[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"total-knee-arthroplasty-recovery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:total-knee-arthroplasty-recovery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,46,77,105,131,157],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100643092","effects-of-progressive-restricted-blood-flow-exercises-in-post-total-knee-arthroplasty-100643092",false,"NCT07601906","Effects of Progressive Restricted Blood Flow Exercises in Post Total Knee Arthroplasty","Effects of Progressive Restricted Blood Flow Exercise on Pain, Range of Motion, Swelling, Proprioception and Kinesiophobia on Patients With Total Knee Arthoplasty","TKA PBFR","Inclusion Criteria:\n\n1. Patients of age 50-65 years.\n2. Primary unilateral TKA due to osteoarthritis.\n3. Individuals with mild to moderate postoperative pain (NPRS score 4-7).\n4. Minimum active knee flexion of 30° \\& an extension lag of no more than 15°.\n5. Patients should be medically stable, cognitively able to follow instructions in Urdu or english, and willing to provide written informed consent\n\nExclusion Criteria:\n\n1. History of deep vein thrombosis within the last six months.\n2. Peripheral vascular disease and active infection.\n3. Severe cardiovascular conditions\n4. Neurological disorders affecting lower limb function","ALL","50 Years","65 Years",{"count":21,"type":22},48,"ESTIMATED","INTERVENTIONAL",[25],"NA","Total knee arthroplasty (TKA) is a commonly performed procedure for advanced knee osteoarthritis. Despite successful surgery, many patients experience postoperative impairments including pain, reduced range of motion (ROM), swelling, impaired proprioception, and kinesiophobia, which may delay functional recovery.\n\nConventional physiotherapy is the standard rehabilitation approach following TKA; however, high-load strengthening exercises are often limited in the early postoperative phase due to pain and reduced tolerance.\n\nBlood flow restriction (BFR) exercise is an emerging rehabilitation technique that enables low-load exercise to produce strength adaptations similar to high-intensity training. While evidence supports its effectiveness for improving muscle strength, its effects on other outcomes such as pain, swelling, proprioception, and kinesiophobia are not well established.\n\nThis randomized controlled trial will compare progressive BFR exercise combined with conventional physiotherapy versus conventional physiotherapy alone in patients following unilateral TKA. A total of 48 participants will be randomly allocated to two groups. The intervention will be delivered over 6 weeks with supervised sessions conducted three times per week.\n\nOutcomes will include pain, knee ROM, swelling, proprioception, kinesiophobia, and functional performance. This study aims to determine whether BFR exercise provides additional benefits in postoperative rehabilitation following TKA.",[28],"Total Knee Arthroplasty Recovery",[30,31,32],"Blood Flow Restriction Exercises","Post-Total Knee Arthroplasty","Conventional Physical Therapy","RECRUITING","2026-06-05",{"date":36,"type":37},"2026-06-09","ACTUAL",{"date":39,"type":37},"2026-05-25",{"date":41,"type":22},"2026-11-20",{"name":43,"class":44},"Lahore University of Biological and Applied Sciences","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":45},"100611336","the-effects-of-mir-shakeel-teleintegrated-therapy-plan-in-patients-undergoing-total-knee-arthroplasty-100611336","NCT07239258","The Effects of Mir Shakeel Teleintegrated Therapy Plan in Patients Undergoing Total Knee Arthroplasty","The Effects of Mir Shakeel Teleintegrated Therapy Plan and Conventional Physical Therapy on Pain, Range of Motion, Gait, Functional Outcomes and Quality of Life in Patients Undergoing Total Knee Arthroplasty","RCT","Inclusion Criteria:\n\n* Patients who have underwent a primary unilateral total knee arthroplasty due to osteoarthritis\n* Able to participate in a rehabilitation program, either telerehabilitation or in-person, and demonstrate sufficient mobility with or without assistive devices (e.g., crutches, walker) as deemed appropriate for post-TKA therapy.\n* Participants must have reliable access to a smartphone, tablet, or computer with internet connectivity and the ability to engage in video calls.\n* Willing and able to provide informed consent, and to comply with all study protocols, including scheduled therapy sessions and follow-up assessments.