[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"total-knee-arthroplasty\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:total-knee-arthroplasty":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,70,0,25,[9,55,92,118,146,175,203,236,259,278,298,316,337,363,394,421,448,471,499,522,546,571,594,619,640],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100641778","early-cognitive-changes-after-same-day-discharge-hip-and-knee-arthroplasty-100641778",false,"NCT07598552","Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty","Early Cognitive Changes in Patients Aged 70 Years or Older After Same-day Discharge Hip and Knee Arthroplasty: A Prospective Cohort Study","Inclusion Criteria:\n\n* Unilateral elective primary Total Hip Arthroplasty, Total Knee Arthroplasty, or Unicompartmental Knee\n* Native Danish speaker\n* Spinal anesthesia\n\nExclusion Criteria:\n\n* Inability or unwillingness to provide informed consent\n* Inability to comply with virtual study procedures or follow-up sessions, including because of visual or hearing impairment\n* Known dementia or other diagnosed cognitive disorders or Brief Assessment of Impaired Cognition (BASIC)≤20\n* Parkinson's disease or other neurological conditions causing functional impairment\n* History of alcohol abuse (≥35 units per week)\n* Daily use of anxiolytics or hypnotics\n* Not discharged on the day of surgery","ALL","70 Years",{"count":20,"type":21},48,"ESTIMATED","7 Days","OBSERVATIONAL","The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery. The main question it aims to answer is:\n\nDoes patients experience cognitive changes in cognitive test performance from before surgery to the first day after surgery?\n\nParticipants will:\n\n* Complete a cognitive test battery virtually about 14 days before surgery, and on the first and seventh day after their operation.\n* Record pain levels and pain medicine use during the first week after surgery",[26,27,28,29],"Postoperative Cognitive Dysfunction (POCD)","Cognitive Change","Total Knee Arthroplasty","Unicompartmental Knee Arthroplasty",[31,32,33,34,35,36,37,38,39,40,41],"Same-day discharge","Fast-track surgery","Hip arthroplasty","Knee arthroplasty","Unicompartmental knee arthroplasty","Cognitive function","SDMT","Stroop test","Verbal fluency","Older adults","recovery","RECRUITING","2026-06-17",{"date":45,"type":46},"2026-06-22","ACTUAL",{"date":48,"type":46},"2026-05-18",{"date":50,"type":21},"2026-11-30",{"name":52,"class":53},"Odense University Hospital","OTHER",1,{"id":56,"slug":57,"hasResults":12,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":54},"100594505","phase-2-brain-computer-interface-visualization-training-to-optimize-muscle-activation-following-orthopaedic-surgery-100594505","NCT07020312","Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery","Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery: A Blinded Randomized Controlled Trial","iBrainTechRCT","Participants\n\n* Inclusion Criteria:\n\n  * Patient age \\>18 years\n  * Ability to complete neurofeedback training and follow study follow-ups\n  * Indicated for one of the four investigated orthopedic procedures\n* Exclusion Criteria:\n\n  * Inability to participate in neurofeedback training\n  * Lack of decisional capability\n  * History of stroke, movement disorder (e.g. Parkinson's), peripheral neuropathy\n  * Cardiac pacemaker or other internal electronic device\n  * BMI \\>35\n  * Previous surgery or specific pathology on the affected joint (refer to procedure specific indications below)\n\nProcedure Specifics:\n\nAnterior cruciate ligament reconstruction (ACLR) Procedure-specific Inclusion Criteria\n\n* Patients undergoing primary ACLR with autograft or allograft tissue\n* Adjunct lateral Extra-articular tenodesis will be included\n* Additional meniscus debridement and repair will be included Procedure-specific exclusion criteria\n* Revision ACL surgery\n* Moderate to Severe arthritis - Kellgren-Lawerence (KL) Grade \\> 3\n* Patients with meniscus root repair\n* Non-weight-bearing status exceeding 1 week postoperatively\n\nTotal knee arthroplasty (TKA) Procedure specific inclusion criteria\n\n* Patients undergoing primary TKA\n* Preoperative total knee range of motion of at least 100 degrees (combined flexion and extension)\n* Prior extensor mechanism tendon repair, quadriceps or patella tendon. Procedure specific exclusion criteria\n* Revision surgery\n* Hinged implant\n* Any open procedure involving the knee joint\n* Symptomatic arthritis in the contralateral knee with planned or expected total knee arthroplasty within 6 months\n* Inflammatory Arthritis\n\nTotal hip arthroplasty (THA) Procedure Specific Inclusion Criteria\n\n* Patients undergoing primary THA Procedure Specific Exclusion Criteria\n* Revision Surgery\n* Any open procedure involving the hip joint\n* Bilateral THA procedures\n* Inflammatory Arthritis\n\nHip arthroscopy (HA) for femoroacetabular impingement syndrome (FAIS) Procedure Specific Inclusion Criteria\n\n· Patients undergoing HA for FAIS Procedure Specific Exclusion Criteria\n\n* Revision Surgery\n* Diagnosis of hip dysplasia","18 Years",{"count":65,"type":21},240,"INTERVENTIONAL",[68],"PHASE2","After orthopedic surgeries like knee or hip replacement, some patients struggle to fully activate their muscles due to a condition called Arthrogenic Muscle Inhibition (AMI). AMI can slow recovery and make physical therapy less effective. This clinical trial is testing whether a special type of brain training-called neurofeedback visualization training-can help improve muscle activation and speed up recovery.\n\nIn this study, patients will receive standard physical therapy after surgery. Half of them will also use a device that helps them \"visualize\" exercises while wearing a cap that reads brain signals (EEG). The cap tracks brain activity when patients imagine doing specific movements. A computer then shows a virtual avatar performing the movements, giving feedback in real time-like a video game controlled by the brain.\n\nThe study includes patients recovering from one of four surgeries:\n\n1. Anterior cruciate ligament reconstruction (ACLR)\n2. Total knee arthroplasty (TKA)\n3. Total hip arthroplasty (THA)\n4. Hip arthroscopy (HA) for femoroacetabular impingement (FAI)\n\nThe goal is to see if this training improves muscle strength, movement, and daily function more than standard therapy alone. The study will take place at Rush University Medical Center in Chicago and enroll 240 adults, with 60 patients per type of surgery. Each participant will be followed for up to 6 months after surgery and complete strength tests, movement assessments, and questionnaires about their recovery.\n\nThe hope is that combining brain training with physical therapy will lead to faster, more complete recoveries and improve how patients move after surgery.",[71,72,28,73],"Anterior Cruciate Ligament Reconstruction","Total Hip Arthroplasty (THA)","Hip Arthroscopy",[75,76,77,73,78,79,80,81,82,83],"ACLR","THA","TKA","Arthrogenic muscle inhibition","Electroencephalography","Gait","Motion Analysis","Biomechanics","Strength",{"date":85,"type":46},"2026-06-18",{"date":87,"type":46},"2025-08-14",{"date":89,"type":21},"2028-08-01",{"name":91,"class":53},"Rush University Medical Center",{"id":93,"slug":94,"hasResults":12,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":12,"sex":17,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":4,"studyType":66,"phases":103,"briefSummary":105,"conditions":106,"keywords":107,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":54},"100630294","phase-4-methadone-in-the-management-of-post-operative-pain-in-total-knee-replacement-100630294","NCT07485803","Methadone in the Management of Post-Operative Pain in Total Knee Replacement","A Prospective, Randomized Trial Utilizing Methadone in the Management of Post-Operative Pain in Total Knee Replacement","Inclusion Criteria:\n\n1. Provision of signed and dated informed consent from\n2. Stated willingness to comply with all study procedures and availability to attend all required visits for the duration of the study.\n3. Age 21- 75\n4. Unilateral total knee arthroplasty at Colorado Joint Replacement\n5. All individuals will be screened for drug use (opioid use, illicit drug use) at their preoperative appointment\n6. For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation.