[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"total-intravenous-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:total-intravenous-anesthesia":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,53,91,117,140,169,198,224],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100642003","transition-from-sevoflurane-to-total-intravenous-anesthesia-in-pediatric-patients-100642003",false,"NCT07644260","Transition From Sevoflurane to Total Intravenous Anesthesia in Pediatric Patients","Observational Analysis of the Transition From Inhalational Anesthesia to Total Intravenous Anesthesia Guided by Bispectral Index and the Eleveld Model in Pediatric Patients","TSTP","Inclusion Criteria:\n\n* Age 2 to 12 years\n* Scheduled for elective low- or intermediate-risk surgery according to the National Institute for Health and Care Excellence (NICE) surgical risk stratification (e.g., tonsillectomy, adenoidectomy, postioplasty, orchidectomy, orchidopexy, inguinal herniorrhaphy)\n* American Society of Anesthesiologists (ASA) Physical Status Classification I or II\n\nExclusion Criteria:\n\n* Refusal of parents\u002Flegal guardians to sign informed consent, or refusal of the child to provide assent when applicable\n* Cardiovascular or neurological disease that may interfere with anesthesia or with the pharmacokinetic model\n* History of allergy or adverse reaction to inhalational or intravenous anesthetic agents used in the protocol\n* Airway malformations or conditions that complicate standard intubation or airway management\n* Psychological or neurological conditions requiring sedative or hypnotic premedication prior to the anesthetic procedure\n* Treatment with drugs that may alter the pharmacokinetics or pharmacodynamics of the anesthetic agents\n* Difficult peripheral venous access","ALL","2 Years","12 Years",{"count":21,"type":22},50,"ESTIMATED","1 Day","OBSERVATIONAL","his prospective, observational, exploratory, and multicenter study aims to describe the evolution of propofol effect-site concentration administered via target-controlled infusion (TCI) based on the Eleveld model-with adjustments for opioid co-administration-guided by the bispectral index (BIS) during the transition from inhalational anesthesia with sevoflurane to total intravenous anesthesia (TIVA) in pediatric patients.The study population will include 50 pediatric patients, aged 2 to 12 years, scheduled for elective low- or medium-complexity surgeries. Induction will be performed with sevoflurane, followed by intravenous access placement and transition to TIVA using propofol and remifentanil via TCI. As part of the neuromonitoring, the bispectral index, spectral edge frequency (SEF), and median frequency (MF) will be recorded. Additionally, hemodynamic parameters will be recorded on a minute-by-minute basis.The primary objective is to describe BIS-guided adjustments of propofol during the anesthetic transition. Secondary objectives include describing interindividual variability in propofol titration, time to reach a BIS of 40-60, burst suppression patterns, SEF, MF, drug consumption, hemodynamic stability, and clinical adverse events. Statistical analysis will be primarily descriptive, examining correlations between BIS, propofol, and the minimum alveolar concentration (MAC) of sevoflurane.",[27,28,29],"Anesthesia","Pediatric Anesthesia","Total Intravenous Anesthesia",[29,31,32,33,34,35,36,37,38,28,39],"TIVA","Bispectral Index","BIS","Propofol","Sevoflurane","Eleveld","Target-Controlled Infusion","TCI","Anesthesia Transition","NOT_YET_RECRUITING","2026-06-08",{"date":43,"type":44},"2026-06-12","ACTUAL",{"date":46,"type":22},"2026-05-26",{"date":48,"type":22},"2027-03-28",{"name":50,"class":51},"Hospital de Clinicas José de San Martín","OTHER",2,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":64,"studyType":24,"phases":4,"briefSummary":65,"conditions":66,"keywords":75,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":90},"100643122","the-effects-of-anesthesia-on-postoperative-cognitive-functions-in-patients-undergoing-sleeve-gastrectomy-100643122","NCT07637357","The Effects of Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy","The Effects of Total Intravenous Anesthesia and Inhalational Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy","Inclusion Criteria:\n\nPatients of both sexes, Patients Aged between 18 and 65 years, Patients classified as ASA(American Society of Anesthesiologists) physical status I- III, Patients with a BMI (Body Mass Index) between 35 and 50 kg\u002Fm² scheduled to undergo sleeve gastrectomy as a type of bariatric surgery for the first time.