[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"total-knee-anthroplasty\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:total-knee-anthroplasty":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,48,71,98,131,157,186,216,229,260,283,307,330,354,378,405,437,462,489],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100053870","phase-1-contralateral-corticosteroid-injection-in-total-knee-arthroplasty-100053870",false,"NCT06809998","COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty","COSTI: COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty - A Triple Blinded, Randomized Controlled Trial Pilot Study","COSTI","Inclusion Criteria:\n\n* Patients 18 years of age and older\n* Primary osteoarthritis diagnosis with indication for primary elective unilateral TKA\n* No previous contralateral knee injections (steroids\u002Fbiologics) within one year of study\n* Not scheduled for bilateral TKA or a subsequent staged contralateral TKA within the next six months\n* No previous or active infection or trauma (osseous\u002Fligamentous\u002Fextensor mechanism) on the contralateral knee\n* Contralateral knee pain \\& symptoms - defined as a VAS of \\>4\u002F10 at initial pre-op visit\n* Contralateral knee OA quantified as: Kellgren and Lawrence grade \\>2-4\n\n  * Assessed by PI (AK) who will not be contributing any patients to the study through examination of blinded knee radiographs (3 views: AP\u002Flateral\u002FSunrise)\n* Patient is able to read and understand English and provide informed consent to participation in the study\n\nExclusion Criteria:\n\n* Other aetiologies of OA that warrants TKA (inflammatory or post traumatic arthritis)\n* Cognitive impairment (dementia, Alzheimer's, uncontrolled delirium) which will prevent patients from completing primary outcome measure or comply with follow-up requirements\n* Previous TKA or ORIF or nailing on either knee\n* Previous or active knee infection or extensor mechanism disruption\n* Previous arthroscopy on either knee\n* Medical contraindication to elective TKA surgery","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA. The secondary outcome was to assess the effect of contralateral corticosteroid injection on pain and functional outcomes of patients undergoing TKA.",[28,29,30,31],"Total Knee Anthroplasty","Osteoarthritis(Primary)","Osteoarthritis (OA) of the Knee","Bilateral Knee Osteoarthritis",[15,33,34],"Total Knee Arthroplasty","Corticosteroid Injection","RECRUITING","2026-07-09",{"date":38,"type":39},"2026-07-13","ACTUAL",{"date":41,"type":39},"2025-01-24",{"date":43,"type":21},"2027-08-30",{"name":45,"class":46},"Unity Health Toronto","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":47},"100638103","investigation-of-the-individual-fatigue-response-during-blood-flow-restriction-training-100638103","NCT07611526","Investigation of the Individual Fatigue Response During Blood Flow Restriction Training","Investigation of the Individual Fatigue Response During Blood Flow Restriction Training on a Cycle Ergometer Following Orthopedic Surgical Interventions","Inclusion Criteria:\n\n* Elective TKA caused by osteoarthritis of the knee\n* Ability to perform cycling exercise\n* Participant of the Rehab center\n\nExclusion Criteria:\n\n* Open Wounds\n* Iatrogenic Vessel Changes (e.g. Bypasses, Stenting)\n* Sickle Cell Anemia","85 Years",{"count":57,"type":21},20,[59],"NA","The aim of the present pilot study is to investigate the feasibility of an exercise pressure response approach for assessing physiological strain during BFR training in a clinically supervised setting. Patients undergoing rehabilitation following total knee arthroplasty (TKA) will be included. The results are intended to contribute to an improved evaluation of load management during BFR training.",[28],"2026-06-27",{"date":64,"type":39},"2026-07-01",{"date":66,"type":39},"2026-06-26",{"date":68,"type":21},"2027-03-31",{"name":70,"class":46},"University Hospital, Bonn",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":77,"targetDuration":79,"studyType":80,"phases":4,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":97},"100564324","prospective-in-vivo-post-market-safety-and-efficacy-surveillance-registry-of-the-maxx-orthopedics-freedom-total-knee-system-100564324","NCT06627699","Prospective, In-Vivo, Post-Market Safety and Efficacy Surveillance Registry of the MAXX Orthopedics, Freedom Total Knee® System","INCLUSION CRITERIA:\n\nCandidates for this registry must meet ALL of the following criteria:\n\n* Patient is \\> 18 years of age\n* Patient has failed attempts at non-operative conservative therapy\n* Patient has participated in the informed consent process and signed an IRB approved informed consent\n* Patient is scheduled to undergo unilateral or bilateral primary TKA of the knee\n\nEXCLUSION CRITERIA:\n\nCandidates will be excluded from the evaluation if ANY of the following apply:\n\n* Patients with previous TKA, UKA, HTO or knee fusion of the indicated knee\n* Patients that have undergone previous surgery of indicated knee for tumor, trauma or fracture\n* Evidence of active or suspected (systemic or local) infection at time of surgery\n* Other significant disabling problems from the musculoskeletal system than in the knee (i.e.: muscular dystrophy, polio, neuropathic joints)\n* Patients with or having; malignancy - active malignancy, Paget's disease, renal osteodystrophy, immunologically suppressed, sickle cell anemia and systemic lupus erythematosus\n* Patients with neuromuscular or neurosensory deficit\n* Women who are pregnant\n* Prisoner or transient\n* Recent history of known narcotic abuse\n* Any significant psychological disturbance past or present, that could impair the consent process or ability to complete subject self-report questionnaires",{"count":78,"type":21},300,"2 Years","OBSERVATIONAL","In an effort to satisfy regulatory requirements for post-market surveillance of product safety and efficacy, a representative sample of patients will be recruited for prospective monitoring.",[83,28],"Knee Osteoarthristis",[85,86,33,87],"Registry","Primary TKA","Total Knee Replacement","2026-06-23",{"date":66,"type":39},{"date":91,"type":39},"2025-11-01",{"date":93,"type":21},"2029-03-01",{"name":95,"class":96},"Maxx Orthopedics