[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"total-knee-arthroplasty-tka\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:total-knee-arthroplasty-tka":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,77,106,136],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100644533","phase-1-total-intravenous-anesthesia-vs-spinal-anesthesia-in-patients-undergoing-unilateral-primary-total-knee-arthroplasty-100644533",false,"NCT07672301","Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty","Inclusion Criteria:\n\n* Adults aged ≥18 years.\n* Scheduled to undergo elective primary total knee arthroplasty (TKA) or robotic total knee arthroplasty (TKA) at the University of Chicago.\n* Eligible for same-day discharge (SDD) based on established orthopedic and anesthesia criteria.\n* Able to provide written informed consent.\n* The ability to comprehend and complete cognitive assessment surveys and questionnaires.\n* Consent to receive either Total IntraVenous Anesthesia (TIVA) or Spinal-block Anesthesia in a randomized manner\n* No contraindication to either TIVA or spinal anesthesia\n\nExclusion Criteria:\n\n* Age \\\u003C18 years.\n* Patients undergoing revision TKA or procedures other than elective primary TKA.\n* Ineligibility for same-day discharge as determined by the surgical or anesthesia team.\n* Contraindications to either anesthetic technique (e.g., spinal block anesthesia contraindicated due to coagulopathy, infection at puncture site, or patient refusal).\n* Known allergy or hypersensitivity to study-related medications.\n* Significant pre-existing cognitive impairment or dementia that would preclude valid participation in Short Portable Mental Status Questionnaire (SPMSQ), and 3-Minute Diagnostic Assessment for Confusion Assessment Method (3D-CAM) assessments.\n* Severe chronic pain syndromes (e.g., fibromyalgia, centrally mediated pain disorders) that could confound perioperative pain assessment.\n* Body mass index (BMI) \\> 40.\n* Prisoners or other vulnerable populations unable to provide voluntary consent.\n* Unable to give appropriate consent or difficult to comprehend and complete cognitive assessment surveys and questionnaires","ALL","18 Years",{"count":18,"type":19},150,"ESTIMATED","INTERVENTIONAL",[22,23],"PHASE1","PHASE2","The purpose of this study is to compare same-day discharge rates and recovery outcomes across an adult patient population undergoing elective Total Knee Arthroplasty (TKA), and randomized to receive either spinal block anesthesia or Total IntraVenous Anesthesia (TIVA).\n\nPrimary Aim: assess same-day discharge rates between study arms (TIVA vs spinal).\n\nSecondary Aim: Postoperative comparison of recovery during PostOperative Anesthesia Care Unit (PACU) admission, diagnostic assessment scores; outcomes related to cognition, hemodynamic stability, pain, nausea and vomiting; analysis of IntraOperative electroencephalogram (EEG) monitoring metrics, e.g., total suppression time, average Bi-spectral Index monitor (BIS) value, Spectral Edge Frequency (SEF); ability for Physical Therapy (PT) evaluation prior to discharge; longterm-followup (LTFU), hospital readmission, return to surgery, etc.; adverse event (AE) monitoring.",[26],"Total Knee Arthroplasty (TKA)",[28,29,30,31],"Total IntraVenous Anesthesia (TIVA)","Spinal block","Delirium - Postoperative","Postoperative Recovery","RECRUITING","2026-06-23",{"date":35,"type":36},"2026-06-26","ACTUAL",{"date":38,"type":36},"2026-03-11",{"date":40,"type":19},"2028-06",{"name":42,"class":43},"University of Chicago","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":20,"phases":54,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":44},"100633115","imageless-navigation-versus-image-based-navigation-in-robotic-assisted-total-knee-arthroplasty-for-knee-osteoarthritis-100633115","NCT07522489","Imageless Navigation Versus Image-Based Navigation in Robotic-Assisted Total Knee Arthroplasty for Knee Osteoarthritis","Outcomes of Robotic-Assisted Total Knee Arthroplasty With Imageless Navigation Versus Image-Based Navigation: A Randomised, Single-Blinded, Non-Inferiority Trial","Inclusion Criteria:\n\n1. Symptomatic, radiologically confirmed advanced osteoarthritis of the knee.\n2. Patients referred for primary robotic-assisted total knee arthroplasty.\n3. Patients in whom a correctly performed radiograph with designated sensors has confirmed the possibility of performing robotic-assisted total knee arthroplasty with image-based navigation.