-platelet-rich-fibrin-100623235","NCT07393997","Autogenous Tooth Transplantation With Instrumentally Simulated Open Apex and Platelet-Rich Fibrin","Clinical Evaluation of Autogenous Tooth Transplantation With Instrumentally Simulated Open Apex and Autologous Platelet-Rich Fibrin (PRF) Support in Teeth With Complete Root Formation","OpenApexT","Inclusion Criteria:\n\nAutotransplantation will be performed in selected cases with favorable biological and functional prognosis, including:\n\n* Early loss of permanent teeth due to trauma, extensive caries, or agenesis.\n* Dental agenesis, particularly involving premolars or incisors, when a suitable donor tooth is available.\n* Replacement of non-restorable teeth (fractures or destructive caries).\n* Preservation of alveolar bone in growing patients where implant therapy is contraindicated.\n* Functional and aesthetic rehabilitation of anterior teeth in pediatric and adolescent patients.\n* Post-traumatic oral rehabilitation in young patients.\n* Good general and oral health.\n* Presence of a vital and intact periodontal ligament on the donor tooth.\n* Adequate recipient site dimensions and morphology, or surgically adaptable.\n* Absence of active infection at the recipient site. Donor Tooth Selection Criteria\n* Tooth extracted for orthodontic purposes.\n* Impacted or erupting third molars with compatible morphology.\n* Suitable supernumerary teeth.\n\nExclusion Criteria:\n\n* Poor patient compliance.\n* Active infection at the recipient site.\n* Smoking of more than 15 cigarettes a day\n\n  •. Untreated periodontal disease\n* Pregnancy or breastfeeding at date of inclusion\n* Acute infections","10 Years",{"count":302,"type":20},5,[23],"Autogenous tooth transplantation (autotransplantation) represents a biologically valid alternative to implant therapy, particularly in young patients where implant placement is contraindicated due to ongoing skeletal growth. This approach preserves alveolar bone volume, maintains periodontal proprioception, and allows physiological adaptation over time.",[26,306,307],"Tooth Diseases","Reimplant; Complications","2026-01-30",{"date":310,"type":43},"2026-02-06",{"date":312,"type":43},"2026-01-01",{"date":314,"type":20},"2026-09-01",{"name":316,"class":132},"University of Bari Aldo Moro",{"id":318,"slug":319,"hasResults":11,"nctId":320,"briefTitle":321,"officialTitle":322,"acronym":4,"eligibilityCriteria":323,"healthyVolunteers":248,"sex":16,"minAge":17,"maxAge":324,"enrollmentInfo":325,"targetDuration":4,"studyType":21,"phases":327,"briefSummary":328,"conditions":329,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":51},"100606589","primary-stability-and-peri-implant-outcomes-of-short-implants-in-post-extraction-single-tooth-sites-100606589","NCT07177521","Primary Stability and Peri-implant Outcomes of Short Implants in Post-extraction Single-tooth Sites","Primary Stability and Peri-implant Outcomes of Short Implants in Post-extraction Single-tooth Sites: a Randomized Controlled Trial.","Inclusion Criteria:\n\n* Age ≥18 years.\n* Single-tooth post-extraction sites requiring immediate implant placement in posterior regions (premolars\u002Fmolars) or selected anterior sites.\n* Planned short implant (≤7-8 mm length, 3.5-5.0 mm diameter).\n* Adequate oral hygiene, no active periodontal disease.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Heavy smoking (\\>20 cigarettes\u002Fday).\n\n  * Uncontrolled diabetes or systemic conditions affecting bone healing.\n  * Current bisphosphonate\u002Fantiresorptive therapy.\n  * Immunosuppression, pregnancy.\n  * Poor oral hygiene or acute infection at site.