\n\nExclusion Criteria:\n\n* Presence of significant comorbidities or complications that could interfere with safe participation in rehabilitation, such as severe cardiovascular disease, or conditions causing significant immobility (e.g., severe osteoarthritis in other joints or Rheumatoid Arthritis.\n* Previous knee replacement or other significant knee surgeries on the same knee, as this may impact the standardization of rehabilitation outcomes.\n* Currently enrolled in another physical therapy or rehabilitation trial, or engaging in additional rehabilitation outside the study protocol.\n* Cognitive impairment or severe visual or hearing impairments that would prevent them from following therapy instructions or engaging with telerehabilitation technology.\n* Any other conditions or factors that, in the opinion of the investigators, could hinder compliance with the study procedures or put the participant at undue risk.",{"count":55,"type":22},120,[25],"This randomized controlled trial aims to evaluate the effectiveness of a newly developed Modified Structured Telerehabilitation Intervention Protocol (MSTITP) compared with conventional in-person physical therapy in patients recovering from Total Knee Arthroplasty (TKA). The study also explores whether a hybrid rehabilitation approach may further optimize patient outcomes.\n\nA total of eligible participants aged 50-65 years who have undergone primary TKA will be randomly assigned to one of two groups:\n\nGroup A (Intervention): Telerehabilitation-based structured exercise program (MSTITP) delivered through digital platforms with remote supervision.\n\nGroup B (Control): Standard conventional face-to-face physiotherapy in a clinical setting.\n\nBoth groups will receive rehabilitation programs of equal duration focusing on pain management, range of motion (ROM), muscle strengthening, gait training, and functional mobility.\n\nThe primary objective is to compare the effectiveness of telerehabilitation and conventional therapy in improving pain, ROM, and gait performance. Secondary objectives include evaluation of exercise adherence, kinesiophobia, functional outcomes, quality of life, and patient satisfaction. Additionally, the study will explore whether integrating telerehabilitation with conventional rehabilitation could provide superior outcomes.\n\nOutcome assessments will be conducted using validated tools including pain scales (VAS), goniometric ROM measurements, gait analysis, functional performance tests, and standardized questionnaires for quality of life, exercise adherence, and fear of movement.\n\nThis study addresses the increasing burden of osteoarthritis and the growing number of TKA procedures in Pakistan. Telerehabilitation may offer a cost-effective, accessible, and scalable rehabilitation model that ensures continuity of care and improved access to physiotherapy services, particularly in resource-limited settings.\n\nThe findings of this trial are expected to provide evidence for developing standardized, technology-assisted rehabilitation protocols to improve post-TKA recovery outcomes and reduce healthcare burden.",[59,28],"Total Knee Anthroplasty",[61,62,63,64,65,66,67],"pain","range of motion","gait","functional outcomes","quality of life","conventional physical therapy","total knee arthroplasty","2026-05-09",{"date":70,"type":37},"2026-05-13",{"date":72,"type":37},"2025-06-26",{"date":74,"type":22},"2026-06",{"name":76,"class":44},"Lincoln University College",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100638465","effects-of-stress-ball-use-and-breathing-exercises-on-pain-and-vital-signs-during-drain-removal-after-total-knee-arthroplasty-100638465","NCT07586436","Effects of Stress Ball Use and Breathing Exercises on Pain and Vital Signs During Drain Removal After Total Knee Arthroplasty","The Effect of Stress Ball Use and Breathing Exercises on Procedural Pain and Vital Signs During Drain Removal After Total Knee Arthroplasty: A Randomized Controlled Trial","TDP","Inclusion Criteria:\n\n* Adults aged 18 years and older undergoing primary total knee arthroplasty\n* Patients with a surgical drain in place and scheduled for drain removal in the postoperative period\n* Able to provide informed consent\n* Able to communicate and understand instructions\n\nExclusion Criteria:\n\n* Patients with chronic pain syndromes or regular opioid use\n* Patients with cognitive impairment, delirium, or communication difficulties\n* Patients with contraindications to drain removal (e.g., active bleeding, hemodynamic instability)\n* Patients with neurological conditions affecting pain perception",true,{"count":87,"type":22},105,[25],"This randomized controlled trial aims to evaluate the effects of stress ball use and breathing exercises on procedural pain and vital signs during drain removal in patients undergoing total knee arthroplasty. Although drain removal is a short procedure, it is often associated with sudden and intense pain and may trigger physiological stress responses such as increased heart rate, blood pressure, and respiratory rate.