Inc","INDUSTRY",2,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":47},"100637370","programmed-intermittent-epidural-bolus-versus-continuous-epidural-infusion-for-postoperative-analgesia-after-total-knee-arthroplasty-100637370","NCT07605208","Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Postoperative Analgesia After Total Knee Arthroplasty","Effect of Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion on Postoperative Analgesia and Quality of Recovery After Total Knee Arthroplasty: A Prospective Randomized Double-Blind Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 to 80 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective primary total knee arthroplasty\n* Eligible for combined spinal-epidural anesthesia and postoperative epidural analgesia\n* Able to understand and use patient-controlled epidural analgesia\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Known allergy or hypersensitivity to study medications\n* Body mass index (BMI) ≥ 40 kg\u002Fm²\n* Body weight \\\u003C 40 kg\n* Severe cardiac disease, including symptomatic arrhythmia or advanced conduction abnormalities\n* Coagulopathy (INR \\> 1.5 or platelet count \\\u003C 100,000\u002Fmm³)\n* Pregnancy or breastfeeding\n* Revision total knee arthroplasty or emergency surgery\n* Active infection at the site of regional anesthesia\n* Chronic opioid use or opioid dependence\n* Neurological disease or preexisting motor\u002Fsensory deficit in the lower extremities\n* ASA physical status IV or V\n* Requirement for intraoperative epidural local anesthetic supplementation due to inadequate spinal anesthesia","80 Years",{"count":107,"type":21},90,[59],"The goal of this clinical trial is to compare two different epidural analgesia delivery methods for pain control after total knee arthroplasty in adults undergoing elective surgery. The study will evaluate whether programmed intermittent epidural bolus (PIEB) provides better postoperative analgesia and recovery outcomes than continuous epidural infusion (CEI).\n\nThe main questions it aims to answer are:\n\nDoes PIEB reduce total epidural local anesthetic consumption during the first 24 postoperative hours compared with CEI? Does PIEB improve postoperative pain control and quality of recovery? Are there differences between the two methods regarding motor block, rescue analgesic requirement, patient-controlled epidural analgesia use, and adverse effects?\n\nResearchers will compare PIEB plus patient-controlled epidural analgesia (PCEA) with CEI plus PCEA in patients undergoing total knee arthroplasty.\n\nParticipants will:\n\nReceive combined spinal-epidural anesthesia during surgery Receive postoperative epidural analgesia using either PIEB or CEI Be evaluated for pain scores, motor block, recovery quality, epidural local anesthetic consumption, rescue analgesic requirement, and adverse events during the first 24 postoperative hours",[28,111],"Epidural Analgesia",[113,114,115,116,117,118,33,119,120],"Programmed Intermittent Epidural Bolus","PIEB","Continuous Epidural Infusion","CEI","Patient-Controlled Epidural Analgesia","PCEA","Postoperative Analgesia","QoR-15","NOT_YET_RECRUITING","2026-05-24",{"date":124,"type":39},"2026-05-28",{"date":126,"type":21},"2026-06-01",{"date":128,"type":21},"2027-12-01",{"name":130,"class":46},"Sakarya University",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":4},"100588538","efficacy-of-genicular-block-on-total-knee-arthroplasty-surgery-100588538","NCT06942702","Efficacy of Genicular Block on Total Knee Arthroplasty Surgery","Assesment of Postoperative Analgesic Efficacy of Preoperatively Applied Genicular Block on Total Knee Arthroplasty: A Randomized Controlled Study","Inclusion Criteria:\n\n* Scheduled for unilateral and primary total knee arthroplasty\n* Older than 18 years of age\n\nExclusion Criteria:\n\n* Younger than 18 years\n* Bilateral knee arthroplasty\n* Revision case of knee arthroplasty",{"count":139,"type":21},44,[59],"The aim of this study is to investigate the postoperative pain relieving effect of preoperative genicular block in total knee arthroplasty surgery. The main questions it aims to answer are:\n\n1. Do visual analog scale (VAS) scores decrease in patients who underwent geniculate block?\n2. Does opioid consumption decrease in patients who underwent geniculate block?\n\nResearchers will compare postoperative pain in patients who received genicular block with those who did not.One group of patients will be administered 0.25% bupivacaine with the geniculate block method. The other group will not undergo any intervention. Both groups will be administered intravenous morphine for postoperative analgesia.",[28,143],"Genicular Nerves Block",[145,146,147],"total knee arthroplasty","genicular block","postoperative pain","2026-05-15",{"date":150,"type":39},"2026-05-19",{"date":152,"type":21},"2026-05-20",{"date":154,"type":21},"2026-12-20",{"name":156,"class":46},"Mersin University",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":165,"sex":17,"minAge":166,"maxAge":105,"enrollmentInfo":167,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":169,"conditions":170,"keywords":173,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":4},"100638728","impact-of-chronic-venous-insufficiency-on-outcomes-after-total-knee-arthroplasty-100638728","NCT07577141","Impact of Chronic Venous Insufficiency on Outcomes After Total Knee Arthroplasty","The Impact of Chronic Venous Insufficiency on Postoperative Outcomes and Wound Healing After Total Knee Arthroplasty: A Prospective Observational Study","VENOUS-TKA","Inclusion Criteria:\n\n* Patients undergoing primary total knee arthroplasty\n* Age ≥ 50 years\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Revision TKA\n* Peripheral arterial disease (ABI \\\u003C 0.9)\n* Active infection\n* History of deep vein thrombosis within 6 months\n* Immunosuppressive therapy\n* Severe uncontrolled diabetes mellitus",true,"50 Years",{"count":168,"type":21},100,"Total knee arthroplasty (TKA) is an effective treatment for end-stage knee osteoarthritis; however, postoperative complications-particularly wound healing problems-remain a significant concern. Chronic venous insufficiency (CVI) is associated with venous hypertension, impaired microcirculation, and tissue hypoxia, which may negatively affect wound healing and increase complication rates.