\n  * Severe bone dehiscence preventing primary stability.","75 Years",{"count":326,"type":20},10,[23],"The placement of short implants in post-extraction sockets is a valuable option when residual bone height is limited, minimizing morbidity and treatment time. The management of the peri-implant gap and soft tissues may influence primary stability, hard\u002Fsoft tissue remodeling, and implant success.",[330,26,331],"Edentulous Jaw","Toothless Mouth","2026-01-23",{"date":334,"type":43},"2026-01-27",{"date":336,"type":43},"2025-01-10",{"date":338,"type":20},"2026-08-10",{"name":316,"class":132},{"id":341,"slug":342,"hasResults":11,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":346,"eligibilityCriteria":347,"healthyVolunteers":11,"sex":16,"minAge":348,"maxAge":349,"enrollmentInfo":350,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":352,"conditions":353,"keywords":355,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":381,"locationsCount":51},"100617127","clinical-and-radiological-evaluation-of-dental-autotransplantation-in-the-anterior-region-in-young-patients-100617127","NCT07314580","Clinical and Radiological Evaluation of Dental Autotransplantation in the Anterior Region in Young Patients","Clinical, Radiographic, Functional and Psychosocial Evaluation of Premolar Autotransplantation to the Anterior Maxillary Region in Young Patients: An Ambispective Observational Study","YATA","Inclusion Criteria:\n\n* Patients aged 7 to 15 years.\n* ASA I classification.\n* Loss or indication for extraction of a maxillary anterior tooth (teeth 12, 11, 21, or 22) due to trauma, resorption, or restorative reasons.\n* Availability of a donor first or second premolar with root development between one-half and complete root length.\n* Ability to complete at least 2 years of follow-up.\n* Parent\u002Fguardian consent and minor assent obtained for prospective cases.\n\nExclusion Criteria:\n\n* Patients older than 15 years.\n* Severe systemic disease.\n* Inability or unwillingness to attend scheduled follow-up visits.\n* Lack of a suitable donor premolar.","7 Years","15 Years",{"count":351,"type":20},50,"This study aims to evaluate the clinical, radiographic, functional, and patient-reported outcomes of premolar autotransplantation used to replace anterior maxillary teeth in young patients. The study has an ambispective observational design, including a retrospective cohort (patients treated between December 2019 and December 2025) and a prospective cohort (patients enrolled until December 2028).\n\nParticipants aged 7 to 15 years who received or will receive premolar autotransplantation to replace an anterior tooth will be followed clinically and radiographically for up to 5 years. Outcomes include tooth survival, periodontal and pulpal healing, root development, complications, orthodontic interactions, restorative needs, and patient satisfaction. The study seeks to identify prognostic factors and long-term success indicators for dental autotransplantation in growing patients.",[26,354],"Tooth Injury",[356,357,358,359,360,361,362,363,364,365,366,367,368,369,370,371,372,373],"autotransplantation","tooth autotransplant","premolar donor tooth","anterior maxilla","young patients","root development","CBCT","digital planning","guided surgery","orthodontics","periodontal healing","pulpal healing","traumatic tooth loss","avulsion injuries","trauma-related anterior tooth loss","Dental autotransplantation","Anterior maxillary tooth loss","tooth root development","2025-12-17",{"date":376,"type":43},"2026-01-02",{"date":378,"type":43},"2019-12-01",{"date":380,"type":20},"2029-12-31",{"name":382,"class":132},"University of Barcelona",{"id":384,"slug":385,"hasResults":11,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":389,"eligibilityCriteria":390,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":391,"enrollmentInfo":392,"targetDuration":4,"studyType":21,"phases":393,"briefSummary":394,"conditions":395,"keywords":397,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":405,"startDateStruct":407,"completionDateStruct":409,"leadSponsor":410,"locationsCount":51},"100384082","impact-of-tooth-loss-and-denture-on-oral-senses-and-food-preferences-100384082","NCT04281056","Impact of Tooth Loss and Denture on Oral Senses and Food Preferences","Impact of Complete Tooth Loss and Denture on Oral Sensory Abilities and Food Preference","AlimaPAC","Inclusion Criteria:\n\nStudy Group : being completely edentulous and wearing denture for at least one year, wearing denture during meals, with clean and stable dentures. Controls:\n\ncontrols Group : dentate subjects (25 teeth at leas, non endodontically treated) with molars in Angle's Class I occlusion, having no functional disturbance of mastication and not undergoing dental treatment at the time of the recording. Matched with subjects of the study group for age, sex, tabacco consumption, and saliva flow rate.