[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"total-hip-arthroplasty\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:total-hip-arthroplasty":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,44,65,91,114,137,168,192,221,247,272,296,325,352,374,393,410],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100640892","supra-iliac-anterior-quadratus-lumborum-block-and-pericapsular-nerve-group-peng-block-for-analgesia-after-total-hip-arthroplasty-100640892",false,"NCT07606794","Supra-Iliac Anterior Quadratus Lumborum Block and Pericapsular Nerve Group (PENG) Block for Analgesia After Total Hip Arthroplasty","A Randomized Clinical Non-Inferiority Trial Comparing Supra-Iliac Anterior Quadratus Lumborum Block and Pericapsular Nerve Group (PENG) Block for Analgesia After Total Hip Arthroplasty","Inclusion Criteria:\n\n* Age from 18 to 75 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) classification I-III.\n* Scheduled for primary elective unilateral total hip arthroplasty (THA) under spinal anesthesia.\n\nExclusion Criteria:\n\n* Known allergies to the drugs used.\n* Infection at the injection site.\n* Bleeding disorders.\n* Recognized neuromuscular disorders.\n* Opioid addiction or dependence.\n* Contraindications to regional anesthesia or peripheral nerve blockade.\n* Body mass index (BMI) \\> 40 kg\u002Fm².\n* Associated decompensated cardiac, hepatic, respiratory, or renal diseases.","ALL","18 Years","75 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to compare the analgesic efficacy of supra-iliac anterior quadratus lumborum block (SA-QLB) and pericapsular nerve group (PENG) block in patients undergoing total hip arthroplasty (THA).",[27,28,29,30],"Supra-Iliac Anterior Quadratus Lumborum Block","Pericapsular Nerve Group Block","Analgesia","Total Hip Arthroplasty","RECRUITING","2026-06-22",{"date":34,"type":35},"2026-06-23","ACTUAL",{"date":37,"type":35},"2026-05-23",{"date":39,"type":21},"2026-10-30",{"name":41,"class":42},"Tanta University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":59,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":43},"100634234","analgesic-efficacy-of-quadro-iliac-plane-block-versus-erector-spinae-plane-in-total-hip-arthroplasty-100634234","NCT07537036","Analgesic Efficacy of Quadro-Iliac Plane Block Versus Erector Spinae Plane in Total Hip Arthroplasty","Analgesic Efficacy of Quadro-Iliac Plane Block Versus Erector Spinae Plane in Total Hip Arthroplasty: A Randomized Non-Inferiority Trial","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I-III.\n* Undergoing total hip arthroplasty (THA) under spinal anesthesia.\n\nExclusion Criteria:\n\n* History of allergies to local anesthetics.\n* Opioid dependency.\n* Body mass index (BMI) \\> 35 kg\u002Fm2.\n* Cognitive impairment.\n* Bleeding or coagulation disorders.\n* Psychiatric and neurological disorder.\n* Local infection at the site of injection.\n* Severe heart, lung, liver, and renal dysfunction.\n* Emergency surgery.",{"count":52,"type":21},76,[24],"This study aims to compare the Quadro-Iliac Plane Block versus Erector Spinae Plane Block after total hip arthroplasty.",[56,57,58,30],"Analgesic Efficacy","Quadro-Iliac Plane Block","Erector Spinae Plane Block",{"date":34,"type":35},{"date":61,"type":35},"2026-04-18",{"date":63,"type":21},"2026-11-30",{"name":41,"class":42},{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":43},"100624466","ultrasound-guided-quadro-iliac-plane-block-for-pain-management-after-total-hip-arthroplasty-100624466","NCT07410000","Ultrasound-Guided Quadro-Iliac Plane Block for Pain Management After Total Hip Arthroplasty","Effectiveness of Ultrasound-Guided Quadro-Iliac Plane Block for Pain Management After Total Hip Arthroplasty: A Prospective Randomized Study","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) classification I-III\n* Age between 18 and 80 years\n* Patients scheduled for elective primary total hip arthroplasty\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Allergy to local anesthetics or opioids\n* Known or suspected coagulopathy\n* Infection at the injection site\n* History of previous hip surgery\n* Severe cardiovascular disease\n* Liver or kidney failure\n* Pregnancy, suspected pregnancy, or breastfeeding\n* Severe neurological or psychiatric disorder\n* Chronic opioid use","80 Years",{"count":74,"type":21},100,[24],"This prospective, randomized, double-blind study evaluates the analgesic effectiveness of the ultrasound-guided Quadro-Iliac Plane (QIP) block in patients undergoing primary total hip arthroplasty. The QIP block is a recently described fascial plane block. Patients will be randomized to receive either a QIP block with local anesthetic or a sham block with saline. The primary outcome is 24-hour opioid consumption. Secondary outcomes include motor block, dermatomal sensory assessment, pain scores, rescue analgesic requirement, quality of recovery (QoR-15), and opioid-related