\n\nThis prospective observational cohort study aims to evaluate the impact of preoperative CVI on postoperative outcomes following TKA. Patients will be assessed preoperatively using the CEAP classification and Doppler ultrasonography to identify and stratify venous insufficiency.\n\nParticipants will be followed for 12 months postoperatively. The primary outcome will be wound healing complications in the early postoperative period. Secondary outcomes will include functional outcomes assessed by the Knee Society Score (KSS), patient-reported outcomes using the WOMAC score, and overall complication rates.\n\nThe findings of this study are expected to clarify the role of venous insufficiency as a potential risk factor in TKA and may contribute to improved preoperative risk stratification and postoperative management strategies.",[28,171,172],"Venous Insufficiency (Chronic)(Peripheral)","Doppler Ultrasound Diagnosis",[145,174,175,176],"chronic venous insufficiency","doppler","wound","2026-05-12",{"date":179,"type":39},"2026-05-18",{"date":181,"type":21},"2026-06",{"date":183,"type":21},"2027-06",{"name":185,"class":46},"SB Istanbul Education and Research Hospital",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":17,"minAge":166,"maxAge":194,"enrollmentInfo":195,"targetDuration":4,"studyType":22,"phases":197,"briefSummary":198,"conditions":199,"keywords":201,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":214,"locationsCount":47},"100611336","the-effects-of-mir-shakeel-teleintegrated-therapy-plan-in-patients-undergoing-total-knee-arthroplasty-100611336","NCT07239258","The Effects of Mir Shakeel Teleintegrated Therapy Plan in Patients Undergoing Total Knee Arthroplasty","The Effects of Mir Shakeel Teleintegrated Therapy Plan and Conventional Physical Therapy on Pain, Range of Motion, Gait, Functional Outcomes and Quality of Life in Patients Undergoing Total Knee Arthroplasty","RCT","Inclusion Criteria:\n\n* Patients who have underwent a primary unilateral total knee arthroplasty due to osteoarthritis\n* Able to participate in a rehabilitation program, either telerehabilitation or in-person, and demonstrate sufficient mobility with or without assistive devices (e.g., crutches, walker) as deemed appropriate for post-TKA therapy.\n* Participants must have reliable access to a smartphone, tablet, or computer with internet connectivity and the ability to engage in video calls.\n* Willing and able to provide informed consent, and to comply with all study protocols, including scheduled therapy sessions and follow-up assessments.\n\nExclusion Criteria:\n\n* Presence of significant comorbidities or complications that could interfere with safe participation in rehabilitation, such as severe cardiovascular disease, or conditions causing significant immobility (e.g., severe osteoarthritis in other joints or Rheumatoid Arthritis.\n* Previous knee replacement or other significant knee surgeries on the same knee, as this may impact the standardization of rehabilitation outcomes.\n* Currently enrolled in another physical therapy or rehabilitation trial, or engaging in additional rehabilitation outside the study protocol.\n* Cognitive impairment or severe visual or hearing impairments that would prevent them from following therapy instructions or engaging with telerehabilitation technology.\n* Any other conditions or factors that, in the opinion of the investigators, could hinder compliance with the study procedures or put the participant at undue risk.","65 Years",{"count":196,"type":21},120,[59],"This randomized controlled trial aims to evaluate the effectiveness of a newly developed Modified Structured Telerehabilitation Intervention Protocol (MSTITP) compared with conventional in-person physical therapy in patients recovering from Total Knee Arthroplasty (TKA). The study also explores whether a hybrid rehabilitation approach may further optimize patient outcomes.\n\nA total of eligible participants aged 50-65 years who have undergone primary TKA will be randomly assigned to one of two groups:\n\nGroup A (Intervention): Telerehabilitation-based structured exercise program (MSTITP) delivered through digital platforms with remote supervision.\n\nGroup B (Control): Standard conventional face-to-face physiotherapy in a clinical setting.\n\nBoth groups will receive rehabilitation programs of equal duration focusing on pain management, range of motion (ROM), muscle strengthening, gait training, and functional mobility.\n\nThe primary objective is to compare the effectiveness of telerehabilitation and conventional therapy in improving pain, ROM, and gait performance. Secondary objectives include evaluation of exercise adherence, kinesiophobia, functional outcomes, quality of life, and patient satisfaction. Additionally, the study will explore whether integrating telerehabilitation with conventional rehabilitation could provide superior outcomes.\n\nOutcome assessments will be conducted using validated tools including pain scales (VAS), goniometric ROM measurements, gait analysis, functional performance tests, and standardized questionnaires for quality of life, exercise adherence, and fear of movement.\n\nThis study addresses the increasing burden of osteoarthritis and the growing number of TKA procedures in Pakistan. Telerehabilitation may offer a cost-effective, accessible, and scalable rehabilitation model that ensures continuity of care and improved access to physiotherapy services, particularly in resource-limited settings.\n\nThe findings of this trial are expected to provide evidence for developing standardized, technology-assisted rehabilitation protocols to improve post-TKA recovery outcomes and reduce healthcare burden.",[28,200],"Total Knee Arthroplasty Recovery",[202,203,204,205,206,207,145],"pain","range of motion","gait","functional outcomes","quality of life","conventional physical therapy","2026-05-09",{"date":210,"type":39},"2026-05-13",{"date":212,"type":39},"2025-06-26",{"date":181,"type":21},{"name":215,"class":46},"Lincoln University