\n\nExclusion Criteria:\n\n* Aged under 18 or over 80 Y,\n* not consenting to participate\n* suffering from dental\n* periodontal or gum pain for the last month.","79 Years",{"count":143,"type":20},[23],"Tooth loss impacts taste abilities and food intake. Present study aims at pertaining the impact of teeth loss and the replacement by means of complete denture on taste and trigeminal abilities, and on food preferences, and taste appetence.",[396],"Tooth-loss",[398,399,400,401,402,403],"Teeth loss","edentulousness","denture","tast","trigeminal senses","oral sensory ability","2025-12-12",{"date":406,"type":43},"2025-12-19",{"date":408,"type":43},"2022-03-16",{"date":185,"type":20},{"name":411,"class":132},"Assistance Publique - Hôpitaux de Paris",{"id":413,"slug":414,"hasResults":11,"nctId":415,"briefTitle":416,"officialTitle":417,"acronym":4,"eligibilityCriteria":418,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":419,"targetDuration":4,"studyType":21,"phases":420,"briefSummary":422,"conditions":423,"keywords":424,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":51},"100614489","phase-4-clinical-performance-of-nobel-n1-system-100614489","NCT07280260","Clinical Performance of Nobel N1 System","Effects of Early Loading Protocol on the Survival of the Nobel N1 Implant System: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Males and females, age 18 or older\n\n  * Can provide an Informed Consent in English.\n  * Absence of a single posterior tooth in mandible or maxilla with presence of natural neighboring teeth (except for second molar which only requires presence of first molar)\n  * Presence of antagonist teeth\n  * Possibility and will for an immediate restoration.\n  * Systemic health recorded as an American Society of Anesthesiologists (ASA) I or II\n\nExclusion Criteria:\n\n* · Unavailability to attend the follow-up visits.\n\n  * A systemic contraindication for oral surgical procedures; ASA III or IV.\n  * Pregnancy or nursing on screening or before the surgical procedure.\n  * Diseases that could alter healing or bone metabolism (uncontrolled diabetes, diagnostic osteoporosis, etc.),\n  * Taking medications that are altering healing or bone metabolism (bisphosphonates, long-time corticosteroids intake, RANK inhibitors, etc.)\n  * Alcohol or drug abuse.\n  * Current heavy smoking behavior (≥10 cigarettes\u002Fday).\n  * Radiation therapy to the head or neck region.\n  * Pathology in the implant planned sites that prevent implant placement.\n  * Current diagnosis of Diabetes, which is uncontrolled (\\>7 HbA1C).\n  * Need for sinus lift or vertical bone augmentation\n  * Previously failed implant site",{"count":351,"type":20},[421],"PHASE4","The purpose of the study is to evaluate whether N1 dental implants are successful when a final crown is placed on them at 6 weeks from implant placement surgery.",[26,169],[425,426,427],"Tooth loss","Edentulous","Dental implants","2025-12-11",{"date":404,"type":43},{"date":431,"type":20},"2025-12-15",{"date":433,"type":20},"2028-01-30",{"name":435,"class":132},"Louisiana State University Health Sciences Center in New Orleans",{"id":437,"slug":438,"hasResults":11,"nctId":439,"briefTitle":440,"officialTitle":441,"acronym":442,"eligibilityCriteria":443,"healthyVolunteers":11,"sex":16,"minAge":196,"maxAge":444,"enrollmentInfo":445,"targetDuration":4,"studyType":21,"phases":447,"briefSummary":448,"conditions":449,"keywords":452,"overallStatus":210,"whyStopped":4,"lastUpdateSubmitDate":458,"lastUpdatePostDateStruct":459,"startDateStruct":461,"completionDateStruct":463,"leadSponsor":465,"locationsCount":4},"100602617","efficacy-of-bioactive-glass-vs-xenograft-in-maxillary-sinus-augmentation-100602617","NCT07125846","Efficacy of Bioactive Glass vs. Xenograft in Maxillary Sinus Augmentation","Clinical, Radiographic and Histologic Assessment of the Efficacy of Bioactive Glass as a Novel Grafting Material in Maxillary Sinus Floor Augmentation: A Randomized Controlled Study","BIOXENO","Inclusion Criteria:\n\n* Patients requiring maxillary sinus floor augmentation for dental implant placement.