\n\nExclusion Criteria:\n\nPatients classified as ASA physical status 4 or high, Patients with known allergy to any of the drugs used in the study, Patients with bleeding disorders, Patients with serum creatinine levels \\>2 mg\u002FdL, Patients with severe arrhythmias and EF\\\u003C30%, Patients with a known history of drug abuse are excluded.","18 Years","65 Years",{"count":63,"type":22},60,"3 Months","In this study, the investigators want to examine the effects of intravenous anesthetic drugs and gases on cognitive functions in the postoperative period in individuals who will undergo surgery for obesity. The investigators believe that the anesthesia method we apply with inhalation gases is also as reliable method as total intravenous anesthesia for postoperative cognitive functions in these patients who undergoe sleeve gastrectomy.\n\nThe anesthesia method applied intravenously and with inahalational gases have been applied safely for many years. Comparisons between these two anesthesia technics in obese individuals and for postoperative cognitive dysfunctions are limited.\n\nStudies on the examination of cognitive functions in postoperative patients have gained momentum with the use of neuropsychiatric tests performed on patients who have undergone cardiac surgery and these tests have also been performed on individuals who have undergone non-cardiac surgery. And yet, similar declines in cognitive functions have been observed. For these reasons, the effects of surgery itself and anesthesia methods on cognitive functions have been studied up to date.\n\nIn this study, the investigators plan to evaluate patients who will undergo obesity surgery in both anesthesia methods by the recovery times from anesthesia and the residual effects of anesthesia, and after awakening they plan to evaluate their cognitive functions with neuropsychiatric tests that will be performed at certain intervals.",[67,68,69,70,71,72,29,73,74],"POCD - Postoperative Cognitive Dysfunction","Recovery Time","Postoperative Neurocognitive Disorder","Postoperative Delirium","Bariatric Sleeve Gastrectomy","Delayed Neurocognitive Recovery","Inhalational Anesthesia","Cognitive Functions",[76,77,78,79],"total intravenous anesthesia","inhalational anesthesia","sleeve gastrectomy","postoperative cognitive dysfunctions","RECRUITING","2026-06-04",{"date":83,"type":44},"2026-06-09",{"date":85,"type":44},"2025-09-30",{"date":87,"type":22},"2026-07-30",{"name":89,"class":51},"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital",1,{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":99,"conditions":100,"keywords":105,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":113,"leadSponsor":115,"locationsCount":90},"100640534","comparison-of-hemodynamic-responses-during-anesthesia-induction-using-eleveld-and-schnider-100640534","NCT07586189","Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider","Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider Target-Controlled Infusion Models. A Randomized Trial","Inclusion Criteria:\n\n* Patients scheduled for elective spinal surgery under general anesthesia\n* Patients who will undergo surgery at the Neurosurgery Department of Istanbul University, Istanbul Faculty of Medicine\n* Patients aged 18 years or older\n* Patients who provide written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients with uncontrolled hypertension\n* Patients with uncontrolled diabetes mellitus\n* Patients younger than 18 years of age\n* Patients who do not provide informed consent to participate in the study",{"count":21,"type":22},"This randomized prospective study aims to compare the effects of two target-controlled infusion models, the Schnider and Eleveld models, on anesthetic depth and hemodynamic responses during anesthesia induction in adult patients undergoing spinal surgery.