\n\nExclusion Criteria:\n\n1. Narcotic use in the past 6 weeks\n2. Current or previous history of drug and alcohol abuse\n3. Tobacco use in the previous 90 days\n4. Treatment with another investigational drug\n5. Patients that cannot receive spinal anesthesia\n6. Patients that cannot receive the standardized multimodal pain medications (i.e. Tylenol, gabapentin and meloxicam)'\n7. Patients that are not able to go home after leaving the hospital and require a short-term rehabilitation facility\n8. Obstructive sleep apnea\n9. Morbid obesity (BMI \\>40)\n10. Patients with liver disease.\n11. Significant kidney disease - stage 3 CKD or greater\n12. Pregnant or nursing females\n13. Baseline QTc \\>480\n14. severe COPD (GOLD 3 or 4)\n15. home oxygen requirement","21 Years","75 Years",{"count":102,"type":21},192,[104],"PHASE4","The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.",[28],[108,77,109],"pain management","methadone","2026-06-16",{"date":45,"type":46},{"date":113,"type":46},"2026-06-01",{"date":115,"type":21},"2028-06",{"name":117,"class":53},"AdventHealth",{"id":119,"slug":120,"hasResults":12,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":66,"phases":128,"briefSummary":130,"conditions":131,"keywords":132,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":145},"100559534","multimodal-biopsychosocial-teleprehabilitation-for-total-knee-arthroplasty-100559534","NCT06565377","Multimodal Biopsychosocial Teleprehabilitation for Total Knee Arthroplasty","The Added Value of Multimodal Biopsychosocial Teleprehabilitation in People Undergoing Total Knee Arthroplasty: a Pilot\u002FFeasibility Trial","MULTIPREP","Inclusion Criteria:\n\n* People scheduled for elective primary TKA at one of the participating hospitals;\n* Being over 18 years old;\n* Dutch speaking\u002Freading\n\nExclusion Criteria:\n\n* Doing activities that make them feel out of breath for 300 minutes or more per week on average;\n* Orthopedic, neurological, cardiovascular or any other condition\u002Fcomorbidity that leads to an overall contraindication for moderate physical activity;\n* Cognitive impairment (≥11 on 6-item Cognitive Impairment Test and\u002For unable to understand the study instructions);\n* Presence of uncontrolled inflammatory arthritides (e.g., rheumatoid arthritis, gout);\n* Uncontrolled psychiatric disorders;\n* Active cancer and\u002For active cancer treatment ((hormonal) maintenance therapy is allowed);\n* People undergoing emergency (non-elective) TKA.",{"count":127,"type":21},40,[129],"NA","Knee replacement surgeries are one of the most frequently performed elective surgeries, with approximately 29,000 such procedures carried out annually in Belgium. Although these surgeries have been increasingly refined over the years, leading to better surgical outcomes, there is still room for improvement in terms of pre-surgical biopsychosocial patient preparation. Such preparation aims to optimally inform patients before their surgery and to start preparing them for rehabilitation and resumption of activities after surgery. Therefore, we aim to assess the added value and feasibility of prehabilitation within the knee replacement care pathway.\n\nThe primary objective is to investigate the feasibility, acceptability and safety of multimodal biopsychosocial teleprehabilitation (BPS-teleprehab) for people undergoing total knee arthroplasty (TKA).\n\nThe secondary objective is to explore the effect of BPS-teleprehab versus best-evidence preoperative advice for people undergoing TKA on activity outcomes, functioning, pain, symptoms of central sensitization, quality of life, cognitive-emotional factors, joint awareness, satisfaction with the surgery, healthcare and medication use and productivity loss.\n\nThe tertiary objective is to explore baseline associations between the collected outcome measures, demographics and medical data in people scheduled for TKA.\n\nFurthermore, this pilot trial will inform potential protocol modifications in prepara- tion of an eventual fully powered randomized controlled trial to investigate the ef- fectiveness of BPS-teleprehab in people undergoing TKA.",[28],[133,134,135],"total knee arthroplasty","knee replacement","prehabilitation","2026-06-11",{"date":138,"type":46},"2026-06-15",{"date":140,"type":46},"2024-07-31",{"date":142,"type":21},"2027-08-31",{"name":144,"class":53},"Universitair Ziekenhuis Brussel",2,{"id":147,"slug":148,"hasResults":12,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":153,"sex":154,"minAge":155,"maxAge":156,"enrollmentInfo":157,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":4},"100642517","balance-fall-risk-and-gait-in-women-with-total-knee-arthroplasty-100642517","NCT07650175","Balance, Fall Risk, and Gait in Women With Total Knee Arthroplasty","Investigation of Balance, Fall Risk, Gait Performance, and Quality of Life in Postmenopausal Women Undergoing Total Knee Arthroplasty","Inclusion Criteria:\n\n* Volunteering to participate in the study.\n* Being 60 years of age or older.\n* Having a Mini Mental Test score of 24 or higher.\n* Not having undergone previous arthroplasty surgery on the knee where surgery is planned.\n* Having experienced unilateral TDA.\n* Being a postmenopausal woman\n\nExclusion Criteria:\n\n* Individuals whose vital signs are unstable after surgery, or who develop any major complications such as deep vein thrombosis, pulmonary embolism, wound infection, or prolonged anesthesia side effects.\n* Presence of any neurological, vestibular, visual, cardiopulmonary, auditory, or cognitive deficits that may affect measurements.\n* Individuals diagnosed with diabetes.",true,"FEMALE","60 Years","85 Years",{"count":158,"type":21},30,"Total knee arthroplasty (TKA) is a commonly performed surgical procedure aimed at reducing pain, restoring joint function, and improving quality of life, particularly among older women. Despite improvements in pain and functional outcomes following TKA, findings regarding balance, fall risk, and gait performance remain inconsistent. Impairments in these parameters may adversely affect daily activities, independence, and overall quality of life.\n\nUnlike previous studies that have primarily focused on one or two outcomes, this study will comprehensively evaluate balance, fall risk, gait performance, and quality of life in postmenopausal women who have undergone TKA. The findings are expected to provide a more holistic understanding of long-term functional outcomes following TKA and contribute to the planning of rehabilitation programs. Therefore, the aim of this study is to compare balance, fall risk, gait performance, and quality of life between postmenopausal women who have undergone TKA and healthy postmenopausal women.",[28,161,162,163,164,165],"Postmenopausal Women","Quality of Life (QOL)","Balance","Risk of Falling","Walking","NOT_YET_RECRUITING","2026-06-10",{"date":110,"type":46},{"date":170,"type":21},"2026-06-20",{"date":172,"type":21},"2026-07-22",{"name":174,"class":53},"Karabuk University",{"id":176,"slug":177,"hasResults":12,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":181,"eligibilityCriteria":182,"healthyVolunteers":153,"sex":17,"minAge":63,"maxAge":183,"enrollmentInfo":184,"targetDuration":4,"studyType":66,"phases":186,"briefSummary":187,"conditions":188,"keywords":190,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":54},"100642144","biceps-femoris-short-head-bifes-block-and-adductor-canal-block-for-postoperative-analgesia-following-total-knee-arthroplasty-100642144","NCT07577869","Biceps Femoris Short Head (BiFeS) Block and Adductor Canal Block for Postoperative Analgesia Following Total Knee Arthroplasty","A Comparison of the Effects of Biceps Femoris Short Head Block and Adductor Canal Block in Total Knee Arthroplasty on Postoperative Analgesia Using Multimodal Analgesia Methods","BiFeS Adductor","Inclusion Criteria:\n\n* Patients aged 18 and older\n* ASA I-III\n* Patients scheduled for elective unilateral knee replacement\n* Eligibility for and consent to spinal anesthesia\n\nExclusion Criteria:\n\n* History of allergy or anaphylaxis to local anesthetics, animal gelatin, or chlorhexidine\n* Bleeding diathesis\u002Finability to discontinue anticoagulants\n* Infection (at the injection site\u002Fsepsis)\n* Neurological disorders or cognitive impairment affecting pain perception\n* Pregnancy, breastfeeding\n* Patients under 18 years of age","80 Years",{"count":185,"type":21},60,[129],"This prospective randomized controlled study aims to evaluate the effect of ultrasound-guided Biceps Femoris Short Head (BiFeS) block combined with adductor canal block on postoperative opioid consumption and pain control in patients undergoing elective total knee arthroplasty under spinal anesthesia.