\n* Residual alveolar bone height ≤ 4 mm in posterior maxilla (SA4 classification).\n* Age between 20 to 65 years.\n* Good general health and able to attend scheduled follow-up visits.\n* Signed written informed consent.\n\nExclusion Criteria:\n\n* Presence of systemic conditions that could affect bone healing (e.g., uncontrolled diabetes, osteoporosis).\n\nHistory of radiotherapy in the head and neck region.\n\n* Heavy smoking (more than 10 cigarettes\u002Fday).\n* Active sinus pathology or previous sinus surgery.\n* Pregnant or breastfeeding women.\n* Use of medications affecting bone metabolism (e.g., bisphosphonates or corticosteroids).\n* Poor oral hygiene or untreated periodontal disease.","65 Years",{"count":446,"type":20},20,[23],"This randomized controlled study aims to evaluate the clinical, radiographic, and histologic efficacy of using bioactive glass bone graft (UNIGRAFT by Biomed Inc., USA) compared to a conventional xenograft in maxillary sinus augmentation procedures. A total of 20 patients classified as SA4 according to the Misch classification will be enrolled and randomly allocated into two groups. Outcomes will be assessed using Cone Beam Computed Tomography (CBCT) for vertical bone gain and, where applicable, histologic analysis. The study is conducted at the Faculty of Dentistry, Suez Canal University.",[450,451,26],"Alveolar Bone Loss","Maxillary Sinus Disease",[453,454,455,456,457,169],"Maxillary Sinus Augmentation","Bioactive Glass","Xenograft","Sinus Lift","Bone Grafting","2025-08-14",{"date":460,"type":43},"2025-08-15",{"date":462,"type":20},"2025-10-15",{"date":464,"type":20},"2026-04-01",{"name":466,"class":132},"Suez Canal University",{"id":468,"slug":469,"hasResults":11,"nctId":470,"briefTitle":471,"officialTitle":471,"acronym":4,"eligibilityCriteria":472,"healthyVolunteers":11,"sex":16,"minAge":473,"maxAge":474,"enrollmentInfo":475,"targetDuration":4,"studyType":21,"phases":476,"briefSummary":477,"conditions":478,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":51},"100371769","3d-autotransplantation-of-teeth-100371769","NCT04120688","3D Autotransplantation of Teeth","Inclusion Criteria:\n\n* Need for tooth transplantation\n* Open apex tooth available for transplantation\n\nExclusion Criteria:\n\n* Facial syndrome\n* Chronic facial pain\n* Allergy to replica material","9 Years","23 Years",{"count":19,"type":20},[23],"The study aims to clarify the usefulness of 3D-printed replicas in association with autotransplantation of teeth in children and young adults.",[26],"2025-05-09",{"date":481,"type":43},"2025-05-14",{"date":483,"type":43},"2020-03-09",{"date":485,"type":20},"2025-12-31",{"name":487,"class":488},"Turku University Hospital","OTHER_GOV",{"id":490,"slug":491,"hasResults":11,"nctId":492,"briefTitle":493,"officialTitle":494,"acronym":4,"eligibilityCriteria":495,"healthyVolunteers":248,"sex":16,"minAge":496,"maxAge":497,"enrollmentInfo":498,"targetDuration":4,"studyType":21,"phases":499,"briefSummary":500,"conditions":501,"keywords":4,"overallStatus":210,"whyStopped":4,"lastUpdateSubmitDate":502,"lastUpdatePostDateStruct":503,"startDateStruct":505,"completionDateStruct":507,"leadSponsor":509,"locationsCount":4},"100573729","evaluation-of-3d-printed-space-maintainers-versus-conventional-space-maintainer--a-randomized-clinical-trial-100573729","NCT06750068","Evaluation of 3D-printed Space Maintainers Versus Conventional Space Maintainer : a Randomized Clinical Trial","Clinical Evaluation of Digitally Fabricated 3D-printed Band and Loop Space Maintainers Versus Conventional Band and Loop Space Maintainer : a Randomized Clinical Trial","Inclusion Criteria:\n\n* Lower first permanent molar in active state of eruption\n* Patient and parent showing cooperation and compliance.\n* Medically free children.\n* According to space analysis available space is less than or equal to needed space\n* Primary molar loss in the last 1 week due to caries, infection, and resorption (to eliminate possible space loss)\n* Caries free, non-restored buccal surfaces of the mandibular second primary molars and deciduous canines.\n\nExclusion Criteria:\n\n* Children with previous allergies to stainless steel.