[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tooth-staining\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tooth-staining":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":5},"100628634","effectiveness-of-dental-bleaching-using-different-designs-of-3d-printed-and-conventional-customized-nightguards-100628634",false,"NCT07464197","Effectiveness of Dental Bleaching Using Different Designs of 3D-Printed and Conventional Customized Nightguards","Evaluation of the Effectiveness in Dental Bleaching by Different Designs of 3D-Printed Digital Customized Nightguards","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Good general and oral health\n* No current medical treatment (self-reported)\n* No need for surgical, endodontic, periodontal, or restorative dental treatment\n* At least six upper and six lower anterior teeth free of caries and restorations\n* Maxillary central incisors with baseline shade A2 or darker\n* Willingness to follow the study protocol and use the study-provided oral hygiene products\u002Finstructions\n\nExclusion Criteria:\n\n* Previous tooth bleaching treatment\n* Orthodontic appliances or prostheses that interfere with treatment\n* Severe intrinsic discoloration (e.g., tetracycline staining, fluorosis, or endodontically treated teeth with discoloration)\n* Pregnancy or lactation\n* Bruxism\n* Gingival recession, dentin exposure, visible enamel cracks, or other conditions associated with increased sensitivity\n* Use of anti-inflammatory or analgesic medication during the study period (according to protocol)",true,"ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized, double-blind, split-mouth clinical trial evaluates the effectiveness of at-home dental bleaching using customized nightguards fabricated by digital (3D-printed CAD-CAM) and conventional methods, with and without reservoirs. Adult participants with good general and oral health and a baseline tooth shade of A2 or darker undergo bleaching with 10% carbamide peroxide. Outcomes include tooth color change (subjective and spectrophotometric measures), tooth sensitivity, gingival irritation, patient comfort, and patient satisfaction over time.",[27,28],"Tooth Discoloration","Tooth Staining",[30,31,32,33,34,35,36,37,38,39,40],"dental bleaching","custom tray","3D-printed tray","CAD-CAM","Carbamide peroxide","Nightguard vital bleaching","Tooth sensitivity","Gingival irritation","Spectrophotometer","Split-mouth trial","tooth whitening","RECRUITING","2026-03-11",{"date":44,"type":45},"2026-03-16","ACTUAL",{"date":47,"type":45},"2022-05-01",{"date":49,"type":21},"2026-07",{"name":51,"class":52},"Universitat Internacional de Catalunya","OTHER"]