\n\nA total of 60 patients aged 18-80 years with ASA physical status I-III scheduled for unilateral elective total knee arthroplasty will be randomized into two groups. The intervention group will receive spinal anesthesia followed by BiFeS block and adductor canal block before surgery, in addition to standard multimodal analgesia and postoperative morphine patient-controlled analgesia (PCA). The control group will receive spinal anesthesia and standard multimodal analgesia with postoperative morphine PCA without peripheral nerve block.\n\nThe primary outcome is total morphine consumption during the first 24 postoperative hours. Secondary outcomes include postoperative pain scores assessed by Numeric Rating Scale (NRS), time to first analgesic requirement, time to first foot movement, and Quality of Recovery-15 (QoR-15) scores.",[189,28],"Postoperative Pain Following Knee Arthroplasty",[191,192,193],"Postoperative Pain","BiFeS","BiFeS and Adductor Canal Block",{"date":195,"type":46},"2026-06-12",{"date":197,"type":46},"2026-06-02",{"date":199,"type":21},"2027-07-02",{"name":201,"class":202},"Ömer Kayar","OTHER_GOV",{"id":204,"slug":205,"hasResults":12,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":209,"eligibilityCriteria":210,"healthyVolunteers":12,"sex":17,"minAge":211,"maxAge":212,"enrollmentInfo":213,"targetDuration":4,"studyType":66,"phases":215,"briefSummary":216,"conditions":217,"keywords":219,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":235},"100643184","phase-4-branched-chain-amino-acids-for-sarcopenia-in-patients-undergoing-total-knee-arthroplasty-100643184","NCT07634523","Branched Chain Amino Acids for Sarcopenia in Patients Undergoing Total Knee Arthroplasty","The Effect of BCAA on Sarcopenia in Total Knee Arthroplasty Patients: A Multi-center, Randomized Controlled Trial","LIVACT IIT","Inclusion Criteria:\n\n1\\. Patients aged 40 to 100 years who are scheduled to undergo total knee arthroplasty.\n\nExclusion Criteria:\n\n1. Participants who used antiretroviral agents within 4 weeks before the first administration of Livact.\n2. Participants who used medications associated with fatty liver within 4 weeks before the first administration of Livact, including thiazolidinediones, sodium glucose cotransporter 2 inhibitors, amiodarone, methotrexate, tamoxifen, valproate, or corticosteroids.\n3. Participants who used branched chain amino acid products or multinutritional supplements within 4 weeks before the first administration of Livact.\n4. Participants who used pain medications other than those prescribed for total knee arthroplasty treatment within 2 weeks before the first administration of Livact.\n5. Participants with markedly decreased hepatic protein synthetic function.\n6. Participants with congenital branched chain amino acid metabolism disorders.\n7. Participants with hereditary galactose intolerance, Lapp lactase deficiency, or glucose galactose malabsorption.\n8. Participants with a history of high tibial osteotomy.\n9. Participants with neurologic diseases such as stroke or Parkinson disease.\n10. Participants with gait disturbance due to causes other than arthritis.\n11. Participants taking medication for spinal stenosis.\n12. Participants with a history of hypersensitivity to the investigational product or its components.\n13. Pregnant or breastfeeding participants.\n14. Participants planning pregnancy during the trial or who have the possibility of pregnancy but do not agree to use appropriate contraception during the trial.\n15. Participants judged by the investigator to be inappropriate for participation in the clinical trial.","40 Years","100 Years",{"count":214,"type":21},140,[104],"This multicenter, prospective, randomized controlled trial evaluates whether postoperative administration of branched chain amino acids affects skeletal muscle mass index and sarcopenia related functional outcomes in patients undergoing total knee arthroplasty.\n\nParticipants are randomly assigned to receive Livact granules 4.15 g three times daily for 3 months after surgery or to receive standard postoperative care without branched chain amino acid administration. Skeletal muscle mass index, physical function, patient reported outcomes, laboratory findings, medication compliance, and adverse events are assessed at baseline, 5 weeks, and 15 weeks after surgery.",[218,28],"Sarcopenia",[220,221,222,223,224,28,218,225],"Branched Chain Amino Acids","BCAA","Livact","Skeletal Muscle Mass Index","Bioelectrical Impedance Analysis","Randomized Controlled Trial","2026-06-04",{"date":228,"type":46},"2026-06-09",{"date":230,"type":46},"2025-02-06",{"date":232,"type":21},"2027-05-31",{"name":234,"class":53},"Seoul National University Hospital",3,{"id":237,"slug":238,"hasResults":12,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":4,"enrollmentInfo":244,"targetDuration":4,"studyType":66,"phases":246,"briefSummary":247,"conditions":248,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":145},"100586807","infiltration-or-nerve-blocks-in-addition-to-adductor-canal-block-100586807","NCT06920186","Infiltration or Nerve Blocks in Addition to Adductor Canal Block","Comparison of the Benefit of Peripheral Nerve Quadri-block Versus Adductor Canal Block + Surgical Infiltration in Total Knee Arthroplasty","INCA","Inclusion Criteria:\n\n* Adult male or female\n* Patient with signed consent to participate in the study,\n* Patient with uni or bilateral primary gonarthrosis\n* Indication for total knee arthroplasty.\n\nExclusion Criteria:\n\n* History of knee fracture, arthroplasty or osteotomy\n* Known or unknown contraindication to ALR or locoregional anesthesia products\n* Neurological disease, stroke sequelae\n* Mental deficiency or any other reason that may hinder understanding or strict application of the protocol\n* Patient not affiliated to the French social security system\n* Patient under court protection, guardianship or curatorship\n* Pregnant or potentially pregnant women (women of childbearing age without effective contraception)\n* Patient already included in another therapeutic study protocol",{"count":245,"type":21},100,[129],"The aim of this study is to evaluate the analgesic efficacy of this quadruple sensory block compared with the currently recommended procedure (adductor canal block + infiltration).",[249,28],"Gonarthrosis","2026-06-03",{"date":252,"type":46},"2026-06-05",{"date":254,"type":46},"2026-05-04",{"date":256,"type":21},"2027-06",{"name":258,"class":53},"GCS Ramsay Santé pour l'Enseignement et la Recherche",{"id":260,"slug":261,"hasResults":12,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":4,"enrollmentInfo":267,"targetDuration":4,"studyType":66,"phases":268,"briefSummary":269,"conditions":270,"keywords":4,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":274,"leadSponsor":276,"locationsCount":54},"100642896","phase-4-io-vancomycin-administration-in-tka-100642896","NCT07633418","IO Vancomycin Administration in TKA","Systemic Vancomycin Levels in Intraosseous Administration During Total Knee Arthroplasty","IO Vanco","Inclusion Criteria:\n\n1. Is a patient over the age of 18 receiving treatment at UC San Diego\n2. Is undergoing primary unilateral total knee arthroplasty\n3. Is able to provide consent\n4. Is candidate for IO administration of Vancomycin\n\nExclusion Criteria:\n\n1. Has had a previous surgery on the knee of interest (with the exception of arthroscopy)\n2. Has a BMI \\>35\n3. Has a contraindication to receiving vancomycin, cefepime, or cefazolin (i.e. allergy)\n4. Has diabetes with A1c \\>7.5% (unless with controlled fructosamine)\n5. Is immunocompromised\u002Fimmunosuppressed (i.e. due to HIV, hepatitis C, end-stage renal disease, post-transplant status, chemotherapy or radiation therapy within 6 months of surgery, immunomodulating medications)\n6. Has a history of active infection\n7. Inability to provide consent\n8. Prisoner\n9. Pregnant women",{"count":158,"type":21},[104],"This is a prospective, single-center, open-label study evaluating systemic vancomycin levels following preoperative