\n\nPatients scheduled for spinal surgery will be randomized into either the Schnider or Eleveld group. Before induction, standard monitoring will be applied, including electrocardiography, peripheral oxygen saturation, invasive arterial blood pressure monitoring, heart rate monitoring, and bispectral index monitoring. Anesthesia induction will be performed with fentanyl 2 mcg\u002Fkg, rocuronium 0.6 mg\u002Fkg, and propofol administered by target-controlled infusion with an effect-site target concentration of 3 mcg\u002FmL according to the allocated pharmacokinetic model.\n\nHemodynamic parameters and bispectral index values will be recorded before induction and at the 1st, 3rd, 5th, and 10th minutes after induction. Additional parameters, including time to BIS below 40, time to delta activity, burst suppression duration, total propofol dose during the first 5 minutes, need for additional propofol, hemodynamic response to intubation, vasopressor requirement within the first 10 minutes, and use of esmolol, will also be documented. The primary aim is to evaluate whether the Schnider and Eleveld models differ in terms of induction-related hemodynamic stability and anesthetic depth during the early induction period.",[101,29,102,103,104],"Spinal (Fusion) Surgery","Target Controlled Infusion of Propofol","Anesthesia Depth Monitoring","BIS-EEG",[106,76,107,108],"spinal surgery","target controlled infusion","anesthesia depth monitoring","2026-05-18",{"date":111,"type":44},"2026-05-20",{"date":109,"type":44},{"date":114,"type":22},"2026-08-30",{"name":116,"class":51},"Istanbul University",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":124,"enrollmentInfo":125,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":52},"100635803","relationship-between-induction-burst-suppression-and-bispectral-index-100635803","NCT07557433","Relationship Between Induction Burst Suppression and Bispectral Index","The Relationship Between Burst Suppression Observed During Anesthesia Induction and the Bispectral Index Value During the Maintenance Phase of Anesthesia","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective surgery\n* Surgery planned to be performed under total intravenous anesthesia (TIVA)\n\nExclusion Criteria:\n\n* Presence of neurological disease\n* Chronic use of sedative medications or antiepileptic drugs\n* Severe hepatic or renal dysfunction\n* Intraoperative administration of ketamine or dexmedetomidine","75 Years",{"count":126,"type":22},200,"The purpose of this study is to understand whether certain brain activity patterns that can appear at the beginning of anesthesia are related to how deep anesthesia remains during the operation.\n\nThe main question of the study is:\n\nDo patients who show a pattern called burst suppression during the start of anesthesia experience deeper anesthesia during surgery?\n\nPatients who are scheduled for elective surgery under total intravenous anesthesia (TIVA) may take part in this study. During the operation, brain activity will be monitored using a sensor placed on the forehead (Bispectral Index, BIS monitor), which is already commonly used during anesthesia. Information such as BIS values and the doses of anesthesia medications given during the operation will be recorded.\n\nParticipation in this study will not change the type of anesthesia or the routine care that patients receive during surgery. The study only involves recording and analyzing information collected during standard anesthesia monitoring.",[129,130,29],"Bispectral Index Monitoring","Burst Suppression","2026-04-23",{"date":133,"type":44},"2026-04-29",{"date":135,"type":22},"2026-06-01",{"date":137,"type":22},"2027-08-01",{"name":139,"class":51},"Amasya University",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":147,"targetDuration":4,"studyType":148,"phases":149,"briefSummary":151,"conditions":152,"keywords":156,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":90},"100629826","phase-4-anesthesia-maintenance-with-target-controlled-infusion-of-propofol-and-remifentanil-at-fixed-ratio-100629826","NCT07479719","Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio","Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio on Neurocognitive Recovery in Older Patients After Surgery: a Randomized Trial","Inclusion Criteria:\n\n1. Aged ≥ 65 years.