side effects.",[78,30],"Pain Management",[30,80,57],"Postoperative Analgesia","2026-03-26",{"date":83,"type":35},"2026-03-27",{"date":85,"type":35},"2026-03-16",{"date":87,"type":21},"2027-03-15",{"name":89,"class":90},"Bursa City Hospital","OTHER_GOV",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":98,"targetDuration":4,"studyType":22,"phases":100,"briefSummary":102,"conditions":103,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":43},"100610398","phase-3-methadone-in-tha-for-post-op-pain-and-opioid-reduction-100610398","NCT07227064","Methadone in THA for Post-op Pain and Opioid Reduction","Reduction of Post-op Pain and Opioid Consumption With the Addition of Methadone in Total Hip Arthroplasty: a Double-blind Randomized Control Trial","Inclusion\n\n* Ages 18-75 years of age\n* Undergoing elective primary total hip arthroplasty with mepivacaine in the spinal anesthesia\n\nExclusion\n\n* Allergy to methadone or mepivacaine\n* Severe liver disease defined as Child's Pugh Class C\n* End stage renal disease requiring dialysis\n* Known diagnosis of prolonged QT syndrome\n* Currently pregnant\n* Unable to provide written, informed consent\n* Non-English speaking",{"count":99,"type":21},162,[101],"PHASE3","This randomized, double-blind controlled trial investigates whether intraoperative intravenous methadone (0.15 mg\u002Fkg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total hip arthroplasty under spinal anesthesia with mepivacaine. The primary outcome is patient-reported pain on a visual analog scale (VAS) 30-60 minutes after arrival in the post-anesthesia care unit (PACU). Secondary outcomes include opioid use, pain scores over time, incidence of nausea\u002Fvomiting, and quality of recovery. A total of 162 subjects will be enrolled at MUSC surgical sites.",[104,30],"Post Operative Pain","2026-02-03",{"date":107,"type":35},"2026-02-05",{"date":109,"type":35},"2026-01-12",{"date":111,"type":21},"2027-01-31",{"name":113,"class":42},"Medical University of South Carolina",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":72,"enrollmentInfo":121,"targetDuration":4,"studyType":123,"phases":4,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":43},"100502179","multicenter-mpact-dm-france-100502179","NCT05818891","Multicenter Mpact DM France","Prospective, Multicenter, Non-Controlled, Non-Randomized, Open-Label Study To Evaluate The Efficacy And Performance Of The Mpact® Dual Mobility Hemispheric Cup","Inclusion Criteria:\n\n1. Patient with a disease that meets the indications for use of Medacta implants (according to the instructions for use)\n2. Patient eligible for first-line total hip replacement\n3. Patient between 18 and 80 years of age\n4. Patient covered by the Social Security system or an equivalent protection plan\n5. Patient who is capable, in the opinion of the investigator, of fulfilling the requirements of the study\n\nExclusion Criteria:\n\n1. Patient requiring a transplant\n2. Patient with progressive local or systemic infection\n3. Patient with muscle loss, neuromuscular disease, or vascular impairment of the affected limb making surgery unwarranted\n4. Patient with known medical problems that may compromise independent recovery of mobility\n5. Patient with a BMI greater than 40 kg\u002Fm².\n6. Patient with major cognitive problems that do not allow a good understanding of the study requirements\n7. Patient living in a geographical area that does not allow the study follow-up\n8. Patient participating in interventional research.\n9. Minor patient\n10. Protected adult patient\n11. Vulnerable person according to article L1121-6 of the Public Health Code\n12. Pregnant or nursing woman.",{"count":122,"type":21},600,"OBSERVATIONAL","The primary objective of the study is to evaluate the 10-year performance of the MPACT DM cup in the treatment of patients requiring total hip arthroplasty.\n\nThe primary endpoint is the 10-year life span of the prosthesis according to the Kaplan Meier curve.",[30,126],"Survival, Prosthesis","2025-09-23",{"date":129,"type":35},"2025-09-29",{"date":131,"type":35},"2018-04-05",{"date":133,"type":21},"2031-04",{"name":135,"class":136},"Medacta International SA","INDUSTRY",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":144,"sex":16,"minAge":145,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":22,"phases":148,"briefSummary":149,"conditions":150,"keywords":151,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":167},"100538145","bone-remodeling-around-a-trabecular-titanium-cup-in-total-hip-arthroplasty-100538145","NCT06287021","Bone Remodeling Around a Trabecular Titanium Cup in Total Hip Arthroplasty","Bone Remodeling Around a 3D-printed Highly-porous Trabecular Titanium Acetabular Cup in Primary Total Hip Arthroplasty","Inclusion Criteria:\n\n* Patient candidated to undergo unilateral cementless primary total hip arthroplasty with Jump System Traser® cup or Jump System HAX-Pore® cup by Permedica Orthopaedics (study sponsor).