\n* There was less than one year left for the permanent tooth to erupt (to prevent possible abutment toot loss)\n* The patient's oral hygiene is not sufficient and has periodontal problems (to accurately assess the periodontal effects)","4 Years","8 Years",{"count":351,"type":20},[23],"This study aims to compare the clinical evaluation and patients' satisfaction of space maintainers produced by digital workflow using the 3D-printing method (3D-SMs) versus conventional band and loop space maintainers (C-SMs) produced by traditional methods.",[26],"2025-03-17",{"date":504,"type":43},"2025-03-19",{"date":506,"type":20},"2025-03-20",{"date":508,"type":20},"2026-06-01",{"name":219,"class":132},{"id":511,"slug":512,"hasResults":11,"nctId":513,"briefTitle":514,"officialTitle":514,"acronym":4,"eligibilityCriteria":515,"healthyVolunteers":11,"sex":16,"minAge":516,"maxAge":444,"enrollmentInfo":517,"targetDuration":4,"studyType":21,"phases":519,"briefSummary":520,"conditions":521,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":523,"startDateStruct":525,"completionDateStruct":527,"leadSponsor":529,"locationsCount":51},"100583025","research-on-the-development-and-clinical-evaluation-of-biomimetic-abutments-100583025","NCT06870955","Research on the Development and Clinical Evaluation of Biomimetic Abutments","Inclusion Criteria:\n\n* aged between 25 and 65 years old\n* had one single edentulous site\n* implant embedded healed and required secondary surgery to expose\n* good treatment compliance and could attend follow-up appointment regularly\n\nExclusion Criteria:\n\n* soft tissue grafting was needed\n* severe acute or chronic periodontitis\n* heavy smoking habit (\\> 10 cigarettes\u002Fday)\n* poor oral hygiene","25 Years",{"count":518,"type":20},30,[23],"This study aims to evaluate the clinical effectiveness of biomimetic abutments in implant restoration.",[26],"2025-03-06",{"date":524,"type":43},"2025-03-11",{"date":526,"type":43},"2023-11-23",{"date":528,"type":20},"2025-09-30",{"name":530,"class":132},"Stomatological Hospital Affiliated with Fujian Medical University",{"id":532,"slug":533,"hasResults":11,"nctId":534,"briefTitle":535,"officialTitle":536,"acronym":4,"eligibilityCriteria":537,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":538,"targetDuration":4,"studyType":21,"phases":540,"briefSummary":541,"conditions":542,"keywords":543,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":546,"lastUpdatePostDateStruct":547,"startDateStruct":549,"completionDateStruct":551,"leadSponsor":553,"locationsCount":51},"100566358","influence-of-healing-time-on-the-outcomes-of-alveolar-ridge-preservation-in-periodontally-compromised-extraction-sockets-100566358","NCT06654141","Influence of Healing Time on the Outcomes of Alveolar Ridge Preservation in Periodontally Compromised Extraction Sockets","Influence of Healing Time on the Outcomes of Alveolar Ridge Preservation in Periodontally Compromised Extraction Sockets: a Randomized Controlled Trial","Inclusion Criteria:\n\n* 18 years of age or older\n* ASA (American Society of Anesthesia) status I or II\n* Need for molar extraction due to periodontal disease with or without chronic endodontic involvement, complying with the presentation of periodontitis stage III\u002FIV\n* Radiographic evidence of a bone dehiscence on at least one socket wall, where the height of the horizontal (suprabony) component of the defect (alveolar bone crest - cement-enamel junction) is \\>50% of the corresponding root length as measured on CBCT scans prior to extraction (Ben Amara et al., 2021)\n* Radiographic evidence of at least 3 mm of residual bone wall height\n* Presence of at least one adjacent tooth to the extraction site\n* Treatment plan must include tooth replacement with an implant-supported fixed dental prosthesis\n\nExclusion Criteria:\n\n* Extraction of multiple adjacent teeth\n* Acute infection associated with the tooth to be extracted or with adjacent teeth\n* Current smokers (\\>10 cigarettes per day)\n* Uncontrolled diabetes mellitus (HbA1c \\>7.0)\n* Any active oral or systemic acute infections\n* Currently receiving chemo- or radiotherapy or a history of radiotherapy in the head and neck area\n* Diseases or medications that may compromise normal wound healing",{"count":539,"type":20},42,[23],"The goal of this clinical trial is to histologically, clinically, and radiographically evaluate the healing sequelae of periodontally compromised extraction sockets grafted with Bio-Oss Collagen® at 3 and 6 months following tooth extraction in molar sites. The main question it aims to answer is:\n\nDoes healing time influence the histologic, clinical, and radiographic outcomes following socket grafting (alveolar ridge preservation) in periodontally compromised extraction sockets.