intraosseous administration in patients undergoing primary unilateral total knee arthroplasty. Eligible participants will receive preoperative intraosseous vancomycin (500 mg in 100 mL saline) as part of standard perioperative infection prophylaxis. The study is open-label due to the nature of the intervention. Blood samples will be collected at predefined time points intraoperatively to measure serum vancomycin concentrations. Patients will be randomized to either a tourniquet or no tourniquet for these blood draws.",[28],{"date":272,"type":46},"2026-06-08",{"date":113,"type":21},{"date":275,"type":21},"2029-04-29",{"name":277,"class":53},"University of California, San Diego",{"id":279,"slug":280,"hasResults":12,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":4,"enrollmentInfo":285,"targetDuration":4,"studyType":66,"phases":287,"briefSummary":288,"conditions":289,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":291,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":54},"100638529","cryotherapy-versus-standard-care-in-reducing-opioid-consumption-after-total-knee-arthroplasty-100638529","NCT07630337","Cryotherapy Versus Standard Care in Reducing Opioid Consumption After Total Knee Arthroplasty","Efficacy of Cryotherapy Versus Standard Care in Reducing Opioid Consumption After Total Knee Arthroplasty: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 60 and 80 years\n* Scheduled to undergo primary total knee arthroplasty for knee osteoarthritis\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Revision total knee arthroplasty\n* Vascular disorders affecting the lower limbs\n* Body mass index (BMI) greater than 35 kg\u002Fm²\n* Active knee infection\n* Severe preoperative limitations in knee mobility",{"count":286,"type":21},74,[129],"The goal of this clinical trial is to learn if compressive cryotherapy can reduce postoperative opioid consumption in patients undergoing primary total knee arthroplasty. It will also evaluate whether compressive cryotherapy improves postoperative recovery compared with standard care using conventional ice application. The main questions it aims to answer are:\n\nDoes compressive cryotherapy reduce the total consumption of opioids during the first 7 days after total knee arthroplasty?\n\nDoes compressive cryotherapy reduce postoperative pain and improve early recovery compared with standard cryotherapy?\n\nResearchers will compare compressive cryotherapy using the Game Ready® device with standard care using traditional ice packs to determine whether the intervention reduces opioid consumption and improves postoperative outcomes.\n\nParticipants will:\n\nBe randomly assigned to receive compressive cryotherapy or standard cryotherapy with ice packs after surgery.\n\nApply the assigned treatment four times per day during the first 7 postoperative days.\n\nRecord daily pain levels using a visual analog scale (VAS) and document opioid consumption in a pain diary.\n\nAttend a follow-up visit on postoperative day 7 for evaluation of knee swelling, hematoma size, and recovery using the QoR-15 questionnaire.",[290,191,28],"Osteoarthritis, Knee",{"date":252,"type":46},{"date":293,"type":46},"2026-02-01",{"date":295,"type":21},"2027-06-01",{"name":297,"class":53},"Hospital Italiano de Buenos Aires",{"id":299,"slug":300,"hasResults":12,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":4,"eligibilityCriteria":304,"healthyVolunteers":153,"sex":17,"minAge":63,"maxAge":4,"enrollmentInfo":305,"targetDuration":4,"studyType":66,"phases":306,"briefSummary":307,"conditions":308,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":54},"100614683","phase-4-vancomycin-in-tkas-100614683","NCT07282782","Vancomycin in TKAs","A Prospective, Randomized Parallel Group Study of the Efficacy of Vancomycin Administered Through Intraarticular Injection Versus Intraosseous Injection Versus Intravenous Infusion in Patients Undergoing Total Knee Arthroplasty","Inclusion Criteria:\n\n* Any patient over the age of 18 years of age receiving treatment at UC San Diego Health\n* Undergoing primary unilateral TKA\n* Ability to provide consent\n\nExclusion Criteria:\n\n* previous surgery on the knee (with the exception of arthroscopy)\n* BMI \\> 35\n* contraindication to receiving vancomycin, cefepime or cefazolin (ie, allergy, etc)\n* diabetics with A1c\\>7.5% (unless controlled fructosamine)\n* immunocompromised or immunosuppressed patients (HIV, Hepatitis C, end stage renal disease (ESRD), post transplant, chemotherapy or radiation therapy within 6 months of surgery, immunomodulating meducations)\n* no history of active infections\n* no history of chronic kidney disease",{"count":158,"type":21},[104],"Periprosthetic joint infection (PJI) is a national health crisis and leads to very poor outcomes for patients undergoing elective joint replacement. Within the realm of elective total knee arthroplasty (TKA), various methods of infection prophylaxis are in place. These include sterile precautions, would\u002Ftissue handling, and antibiotic prophylaxis. With respect to the latter, various approaches have been utilized including intravenous and intraosseous administration of vancomycin, preoperatively. Intraosseous administration does require another wound and a specific device to administer. The investigators proposed that intraarticular injection of vancomycin is non-inferior to intraosseous administration, thus reducing wounds, time, and cost.",[28],"2026-05-31",{"date":250,"type":46},{"date":312,"type":46},"2024-06-10",{"date":314,"type":21},"2028-12-31",{"name":277,"class":53},{"id":317,"slug":318,"hasResults":12,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":4,"enrollmentInfo":323,"targetDuration":4,"studyType":66,"phases":325,"briefSummary":326,"conditions":327,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":54},"100469363","persona-mc-vs-ps-rct-with-rosa-100469363","NCT05391828","Persona MC vs PS RCT With ROSA","Randomized Control Trial Comparing Zimmer Biomet Persona Medial Congruent Versus Posterior Stabilized Total Knee Arthroplasty for Treatment of Knee Arthritis Using the ROSA Knee System","Inclusion Criteria:\n\n1. Patients ≥18 years of age\n2. Patients scheduled an elective primary TKA for a diagnosis of osteoarthritis or inflammatory arthritis using the ROSA Knee System.\n3. Patient is willing to cooperate and follow study protocol and visit schedule\n4. Subject has access to a device is capable of pairing to the Apple Watch, supporting application updates and is compatible with the mymobility App.\n\nExclusion Criteria:\n\n1. Patient is pregnant\n2. Patient is unable to provide written consent\n3. Revision TKA\n4. History of prior infection in the affected knee\n5. History of prior open surgery with significant hardware in place on the affected knee (i.e. prior distal femur or proximal tibia fracture or osteotomy)\n6. Preoperative diagnosis of post-traumatic arthritis, avascular necrosis, or fracture",{"count":324,"type":21},200,[129],"A randomized, controlled study comparing two total knee implant devices, Persona medial congruent (MC) vs posterior stabilized (PS). These surgeries will be performed using the ROSA robotic system. Patients will be followed up to 5 years.",[28],"2026-05-27",{"date":330,"type":46},"2026-05-29",{"date":332,"type":46},"2023-09-27",{"date":334,"type":21},"2028-12",{"name":336,"class":53},"NYU Langone Health",{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":77,"eligibilityCriteria":343,"healthyVolunteers":12,"sex":17,"minAge":344,"maxAge":183,"enrollmentInfo":345,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":347,"conditions":348,"keywords":351,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":357,"completionDateStruct":359,"leadSponsor":361,"locationsCount":54},"100626990","oral-vs-intravenous-dexamethasone-in-total-knee-arthroplasty-100626990","NCT07442812","Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty","The Role of Dexamethasone in Total Knee Arthroplasty: Effects of Oral and Intravenous Administration on Early Postoperative Pain and Mobilization","Inclusion Criteria:\n\n* Age between 50 and 80 years\n* Diagnosis of primary knee osteoarthritis (primary gonarthrosis)\n* Scheduled for elective primary total knee arthroplasty\n* ASA physical status I or II\n* Ability to ambulate independently (with or without assistive devices) preoperatively\n* Ability to understand study procedures and complete pain and functional assessments\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Revision total knee arthroplasty\n* History of knee joint infection\n* Inflammatory arthritis (e.g., rheumatoid arthritis)\n* Chronic systemic corticosteroid use\n* Uncontrolled diabetes mellitus\n* Known endocrine disorders affecting glucose metabolism\n* Active infection at any site\n* Known hypersensitivity to corticosteroids\n* Severe hepatic, renal, or cardiac disease\n* Neurological or musculoskeletal disorders affecting gait or balance\n* Inability or unwillingness to comply with study procedures","50 Years",{"count":346,"type":21},270,"This prospective observational cohort study aims to evaluate the association between perioperative dexamethasone administration and early postoperative recovery following primary total knee arthroplasty. In routine clinical practice, dexamethasone may be administered orally, intravenously, or not administered, depending on the surgeon's established perioperative protocol.