\n\nA total of 105 patients will be randomly assigned to three groups: stress ball group, breathing exercise group, and standard care group. The interventions will be applied starting one minute before drain removal, continuing throughout the procedure, and for two minutes afterward.\n\nPain levels will be assessed using the Numeric Rating Scale (NRS), and vital signs (heart rate, blood pressure, respiratory rate, and oxygen saturation) will be measured at predefined time points before, during, and after the procedure. The findings of this study are expected to provide evidence on the effectiveness of simple, non-pharmacological interventions in reducing procedural pain and improving physiological stability during drain removal",[91,28,92],"Total Knee Arthroplasty","Pain After Knee Arthroscop",[91,61,94],"Vital Signs","NOT_YET_RECRUITING","2026-05-08",{"date":98,"type":37},"2026-05-14",{"date":100,"type":22},"2026-05-05",{"date":102,"type":22},"2026-08-30",{"name":104,"class":44},"TC Erciyes University",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":23,"phases":115,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":127,"leadSponsor":129,"locationsCount":45},"100633261","femoral-triangle-block-vs-adductor-canal-block-on-early-quadriceps-function-after-total-knee-arthroplasty-100633261","NCT07524387","Femoral Triangle Block vs Adductor Canal Block on Early Quadriceps Function After Total Knee Arthroplasty","Postoperative Effects of Femoral Triangle Block Versus Adductor Canal Block on Early Quadriceps Function After Total Knee Arthroplasty Under a Multimodal Analgesia Protocol: A Randomized Double-Blind Controlled Trial","Inclusion Criteria:\n\n1. Adult patients (≥ 20 years of age) are scheduled to undergo primary unilateral TKA.\n2. American Society of Anesthesiologists (ASA) physical status I-III.\n3. Ability to ambulate independently prior to surgery.\n4. Ability to understand the study procedures and provide written informed consent.\n5. Planned perioperative anesthesia management including regional anesthesia as part of standard clinical care.\n6. Ability to extend the knee below 30 degrees preoperatively (no knee extension contracture)\n\nExclusion Criteria:\n\n1. Known allergy or contraindication to local anesthetic agents used in this study.\n2. Pre-existing neurological or neuromuscular disorders affect lower limb strength or motor control.\n3. Severe cognitive impairment or psychiatric conditions interfere with study participation or assessment.\n4. History of revision knee arthroplasty on the operative side.\n5. Severe preoperative quadriceps weakness that precludes reliable baseline strength assessment.\n6. Any condition deemed by the investigator to make participation inappropriate.","20 Years",{"count":114,"type":22},136,[25],"The goal of this clinical trial is to compare the effects of femoral triangle block (FTB) and adductor canal block (ACB) on early quadriceps function after total knee arthroplasty (TKA).\n\nThe main question it aims to answer is whether FTB causes more early quadriceps functional impairment than ACB under a standardized multimodal analgesia protocol.\n\nResearchers will compare FTB and ACB using a composite binary functional outcome measured 6 hours after block completion. Quadriceps functional impairment is defined as the inability to perform a structured straight leg raise or quadriceps muscle strength \\\u003C50% of the preoperative baseline.\n\nParticipants will be randomly assigned to receive ultrasound-guided FTB or ACB. All participants will also receive a popliteal plexus block and standardized multimodal analgesia.",[91,28,118],"Total Knee Arthroplasty Postoperative Pain",[120,91,121,122],"Postoperative Pain","Peripheral Nerve Block","Postoperative Recovery","2026-04-13",{"date":125,"type":37},"2026-04-16",{"date":123,"type":37},{"date":128,"type":22},"2029-03-31",{"name":130,"class":44},"Social Medical Corporation Daiyukai",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":17,"minAge":137,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":23,"phases":140,"briefSummary":141,"conditions":142,"keywords":143,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":4},"100622233","mirror-therapy-as-an-adjunct-to-rehabilitation-following-total-knee-arthroplasty-100622233","NCT07380958","Mirror Therapy as an Adjunct to Rehabilitation Following Total Knee Arthroplasty","Inclusion Criteria:\n\n1. Candidates that have been screened and deemed eligible for a TKA and received a TKA 14 days or less post operation.