\n\nResearchers will compare a healing time of 3 months to a healing time of 6 months (conventional healing duration) to see if a shorter duration is viable for implant placement.\n\nParticipants will:\n\nTake a cone-beam computed tomography (CBCT) scan to prepare for the surgical procedure.\n\nUndergo tooth extraction and the extraction socket will be grafted with Bio-Oss Collagen® and a collagen membrane Bio-Gide® will be placed to stabilize the graft material.\n\nReturn at 2 weeks for suture removal and either 3- or 6-months post-extraction for implant placement.\n\nReturn at 2 weeks post-implant placement for suture removal, 3 months for prosthesis fabrication, 4 months for final prosthesis loading, and 1 year post-loading.",[26],[544,545],"ridge preservation","tooth extraction","2025-02-17",{"date":548,"type":43},"2025-02-19",{"date":550,"type":43},"2025-02-06",{"date":552,"type":20},"2029-12",{"name":554,"class":132},"Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University",{"id":556,"slug":557,"hasResults":11,"nctId":558,"briefTitle":559,"officialTitle":560,"acronym":4,"eligibilityCriteria":561,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":562,"targetDuration":4,"studyType":21,"phases":564,"briefSummary":565,"conditions":566,"keywords":570,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":582,"locationsCount":584},"100408974","one-vs-two-visits-root-canal-treatments-in-infected-teeth-100408974","NCT04605445","One Vs Two Visits Root Canal Treatments in Infected Teeth","One Vs Two Visits Endodontics - a Prospective Randomized Multicenter Study in General Dental Practice","Inclusion Criteria:\n\n* Patient older than 17 years.\n* Permanent tooth excluding third molars.\n* Necrotic tooth with\u002Fwithout clinical and\u002For radiological signs of apical (juxta radicular) periodontitis (non-bleeding pulp in the canal orifice. In case of a multi rooted tooth, a non-bleeding pulp in at least one root canal orifice) where orthograde endodontic treatment is planned.\n\nExclusion Criteria:\n\n* Patients with severe general disease and\u002F or where endodontic treatment requires special consideration for health reasons (eg radiation-treated jaw bone in the area or increased susceptibility to infection).\n* Systemic involvement (fever).\n* Swelling (extra- and\u002For intra oral).\n* Previously root canal treated tooth (instrumented and\u002For rotfilled).\n* Confirmed or strong suspicion of transverse or longitudinal root fracture.\n* Trauma to the tooth (\\\u003C6 month).\n* Marginal bone loss \\>1\u002F3 of the root lenght.\n* Root resorption.\n* Non restorable tooth.\n* Endodontic treatment is not considered feasible because rubberdam cannot be used on the tooth.\n* Follow-up at the clinic of the treatment after\\> 1 year is considered not feasible.",{"count":563,"type":20},1000,[23],"The primary aim of the study is to compare the outcome of one vs two visits endodontics (root canal treatments) performed in general dental practice of infected (necrotic) teeth, one and four years after treatment. Secondary aims are to compare the root filling quality and the frequency of complications for both treatment modalities.\n\nA pilot study will identify the shortcomings of the protocol, which will be revised accordingly.\n\nA multi-center study in several clinics from five counties throughout Sweden is planned. Consecutive eligible patients (see inclusion and exclusion criteria) with one tooth each will be included.