College",{"id":217,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":218,"targetDuration":4,"studyType":22,"phases":219,"briefSummary":26,"conditions":220,"keywords":221,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":226,"leadSponsor":228,"locationsCount":47},"100578338",{"count":20,"type":21},[24,25],[28,29,30,31],[15,33,34],"2026-04-29",{"date":224,"type":39},"2026-05-01",{"date":41,"type":39},{"date":227,"type":21},"2027-07-30",{"name":45,"class":46},{"id":230,"slug":231,"hasResults":11,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":236,"targetDuration":4,"studyType":22,"phases":237,"briefSummary":238,"conditions":239,"keywords":243,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":256,"leadSponsor":258,"locationsCount":47},"100632144","liposomal-bupivacaine-versus-ropivacaine-with-perineural-dexamethasone-or-dexmedetomidine-as-adjuncts-for-adductor-canal-block-combined-with-ipack-block-in-total-knee-arthroplasty-100632144","NCT07509866","Liposomal Bupivacaine Versus Ropivacaine With Perineural Dexamethasone or Dexmedetomidine as Adjuncts for Adductor Canal Block Combined With IPACK Block in Total Knee Arthroplasty","A Randomized Trial of Liposomal Bupivacaine, Ropivacaine With Perineural Dexamethasone, and Ropivacaine With Perineural Dexmedetomidine for Adductor Canal Block Combined With IPACK Block in Total Knee Arthroplasty","Inclusion Criteria:\n\n* Patients scheduled for elective primary unilateral total knee arthroplasty\n* Age ≥ 18 years and ≤ 80 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Body mass index (BMI) ≥ 18 kg\u002Fm² and ≤ 35 kg\u002Fm²\n* Ability to understand and provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy or contraindication to local anesthetics (bupivacaine, ropivacaine), dexamethasone, dexmedetomidine, or opioids\n* Infection at the injection site\n* Coagulopathy or current use of anticoagulants\n* Severe cardiovascular disease (New York Heart Association \\[NYHA\\] functional class III or IV, or recent myocardial infarction within 6 months)\n* Severe hepatic impairment (Child-Pugh class C) or renal impairment (estimated glomerular filtration rate \\[eGFR\\] \\\u003C 30 mL\u002Fmin\u002F1.73 m²)\n* Uncontrolled hypertension (systolic blood pressure \\> 180 mmHg or diastolic blood pressure \\> 110 mmHg despite medical therapy)\n* Uncontrolled diabetes mellitus (HbA1c \\> 8.5%)\n* Bilateral TKA or revision TKA\n* Chronic opioid use (daily opioid consumption for \\> 3 months prior to surgery)\n* Participation in another interventional clinical trial within 30 days prior to enrollment\n* Inability to communicate with study personnel or complete pain assessments (e.g., language barrier, cognitive impairment)",{"count":107,"type":21},[59],"Effective postoperative pain management remains a cornerstone of enhanced recovery protocols following total knee arthroplasty (TKA). Inadequate analgesia not only compromises patient satisfaction but also impedes early mobilization and rehabilitation, thereby increasing the risk of perioperative complications. Current multimodal analgesic strategies frequently incorporate regional techniques, with the adductor canal block (ACB) and infiltration between the popliteal artery and capsule of the knee (IPACK) block emerging as established modalities that provide motor-sparing analgesia.\n\nDespite their widespread adoption, the optimal local anesthetic regimen for these blocks remains undefined. While liposomal bupivacaine has garnered interest for its extended duration of action, its clinical efficacy relative to conventional local anesthetics combined with perineural adjuncts remains a subject of ongoing debate. Specifically, perineural dexamethasone and dexmedetomidine have each demonstrated the capacity to prolong the analgesic duration of ropivacaine; however, direct comparative data among these three distinct strategies-liposomal bupivacaine alone versus ropivacaine supplemented with either adjunct-are notably limited.\n\nGiven the absence of head-to-head randomized trials evaluating these three clinically viable techniques, the optimal approach to maximize analgesic duration while minimizing opioid-related adverse effects remains unclear. This study therefore aims to compare the analgesic efficacy and safety profiles of liposomal bupivacaine, ropivacaine with perineural dexamethasone, and ropivacaine with perineural dexmedetomidine when administered via ACB and IPACK blocks in patients undergoing TKA.",[28,240,241,242],"Nerve Block","Ropivacaine","Liposomal Bupivacaine",[145,244,245,246,247,248,249,250,251],"adductor canal block","IPACK block","liposomal bupivacaine","ropivacaine","perineural adjuncts","dexamethasone","dexmedetomidine","multimodal analgesia","2026-04-09",{"date":254,"type":39},"2026-04-14",{"date":252,"type":39},{"date":257,"type":21},"2026-12-30",{"name":259,"class":46},"Huazhong University of Science and Technology",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":267,"targetDuration":4,"studyType":22,"phases":269,"briefSummary":270,"conditions":271,"keywords":273,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":279,"leadSponsor":281,"locationsCount":47},"100631880","tourniquet-vs-no-tourniquet-technique-in-total-knee-arthroplasty-at-the-university-hospital-of-the-west-indies-100631880","NCT07506434","Tourniquet Vs. No-Tourniquet Technique in Total Knee Arthroplasty at the University Hospital of the West Indies","Is Routine Tourniquet Use Still Warranted? A Randomized Controlled Equivalence Trial Comparing Tourniquet Vs. No-Tourniquet Technique in Total Knee Arthroplasty at the University Hospital of the West Indies","Inclusion Criteria:\n\n* • Age ≥ 18 years.\n\n  * Clinical and radiographic diagnosis of knee osteoarthritis requiring primary unilateral Total Knee Arthroplasty.\n  * Medically fit for elective surgery (typically ASA I-III).\n  * Able to provide informed consent.\n\nExclusion Criteria:\n\n* • Revision TKA or bilateral simultaneous TKA.\n\n  * Preexisting coagulopathy or active anticoagulation that cannot be perioperatively managed per protocol.\n  * Known allergy or contraindication to tranexamic acid.\n  * Active infection or immunosuppression.\n  * Severe peripheral vascular disease in the operative limb.\n  * BMI \\> 45 kg\u002Fm²\n  * Inability to provide informed consent or comply with follow-up",{"count":268,"type":21},30,[59],"The goal of this clinical trial is to determine whether performing total knee replacement surgery (total knee arthroplasty, TKA) without a tourniquet is clinically equivalent to performing the procedure with a tourniquet in adults with symptomatic knee osteoarthritis.\n\nA tourniquet is commonly used during surgery to reduce bleeding and improve the surgeon's view. However, some studies suggest it may be associated with certain complications. It is currently unclear whether using a tourniquet meaningfully changes outcomes compared to not using one. This study aims to assess whether both approaches result in similar outcomes within a clinically acceptable range.