\n\nThe primary objective is to assess early postoperative recovery in terms of pain intensity, functional mobility, and knee joint range of motion. Secondary objectives include evaluation of inflammatory response, postoperative metabolic changes, opioid requirement, and the severity of postoperative nausea and vomiting (PONV).\n\nGroup allocation is non-randomized and determined solely by the standard perioperative management approach routinely applied by the surgeon selected by the patient. No additional interventions are introduced for research purposes. All outcomes are assessed prospectively during the early postoperative period.",[349,350,28],"Knee Osteoarthritis","Gonarthrosis; Primary",[28,352,349,249,353],"Intravenous Dexamethasone","Multimodal Analgesia","2026-05-19",{"date":356,"type":46},"2026-05-20",{"date":358,"type":46},"2026-03-31",{"date":360,"type":21},"2027-10",{"name":362,"class":53},"Haseki Training and Research Hospital",{"id":364,"slug":365,"hasResults":12,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":369,"eligibilityCriteria":370,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":100,"enrollmentInfo":371,"targetDuration":4,"studyType":66,"phases":372,"briefSummary":373,"conditions":374,"keywords":376,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":386,"lastUpdatePostDateStruct":387,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":54},"100612014","effect-of-ipack-and-bifes-blocks-on-quality-of-recovery-after-total-knee-arthroplasty-100612014","NCT07248072","Effect of iPACK and BiFeS Blocks on Quality of Recovery After Total Knee Arthroplasty","Effects of iPACK and Biceps Femoris Short Head (BiFeS) Blocks Combined With Adductor Canal Block on Quality of Recovery After Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind Clinical Trial","BiFeS-TKA","Inclusion Criteria:\n\n* Age 18-75 years\n* Scheduled for elective primary unilateral total knee arthroplasty (TKA)\n* Planned spinal anesthesia\n* ASA physical status I-III\n* Ability to understand study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to local anesthetics or other study medications\n* Coagulopathy or current anticoagulant therapy\n* Severe hepatic, renal, or cardiac failure\n* History of neuropathic pain\n* Infection at the site of proposed nerve block\n* Pre-existing neuromuscular disorders in the lower extremities\n* Inability to cooperate or refusal to participate in the study\n* Pregnancy",{"count":286,"type":21},[129],"This prospective, randomized, double-blind clinical trial aims to compare the effects of two different posterior knee analgesia techniques-iPACK block (Interspace Between the Popliteal Artery and the Capsule of the posterior Knee) and the Biceps Femoris Short Head (BiFeS) block-when combined with an adductor canal block (ACB) in patients undergoing elective unilateral total knee arthroplasty (TKA). Effective postoperative analgesia is essential for early mobilization, enhanced recovery, and patient satisfaction after TKA. Although ACB provides good anterior knee analgesia while preserving quadriceps strength, additional posterior knee analgesia is often required.\n\nThe iPACK block is a commonly used technique that targets the posterior knee capsule, whereas the newer BiFeS block aims to provide more selective posterolateral sensory blockade with potentially reduced risk of motor involvement. However, comparative clinical data between these two techniques are limited.\n\nThe primary objective of this study is to evaluate the difference between the iPACK and BiFeS blocks in terms of Quality of Recovery-15 (QoR-15) scores at 24 hours postoperatively. Secondary objectives include comparisons of postoperative pain scores, opioid consumption, time to first analgesic request, quadriceps and anterior tibialis muscle strength, functional test performance, time to mobilization, active range of motion, and the incidence of adverse events.\n\nA total of 74 adult patients scheduled for elective unilateral TKA under spinal anesthesia will be randomized in a 1:1 ratio into two groups: ACB + iPACK block or ACB + BiFeS block. All blocks will be performed under ultrasound guidance by an experienced anesthesiologist. Outcome assessments will be conducted by blinded investigators. The study aims to provide high-quality clinical evidence regarding the effectiveness of the BiFeS block compared to the widely used iPACK technique.",[349,375,28],"Postoperative Pain Management",[28,377,378,379,380,381,382,383,384,385],"Knee Replacement","Adductor Canal Block","iPACK Block","BiFeS Block","Regional Anesthesia","Postoperative Analgesia","QoR-15","Posterior Knee Pain","Ultrasound-Guided Nerve Block","2026-05-15",{"date":48,"type":46},{"date":389,"type":46},"2025-12-01",{"date":391,"type":21},"2026-07-02",{"name":393,"class":53},"Ataturk University",{"id":395,"slug":396,"hasResults":12,"nctId":397,"briefTitle":398,"officialTitle":399,"acronym":400,"eligibilityCriteria":401,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":183,"enrollmentInfo":402,"targetDuration":4,"studyType":66,"phases":403,"briefSummary":404,"conditions":405,"keywords":408,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":416,"completionDateStruct":417,"leadSponsor":419,"locationsCount":54},"100638168","genicular-nerve-block-in-knee-arthroplasty-100638168","NCT07589127","GENicular Nerve Block in KNEE Arthroplasty","GENicular Nerve Block in KNEE Arthroplasty - The GENKNEE Trial","GENKNEE","Inclusion Criteria:\n\n* Symptomatic knee OA grade II-IV according to the Kellgren-Lawrence classification system scheduled for primary total knee arthroplasty\n* American Society of Anesthesiologists (ASA) Physical Status grade I-III\n* Able to provide written informed consent\n* Able to undergo surgery under spinal anesthesia\n\nExclusion Criteria:\n\n* Younger than 18 or older than 80 years\n* ASA physical status IV\n* Allergy to local anesthetics\n* Revision surgery\n* Chronic opioid use (\\> 3 months)\n* Coagulopathy\n* Cognitive impairment\n* Inability to comply with study procedures\n* Patients scheduled for day care surgery.",{"count":5,"type":21},[129],"The goal of this clinical trial is to learn whether a preoperative genicular nerve block (GNB) can reduce pain after knee replacement surgery in adults with knee osteoarthritis (OA) undergoing total knee arthroplasty (TKA). It will also assess whether this treatment can reduce opioid use and improve recovery.\n\nThe main questions it aims to answer are:\n\n* Does a preoperative GNB reduce pain during movement 24 hours after surgery compared with placebo?\n* Does it reduce opioid consumption and improve physical activity and functional outcomes after surgery?\n\nResearchers will compare patients receiving a GNB to patients receiving a placebo injection to see if the nerve block improves postoperative pain and recovery.