\n2. English speaking\n3. Able to understand and follow instructions\n4. Has at least 5 degrees of knee extension to 100 degrees of knee flexion AROM on the contralateral knee\n5. Able to perform unilateral stance on contralateral side for at least 5 seconds (balance assistance allowed)\n6. Able to perform exercises\n\nExclusion Criteria:\n\n1. Post-surgical complications (DVT, infection, nerve injury, vascular injury)\n2. Pain rating on NPRS no more than a 4\u002F10 on the contralateral LE\n3. Significant scar or deformity of the contralateral LE\n4. Visual impairments causing an inability to see the reflection in a mirror","18 Years",{"count":139,"type":22},30,[25],"The investigators are looking to see if using a mirror during knee exercises after a knee replacement helps participants with less pain and\u002For better knee range of motion.",[28],[144,61,145,62,146,147],"Total knee replacement","mirror therapy","joint replacement","rehabilitation following a knee replacement","2026-01-24",{"date":150,"type":37},"2026-02-02",{"date":152,"type":22},"2026-02",{"date":154,"type":22},"2026-10",{"name":156,"class":44},"State University of New York - Upstate Medical University",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":17,"minAge":137,"maxAge":4,"enrollmentInfo":164,"targetDuration":4,"studyType":23,"phases":166,"briefSummary":167,"conditions":168,"keywords":172,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":45},"100599155","the-effect-of-balance-training-using-a-dynamometric-platform-in-patients-undergoing-total-knee-arthroplasty-100599155","NCT07080814","The Effect of Balance Training Using a Dynamometric Platform in Patients Undergoing Total Knee Arthroplasty","The Effect of Balance Training Using a Dynamometric Platform on Muscle Strength, Proprioception, Balance, and Gait in Patients Undergoing Total Knee Arthroplasty: A Single-Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients who have undergone total knee arthroplasty within the past 2 years and are hospitalized at the Orthopedic Rehabilitation Clinic of Ankara Etlik City Hospital, Physical Therapy Hospital.\n* Able to fully bear weight on the operated lower extremity in the third postoperative week.\n* Willingness to participate and signing of the written informed consent form.\n\nExclusion Criteria:\n\n* Bilateral knee arthroplasty\n* Age under 18 years\n* Receiving treatment at a physical therapy unit within the first 2 weeks after knee arthroplasty\n* Presence of significant visual or hearing impairment, active infection\n* Clinically unstable condition\n* Presence of central nervous system lesions (e.g., stroke, multiple sclerosis)\n* Presence of malignancy\n* Presence of a fracture in the lower extremity\n* Presence of any condition that would prevent participation in the treatment\n* History of lumbar disc surgery\n* History of previous surgery in the lower extremity\n* Presence of advanced osteoarthritis in the non-operated lower extremity",{"count":165,"type":22},46,[25],"Total knee arthroplasty (TKA) is a common surgery used to treat advanced knee osteoarthritis, especially when other treatments no longer help. While the surgery often reduces pain and improves joint alignment, many patients still have problems with balance and movement afterward.\n\nThis study will explore whether adding balance training using the Tecnobody ProKin system to standard physical therapy helps patients recover better after TKA. The researchers will measure balance, walking ability, leg strength, and body awareness (also called proprioception) using special equipment.\n\nThe main goal is to test the hypothesis that technology-supported balance training improves recovery outcomes more effectively than standard rehabilitation alone.",[169,28,170,171],"Knee Osteoarthritis","Postoperative Rehabilitation","Balance Training",[91,173,174,175,176,177,178],"Muscle Strength","Proprioception","Gait","balance training","Static Balance","Dynamic Balance","2025-07-20",{"date":181,"type":37},"2025-07-23",{"date":183,"type":37},"2025-05-01",{"date":185,"type":22},"2027-05-01",{"name":187,"class":188},"Ankara Etlik City Hospital","OTHER_GOV"]