\n* Patient with primary or secondary hip osteoarthritis;\n* Patient who has given informed consent;\n\nExclusion Criteria:\n\n* Male patients younger than 40 years or older than 85 years;\n* Female patients younger than 50 years or older than 85 years;\n* Childbearing;\n* Patients not indicated for receiving the investigational devices;\n* Patients not indicated for receiving cementless metaphyseal short femoral stems by Permedica Orthopaedics as the \"Exacta RS\" or \"Exacta S\" brand;\n* Patients with rheumatoid arthritis, avascular osteonecrosis, severe hip dysplasia (grade III-IV according to Crowe classification), Perthes disease, Paget disease, femoral neck fracture, pelvic fracture or sequelae of previous surgical procedures or trauma to the ipsilateral hip;\n* Patients with bone disorders;\n* Patients with diabetes;\n* Patients under PTH (parathyroid hormone), corticosteroid, or osteoporosis pharmacological therapy;\n* Patients with disabling disease in the contralateral limb;\n* Patients with BMI \\> 30 or \\\u003C 18;\n* Patients not willing to follow the study protocol;\n* Patients incapable to understand the study protocol;\n* Patients addicted to alcohol or drugs;\n* Patients already enrolled in other clinical investigations;",true,"40 Years","85 Years",{"count":20,"type":21},[24],"The goal of this randomized controlled trial is to measure the periprosthetic bone mineral density changes around a 3D-printed highly-porous titanium acetabular cup used in primary total hip arthroplasty compared to a standard hydroxyapatite\u002Ftitanium plasma-sprayed acetabular cup up to 2-year follow-up.",[30],[152,153,154,155,156,157],"Bone Mineral Density","DEXA","Additive Manufacturing","3D-Printing","Selective Laser Melting","Highly-Porous Titanium","2025-08-25",{"date":160,"type":35},"2025-09-02",{"date":162,"type":35},"2024-04-09",{"date":164,"type":21},"2028-06",{"name":166,"class":136},"Permedica spa",2,{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":123,"phases":4,"briefSummary":177,"conditions":178,"keywords":179,"overallStatus":182,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":4},"100601191","evaluation-of-a-software-to-predict-the-postoperative-component-position-in-total-hip-arthroplasty-tha-100601191","NCT07107282","Evaluation of a Software to Predict the Postoperative Component Position in Total Hip Arthroplasty (THA)","Evaluation of a Software to Predict the Postoperative Component Position in Total Hip Arthroplasty (THA): Accuracy of Predictions and Impact on Interoperative Placement in a Single Centre","Inclusion Criteria:\n\n1. Scheduled for THA\n2. Age of 18 or above\n\nExclusion Criteria:\n\n1. Patients with anatomical conditions which reduce the applicability of the software\n2. Patients with implants which reduce the applicability of the software\n3. Patients who cannot perform an upright X-ray",{"count":176,"type":21},60,"The goal of this observational study is to learn about the accuracy of a software determining the implant position during THA surgery.\n\nMeasurements made with the software are compared to reference values determined on X-rays.",[30],[180,181],"implant position","leg length","NOT_YET_RECRUITING","2025-07-30",{"date":185,"type":35},"2025-08-06",{"date":187,"type":21},"2025-09",{"date":189,"type":21},"2026-08",{"name":191,"class":42},"Marcel Jakob",{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":144,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":22,"phases":201,"briefSummary":202,"conditions":203,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":220},"100420387","g7-acetabular-system-with-vivacit-e-or-longevity-liner-pmcf-study-100420387","NCT04754087","G7 Acetabular System With Vivacit-E or Longevity Liner PMCF Study","Global, Multicenter, and Prospective Post-Market Clinical Follow-Up Study of the G7 Acetabular System With Vivacit-E and Longevity Highly Crosslinked Polyethylene (HXLPE) Liners & Instrumentation","Inclusion Criteria:\n\n* Patient must be a legal adult who has reached full skeletal maturity.\n* Patient must be treated for one of the following indications:\n* Noninflammatory degenerative joint disease including osteoarthritis and avascular necrosis\n* Rheumatoid arthritis\n* Correction of functional deformity\n* Treatment of non-union, femoral neck fracture, and trochanteric fractures of the proximal femur with head involvement, unmanageable by other techniques\n* Revision procedures where other treatment or devices have failed\n* Patient must be able and willing to complete the protocol required follow-up visits.\n* Patient must be able and willing to sign the Institutional Review Board or Ethics Committee (IRB\u002FEC) approved informed consent.\n\nExclusion Criteria:\n\n* Patient presents with osteoporosis, which in the opinion of the Principal Investigator, may limit the subject's ability to support total hip arthroplasty using the study device.