\n\nThe study sample size calculation was based on a judgement that a minimal worthwhile effect of less than 10% was not clinically relevant. The presumption was that successful outcomes would be of 75% and 65% for the different treatment arms, respectively. Three hundred and fifty six patients per group are thus needed to detect that difference as statistical significant with a power of 80% and an alfa-error of 5%. To compensate for around 30% drop-outs a number of 1000 patients will be recruited.\n\nPatients will be randomly enrolled in two arms: one in which the endodontic treatment (root canal treatment) is performed in one visit, and in the other arm in two visits. The allocation sequences for one vs multiple visit endodontics will be computer generated followed by a dark colored envelope concealed allocation.\n\nThe patients will be contacted by telephone 5-7 days post-operatively, and a control visit at the clinic will be scheduled one month post-operatively to assess complications related to the treatment.\n\nA clinical control will be performed at the clinic one and four years after treatment. Intra-oral radiographs will be taken. The radiographs will be examined by two blinded and independent observers. A successful outcome is defined by clinical and radiographic normalcy.\n\nThe statistical methods selected to analyse the primary outcome will be the Chi square test of 2x2 tables, or Fisher´s exact test when proportions are small and the expected value \\\u003C5. The calculations will be two-tailed. Results will be considered statistically significant at p\\\u003C0.05.",[567,568,26,569],"Apical Periodontitis","Pain","Dental Pulp Necrosis",[571,572,573,574,575],"Endodontics","General Dental Practice","Single Visit","Multiple Visits","Infection Barrier",{"date":577,"type":43},"2024-12-16",{"date":579,"type":43},"2020-11-18",{"date":581,"type":20},"2031-12",{"name":583,"class":132},"Malmö University",7,{"id":586,"slug":587,"hasResults":11,"nctId":588,"briefTitle":589,"officialTitle":589,"acronym":4,"eligibilityCriteria":590,"healthyVolunteers":248,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":591,"targetDuration":593,"studyType":89,"phases":4,"briefSummary":594,"conditions":595,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":597,"startDateStruct":599,"completionDateStruct":601,"leadSponsor":603,"locationsCount":51},"100560372","a-36-month-analysis-of-the-clinical-performance-of-individualized-cadcam-produced-dental-implants-a-cohort-study-100560372","NCT06576284","A 36-month Analysis of the Clinical Performance of Individualized CAD\u002FCAM-produced Dental Implants: a Cohort Study","Inclusion Criteria:\n\n* Received a personalized dental implant using the iDENTICAL Dental Implant System during the previous interventional phase;\n* Completed the 12-month follow-up period after implant placement in the previous interventional phase;\n* Available for follow-up evaluations during the 36 months of the observational study.\n\nExclusion Criteria:\n\n* Occurrence of serious complications (implant loss, infection, etc.) during the previous interventional phase;\n* Development of uncontrolled medical conditions during the follow-up period;\n* Inability to attend scheduled follow-up visits;\n* Refusal to participate in the observational study.",{"count":592,"type":20},12,"36 Months","The goal of this prospective cohort study is to evaluate the clinical performance of a new generation of customized CAD\u002FCAM pre-fabricated root-analog dental implants over a 36-month period. The main questions it aims to answer are:\n\n1. Are these novel implants safe, effective, and clinically viable for 36 months?\n2. Do these drilling-free implants result in better post-operative outcomes compared to traditional implant techniques? Twelve patients receiving these customized implants immediately after tooth extraction will undergo clinical and radiographic examinations at 12, 24, and 36 months after prosthesis installation. The study will assess peri-implant tissue health, post-operative comfort, bone preservation, tissue integration, and implant survival rates.",[26,169],"2024-11-18",{"date":598,"type":43},"2024-11-20",{"date":600,"type":43},"2024-10-02",{"date":602,"type":20},"2026-10",{"name":604,"class":132},"University of Sao