\n\nThe main question this study aims to answer is:\n\nIs total blood loss during surgery equivalent between TKA performed with a tourniquet and TKA performed without a tourniquet, within a predefined margin of ±100 mL?\n\nAdditional questions include:\n\nAre surgical field quality, postoperative pain, functional recovery, and complication rates comparable between the two techniques?\n\nResearchers will compare:\n\nTKA performed with a pneumatic tourniquet TKA performed without a tourniquet\n\nto determine whether outcomes between the two approaches are equivalent rather than whether one is superior to the other.\n\nParticipants will:\n\nBe randomly assigned to one of the two surgical groups using a computer-generated process Undergo standard total knee replacement surgery and routine perioperative care Have blood loss assessed during and after surgery Be monitored for pain, recovery of function, wound healing, and complications during hospital stay and follow-up visits\n\nThis study is designed as a randomized controlled equivalence trial to determine whether both surgical approaches produce comparable outcomes within clinically acceptable limits, in a standardized local setting.",[272,28],"Knee Osteoarthritis (OA)",[274],"tourniquet use","2026-03-27",{"date":277,"type":39},"2026-04-01",{"date":181,"type":21},{"date":280,"type":21},"2027-09",{"name":282,"class":46},"The University of The West Indies",{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":17,"minAge":290,"maxAge":4,"enrollmentInfo":291,"targetDuration":4,"studyType":22,"phases":293,"briefSummary":294,"conditions":295,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":47},"100627878","knee-flexionater-to-avoid-motion-restoring-surgery-100627878","NCT07454356","Knee Flexionater to Avoid Motion Restoring Surgery","Comparing High Intensity Stretch Device Combined With Physical Therapy Versus Physical Therapy Alone to Prevent Motion-Restoring Surgery Following Primary Total Knee Arthroplasty: Study Protocol for a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 40 years or older\n* Undergoing primary total knee replacement surgery\n* Knee flexion less than 105 degrees at approximately 4 weeks after surgery\n* Considered a candidate for motion-restoring surgery, with any surgery delayed until after 2 months of nonoperative treatment\n\nExclusion Criteria:\n\n* Not willing to participate\n* Diagnosis of advanced rheumatoid arthritis\n* Neurological deficit affecting the operative leg\n* Revision total knee replacement or previous major surgery on the same knee\n* Cognitive impairment\n* Prior total hip replacement on the same side (ipsilateral total hip arthroplasty)\n* Living more than 2 hours from the study site or unwilling to attend required local physical therapy visits","40 Years",{"count":292,"type":21},150,[59],"The goal of this clinical trial is to learn whether adding a stretching device to standard physical therapy can help people regain knee bending after total knee replacement surgery.\n\nSome people have difficulty bending their knee during recovery. When this happens, doctors may recommend another procedure called motion-restoring surgery to improve knee movement.\n\nThis study aims to answer two main questions. First, does adding a hydraulic high-intensity stretching device to physical therapy help people regain knee bending after surgery? Second, does using the device affect recovery, daily activities, or the chance of needing another procedure?\n\nResearchers will compare two treatment approaches. One group will receive standard physical therapy alone. The other group will receive standard physical therapy and will also use a hydraulic high-intensity stretching device called the Ermi Knee Flexionater at home.\n\nParticipants who receive the device will use it at home each day in addition to attending their physical therapy sessions. Researchers will measure how well participants can bend their knee and will ask questions about pain, daily function, and activity level. Participants will also complete simple walking and mobility tests.\n\nStudy visits will occur about four weeks after surgery when participants enroll, and again at about eight weeks, twelve weeks, six months, one year, and two years after surgery. Researchers will compare results between the two groups to see whether the stretching device improves recovery after knee replacement.",[296,28,297],"Joint Contractures","Knee Arthrofibrosis","2026-03-02",{"date":300,"type":39},"2026-03-06",{"date":302,"type":39},"2025-12-09",{"date":304,"type":21},"2029-12",{"name":306,"class":96},"Ermi LLC",{"id":308,"slug":309,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":311,"acronym":312,"eligibilityCriteria":313,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":314,"targetDuration":4,"studyType":22,"phases":316,"briefSummary":317,"conditions":318,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":47},"100621139","monocentric-randomised-controlled-trial-assessing-cryocompression-following-total-knee-replacement-100621139","NCT07366736","Monocentric Randomised Controlled Trial Assessing Cryocompression Following Total Knee Replacement","CryoTKR","Inclusion Criteria:\n\n* aged ≥18 years\n* scheduled for primary TKR\n* BMI \\\u003C40 kg\u002Fm2\n* who signed the informed consent and are willing to comply with the protocol requirements based on the investigator's judgment\n* affiliated with a social security scheme\n* with an ability to answer questionnaires and to communicate freely in French.\n\nExclusion Criteria:\n\n* underwent revision TKR\n* underwent bilateral TKR\n* who cannot comply with the protocol requirements based on the investigator's judgment\n* that are pregnant or breastfeeding\n* with protected status under articles L1121-6, LL121-8 and L1122-2 of the French Public Health Code",{"count":315,"type":21},138,[59],"Immediately following surgery, icepacks are commonly used to decrease inflammation and reduce pain and have demonstrated to decrease post-operative opioid consumption. New cryocompression devices have been introduced as a non-invasive and non-pharmacological modality used to manage acute inflammation and pain, demonstrating benefits in the post- operative setting promoting vasoconstriction, reducing blood flow and inflammation. The addition of compression may further decrease inflammation and pain, revealed in studies on anterior cruciate ligament reconstruction, total hip replacement, and lumbar fusion.