[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"total-knee-arthroplasty-postoperative-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:total-knee-arthroplasty-postoperative-pain":91},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,78,103],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100633261","femoral-triangle-block-vs-adductor-canal-block-on-early-quadriceps-function-after-total-knee-arthroplasty-100633261",false,"NCT07524387","Femoral Triangle Block vs Adductor Canal Block on Early Quadriceps Function After Total Knee Arthroplasty","Postoperative Effects of Femoral Triangle Block Versus Adductor Canal Block on Early Quadriceps Function After Total Knee Arthroplasty Under a Multimodal Analgesia Protocol: A Randomized Double-Blind Controlled Trial","Inclusion Criteria:\n\n1. Adult patients (≥ 20 years of age) are scheduled to undergo primary unilateral TKA.\n2. American Society of Anesthesiologists (ASA) physical status I-III.\n3. Ability to ambulate independently prior to surgery.\n4. Ability to understand the study procedures and provide written informed consent.\n5. Planned perioperative anesthesia management including regional anesthesia as part of standard clinical care.\n6. Ability to extend the knee below 30 degrees preoperatively (no knee extension contracture)\n\nExclusion Criteria:\n\n1. Known allergy or contraindication to local anesthetic agents used in this study.\n2. Pre-existing neurological or neuromuscular disorders affect lower limb strength or motor control.\n3. Severe cognitive impairment or psychiatric conditions interfere with study participation or assessment.\n4. History of revision knee arthroplasty on the operative side.\n5. Severe preoperative quadriceps weakness that precludes reliable baseline strength assessment.\n6. Any condition deemed by the investigator to make participation inappropriate.","ALL","20 Years",{"count":19,"type":20},136,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to compare the effects of femoral triangle block (FTB) and adductor canal block (ACB) on early quadriceps function after total knee arthroplasty (TKA).\n\nThe main question it aims to answer is whether FTB causes more early quadriceps functional impairment than ACB under a standardized multimodal analgesia protocol.\n\nResearchers will compare FTB and ACB using a composite binary functional outcome measured 6 hours after block completion. Quadriceps functional impairment is defined as the inability to perform a structured straight leg raise or quadriceps muscle strength \\\u003C50% of the preoperative baseline.\n\nParticipants will be randomly assigned to receive ultrasound-guided FTB or ACB. All participants will also receive a popliteal plexus block and standardized multimodal analgesia.",[26,27,28],"Total Knee Arthroplasty","Total Knee Arthroplasty Recovery","Total Knee Arthroplasty Postoperative Pain",[30,26,31,32],"Postoperative Pain","Peripheral Nerve Block","Postoperative Recovery","RECRUITING","2026-04-13",{"date":36,"type":37},"2026-04-16","ACTUAL",{"date":34,"type":37},{"date":40,"type":20},"2029-03-31",{"name":42,"class":43},"Social Medical Corporation Daiyukai","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100626748","neurocuple-as-an-opioid-alternative-following-total-knee-arthroplasty-100626748","NCT07439666","NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty","The Role of NEUROCUPLE™ as an Alternative to Opioids Following Total Knee Arthroplasty Patients","Inclusion Criteria:\n\n* \\>18 years of age\n* Scheduled for elective primary unilateral TKA\n\nExclusion Criteria:\n\n* Children (\\\u003C18 yr.)\n* Pregnant women\n* Active alcoholism (defined as daily use of more than 1 liter of wine and \u002For 3 or more shots of hard liquor) or drug abuse (defined as daily use of illicit drugs)\n* Severe chronic pain condition that requires daily preoperative opioid dependence\n* Other concomitant surgery being performed in addition to TKA\n* Patients undergoing bilateral TKA\n* Patients undergoing knee replacement revision\n* Patients with limited mobility (in a wheelchair or requiring a walker)\n* Patients who are not returning home after surgery","18 Years",{"count":54,"type":20},274,[23],"The goal of this clinical trial is to learn if the NEUROCUPLE device can reduce pain and opioid use after primary unilateral total knee arthroplasty (TKA) in adults.\n\nThe main questions it aims to answer are:\n\n* Does the NEUROCUPLE device reduce postoperative pain at rest during the first 24 hours after TKA?\n* Does the NEUROCUPLE device reduce opioid consumption during the first 24 hours after TKA?\n\nResearchers will compare the NEUROCUPLE device to a placebo device (identical in appearance but inactive) to see if the device reduces pain and opioid use after surgery.