\n* Patient has a metabolic disorder that may impair bone formation.\n* Patient has osteomalacia.\n* Patient has distant foci of infections which may spread to the implant site or patient with infection, sepsis or osteomyelitis.\n* Patient has rapid joint destruction, marked bone loss or bone resorption apparent on roentgenogram.\n* Patient has a vascular insufficiency, muscular atrophy, or neuromuscular disease\n* Patient is a prisoner.\n* Patient is a current alcohol or drug abuser.\n* Uncooperative patient or patient with neurologic disorders who is incapable or unwilling to follow directions.\n* Patient is pregnant.",{"count":200,"type":21},300,[24],"The main objectives of this study are to confirm the long-term safety, performance, and clinical benefits of the G7 Acetabular Shells when used with the Vivacit-E and Longevity HXLPE liners and instrumentation in primary and revision total hip arthroplasty.",[30,204,205,206,207,208,209,210],"Degenerative Joint Disease of Hip","Avascular Necrosis of Hip","Rheumatoid Arthritis of Hip","Osteoarthritis, Hip","Osteoarthritis of Hip","Fractures, Hip","Fracture of Hip","2025-06-13",{"date":213,"type":35},"2025-06-18",{"date":215,"type":35},"2021-07-07",{"date":217,"type":21},"2033-12-31",{"name":219,"class":136},"Zimmer Biomet",11,{"id":222,"slug":223,"hasResults":11,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":4,"eligibilityCriteria":227,"healthyVolunteers":11,"sex":16,"minAge":145,"maxAge":4,"enrollmentInfo":228,"targetDuration":4,"studyType":22,"phases":230,"briefSummary":231,"conditions":232,"keywords":234,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":43},"100456281","pre-op-tha-modelling-100456281","NCT05221554","Pre-Op THA Modelling","Pre-Op Total Hip Arthroplasty Modelling: Individualized Care, Improved Outcomes","Inclusion Criteria:\n\n* osteoarthritis of the hip requiring primary THA\n* 40 years of age or older\n* BMI \\\u003C40 kg\u002Fm2\n* able to provide informed consent, able and willing to do study assessments and follow instructions\n\nExclusion Criteria:\n\n* prior surgery on the indicated hip with insertion of hardware\n* prior surgery on the lower spine with insertion of hardware\n* hip and\u002For spinal fixed deformities or inflammatory\u002Fossification processes of the spine (e.g. DISH, ankylosing spondylolisthesis)\n* limitations to range of motion of the contralateral hip",{"count":229,"type":21},80,[24],"Replacing diseased hip joints with prosthetic implants in a procedure called total hip arthroplasty (THA) is associated with high rates of patient satisfaction, pain relief, and functional improvement when the implant is appropriately placed. Incorrect implant size or placement may lead to a breadth of negative outcomes, which could result in the need for implant revision. It is difficult to assess the precise orientation of patient hips on the operating table, with one study revealing that only 26% of acetabular cups placed without technological assistance are correctly positioned. Using computer navigation as a guide to achieve optimal implant alignment may improve successful placement rates. The additional incorporation of real-time modeling software may further help realize higher rates of successful implant placement. This study, therefore, aims to investigate a computer navigation system coupled with real-time modeling software to establish the benefit of such technology in the operating room, and further improve positive patient outcomes following THA. We hypothesize that including technological assistance in THAs will yield better patient outcomes compared to surgeries performed freehand.",[30,233],"Computer-Assisted Surgery",[235,236,237],"Osteoarthritis","Joint Disease","Musculoskeletal Disease","2025-05-08",{"date":240,"type":35},"2025-05-13",{"date":242,"type":35},"2022-08-01",{"date":244,"type":21},"2025-11-30",{"name":246,"class":42},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's",{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":4,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":16,"minAge":254,"maxAge":4,"enrollmentInfo":255,"targetDuration":4,"studyType":22,"phases":257,"briefSummary":258,"conditions":259,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":43},"100575153","effect-of-oral-melatonin-versus-intraoperative-lidocaine-infusion-on-incidence-of-postoperative-delirium-in-elderly-patients-undergoing-total-hip-arthroplasty-100575153","NCT06768580","Effect of Oral Melatonin Versus Intraoperative Lidocaine Infusion on Incidence of Postoperative Delirium in Elderly Patients Undergoing Total Hip Arthroplasty","Effect of Oral Melatonin Versus Intraoperative Lidocaine Infusion on Incidence of Postoperative Delirium in Elderly Patients Undergoing Total Hip Arthroplasty: Prospective Randomized Controlled Blinded Study","Inclusion Criteria:\n\n* Elderly patients aged \\>65 years old undergoing unilateral total hip arthroplasty.