\n\nRecently, an RCT was published by Marinova et al. that compared cryocompression to icepacks following TKR in terms of pain on VAS, range of motion (ROM), knee circumference, and opioid consumption, but only found significant differences in extension ROM at day 1 and at 2 weeks. Due to the small sample size of Marinova et al. and high rates of losses to follow-up due to COVID-19, there remains doubt on the efficacy of cryocompression for TKR. Furthermore, cryocompression require additional investment in terms of cost to acquire the devices, and in time to train the hospital staff, and the devices may not be available for every patient. Finally, the authors are unsure how cryocompression affects wound healing in the short- and long-term.\n\nThe hypothesis was that both cryocompression and regular icepacks would grant equivalent pain on numeric rating scale at 48 hours postoperatively.",[28,319,320],"Cryotherapy","Compression","2026-01-16",{"date":323,"type":39},"2026-01-26",{"date":325,"type":39},"2025-10-27",{"date":327,"type":21},"2027-07-27",{"name":329,"class":46},"Clinique des Cèdres",{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":4,"eligibilityCriteria":336,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":337,"targetDuration":4,"studyType":22,"phases":339,"briefSummary":340,"conditions":341,"keywords":342,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":47},"100619762","using-a-smart-implantable-device-to-compare-early-recovery-in-two-different-knee-arthroplasty-approaches-100619762","NCT07348835","Using a Smart Implantable Device to Compare Early Recovery in Two Different Knee Arthroplasty Approaches","Continuous Monitoring Using a Smart Implantable Device (Persona IQ®) to Compare Medial Parapatellar vs. Subvastus Approaches in Early Post-Operative Total Knee Arthroplasty Recovery","Inclusion Criteria:\n\n* All patients older than 18 years of age who plan to undergo medial congruent polyethylene bearing primary TKA with a PIQ\n* Eligible for both approaches\n* Have an iPhone and willing to \"wear\" it for two weeks preoperatively to get an estimated average stepcount\n* Provide informed consent\n* Willing to complete follow ups\n\nExclusion Criteria:\n\n* Patients with TKA revisions\n* Patients with insufficient pre-operative range of motion in the operative knee (flexion contracture of \\> 20 degrees or \\\u003C 90° of knee flexion)\n* Patients with Contralateral TKA within study time frame\n* Patients with TKA other than medial congruent polyethylene bearing\n* Patients with bilateral surgery\n* Patients without a valid and active email address\n* Patients not willing or able to participate in study and follow-ups\n* Patients who use assisted devices to ambulate\n* Rheumatoid arthritis",{"count":338,"type":21},110,[59],"This is a single-institution, prospective, randomized study comparing the medial parapatellar and subvastus approaches in primary total knee arthroplasty using continuous, implant-based gait monitoring. Patients receiving a Zimmer Persona IQ smart implant will be followed preoperatively and through the first 30 days post-operatively, with extended follow-up to 6 months. Preoperative activity is captured using iPhone Health step-count data, while post-operative recovery is assessed using continuous tibial implant data, including step count, range of motion, cadence, walking speed, stride length, and distance. These objective metrics are correlated with PROMs. The primary outcome is daily step count. Secondary outcomes include early functional milestones, pain, and patient-reported functional scores. This study is designed to characterize early recovery trajectories and determine whether meaningful differences exist between surgical approaches.",[28],[33,343,344],"Medial Parapatellar Approach","Subvastus Approach","2026-01-09",{"date":321,"type":39},{"date":348,"type":21},"2026-01",{"date":350,"type":21},"2027-01",{"name":352,"class":353},"Total Joint Specialists","NETWORK",{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":360,"eligibilityCriteria":361,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":362,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":364,"conditions":365,"keywords":367,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":369,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":376,"locationsCount":47},"100594281","the-sacral-erector-spinae-plane-block-in-total-knee-arthroplasty-100594281","NCT07017400","The Sacral Erector Spinae Plane Block in Total Knee Arthroplasty","Effectiveness of the Sacral Erector Spinae Plane (ESP) Block in Total Knee Arthroplasty: A Prospective Observational Study","sacral ESP","Inclusion Criteria:\n\n* Adults \\>18 years\n* ASA I-III\n* scheduled for unilateral TKA with expected hospitalization \\> 24 hours\n\nExclusion Criteria:\n\n* Refusal of consent\n* Local anesthetics allergies\n* contraindications to spinal or regional anesthesia\n* coagulation disorders\n* anticoagulation\u002Fantiaggregation medications\n* dementia\n* ASA-PS \\> III\n* ongoing infection\n* emergency surgeries",{"count":363,"type":21},126,"The goal of this observational study is to learn about the analgesic efficacy and postoperative recovery of two locoregional anesthesia combinations in patients \\> 18 years (ASA I-III), scheduled for unilateral TKA under spinal anesthesia with expected hospitalization \\> 24 hours:\n\n* ACB + sacral ESP block\n* ACB + iPACK block\n\nThe main question it aims to answer is: Does the ACB + sacral ESP block combination produce effective postoperative recovery and analgesic effect?