\n\nParticipants will:\n\n* Apply the NEUROCUPLE device or placebo device for 7 days following surgery\n* Have their pain and opioid use monitored through clinical records and patient reporting\n* Report pain at rest and during movement on postoperative Days 2 and 7\n* Be assessed for nausea, vomiting, device-related side effects, length of hospital stay, and overall satisfaction",[28,58],"Opioid Reduction After TKA",[26,30,60,61,62,63,64,65,66],"TKA","Opioid Use","Non opioid Pain Management","NEUROCUPLE Patch","Knee Replacement","Acute Postoperative Pain","Randomized Clinical Trial","NOT_YET_RECRUITING","2026-04-02",{"date":70,"type":37},"2026-04-08",{"date":72,"type":20},"2026-05",{"date":74,"type":20},"2027-11",{"name":76,"class":43},"Jacques E. Chelly",3,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":21,"phases":88,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":44},"100626961","reiki-in-total-knee-arthroplasty-patients-reiki-tka--100626961","NCT07442435","REIKI IN TOTAL KNEE ARTHROPLASTY PATIENTS (REIKI TKA )","THE EFFECT OF REIKI PRACTICE ON POSTOPERATIVE PAIN, MOBILIZATION, AND VITAL SIGNS IN PATIENTS UNDERGOING TOTAL KNEE ARTHROPLASTY: A RANDOMIZED CONTROLLED TRIAL","REIKI TKA","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Undergoing elective (planned) primary total knee arthroplasty\n* Not receiving general anesthesia\n* Able to communicate effectively and understand the study protocol\n* Hospitalized for two days following total knee arthroplasty\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Previous total knee arthroplasty or revision knee surgery\n* Prior experience with Reiki, Therapeutic Touch, Healing Touch, or other energy-based therapies\n* Development of serious postoperative complications (e.g., bleeding, infection)\n* Diagnosis of chronic pain syndrome (e.g., fibromyalgia, chronic low back pain)\n* Neuropsychiatric disorders such as dementia, Alzheimer's disease, schizophrenia, or major depressive disorder\n* Current use of psychotropic medications\n* Regular use of opioids or corticosteroids\n* Use of patient-controlled analgesia (PCA)\n* Major surgery or severe trauma within the past 6 months\n* Admission to the intensive care unit postoperatively",{"count":87,"type":20},90,[23],"Total knee arthroplasty (TKA) is commonly performed to improve mobility and quality of life in patients with degenerative joint diseases. However, severe postoperative pain, limited mobilization, and fluctuations in vital signs negatively affect recovery, particularly within the first 72 hours after surgery.\n\nReiki is a non-invasive complementary therapy aimed at enhancing the body's self-healing capacity through energy transfer. This randomized controlled trial aims to evaluate the effects of Reiki on postoperative pain, mobilization, and vital signs in patients undergoing total knee arthroplasty.\n\nParticipants will be randomly assigned to either a Reiki intervention group or a control group receiving routine postoperative care. Outcomes will be assessed using validated pain and mobility scales and objective vital sign measurements at the 24th, 48th, and 72nd postoperative hours.",[91],"Total Knee Arthroplasty (Postoperative Pain)",[93],"Reiki, Total Knee Arthroplasty, Postoperative Pain, Mobilization, Vital Signs, Nursing, Nursing Care","2026-02-24",{"date":96,"type":37},"2026-03-02",{"date":98,"type":37},"2026-02-09",{"date":100,"type":20},"2026-09",{"name":102,"class":43},"Ondokuz Mayıs University",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":44},"100377841","effects-of-tdcs-combined-with-cbi-on-postsurgical-pain-100377841","NCT04199780","Effects of tDCS Combined With CBI on Postsurgical Pain","tDCS Combined With a Brief Cognitive Intervention to Reduce Perioperative Pain and Opioid Requirements in Veterans","tDCS-CBI","Inclusion Criteria:\n\nParticipants will be 120 patients (132 recruited to account for 10% drop-out rate) undergoing TKA or THA surgery at the Ralph H. Johnson VAMC in Charleston SC.\n\n* Mentally capable of reading, writing, giving consent, and following instructions\n* Cleared for, and scheduled for unilateral TKA or THA surgery\n* Able to hear CB intervention and understand educational materials through headphones in English\n\nExclusion Criteria:\n\n* implanted medical devices above the waist\n* pregnant\n* history of seizures\n* allergic to latex rubber\n* psychiatric conditions except for depression and\u002For anxiety disorders (commonly seen in this population).","90 Years",{"count":113,"type":20},132,[23],"The purpose of this study is to determine whether a new medical technology can help reduce post-operative total knee or hip pain when combined with a Cognitive-Behavioral intervention (CBI).\n\nThis new medical technology, is called transcranial direct current stimulation (tDCS), it uses a very small amount of electricity to temporarily stimulate specific areas of the brain thought to be involved in pain reduction. The electrical current passes through the skin, scalp, hair, and skull and requires no additional medication, sedation, or needles.\n\nThis study will investigate the effects of tDCS, the Cognitive-Behavioral (CB) intervention and their combination on pain among veterans following total knee arthroplasty (TKA) or total hip arthroplasty (THA). The Veteran may benefit in the form of decreased pain and opioid requirements following knee or hip replacement surgery. However, benefit is only likely if Veterans are randomized to one of the 3 (out of 4) groups.\n\nThis study hopes to determine the effects of these interventions and combined effect on post-operative pain, opioid use and functioning during the 48-hour post-operative period following a total knee or hip replacement.",[91,117],"Total Hip Arthroplasty (Postoperative Pain)",[119,120,121,122,123,124,125,126,60,127],"total knee arthroplasty","pain","postsurgical pain","opioid","transcranial direct current stimulation","tDCS","brain stimulation","total hip arthroplasty","THA","2025-07-25",{"date":130,"type":37},"2025-07-30",{"date":132,"type":37},"2021-01-11",{"date":134,"type":20},"2026-07-31",{"name":136,"class":137},"VA Office of Research and Development","FED"]