\n* Patients with body mass index (BMI) (18-30) kg\u002Fm2.\n* American Society of Anesthesiologists (ASA) physical status I-III, scheduled to undergo unilateral total hip arthroplasty.\n\nExclusion Criteria:\n\n* History of mental illness or scoring less than 8 using abbreviated mental test (AMT) before operation.\n* Obvious sinus bradycardia (heart rate of \\\u003C50 beats per minute) or other serious cardiovascular diseases.\n* Symptomatic cerebrovascular disease (such as previous stroke).\n* History of liver and kidney dysfunction.\n* Allergy to lidocaine or melatonin.\n* Metabolic disorders and fluid, electrolytes disturbances.\n* Alcohol dependence or drug abuse.\n* Redo surgery or infectious complications.\n* CNS medications (antipsychotics, anticonvulsants, antiparkinsonian, antidepressants).\n* History of deep vein thrombosis.","65 Years",{"count":256,"type":21},135,[24],"The aim of this study is to assess the effect of oral melatonin versus intraoperative lidocaine infusion on incidence of postoperative delirium in elderly patients undergoing total hip arthroplasty under spinal anesthesia.",[260,261,262,263,30],"Oral Melatonin","Lidocaine Infusion","Postoperative Delirium","Elderly Patients","2025-04-12",{"date":266,"type":35},"2025-04-15",{"date":268,"type":35},"2025-01-15",{"date":270,"type":21},"2026-10-01",{"name":41,"class":42},{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":279,"targetDuration":4,"studyType":22,"phases":281,"briefSummary":282,"conditions":283,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":43},"100585618","pericapsular-nerve-group-and-lumbar-erector-spinae-plane-blocks-for-geriatrics-undergoing-total-hip-arthroplasty-100585618","NCT06904703","Pericapsular Nerve Group and Lumbar Erector Spinae Plane Blocks for Geriatrics Undergoing Total Hip Arthroplasty","Combination of Pericapsular Nerve Group and Lumbar Erector Spinae Plane Blocks for Geriatrics Undergoing Total Hip Arthroplasty Under General Anesthesia: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged \\>75 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) classification I-III.\n* Undergoing total hip arthroplasty under general anesthesia.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Body mass index (BMI) \\> 30 kg\u002Fm2.\n* Allergy to local anesthesia drugs.\n* Infection at the site of intervention.\n* Coagulopathies.\n* Preexisting advanced diseases of the kidney or liver.",{"count":280,"type":21},120,[24],"This study will be conducted to evaluate the effect of pericapsular nerve group and erector spinae plane block as adjuvants to general anesthesia in geriatrics undergoing total hip arthroplasty.",[284,285,286,30,287],"Pericapsular Nerve","Lumbar Erector Spinae Plane Blocks","Geriatrics","General Anesthesia","2025-03-29",{"date":290,"type":35},"2025-04-01",{"date":292,"type":35},"2024-12-01",{"date":294,"type":21},"2026-11-01",{"name":41,"class":42},{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":302,"eligibilityCriteria":303,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":304,"targetDuration":4,"studyType":22,"phases":306,"briefSummary":307,"conditions":308,"keywords":309,"overallStatus":182,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":320,"leadSponsor":322,"locationsCount":4},"100584994","deep-posterior-post-gluteal-compartment-block-in-total-hip-arthroplasty-feasability-and-safety-100584994","NCT06896591","Deep Posterior Post Gluteal Compartment Block in Total Hip Arthroplasty: Feasability and Safety","Effets D'un Bloc Glutéal Postérieur Profond Associé À Un PENG Bloc Dans La Prothèse Totale De Hanche","ANATH","Inclusion Criteria:\n\nAll adults with total hip arthroplasty\n\n\\-\n\nExclusion Criteria:\n\n* Contraindication to regional anesthesia\n* allergy\n* refusal of the injection",{"count":305,"type":21},35,[24],"This study aims to evaluate the effectiveness of a posterior hip capsule block performed in addition to a PENG (Pericapsular Nerve Group) block for patients undergoing hip arthroplasty. The primary objective is to assess whether this combined approach provides enhanced perioperative analgesia compared to the standard analgesic protocol or the PENG block alone. Secondary outcomes will focus on opioid consumption, functional recovery, and any potential complications. By targeting both the anterior and posterior innervation pathways around the hip joint, this combined technique could improve patient comfort, decrease opioid requirements, and potentially expedite rehabilitation after hip arthroplasty.",[30],[310,311,312,313,314],"total hip arthroplasty","peng block","Hip","Anatomy","Sciatic nerve block","2025-03-19",{"date":317,"type":35},"2025-03-26",{"date":319,"type":21},"2025-06-01",{"date":321,"type":21},"2026-03-01",{"name":323,"class":324},"Quincy Anesthésie","NETWORK",{"id":326,"slug":327,"hasResults":11,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":331,"eligibilityCriteria":332,"healthyVolunteers":11,"sex":16,"minAge":254,"maxAge":4,"enrollmentInfo":333,"targetDuration":4,"studyType":22,"phases":335,"briefSummary":336,"conditions":337,"keywords":338,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":43},"100366285","migration-in-total-hip-arthroplasty-with-a-cemented-bimobile-cup-better-stability-with-more-cement-100366285","NCT04049279","Migration in Total Hip Arthroplasty with a Cemented BiMobile Cup: Better Stability with More Cement?","Migration in Total Hip Arthroplasty with a Cemented BiMobile Cup: Better Stability with More Cement? (Be-Mobile)","Be-Mobile","Inclusion Criteria:\n\n* Patient requiring an elective primary cemented THA.