[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tooth-sensitivity-after-composite-restorations\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tooth-sensitivity-after-composite-restorations":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100618255","graphene-reinforced-cadcam-restorations-for-mih-affected-molars-in-adolescents-a-prospective-clinical-study-100618255",false,"NCT07329244","Graphene-Reinforced CAD\u002FCAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study","Clinical Evaluation of Graphene-Reinforced CAD\u002FCAM Indirect Restorations in Molars Affected by Molar-Incisor Hypomineralization (MIH) in Adolescents: A Clinical Study","Inclusion Criteria:\n\n* Adolescents aged 10-16 years.\n* Permanent molars with moderate or severe MIH (EAPD criteria).\n* Vital and restorable teeth.\n* Ability to attend follow-up visits.\n* Informed consent from guardian + assent from the minor.\n\nExclusion Criteria:\n\n* Fluorosis, amelogenesis imperfecta, or other enamel defects.\n* Severe bruxism not controlled.\n* Active extensive caries or irreversible pulpitis.\n* Systemic conditions affecting enamel or healing.\n* Hypersensitivity\u002Fallergy to materials\u002Fadhesives.\n* Use of analgesics\u002FAINEs \\\u003C24 h before baseline VAS.\n\n  * Orthodontic bands on the study molar.","ALL","10 Years","16 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study evaluates the clinical performance, marginal integrity, surface wear, color stability, and postoperative sensitivity of graphene-reinforced CAD\u002FCAM indirect restorations (inlays, onlays, overlays) in molars affected by moderate to severe Molar-Incisor Hypomineralization (MIH) in adolescents. A total of 30 patients aged 10-16 years will receive minimally invasive indirect restorations fabricated from a nano-reinforced graphene polymer (G-CAM®). Clinical outcomes will be assessed using FDI criteria, VAS sensitivity scores, patient satisfaction, and digital 3D scans over a 12-month follow-up. The study aims to determine clinical acceptability and safety compared with historical outcomes reported for composite and lithium-disilicate indirect restorations.",[27,28,29,30,31,32],"Tooth Demineralization","Tooth Sensitivity","Enamel Mineralization Disorders","Tooth Sensitivity After Composite Restorations","Tooth Eruption Disorder","Indirect Restoration",[34,35,36,37,38,39],"molar-incisor hypomineralization","MIH","enamel defects","indirect restorations","minimally invasive dentistry","adhesive dentistry","NOT_YET_RECRUITING","2025-12-28",{"date":43,"type":44},"2026-01-09","ACTUAL",{"date":46,"type":21},"2026-01-10",{"date":48,"type":21},"2027-01-11",{"name":50,"class":51},"Universitat Internacional de Catalunya","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":52},"100607406","phase-2-gluma-compared-with-bonding-agent-for-post-operative-sensitivity-following-composite-restorations-100607406","NCT07188142","Gluma Compared With Bonding Agent for Post-operative Sensitivity Following Composite Restorations","Investigating the Effects of Two Different Desensitizing Agents on Mitigating Post-Operative Sensitivity Following Composite Restorations - a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18-45 years.\n* Good oral hygiene.\n* Active primary class I carious lesions on vital molar teeth with ICDAS score 3\n* Patients complaining of sensitivity to air and osmotic stimulus.\n* Teeth having a positive cold test.\n* No signs of pulp inflammation or spontaneous pain before treatment.\n\nExclusion Criteria:\n\n* Excessive tooth wear due to clenching or abnormal habits.\n* Traumatic occlusion.\n* Periodontal or gingival disease.\n* Patients using analgesics and\u002For anti-inflammatory medicine.","18 Years","45 Years",{"count":63,"type":21},60,[65,66],"PHASE2","PHASE3","* The aim of this study is to compare the effectiveness of Gluma desensitizer in reducing post-operative sensitivity following composite restorations in posterior teeth. -Patients visiting OPD will be selected after fulfilment of inclusion criteria. Patients aged 18-45 meeting inclusion criteria and presenting with active primary class I carious lesions on vital molar teeth with ICDAS score 3 will be randomly assigned into two groups: -Group A: Patients will be provided with Gluma desensitizer, Universal Bonding agent and Composite restoration and -Group B: Patients will receive Universal bonding agent and Composite restoration. -The progress of treatment will be followed up immediately (baseline) and at regular follow up visits at 1 week, 1 month and 3 months.\n* Post-operative sensitivity will be assessed using an air stimulus and rated on a numeric rating scale for post-operative sensitivity assessment ranging from 0 to 10.",[69,70,71,30,72],"Post-operative Sensitivity","Dentin Hypersensitivity","Dental Caries","Post-operative Sensitivity After Class I Composite Restorations",[74,75,76,77,78],"Post-operative sensitivity","Dentinal hypersensitivity","Class I caries","Gluma desensitizer","Composite restoration","2025-09-19",{"date":81,"type":44},"2025-09-23",{"date":83,"type":21},"2025-12-01",{"date":85,"type":21},"2026-06-01",{"name":87,"class":51},"Beenish Hassan"]