\n4. Patients capable of giving informed consent to participate in the study and willing to attend all follow-up visits.\n\nExclusion Criteria:\n\n1. No informed consent for the surgery.\n2. No informed consent for taking part in the study.\n3. Pregnancy.\n4. Active infections.\n5. Diagnosed comorbidities: autoimmune arthritis, malignant tumors, serious neurological disorders affecting a reliable functional outcome measurement (e.g., severe stroke, severe Parkinson's disease).",{"count":53,"type":19},146,[55],"NA","The goal of this clinical trial is to learn if imageless navigation is not inferior to image-based navigation in robotic-assisted total knee arthroplasty (RA-TKA) for treating patients with knee osteoarthritis.\n\nThe main questions the study aims to answer are:\n\n1. Does imageless procedure provide functional results comparable to those of image-based navigation?\n2. Are there differences in postoperative complications patients may experience after RA-TKA with imageless and image-based navigation? Researchers will compare imageless navigation with image-based navigation used in total knee arthroplasty to assess whether imageless navigation is comparable for the treatment of knee osteoarthritis.\n\nParticipants will:\n\n1. Answer survey questions about knee pain and function before RA-TKA.\n2. Undergo RA-TKA with imageless navigation or image-based navigation.\n3. Visit the Clinic after 6 months and 12 months after surgery for checkups and to answer the same survey questions about postoperative knee pain and function.",[58,59,26,60],"Osteoarthritis (OA) of the Knee","Knee Pain Arthritis","Robotic Assisted Arthroplasty",[62,63,64,65,66],"Knee Osteoarthritis","Robotic-Assisted Total Knee Arthroplasty","Patient Reported Outcome Measures","Imageless Navigation","Image-based Navigation","NOT_YET_RECRUITING","2026-04-07",{"date":70,"type":36},"2026-04-13",{"date":72,"type":19},"2026-05",{"date":74,"type":19},"2029-01",{"name":76,"class":43},"Medical University of Warsaw",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":44},"100619684","molecular-mechanisms-underlying-hip-and-knee-osteoarthritis-in-patients-undergoing-primary-elective-arthroplasty-100619684","NCT07347821","Molecular Mechanisms Underlying Hip and Knee Osteoarthritis in Patients Undergoing Primary Elective Arthroplasty","Inclusion Criteria:\n\n* 18 years old and more\n* patient qualified for primary TKA or primary THA\n* patient diagnosed with hip or knee osteoarthritis\n* a complete set of tissues of good quality and volume is available\n* does not meet the exclusion criteria.\n\nExclusion Criteria:\n\n* lack of written consent to participate in the study or surgery\n* any private or professional relationship with the Investigators\n* genetic connective tissue diseases (e.g., Ehlers-Danlos syndrome and others)\n* genetic metabolic diseases (e.g., gout and others)\n* genetic diseases affecting the anatomy of the operated joint (e.g., dysplasia and others)\n* previous surgeries altering the anatomy of the examined joint (e.g., periacetabular osteotomy, unicompartmental endoprosthesis, and others)\n* patients undergoing revision after THA\u002FTKA\n* autoimmune diseases in the patient's medical history\n* traumatic injury to the hip or knee joint\n* previous participation in the study.",{"count":84,"type":19},1000,"OBSERVATIONAL","The aim of this observational study is to determine content of rare metals and other elements, along with the levels of selected immunological parameters, in the tissue of the hip or knee joint in the course of degenerative diseases. Determining potential disturbances in the levels or functions of these parameters may in the future contribute to improving treatment - for example, through supplementation of deficient metals or modulation at the immunological level. The main question it aims to answer is:\n\nAre selected rare metals, trace elements and other selected immunological parameters lowered in the tissue of the hip or knee joint as well as in serum in the course of osteoarthritis?",[88,26,89,90],"Total Hip Arthroplasty (THA)","Hip Osteoarthritis","Knee Osteoarthristis",[92,93,94,95,96,97],"Total Knee Replacement","Total Hip Replacement","Trace Elements","Osteoarthritis","Cytokines","Oxidative Stress","2026-01-08",{"date":100,"type":36},"2026-01-16",{"date":102,"type":36},"2025-11-22",{"date":104,"type":19},"2028-12",{"name":76,"class":43},{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":15,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":20,"phases":118,"briefSummary":120,"conditions":121,"keywords":124,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":44},"100613842","phase-4-nalbuphine-timing-effects-on-hemodynamics-and-analgesia-in-elderly-patients-100613842","NCT07271849","Nalbuphine