\n* Male patient ≥70 years old and female patient ≥65 years old.\n* Ability and willingness to follow instructions and to return for follow-up evaluations.\n* The patient is able to understand the meaning of the study and is willing to sign informed consent.\n* Understanding the Dutch language.\n\nExclusion Criteria:\n\n* The patient is morbidly obese, defined as Body Mass Index (BMI) of ≥ 40.\n* The patient is expected to need lower limb joint replacement for another joint within one year.\n* The patient has a systemic or metabolic disorder leading to progressive bone deterioration.\n* The patient has a deformity or disease located in other joints than the hip that needs surgery and that is limiting their ability to walk.\n* The patient has an active or suspected latent infection in or around the hip joint.\n* The patient's bone stock is compromised by a disease or infection which cannot provide adequate support and\u002For fixation to the prosthesis.\n* The patient is unable or unwilling to sign informed consent for this study.\n* The patient is deemed unsuitable for participation in the study based on the investigator's judgment.",{"count":334,"type":21},75,[24],"Objective: The main objective of this study is to compare the (early) migration of the cemented BiMobile cup at two year post-surgery between two different cup sizes after standard optimal reaming, and consequently adjusting the cement mantle into circa 2 or 4 mm, in patients with a primary cemented total hip arthroplasty (THA). Additionally, the results of the BiMobile cup will be compared to the Avantage cup, which is placed with a standard cup size, resulting in a cement mantle of approximately 2 mm.\n\nStudy design: A prospective single centre blinded randomised controlled trial.\n\nStudy population: All patients who meet the criteria to undergo a cemented THA.",[30,207],[339,340,341,342],"primary total hip arthroplasty","RSA","cement","Dual mobility cup","2025-02-25",{"date":345,"type":35},"2025-02-28",{"date":347,"type":35},"2019-01-01",{"date":349,"type":21},"2029-05-01",{"name":351,"class":42},"JointResearch",{"id":353,"slug":354,"hasResults":11,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":358,"eligibilityCriteria":359,"healthyVolunteers":11,"sex":16,"minAge":360,"maxAge":4,"enrollmentInfo":361,"targetDuration":4,"studyType":22,"phases":363,"briefSummary":364,"conditions":365,"keywords":366,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":369,"startDateStruct":370,"completionDateStruct":371,"leadSponsor":373,"locationsCount":43},"100364944","dual-mobility-cups-compared-to-unipolar-cups-on-dislocation-and-cost-effectiveness-after-primary-total-hip-arthroplasty-100364944","NCT04031820","Dual-mobility Cups Compared to Unipolar Cups on Dislocation and Cost-effectiveness After Primary Total Hip Arthroplasty.","Effectiveness of Dual-mobility Cups for Preventing Dislocation After Primary Total Hip Arthroplasty by a Posterolateral Approach and Their Cost-effectiveness Compared to Unipolar Cups in Elderly Patients.","REDEP","Inclusion Criteria:\n\n* Patients who are eligible for elective primary THA with a cemented cup, with a 32mm or 36 mm liner, for any indication.\n* THA using posterolateral surgical approach.\n* Patients ≥ 70 years old\n* Adequate comprehension of written and spoken Dutch\n\nExclusion Criteria\n\n* Patients unable to complete PROMs\n* Patients with dementia, epilepsy\\*, spasticity\\*, mental retardation or alcoholism. (If dementia or mental retardation is not already mentioned in the medical chart, this can be determined by doctors opinion.)\n* Patients not eligible for either a unipolar or a DM cup\n\n  * These patients will be asked to participate in the non-randomized dual mobility observational cohort.","70 Years",{"count":362,"type":21},1100,[24],"Objective: The primary objective is to investigate whether there is a difference in the number of hip dislocations following primary total hip arthroplasty (THA), using the posterolateral approach, with a DM cup compared to a unipolar cup in elderly patients 1 year after surgery.\n\nStudy design: Prospective multi-center nation wide, single blinded RCT nested in the LROI.