\n\nParticipants will:\n\n* Be randomly assigned to receive either a GNB or a placebo injection before surgery\n* Undergo standard knee replacement surgery and postoperative care\n* Report pain levels at regular intervals after surgery\n* Complete questionnaires on function, quality of life, and recovery\n* Wear an activity monitor to measure physical activity after surgery\n* Attend follow-up assessments at 1 week, 1 month, and 3 months",[406,28,407],"Osteoarthritis (OA) of the Knee","Genicular Nerve Block",[409,410,411,412,413],"Osteoarthritis","Knee","Knee osteoarthritis","Total knee arthroplasty","Genicular nerve block","2026-05-11",{"date":386,"type":46},{"date":113,"type":21},{"date":418,"type":21},"2029-06-01",{"name":420,"class":202},"Helse Møre og Romsdal HF",{"id":422,"slug":423,"hasResults":12,"nctId":424,"briefTitle":425,"officialTitle":426,"acronym":427,"eligibilityCriteria":428,"healthyVolunteers":153,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":429,"targetDuration":4,"studyType":66,"phases":431,"briefSummary":432,"conditions":433,"keywords":436,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":446,"locationsCount":4},"100638465","effects-of-stress-ball-use-and-breathing-exercises-on-pain-and-vital-signs-during-drain-removal-after-total-knee-arthroplasty-100638465","NCT07586436","Effects of Stress Ball Use and Breathing Exercises on Pain and Vital Signs During Drain Removal After Total Knee Arthroplasty","The Effect of Stress Ball Use and Breathing Exercises on Procedural Pain and Vital Signs During Drain Removal After Total Knee Arthroplasty: A Randomized Controlled Trial","TDP","Inclusion Criteria:\n\n* Adults aged 18 years and older undergoing primary total knee arthroplasty\n* Patients with a surgical drain in place and scheduled for drain removal in the postoperative period\n* Able to provide informed consent\n* Able to communicate and understand instructions\n\nExclusion Criteria:\n\n* Patients with chronic pain syndromes or regular opioid use\n* Patients with cognitive impairment, delirium, or communication difficulties\n* Patients with contraindications to drain removal (e.g., active bleeding, hemodynamic instability)\n* Patients with neurological conditions affecting pain perception",{"count":430,"type":21},105,[129],"This randomized controlled trial aims to evaluate the effects of stress ball use and breathing exercises on procedural pain and vital signs during drain removal in patients undergoing total knee arthroplasty. Although drain removal is a short procedure, it is often associated with sudden and intense pain and may trigger physiological stress responses such as increased heart rate, blood pressure, and respiratory rate.\n\nA total of 105 patients will be randomly assigned to three groups: stress ball group, breathing exercise group, and standard care group. The interventions will be applied starting one minute before drain removal, continuing throughout the procedure, and for two minutes afterward.\n\nPain levels will be assessed using the Numeric Rating Scale (NRS), and vital signs (heart rate, blood pressure, respiratory rate, and oxygen saturation) will be measured at predefined time points before, during, and after the procedure. The findings of this study are expected to provide evidence on the effectiveness of simple, non-pharmacological interventions in reducing procedural pain and improving physiological stability during drain removal",[28,434,435],"Total Knee Arthroplasty Recovery","Pain After Knee Arthroscop",[28,437,438],"pain","Vital Signs","2026-05-08",{"date":441,"type":46},"2026-05-14",{"date":443,"type":21},"2026-05-05",{"date":445,"type":21},"2026-08-30",{"name":447,"class":53},"TC Erciyes University",{"id":449,"slug":450,"hasResults":12,"nctId":451,"briefTitle":452,"officialTitle":453,"acronym":4,"eligibilityCriteria":454,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":183,"enrollmentInfo":455,"targetDuration":4,"studyType":66,"phases":457,"briefSummary":458,"conditions":459,"keywords":460,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":464,"lastUpdatePostDateStruct":465,"startDateStruct":466,"completionDateStruct":467,"leadSponsor":469,"locationsCount":54},"100636624","adductor-canal-block-with-or-without-biceps-femoris-short-head-block-in-total-knee-arthroplasty-100636624","NCT07568106","Adductor Canal Block With or Without Biceps Femoris Short Head Block in Total Knee Arthroplasty","Effect of Adding a Biceps Femoris Short Head Block to an Adductor Canal Block on Postoperative Pain and Functional Outcomes After Total Knee Arthroplasty: A Randomized Controlled Trial","Inclusion Criteria:\n\n* ASA I-III\n* Adult patients undergoing unilateral primary TKA\n* Planned spinal anesthesia\n* Written informed consent\n\nExclusion Criteria:\n\n* Coagulopathy\n* Drug allergy\n* BMI \\> 35\n* Renal\u002Fhepatic failure\n* Chronic pain or opioid use\n* Depression or psychiatric disorder\n* Revision or bilateral TKA\n* Neurological deficits\n* Preoperative ROM \\\u003C 90°",{"count":456,"type":21},132,[129],"Total knee arthroplasty is associated with moderate to severe postoperative pain, which may delay mobilization and recovery. Multimodal analgesia including regional anesthesia techniques is widely used to improve outcomes. The adductor canal block (ACB) provides anteromedial knee analgesia but may not adequately cover the posterolateral region.\n\nThe biceps femoris short head (BiFeS) block is a novel motor-sparing regional anesthesia technique targeting the posterolateral capsule of the knee. This randomized controlled trial aims to compare the analgesic efficacy and functional outcomes of ACB combined with BiFeS block versus ACB alone in patients undergoing total knee arthroplasty.\n\nThe primary outcome is posterior knee pain at postoperative 6 hours. Secondary outcomes include pain scores within 48 hours, opioid consumption, early and late functional recovery, and opioid-related adverse effects.",[28],[28,378,461,191,462,463,349],"Biceps Femoris Short Head Block","Functional Recovery","Opioid Consumption","2026-04-29",{"date":443,"type":46},{"date":386,"type":21},{"date":468,"type":21},"2027-02-15",{"name":470,"class":53},"Cukurova University",{"id":472,"slug":473,"hasResults":12,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":4,"eligibilityCriteria":477,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":478,"enrollmentInfo":479,"targetDuration":4,"studyType":66,"phases":481,"briefSummary":482,"conditions":483,"keywords":489,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":464,"lastUpdatePostDateStruct":492,"startDateStruct":494,"completionDateStruct":496,"leadSponsor":497,"locationsCount":54},"100626579","binaural-beats-for-postoperative-pain-and-anxiety-reduction-100626579","NCT07437469","Binaural Beats for Postoperative Pain and Anxiety Reduction","Binaural Beats vs Music of Choice for Early Postoperative Pain After Ambulatory Total Knee and Total Hip Arthroplasty: A Randomized Controlled Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists Physical Status Classification System (ASA) 1-3\n* Spinal anesthesia\n* Patients receiving nerve-block in Post-Anesthesia Care Unit (PACU)\n* Primary total hip or total knee arthroplasty\n\nExclusion Criteria:\n\n* Moderate-severe hearing impairment or use of hearing aids\n* History of significant tinnitus, active delirium, chronic high-dose opioid therapy (\\>60 MME\u002Fday baseline)\n* Major psychiatric pathology\n* General anesthesia","99 Years",{"count":480,"type":21},50,[129],"To deliver a 30-minute binaural beats audio intervention in PACU and collect pain and anxiety outcomes immediately following surgery, and 4 hours following surgery completion in adults undergoing ambulatory total knee arthroplasty and total hip arthroplasty (TKA and THA).",[77,76,484,485,486,72,28,487,488],"Anxiety","Binaural Beats","Music Exposure","Total Knee Replacement","Total Hip Replacement",[76,77,490,412,484,491,485,486],"Total hip arthroplasty","Pain",{"date":493,"type":46},"2026-04-30",{"date":495,"type":46},"2026-03-09",{"date":445,"type":21},{"name":498,"class":53},"University of Miami",{"id":500,"slug":501,"hasResults":12,"nctId":502,"briefTitle":503,"officialTitle":504,"acronym":4,"eligibilityCriteria":505,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":183,"enrollmentInfo":506,"targetDuration":4,"studyType":66,"phases":508,"briefSummary":509,"conditions":510,"keywords":511,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":513,"lastUpdatePostDateStruct":514,"startDateStruct":516,"completionDateStruct":518,"leadSponsor":520,"locationsCount":54},"100636103","comparing-acbipack-and-acbbifes-block-combinations-for-analgesia-in-total-knee-arthroplasty-100636103","NCT07561333","Comparing ACB+IPACK and ACB+BiFeS Block Combinations for Analgesia in Total Knee Arthroplasty","Comparison of Analgesic Efficacy of Infiltration Between the Popliteal Artery and