\n\nParticipants already taking ACB + sacral ESP block as part of their regular peri-operative care for TKA will be followed in the postoperative period for 48 hours.",[28,366],"Regional Anesthesia",[368,145],"regional anesthesia","2025-08-22",{"date":371,"type":39},"2025-08-28",{"date":373,"type":39},"2025-07-16",{"date":375,"type":21},"2027-12",{"name":377,"class":46},"San Giovanni di Dio Hospital",{"id":379,"slug":380,"hasResults":11,"nctId":381,"briefTitle":382,"officialTitle":383,"acronym":384,"eligibilityCriteria":385,"healthyVolunteers":11,"sex":17,"minAge":166,"maxAge":386,"enrollmentInfo":387,"targetDuration":4,"studyType":22,"phases":388,"briefSummary":390,"conditions":391,"keywords":393,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":47},"100603745","phase-4-dinalbuphine-sebacate-in-postoperative-pain-control-after-tka-100603745","NCT07140510","Dinalbuphine Sebacate in Postoperative Pain Control After TKA","Effectiveness of Dinalbuphine Sebacate in Postoperative Pain Control Following Total Knee Arthroplasty: A Randomized Double Blinded Placebo-controlled Trial","Naldebain","Inclusion Criteria:\n\n* Osteoarthritic knee patients underwent unilateral primary TKA\n* Age 50-90 years\n* ASA class I-III\n* Participants understand and consent to the protocol of the trial\n\nExclusion Criteria:\n\n* Morbid obesity (BMI\\>40)\n* Knee osteoarthritis from inflammatory knee arthritis, trauma, infection\n* Previous knee surgery\n* Cognitive disorder\n* Liver disease\n* Allergy to NSAIDs, opioids, sesame oil, and benzyl benzoate\n* CYP3A4 inhibitor and inducer drugs used","90 Years",{"count":168,"type":21},[389],"PHASE4","To evaluate the effectiveness of Dinalbuphine Sebacate for controlling subacute pain after total knee arthroplasty",[392,28],"Osteo Arthritis of the Knee",[394,384,395,147,145],"Dinalbuphine Sebacate","Subacute pain","2025-08-18",{"date":398,"type":39},"2025-08-24",{"date":400,"type":21},"2025-10",{"date":402,"type":21},"2026-09",{"name":404,"class":46},"Thammasat University",{"id":406,"slug":407,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":411,"eligibilityCriteria":412,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":413,"targetDuration":4,"studyType":22,"phases":415,"briefSummary":416,"conditions":417,"keywords":426,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":47},"100602461","acuknee-role-of-acupuncture-in-knee-prosthetic-surgery-100602461","NCT07123805","ACU_Knee: Role of Acupuncture in Knee Prosthetic Surgery","ACU_Knee - Role of Acupuncture in Knee Prosthetic Surgery: Analgesia, Functional Outcome and Inflammatory Markers","ACU_Knee","Inclusion Criteria:\n\n* Patients aged \\> 18 years\n* Patients capable of providing informed consent\n* Unilateral total knee replacement surgery\n* Indication for surgery: primary osteoarthritis degeneration\n* Surgery performed electively\n\nExclusion Criteria:\n\n* Patients aged \\\u003C 18 years\n* Patients incapable of providing informed consent\n* Patients with ASA class \\> 3\n* Pregnant women\n* Patients with rheumatoid arthritis or other autoimmune disorders\n* Patients with active infection under antibiotic treatment\n* Patients on chronic opioid therapy\n* Patients on chronic biological drug therapy\n* Patients with a history of corticosteroid use in the six months prior to surgery\n* Patients with a history of periarticular infiltration in the three months prior to surgery\n* Patients in whom loco-regional anesthesia is contraindicated\n* Patients in whom NSAID, cortisone, and paracetamol therapy is contraindicated\n* Bilateral total knee replacement surgery or prosthetic revision surgeries\n* Indication for surgery for causes other than primary osteoarthritis degeneration",{"count":414,"type":21},80,[59],"Post-operative analgesia after total knee arthroplasty (TKA) has always been a challenge in the anesthesiological setting, having to combine good pain control and the need for early mobilization, both factors that can affect the quality of rehabilitation treatment, prosthetic functional outcome, the onset of chronic pain, joint stiffness and the consequent quality of life of the patient. Recent loco-regional anesthesia (LRA) techniques have made an essential contribution to peri-operative management in the fast-track perspective of surgery, in terms of optimization of analgesia and rapid functional recovery. Inadequate post-operative analgesia, by affecting the normal rehabilitation pathway, is associated with medium-long term complications, such as chronic pain, joint stiffness and patient dissatisfaction, which often compromise functional autonomy and quality of life of the patient and may require invasive treatments (surgical revision, unlocking under general anesthesia). The local and systemic inflammatory state, evidenced by peri-operative dosage of specific biomarkers, appears to be related to prosthetic outcome.",[418,419,420,28,421,422,423,424,425],"Acupuncture Analgesia","Acupuncture","Acupuncture Therapy","Postoperative Pain Management","Pain Threshold","Shoulder Pain","Laparoscopies","Acupuncture Ear",[427,145,202],"acupuncture","2025-08-08",{"date":430,"type":39},"2025-08-14",{"date":432,"type":39},"2024-04-10",{"date":434,"type":21},"2026-12-31",{"name":436,"class":46},"Fondazione IRCCS Policlinico San Matteo di Pavia",{"id":438,"slug":439,"hasResults":11,"nctId":440,"briefTitle":441,"officialTitle":441,"acronym":4,"eligibilityCriteria":442,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":443,"enrollmentInfo":444,"targetDuration":4,"studyType":22,"phases":445,"briefSummary":446,"conditions":447,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":453,"lastUpdatePostDateStruct":454,"startDateStruct":456,"completionDateStruct":458,"leadSponsor":460,"locationsCount":47},"100599804","phase-4-the-perioperative-outcome-of-epinephrine-infusion-and-tranexamic-acid-in-knee-arthroplasty-surgery-100599804","NCT07089251","The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery","Inclusion Criteria:\n\n* Patients undergoing knee joint arthroplasty.\n* Saudi and Non-Saudi Patient.\n* Patients who have Complete medical record.\n\nExclusion Criteria:\n\n* End stage renal disease\n* Liver cirrhosis\n* Coagulopathy\n* Pre-operative Hgb \\\u003C10 5.\n* History of cerebrovascular accident or myocardial infarction in past 12 months.\n* History of Heart failure.\n* History of arrhythmia.\n* History of pheochromocytoma, thyrotoxicosis and glaucoma.\n* Pregnancy or breast feeding\n* History of Deep venous thrombosis or pulmonary embolism\n* Allergy to epinephrine or tranexamic acid","70 Years",{"count":414,"type":21},[389],"The aim of this clinical trial is to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative blood loss, thromboembolic complications, and hospitalization duration in patients undergoing knee joint arthroplasty.