\n2. Scheduled to undergo noncardiac surgery expected to last ≥ 1 hour under general anesthesia.\n3. Require patient-controlled intravenous analgesia after surgery.\n4. Provide written informed consent.\n\nExclusion Criteria:\n\n1. Inability to communicate in the preoperative period because of coma, profound dementia, language barrier, or other reasons.\n2. Previous history of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis.\n3. Traumatic brain injury or neurosurgery.\n4. Severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (eGFR \\\u003C30 ml\u002Fmin\u002F1.73 m2), or critical illness (preoperative American Society of Anesthesiologists physical status classification ≥IV).\n5. Planned ICU admission with endotracheal intubation after surgery.\n6. Enrolled in the other studies.\n7. Other reasons that are considered unsuitable for study participation by the responsible surgeons or investigators.",{"count":126,"type":22},"INTERVENTIONAL",[150],"PHASE4","The impact of anesthesia depths on early postoperative neurocognitive complications after total intravenous anesthesia (TIVA) remains controversial. In some studies investigating TIVA, anesthesiologists mainly achieve the target depth of anesthesia by adjusting the dose of propofol, whereas the doses of opioids remains comparable between different anesthetic depth groups, possibly resulting inadequate analgesia. This study is aimed to investigate the impact of different anesthesia depths maintained by target-controlled infusion of propofol and remifentanil at a fixed ratio on the incidence of early postoperative neurocognitive complications in older patients undergoing noncardiac surgery.",[153,154,155,29,72],"Elderly","Surgery","Depth of Anesthesia",[153,154,157,158,159],"Depth of anesthesia","Total intravenous anesthesia","Delayed neurocognitive recovery","2026-03-15",{"date":162,"type":44},"2026-03-18",{"date":164,"type":22},"2026-04",{"date":166,"type":22},"2027-01",{"name":168,"class":51},"Peking University First Hospital",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":175,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":148,"phases":178,"briefSummary":179,"conditions":180,"keywords":183,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":90},"100602466","phase-4-effect-of-combined-intravenous-inhalational-anesthesia-civia-on-postoperative-recovery-patterns-100602466","NCT07123870","Effect of Combined Intravenous-Inhalational Anesthesia (CIVIA) on Postoperative Recovery Patterns.","Inclusion Criteria:\n\n* Scheduled for spine surgery\n* Expected surgery duration longer than 3 hours\n* Use of intraoperative neuromonitoring\n* BIS-guided anesthesia administered\n* TIVA (with TCI) as the primary anesthetic technique\n* Age \\>18 years\n\nExclusion Criteria:\n\n* Emergency surgeries\n* Patients receiving sole inhaled anesthesia (no TIVA)\n* Perioperative dural injury\n* Intraoperative severe hypotension requiring inotropic support\n* Hypothermia (based on temperature measured before recovery)",true,{"count":177,"type":22},210,[150],"This study was planned as a single-center, prospective, randomized trial. Adult patients undergoing elective spinal surgery lasting longer than three hours, performed in a neurosurgery operating room, will be evaluated. Patients managed with three different anesthesia methods currently used will be examined for recovery patterns:\n\n1. Total intravenous anesthesia (TIVA),\n2. TIVA Combined anesthesia with sevoflurane and intravenous agents (sevoflurane-CIVIA),\n3. TIVA Combined anesthesia with desflurane and intravenous agents (desflurane-CIVIA).\n\nRecovery patterns include; extubation time, eye opening time, emergence agitation, postoperative nausia and vomiting and postoperative recovery unit discharge time.",[181,182,29],"Postoperative Recovery","Inhalation Anesthesia",[184,31,185,186,187],"CIVIA","sevoflurane","desflurane","postoperative recovery","2025-08-08",{"date":190,"type":44},"2025-08-14",{"date":192,"type":44},"2025-07-23",{"date":194,"type":22},"2025-11-15",{"name":196,"class":197},"Kocaeli City Hospital","OTHER_GOV",{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":205,"targetDuration":4,"studyType":148,"phases":207,"briefSummary":209,"conditions":210,"keywords":213,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":90},"100586985","processed-eeg-for-monitoring-of-anesthetic-depth-in-intracranial-tumor-surgery-100586985","NCT06922500","Processed