Timing Effects on Hemodynamics and Analgesia in Elderly Patients","Effects of Different Administration Timings of Nalbuphine on Hemodynamics and Postoperative Analgesia in Elderly Patients Undergoing Total Knee Arthroplasty","TKA","Inclusion Criteria:\n\n* All study participants voluntarily enrolled in the trial and provided written informed consent after being fully informed of the trial's purpose and significance\n* Participants underwent unilateral total knee arthroplasty under general anesthesia\n* Elderly participants (age ≥ 65 years), regardless of gender\n* Body mass index (BMI) ranging from 18 kg\u002Fm² to 30 kg\u002Fm²\n* Absence of psychiatric disorders, normal consciousness, and ability to communicate effectively\n* American Society of Anesthesiologists (ASA) physical status classification I-III;\n* No contraindications to the study medications\n\nExclusion Criteria:\n\n* Study participants with uncontrolled or untreated hypertension (resting systolic\u002Fdiastolic blood pressure \\>180\u002F100 mmHg)\n* Individuals with severe respiratory diseases\n* Subjects with abnormal liver or renal function (ALT and\u002For AST \\>2.5 times the upper limit of normal, total bilirubin \\>1.5 times the upper limit of normal, serum creatinine \\>1.5 times the upper limit of normal)\n* Individuals with a history of drug abuse, illicit drug use, or alcohol abuse, where alcohol abuse is defined as an average daily alcohol intake exceeding 2 units (1 unit = 360 mL of beer, 45 mL of 40% alcohol by volume spirits, or 150 mL of wine)","65 Years","90 Years",{"count":117,"type":19},162,[119],"PHASE4","In total knee arthroplasty (TKA), the use of a tourniquet and controlled hypotension is common. However, ischemia-reperfusion injury induced by the tourniquet and inappropriate controlled hypotension can lead to cardiac and cerebral damage in patients. Consequently, maintaining hemodynamic stability, ensuring adequate cerebral perfusion, and achieving controlled blood pressure during the perioperative period are critical factors influencing patient outcomes. Postoperatively, patients typically experience moderate to severe pain. Severe postoperative pain can result in prolonged hospital stays, increased readmission rates, elevated opioid consumption, and associated nausea and vomiting. Therefore, exploring effective multimodal postoperative pain management strategies is essential. Nalbuphine, an opioid analgesic acting as a full kappa-receptor agonist and a partial mu-receptor antagonist, is considered to provide analgesic efficacy equivalent to morphine while potentially offering advantages in maintaining hemodynamic stability. This study aims to investigate the effects of administering equivalent doses of nalbuphine at different perioperative time points on analgesia and hemodynamics in elderly patients undergoing knee arthroplasty.",[122,123,26],"Postoperative Pain, Acute","Hemodynamics",[26,125,126,123],"Postoperative Pain","Nalbuphine","2025-12-06",{"date":129,"type":36},"2025-12-09",{"date":131,"type":36},"2025-10-28",{"date":133,"type":19},"2026-10-31",{"name":135,"class":43},"Qianfoshan Hospital",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":143,"sex":15,"minAge":16,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":147,"conditions":148,"keywords":149,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":44},"100559416","vras-velys-robot-assisted-solution-operational-excellence-study-100559416","NCT06563843","VRAS (Velys Robot-Assisted Solution) Operational Excellence Study","Comparison Between Velys Robotic-Assisted Solution (VRAS) and Conventional Surgery in Total Knee Arthroplasty: An Operational Excellence Evaluation","Inclusion Criteria:\n\n* Orthopaedic surgeons performing conventional and robot-assisted TKA\n\nExclusion Criteria:\n\n* \u002F",true,"100 Years",{"count":146,"type":19},10,"The aim of this study is to investigate the differences in process set-up, efficiency, OR team workload, instrument trays and OR financial performance when using the VRAS (Velys Robotic Assisted Solution) of DePuy Synthes compared to conventional TKA.",[26],[150,26,151,152,153],"VELYS","Process flow","Robotic-assisted surgery","Operational excellence","2024-08-20",{"date":156,"type":36},"2024-08-21",{"date":158,"type":19},"2024-08-27",{"date":160,"type":19},"2026-07",{"name":162,"class":163},"DEO NV","INDUSTRY"]