\n\nStudy population: Patients ≥ 70 years old, undergoing an elective primary cemented THA.",[30,207],[367,368],"Primary total hip arthroplasty","Dual Mobility cup",{"date":345,"type":35},{"date":347,"type":35},{"date":372,"type":21},"2027-05-01",{"name":351,"class":42},{"id":375,"slug":376,"hasResults":11,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":381,"targetDuration":4,"studyType":123,"phases":4,"briefSummary":383,"conditions":384,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":43},"100499600","a-post-market-surveillance-study-about-the-monocer-cup-100499600","NCT05785364","A Post Market Surveillance Study About the MONOCER Cup","Monocer Cup: Open, Prospective, Multicentric, Non Randomised Observational Study","Inclusion Criteria:\n\n1. Patients undergoing total hip arthroplasty who will receive the Mpact 3D Metal MonoCER acetabular component according to the instructions for use\n2. Patients who have signed the informed consent to participate in the study\n\nExclusion Criteria:\n\n1. Minor patients, patients over 75 years of age at the time of primary surgery;\n2. Any patient who is unable or unwilling to give informed consent to participate in the study.",{"count":382,"type":21},250,"Over the years, the use of large diameter femoral heads has become increasingly common in orthopaedics due to the decreased risk of dislocation due to increased jumping distance and range of motion. The history of total hip arthroplasty does not favour large diameter heads, especially as conventional polyethylene has a high risk of wear. The development of hard-on-hard bearings (CoC) with a second generation ceramic material and the introduction of cross-linked PE have led to the reintroduction of this concept. The Mpact 3D Metal MonoCER cup was developed to offer the advantages of accommodating large diameter heads with an external metal cup with a pre-assembled system that avoids the surgical step of insert-cotile coupling.",[30],"2024-04-30",{"date":387,"type":35},"2024-05-01",{"date":389,"type":35},"2022-01-25",{"date":391,"type":21},"2050-02-01",{"name":135,"class":136},{"id":394,"slug":395,"hasResults":11,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":4,"eligibilityCriteria":399,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":400,"targetDuration":4,"studyType":123,"phases":4,"briefSummary":402,"conditions":403,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":404,"startDateStruct":405,"completionDateStruct":407,"leadSponsor":409,"locationsCount":43},"100424037","mpact-3d-metal-cup-pms-100424037","NCT04801680","Mpact 3D Metal Cup PMS","A Multicentric, Prospective Clinical Survey on Long Term Performance of an Acetabular Component in Primary Total Hip Arthroplasty","Inclusion Criteria:\n\n* Those suffering from hip primary arthrosis, post-traumatic arthrosis, hip dysplasia or avascular necrosis of femoral head, rheumatic arthrosis\n* Those aged between 18 and 75 years old at the surgery time\n* those suitable to undergo to a primary total hip arthroplasty for whom the Mpact 3D Metal cup will be implanted (according to the label indication\u002Fcontraindications)\n* Patients who are willing and able to provide written informed consent for participation in the study. Written informed consent must be obtained prior to patient's surgery\n\nExclusion Criteria:\n\n* Those with acute or chronic infection\n* Those whose mental conditions may compromise their ability to provide informed consent to study participation, ability to complete questionnaires or complete 10-year follow-ups.\n* Those suffered by severe deformation, at the discretion of surgeon\n* Those suffered by osteoporosis\n* Those with metabolic disorders that may involve bone metabolism for which cementless implants are contraindicated\n* Those suffered by muscular atrophy or neuromuscular disease\n* Those allergic to medical device material previewed for the surgery\n* Those unable to give their consent to participate in the study or who do not want to participate\n* Those whose functional recovery is compromised by",{"count":401,"type":21},500,"Cementless fixation, with or without screw augmentation, has evolved during the past few decades as the preferred method for acetabular reconstruction. Although major improvements have been recorded with regard to clinical outcomes and survivorship, acetabular component loosening remains among the most common causes of failure and revision. Patient age, poor bone quality and conditions, such as osteonecrosis and dysplasia, have been observed to influence negatively long-term clinical results.\n\nInitial stability is fundamental for survivorship of cementless cups. Prerequisites to achieve durable cementless cup fixation are close contact with viable native bone, primary mechanical stability and secondary bone integration. Press-fit techniques provide optimal conditions for bone ingrowth and fixation but research focused on cup material in order to improve primary stability. Pore size, bone-implant apposition, and material properties all influence bone ingrowth and long-term stability.