EEG for Monitoring of Anesthetic Depth in Intracranial Tumor Surgery","Anesthetic Depth Assessed by Processed EEG (pEEG) - a Comparison of Manual Total Intravenous Anesthesia and Target Controlled Anesthesia in Tumor Resection Via Craniotomy","Inclusion Criteria:\n\n* Elective craniotomy for tumor resection\n* Adult patient\n* Consent to participation\n\nExclusion Criteria:\n\n* Cognitive impact affecting infrmed consent\n* brain tumor planned for biopsy without resection Tumor localisation not permitting placement of pEEG electrodes.",{"count":206,"type":22},126,[208],"NA","An important feature of neurosurgical anesthesia is early postoperative recovery of consciousness with minimal residual sedation. This is a key factor to enable early neurological assessment and early discovery of postoperative complications.\n\nThe goal of this single centre clinical trial is to compare propofol\u002Fremifentanil anesthesia delivered by manual total intravenous anesthesia (mTIVA) or target controlled infusion (TCI) for intracranial tumor resection via craniotomy. Anesthetic depth will be assessed by a simplified processed EEG (pEEG).\n\nThe main question is time spent within recommended pEEG- levels from anesthesia induction until end of surgery.\n\nSecondary questions are:\n\n* mean pEEG-level, time from end of surgery to consiousness,\n* peroperative propofol\u002Fremifentanil consumption\n* postoperative degree of sleepiness\n* awareness assessment\n\nParticipants are adults having have planned surgery for open resection of a brain tumor and will receive general anesthesia with propofol and remifentanil randomized to mTIVA or TCI. pEEG vill be blinded.\n\n* Participants will be asked to grade postoperative sleepiness using a specific scale\n* Follow up regarding awareness will be performed.",[211,212,29],"Brain Tumor Adult","Processed EEG",[214],"total intavenous anesthesia, target controlled infusion, processed EEG, open resection of brain tumor,","2025-04-09",{"date":217,"type":44},"2025-04-10",{"date":219,"type":44},"2024-11-21",{"date":221,"type":22},"2027-07",{"name":223,"class":51},"Region Skane",{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":175,"sex":17,"minAge":60,"maxAge":232,"enrollmentInfo":233,"targetDuration":4,"studyType":148,"phases":235,"briefSummary":236,"conditions":237,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":90},"100568666","the-impact-of-a-dexmedetomidine-perfusion-on-intraoperative-remifentanil-consumption-100568666","NCT06684197","The Impact of a Dexmedetomidine Perfusion on Intraoperative Remifentanil Consumption","The Impact of a Dexmedetomidine Perfusion on Intraoperative Remifentanil Consumption: a Randomized Controlled Trial","DEXREM","Inclusion Criteria:\n\n* ASA 1-3\n* Laparascopic surgery (including general surgery, gynecology, urology) a small abdominal incision (less than 5 cm) will be tolerated.\n\nExclusion Criteria:\n\n* Patient refusal\n* Chronic use of opioids\n* Allergy to medication used in the trial\n* Pregnant or breastfeeding women\n* Contraindications to dexmedetomidine (Bradycardia, arrythmia or pace- maker, severe ventricular dysfunction)","80 Years",{"count":234,"type":22},72,[208],"Opioids analgesic are the gold standard for intraoperative pain management. Their short- and long-term adverse effect motivate anesthesiologists to explore opioid sparing strategies. Dexmedetomidine is a highly selective α2 adrenergic receptor agonist that could help minimize opioid consumption both intraoperative and postoperative due to its sedative, analgesic and sympatholytic properties. This new randomized controlled trial (RCT) will answer the question whether an intraoperative dexmedetomidine infusion compared to placebo has a clinically significant impact on intraoperative remifentanil consumption during a laparoscopic abdominal elective surgery.",[238,29,239,240,241],"Dexmedetomidine","Remifentanil Consumption","Remifentanil","Laparoscopic Abdominal Surgery","2024-11-08",{"date":244,"type":44},"2024-11-12",{"date":246,"type":22},"2024-11",{"date":248,"type":22},"2025-11",{"name":250,"class":51},"Ciusss de L'Est de l'Île de Montréal"]