Capsule of the Knee (IPACK) Versus Biceps Femoris Short Head Block Combined With Adductor Canal Block in Total Knee Arthroplasty","Inclusion Criteria:\n\n* Scheduled for primary total knee arthroplasty surgery\n* ASA physical status classification I-III\n* Hemodynamically stable\n* Age ≥ 18 years and ≤ 80 years\n* BMI ≤ 35 kg\u002Fm²\n* Signed written informed consent form\n\nExclusion Criteria:\n\n* Revision total knee arthroplasty surgery\n* Simultaneous bilateral total knee arthroplasty\n* BMI \\> 40 kg\u002Fm²\n* ASA physical status classification 4-5\n* Inability to perform NRS pain scoring\n* Known allergy to local anesthetics\n* Pregnancy or breastfeeding\n* Age \\\u003C 18 or \\> 80 years\n* Uncontrolled anxiety disorder\n* Alcohol or drug dependency\n* Neuromuscular disease or peripheral nerve disease\n* High-dose opioid use within 3 days prior to surgery\n* Widespread chronic pain syndrome\n* Diabetes mellitus\n* Hepatic or renal insufficiency\n* Coagulation disorders\n* Current use of anticoagulant medications\n* Infection at the peripheral nerve block needle insertion site\n* Refusal to participate in the study",{"count":507,"type":21},78,[129],"Total knee arthroplasty (TKA) is associated with severe postoperative pain that delays mobilization, prolongs hospital stay, and reduces patient satisfaction. Regional analgesia techniques have gained prominence due to their opioid-sparing effects and favorable complication profiles compared to general anesthesia. While adductor canal block (ACB) effectively manages anterior knee pain with preserved motor function, posterior knee pain remains a challenge. IPACK (Infiltration between the Popliteal Artery and Capsule of the Knee) and the Biceps Femoris Short Head (BiFeS) block are techniques targeting posterior capsule innervation without causing motor block.This prospective study aims to compare the postoperative analgesic efficacy of ultrasound-guided ACB+IPACK versus ACB+BiFeS block combinations in patients undergoing TKA under spinal anesthesia. Patients (ASA I-III, age 18-80, BMI ≤35) will be randomized into two groups (n=39 each). Primary outcomes include NRS pain scores at rest and on movement, and opioid consumption at 0, 1, 3, 6, 12, 18, and 24 hours postoperatively. Secondary outcomes include time to first mobilization, motor block incidence, quadriceps muscle strength assessment, PONV, and quality of recovery (QoR-15).",[191,28],[412,512],"Regional anesthesia","2026-04-27",{"date":515,"type":46},"2026-05-01",{"date":517,"type":46},"2025-10-01",{"date":519,"type":21},"2026-11-01",{"name":521,"class":53},"Hitit University",{"id":523,"slug":524,"hasResults":12,"nctId":525,"briefTitle":526,"officialTitle":527,"acronym":528,"eligibilityCriteria":529,"healthyVolunteers":12,"sex":17,"minAge":530,"maxAge":4,"enrollmentInfo":531,"targetDuration":4,"studyType":66,"phases":533,"briefSummary":534,"conditions":535,"keywords":536,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":539,"lastUpdatePostDateStruct":540,"startDateStruct":542,"completionDateStruct":543,"leadSponsor":545,"locationsCount":4},"100634881","effect-of-ai-assisted-anatomical-visualization-on-anxiety-and-kinesiophobia-in-knee-arthroplasty-patients-100634881","NCT07545447","Effect of AI-Assisted Anatomical Visualization on Anxiety and Kinesiophobia in Knee Arthroplasty Patients","The Effect of AI-Assisted Anatomical Visualization Training on Anxiety and Kinesiophobia in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Study","AI-KNEE","Inclusion Criteria:\n\n* Adults aged 55 years and older\n* Patients scheduled for elective total knee arthroplasty due to knee osteoarthritis\n* Able to understand and communicate in Turkish\n* Willing to participate in the study and provide written informed consent\n* No prior total knee arthroplasty on the study knee\n* Cognitively able to complete questionnaires and follow study procedures\n\nExclusion Criteria:\n\n* Patients scheduled for revision total knee arthroplasty\n* Patients with active infection\n* Presence of severe neurological or psychiatric disease (conditions that would prevent reliable application of scales)\n* Severe visual or hearing loss\n* Diagnosed dementia or cognitive impairment\n* Individuals who refused to participate in the study","55 Years",{"count":532,"type":21},150,[129],"Total knee arthroplasty (TDA) is an effective surgical method applied to reduce pain, improve joint function, and enhance quality of life in patients with advanced osteoarthritis or joint degeneration. However, it is known that surgical success is not limited to the operation itself; pre- and post-operative processes are at least as important as the surgical technique. In particular, active patient participation, early mobilization, and adherence to exercises during the rehabilitation period directly affect treatment outcomes.\n\nPatient education plays a critical role in this process. Accurate and sufficient information reduces patients' anxieties about the surgical process and increases their confidence in the recovery process. It also prevents the development of kinesiophobia (fear of movement), supporting patients in participating in physical activity more quickly and safely.\n\nPatient education can be provided through various methods. Traditional approaches include face-to-face clinical training, verbal information provided by nurses or physiotherapists, written brochures, and visual materials. While this standard clinical training is effective in conveying basic information, it may have limitations in patients' ability to recall information and adapt it to daily life.\n\nIn recent years, technology-based training methods have gained increasing importance. In particular, AI-assisted video-based anatomical visualization training can present the structure of the surgery, the placement of the prosthesis, and the movement mechanism to patients in a more understandable and visual way. Such interactive and visually rich training offers advantages in terms of increasing patients' knowledge levels, reducing anxiety, and strengthening their participation in treatment.\n\nIn conclusion, success after total knee arthroplasty depends not only on the surgical intervention but also on effective patient education. Comparing standard clinical training with AI-assisted visual training methods constitutes an important area of research for improving patient outcomes.",[349,28],[28,537,484,538],"AI-Assisted Training","Kinesiophobia","2026-04-21",{"date":541,"type":46},"2026-04-22",{"date":386,"type":21},{"date":544,"type":21},"2026-11-15",{"name":393,"class":53},{"id":547,"slug":548,"hasResults":12,"nctId":549,"briefTitle":550,"officialTitle":551,"acronym":4,"eligibilityCriteria":552,"healthyVolunteers":12,"sex":17,"minAge":553,"maxAge":4,"enrollmentInfo":554,"targetDuration":4,"studyType":66,"phases":556,"briefSummary":557,"conditions":558,"keywords":560,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":563,"lastUpdatePostDateStruct":564,"startDateStruct":566,"completionDateStruct":567,"leadSponsor":569,"locationsCount":54},"100633261","femoral-triangle-block-vs-adductor-canal-block-on-early-quadriceps-function-after-total-knee-arthroplasty-100633261","NCT07524387","Femoral Triangle Block vs Adductor Canal Block on Early Quadriceps Function After Total Knee Arthroplasty","Postoperative Effects of Femoral Triangle Block Versus Adductor Canal Block on Early Quadriceps Function After Total Knee Arthroplasty Under a Multimodal Analgesia Protocol: A Randomized Double-Blind Controlled Trial","Inclusion Criteria:\n\n1. Adult patients (≥ 20 years of age) are scheduled to undergo primary unilateral TKA.\n2. American Society of Anesthesiologists (ASA) physical status I-III.\n3. Ability to ambulate independently prior to surgery.\n4. Ability to understand the study procedures and provide written informed consent.\n5. Planned perioperative anesthesia management including regional anesthesia as part of standard clinical care.\n6. Ability to extend the knee below 30 degrees preoperatively (no knee extension contracture)\n\nExclusion Criteria:\n\n1. Known allergy or contraindication to local anesthetic agents used in this study.\n2. Pre-existing neurological or neuromuscular disorders affect lower limb strength or motor control.\n3. Severe cognitive impairment or psychiatric conditions interfere with study participation or assessment.