\n\nBiological ingrowth surfaces have become a standard prosthetic element in reconstructive hip surgery. A material's properties, three-dimensional architecture, and surface texture all play integral parts in its biological performance. Trabecular metal is an important new biomaterial that has been introduced to enhance the potential of biological ingrowth as well as provide a structural scaffold in cases of severe bone deficit. The continuity between the porous and solid parts has been specifically developed to overcome the limitations of the traditional porous coatings. In fact, the absence of an interface between the trabecular structure and the bulk material provides greater structural solidity and thus higher resistance to detachment and corrosion. Initial clinical applications have focused on bone restoration in tumor and salvage cases and in primary and revision reconstructive cases where the increased biological fixation would be of clinical benefit. However the bone ingrowth potential and mechanical integrity of this material offer exciting options for orthopedic reconstructive surgeons such as difficult THA cases, such as patients with high demands, subjects affected by severe hip conditions (i.e. osteonecrosis, dysplasia) or with extremely poor bone quality. Medacta Mpact 3D Metal cup, is an acetabular cup realized using the EBM (Electron Beam Melting) powder technology; this production method offers a high friction and scratch-fit feel for the initial stability, without the need of any additional coating. Moreover the 3D Metal structure creates a favorable environment for bone thus providing secondary fixation.\n\nThe aim of this study is to evaluate the long term clinical and radiological performance of MPact 3D Metal acetabular component.",[30],{"date":387,"type":35},{"date":406,"type":35},"2019-11-07",{"date":408,"type":21},"2032-12-07",{"name":135,"class":136},{"id":411,"slug":412,"hasResults":11,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":416,"eligibilityCriteria":417,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":418,"enrollmentInfo":419,"targetDuration":4,"studyType":22,"phases":421,"briefSummary":422,"conditions":423,"keywords":4,"overallStatus":182,"whyStopped":4,"lastUpdateSubmitDate":424,"lastUpdatePostDateStruct":425,"startDateStruct":427,"completionDateStruct":429,"leadSponsor":431,"locationsCount":433},"100542971","phase-3-early-and-late-effects-of-nefopam-in-multimodal-analgesia-after-total-hip-arthroplasty-nefarthro-100542971","NCT06349798","Early and Late Effects of Nefopam in Multimodal Analgesia After Total Hip Arthroplasty (NEFARTHRO)","Early and Late Effects of Nefopam in Multimodal Analgesia After Total Hip Arthroplasty (NEFARTHRO): a Multicentric Randomized Controlled Trial.","NEFARTHRO","Inclusion Criteria:\n\n* Patient aged ≥ 18 years, fluent in French.\n* Planned primary or secondary total hip replacement, regardless of surgical approach or type of prosthesis.\n* Receiving paracetamol and ketoprofen postoperatively.\n* Under general anesthesia or spinal anesthesia (without intrathecal morphine).\n* Participant affiliated to a social security scheme\n* Participant's free, informed and written consent\n\nExclusion Criteria:\n\n* Septic or carcinological surgery\n* Allergy to paracetamol, nefopam or NSAIDs\n* Angle-closure glaucoma\n* Prostate adenoma\n* history of convulsion\n* Nocturnal pollakiuria in men with more than two risings per night\n* Severe hepatic (Child C) or cardiac insufficiency (LVEF \\\u003C 30%)\n* Renal insufficiency with creatinine clearance \\\u003C 50 mL\u002F min according to Cockroft's formula\n* Active peptic ulcer or history of digestive bleeding or peptic perforation\n* Patients with opioid treatment for chronic pain other than coxarthrosis (fentanyl, oral morphine \\> 50mg\u002Fd or equivalent)\n* Protected patient: safeguard of justice, guardianship or curatorship\n* Incomprehension or inability to use a numerical rating scale or to self-assess\u002Fmanage pain\n* Pregnancy or breast-feeding","100 Years",{"count":420,"type":21},546,[101],"NEFARTHRO is a multicentric randomized controlled trial comparing the effects of discontinuous infusions of nefopam (bolus) versus continuous infusion of intravenous nefopam (via an infusion pump) versus placebo on the opioid-request during the first 24 hours following a Total Hip arthroplasty, as part of multimodal analgesia including at least paracetamol and a Non-Steroidal Anti-Inflammatory Drug (NSAID).\n\nThe primary endpoint is cumulative morphine consumption for the first postoperative 24 hours, expressed in mg of iv equivalent morphine, including titration in the Post Anesthesia Care Unit (PACU).\n\nPatients will be followed during 6 months.",[30],"2024-04-02",{"date":426,"type":35},"2024-04-05",{"date":428,"type":21},"2024-04",{"date":430,"type":21},"2027-04",{"name":432,"class":42},"University Hospital, Tours",7]