\n\nAlso aim to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative thromboembolic complications, and hospitalization duration",[448,449,28,450,451,452],"Knee Arthroplasty, Total","Knee Arthritis, Osteoarthritis","Blood Loss","Tranexamic Acid Use","Epinephrine","2025-07-21",{"date":455,"type":39},"2025-07-28",{"date":457,"type":39},"2025-07-15",{"date":459,"type":21},"2027-06-24",{"name":461,"class":46},"King Abdullah International Medical Research Center",{"id":463,"slug":464,"hasResults":11,"nctId":465,"briefTitle":466,"officialTitle":467,"acronym":4,"eligibilityCriteria":468,"healthyVolunteers":11,"sex":17,"minAge":166,"maxAge":469,"enrollmentInfo":470,"targetDuration":4,"studyType":22,"phases":471,"briefSummary":472,"conditions":473,"keywords":474,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":4},"100586164","the-effect-of-kinesio-taping-on-mobility-pain-balance-and-daily-activities-in-total-knee-replacement-patients-100586164","NCT06911814","The Effect of Kinesio Taping on Mobility, Pain, Balance and Daily Activities in Total Knee Replacement Patients","Does Kinesiotaping Really Effective on Mobility, Pain and Daily Activities After Total Knee Arthroplasty?","Inclusion Criteria:\n\n* Patients aged 50-75 who have undergone total knee arthroplasty (TKA)\n* Patients able to mobilize independently\n* Patients willing to participate in the treatment program\n* Patients without any secondary conditions that could cause immobilization\n\nExclusion Criteria:\n\n* Patients who have undergone surgery due to cancer\n* Renal insufficiency (GFR \\<30)\n* Patients with local infection in the kinesiology taping application area\n* Heart failure (Stage III-IV)\n* BMI \\>35\n* Cognitive impairment\n* COPD (GOLD Stage III-IV)","75 Years",{"count":20,"type":21},[59],"Total knee arthroplasty (TKA) is a surgical procedure performed to relieve pain and functional limitations caused by advanced gonarthrosis that cannot be managed with conservative methods. It is known that the postoperative rehabilitation program plays a crucial role in functionality and mobility in the postoperative period. Pain and swelling are the most commonly reported minor complications that lead to functional limitations, often associated with decreased muscle strength. After TKA, various current methods such as compression therapy and electrotherapy are employed to treat postoperative edema. Typically, patients are discharged with a home exercise program once they are ambulatory. However, the return to daily living activities varies among patients, and some may experience prolonged recovery times. In our country and hospital, there is no standardized algorithm for postoperative care following TKA. Patients are often referred to rehabilitation clinics only when complications arise.\n\nDue to issues with patient ambulation, there may be a need for inpatient care following TKA. While traditional rehabilitation programs are used, alternative methods to facilitate early ambulation have emerged in recent years, one of which is kinesiology taping (KT). Developed by Kenso Kase in the 1970s, KT is an elastic, wave-textured, waterproof, breathable cotton tape applied directly to the skin. When applied with various techniques, it helps alleviate pain, reduce edema, and provides mechanical support and joint protection. KT does not restrict movement; instead, its elastic structure opens the space between the dermis and fascia, aiding lymphatic and blood flow, thereby reducing swelling in the extremities. There are studies on the use of KT in postoperative patients beyond musculoskeletal pain conditions, particularly regarding its effectiveness in managing pain, swelling, and joint range of motion after shoulder and anterior cruciate ligament surgeries.\n\nAlthough recent studies in the literature have explored the use of KT after TKA, there is still no consensus on its efficacy and application methods. This study aims to investigate the potential effects or complications of KT treatment on balance, pain, mobility, and quality of life in patients undergoing rehabilitation after TKA.",[28],[475,476,477,478],"Total knee arthroplasty","Kinesiotape","Pain","Edema","2025-04-03",{"date":481,"type":39},"2025-04-04",{"date":483,"type":21},"2025-06-01",{"date":485,"type":21},"2026-01-01",{"name":487,"class":488},"Bursa City Hospital","OTHER_GOV",{"id":490,"slug":491,"hasResults":11,"nctId":492,"briefTitle":493,"officialTitle":494,"acronym":495,"eligibilityCriteria":496,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":497,"targetDuration":4,"studyType":22,"phases":498,"briefSummary":499,"conditions":500,"keywords":501,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":510,"lastUpdatePostDateStruct":511,"startDateStruct":513,"completionDateStruct":515,"leadSponsor":517,"locationsCount":4},"100571956","comparison-of-restricted-versus-unrestricted-kinematic-alignment-in-1ry-tka-100571956","NCT06726993","Comparison of Restricted Versus Unrestricted Kinematic Alignment in 1ry TKA","Comparison of Restricted Kinematic Alignment Versus Unrestricted Kinematic Alignment in Primary Total Knee Arthroplasty:- Randomized Controlled Trial","rKA-KA-TKA","Inclusion Criteria:\n\n-Patients suffered from end stage knee osteoarthritis of grade four according to Kellgren-Lawrence classification in at least one of the three knee compartments, who have an osteoarthritic knees of varus Coronal Plane Alignment of the Knee classification\n\nExclusion Criteria:\n\n1. Any valgus malalignment of the knee joint.\n2. Malalignment more than 10° or less than 3° varus of knee joint.\n3. Ligamentous laxity of the affected knee (medial or lateral collateral ligaments)\n4. any tumors or secondary neoplasia diseases\n5. Knee joint infection\n6. severe cardiopulmonary dysfunction.",{"count":414,"type":21},[59],"Knee osteoarthritis is a growing socioeconomic burden because of the ageing and obesity. By 2030, the majority of individuals undergoing knee arthroplasty in USA will be those younger than 65 years, with up to 1 million achieved annually.\n\nThe definitive treatment for knee joint degeneration is total knee arthroplasty.",[30,28],[475,502,503,504,505,506,507,508,509],"TKA","Total knee replacement","TKR","Restricted kinematic alignment","rKA","Kinematic alignment","KA","Unrestricted kinematic alignment","2024-12-16",{"date":512,"type":39},"2024-12-19",{"date":514,"type":21},"2025-02-01",{"date":516,"type":21},"2027-06-01",{"name":518,"class":46},"Assiut University"]