Paulo",{"id":606,"slug":607,"hasResults":11,"nctId":608,"briefTitle":609,"officialTitle":610,"acronym":611,"eligibilityCriteria":612,"healthyVolunteers":248,"sex":16,"minAge":17,"maxAge":324,"enrollmentInfo":613,"targetDuration":4,"studyType":21,"phases":614,"briefSummary":615,"conditions":616,"keywords":617,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":621,"lastUpdatePostDateStruct":622,"startDateStruct":624,"completionDateStruct":626,"leadSponsor":628,"locationsCount":51},"100530770","removable-partial-dentures-made-of-peek-100530770","NCT06191107","Removable Partial Dentures Made of PEEK","Clinical Performance of Removable Partial Dentures With Clasps Made of PEEK","KLAP","Inclusion Criteria:\n\n* Indication for a clasp-anchored removable partial denture\n\nExclusion Criteria:\n\n* Minors and adults unable to give consent\n* Pregnancy or breastfeeding\n* Severe general illnesses\n* Allergies or other intolerances to one of the materials used (PEEK, PMMA)\n* Suspicion of lack of compliance",{"count":351,"type":20},[23],"As part of the clinical study, 25 patients each were provided with removable partial dentures with clasps made of PEEK in two centres (University Hospital Heidelberg, Department of Prosthodontics and University Hospital for Dental Prosthetics Innsbruck). The patients were examined over a period of 3 years for the number and type of technical or biological complications and questioned about their oral health-related quality of life.",[26],[618,619,620],"Removable Partial Denture","Polyetheretherketone","Oral Health Related Quality of Life","2024-05-10",{"date":623,"type":43},"2024-05-13",{"date":625,"type":43},"2024-02-12",{"date":627,"type":20},"2028-11",{"name":629,"class":132},"University Hospital Heidelberg",{"id":631,"slug":632,"hasResults":11,"nctId":633,"briefTitle":634,"officialTitle":635,"acronym":636,"eligibilityCriteria":637,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":638,"targetDuration":640,"studyType":89,"phases":4,"briefSummary":641,"conditions":642,"keywords":643,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":648,"lastUpdatePostDateStruct":649,"startDateStruct":651,"completionDateStruct":653,"leadSponsor":655,"locationsCount":103},"100538170","5-years-pmcf-study-of-ceramic-dental-implants-one-piece-versus-two-piece-100538170","NCT06287346","5-Years PMCF Study of Ceramic Dental Implants One-piece Versus Two-piece.","5-Years Multicentric Prospective Post-Market Clinical Follow-up (PMCF) Comparative Study of CeraRoot Ceramic Dental Implants One-piece Versus Two-piece.","240101","Inclusion Criteria:\n\n* Clinical Diagnosis of partial or total edentulism.\n* Specially indicated for patients with metal allergies and chronic illness due to metal allergies.\n\nExclusion Criteria:\n\n1. General Contraindications:\n\n   1. Local and Systemic contraindications for surgery.\n   2. Poor oral hygiene\n   3. Patients with health problems, disease or any physical or psychological condition to which an oral surgery may be contraindicated.\n2. Relative Contraindications:\n\n   1. Previously irradiated bone\n   2. diabetes\n   3. anticoagulant medication\n   4. hemodynamic problems\n   5. bruxism\n   6. Para functional habits\n   7. bad bone anatomy\n   8. smokers\n   9. none controlled periodontitis\n   10. malocclusions\n   11. TMJ problems\n   12. diseases in the oral cavity\n   13. pregnancy\n   14. insufficient oral hygiene for adequate health.\n3. Local contraindications\n\n   1. insufficient bone quantity or quality\n   2. remaining of roots\n   3. localized periodontal disease\n   4. Any pathology in the neighboring teeth.",{"count":639,"type":20},652,"1 Year","The goal of this cohort observational study is to compare in the survival rate of ceramic dental implants placed in patients with missing or hopeless teeth . The main question\\[s\\] it aims to answer are:\n\n* Are there any significant differences in survival rate between the use of one-piece ceramic implant versus the two-piece (TL) variant?\n* What are the complications associated to the procedure and differences between the two groups.",[64,26],[93,644,645,646,647],"ceramic dental implant","zirconia implant","y-tzp","metal-free","2024-02-29",{"date":650,"type":43},"2024-03-01",{"date":652,"type":43},"2024-01-01",{"date":654,"type":20},"2030-01-01",{"name":656,"class":50},"CeraRoot SL"]