\n4. History of revision knee arthroplasty on the operative side.\n5. Severe preoperative quadriceps weakness that precludes reliable baseline strength assessment.\n6. Any condition deemed by the investigator to make participation inappropriate.","20 Years",{"count":555,"type":21},136,[129],"The goal of this clinical trial is to compare the effects of femoral triangle block (FTB) and adductor canal block (ACB) on early quadriceps function after total knee arthroplasty (TKA).\n\nThe main question it aims to answer is whether FTB causes more early quadriceps functional impairment than ACB under a standardized multimodal analgesia protocol.\n\nResearchers will compare FTB and ACB using a composite binary functional outcome measured 6 hours after block completion. Quadriceps functional impairment is defined as the inability to perform a structured straight leg raise or quadriceps muscle strength \\\u003C50% of the preoperative baseline.\n\nParticipants will be randomly assigned to receive ultrasound-guided FTB or ACB. All participants will also receive a popliteal plexus block and standardized multimodal analgesia.",[28,434,559],"Total Knee Arthroplasty Postoperative Pain",[191,28,561,562],"Peripheral Nerve Block","Postoperative Recovery","2026-04-13",{"date":565,"type":46},"2026-04-16",{"date":563,"type":46},{"date":568,"type":21},"2029-03-31",{"name":570,"class":53},"Social Medical Corporation Daiyukai",{"id":572,"slug":573,"hasResults":12,"nctId":574,"briefTitle":575,"officialTitle":576,"acronym":4,"eligibilityCriteria":577,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":4,"enrollmentInfo":578,"targetDuration":4,"studyType":66,"phases":580,"briefSummary":582,"conditions":583,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":586,"lastUpdatePostDateStruct":587,"startDateStruct":589,"completionDateStruct":591,"leadSponsor":593,"locationsCount":54},"100617925","phase-1-methylene-blue-in-total-knee-arthroplasty-tka-100617925","NCT07324954","Methylene Blue in Total Knee Arthroplasty (TKA)","Impact of Irrigation Volumes in Revision Total Knee Arthroplasty (TKA) Surgical Washout: A Pilot Study","Inclusion Criteria:\n\n* Primary Total Knee Arthroplasty (TKA) or Primary Total Knee Arthroplasty (TKA) with Prosthetic Joint Infection (PJI)\n* 18 years\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Incomplete irrigation documentation\n* Patients with severe immunosuppression (example: chemotherapy, neutropenia, Human Immunodeficiency Virus \\[HIV\\], steroid use)\n* Positive fungal, parasitic, or mycobacterial cultures\n* Methylene Blue allergy\n* Patients on Monoamine Oxidase (MAO) inhibitors, Selective Serotonin Reuptake Inhibitors (SSRI), Selective Norepinephrine Reuptake Inhibitors (SNRI), and\u002For Tricyclic Antidepressants (TCA)\n* History of methemoglobinemia\n* Glucose-6-Phosphate (G6P) Enzyme Deficiency\n* Chronic Kidney disease or Glomerular Filtration Rate (GFR) less than 30mL\u002Fmin\n* Prisoners\n* Pregnant Woman",{"count":579,"type":21},20,[581],"PHASE1","The purpose of this pilot study is to determine the volume of irrigation required to achieve macroscopic clearance of contaminants during a debridement, antibiotics, and implant retention (DAIR) procedure for periprosthetic joint infection (PJI) of the knee. Given the lack of robust data guiding irrigation volume in this setting, the investigator proposes to use the application of methylene blue dye intraoperatively to simulate contaminant presence. Serial irrigation will be performed, with photographic documentation taken every 2,000mL until visible dye clearance is achieved. This study aims to identify the irrigation volumes that result in gross clearance of simulated contamination, thereby informing the design and stratification of a future randomized controlled trial (RCT) evaluating irrigation strategies in DAIR procedures.",[28,584,585],"Prosthetic-joint Infection","Irrigation","2026-04-10",{"date":588,"type":46},"2026-04-14",{"date":590,"type":46},"2026-02-04",{"date":592,"type":21},"2027-02-01",{"name":498,"class":53},{"id":595,"slug":596,"hasResults":12,"nctId":597,"briefTitle":598,"officialTitle":599,"acronym":4,"eligibilityCriteria":600,"healthyVolunteers":153,"sex":17,"minAge":63,"maxAge":4,"enrollmentInfo":601,"targetDuration":4,"studyType":66,"phases":603,"briefSummary":604,"conditions":605,"keywords":606,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":612,"lastUpdatePostDateStruct":613,"startDateStruct":614,"completionDateStruct":616,"leadSponsor":618,"locationsCount":54},"100446787","phase-4-medrol-dosepak-for-outpatient-total-knee-arthroplasty-100446787","NCT05097976","Medrol Dosepak for Outpatient Total Knee Arthroplasty","An Oral Methylprednisolone Taper Within a Multimodal Analgesic Regimen After Total Knee Arthroplasty: a Double-Blind Randomized Placebo-Controlled Trial","Inclusion Criteria:\n\n* Any patient undergoing primary TKA with a diagnosis of osteoarthritis\n\n  •≥ 18 years old\n* Willingness to undergo randomization\n\nExclusion Criteria:\n\n* Reported chronic corticosteroid or opiate use\n* Suspected or confirmed periprosthetic joint infection\n* Revision TKA\n* Primary diagnosis other than osteoarthritis, including avascular necrosis, fracture, or post-traumatic arthritis\n* American Society of Anesthesiologists (ASA) score ≥ 4\n* Reported history of liver disease, renal disease, or diabetes mellitus\n* Current systemic fungal infection or other local infection\n* Immunocompromised or immunosuppressed\n* Current peptic ulcer disease\n* History of hypothyroidism, psychosis, heart failure, myasthenia gravis, ocular herpes simplex virus, or systemic sclerosis\n* Women with reported current pregnancy\n* Known hypersensitivity to methylprednisolone\n\n  •≤ 18 years old\n* Inability to take oral medications\n* Unable to provide consent",{"count":602,"type":21},420,[104],"The purpose of this study is to evaluate the efficacy of an oral methylprednisolone taper on acute postoperative pain, function, opioid consumption, nausea, and complications following outpatient total knee arthroplasty (TKA). We hypothesize that administration of an oral methylprednisolone taper starting on postoperative day 1 (POD 1) following TKA will be associated with improved pain and decreased opioid use, nausea, and complications at POD1-7, as compared to similar patients who receive placebo. Additionally, those taking methylprednisolone will report decreased pain and greater objective functional outcomes at 3 and 6 weeks postoperatively as compared to controls.",[28],[607,608,609,610,611],"Methylprednisolone","acute postoperative pain","acute function","opioid consumption","complications following total knee arthroplasty","2026-04-09",{"date":588,"type":46},{"date":615,"type":46},"2022-03-01",{"date":617,"type":21},"2026-12",{"name":91,"class":53},{"id":620,"slug":621,"hasResults":12,"nctId":622,"briefTitle":623,"officialTitle":624,"acronym":4,"eligibilityCriteria":625,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":100,"enrollmentInfo":626,"targetDuration":4,"studyType":66,"phases":628,"briefSummary":629,"conditions":630,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":632,"startDateStruct":634,"completionDateStruct":636,"leadSponsor":638,"locationsCount":54},"100600091","comparison-of-two-different-regional-anesthetic-methods-in-total-knee-arthroplasty-patients-100600091","NCT07092982","Comparison of Two Different Regional Anesthetic Methods in Total Knee Arthroplasty Patients","Comparison of the Effects of Ultrasound-Guided Adductor Canal Block With iPACK (Space Between the Popliteal Artery and the Posterior Knee Capsule) Block Combination and Suprainguinal Fascia Iliaca Block on Postoperative Pain and Stress Response in Patients Undergoing Total Knee Arthroplasty","Inclusion Criteria:\n\n* Patients undergoing total knee arthroplasty\n* Patients aged 18-75\n* Patients with ASA I-II-III\n\nExclusion Criteria:\n\n* Coagulation disorders\n* Allergy to local anesthetics\n* Liver and renal failure\n* Alcohol and drug addiction\n* Cognitive dysfunction that may prevent pain assessment\n* Systemic or needle insertion site infection\n* Analgesic use for more than 3 months\n* Patient refusal to participate in the study\u002Frefusal to consent\n* Presence of a hematoma, hernia, neoplasm, etc. in the area where the block will be performed\n* Pre-existing neurological deficit\n* Patients with contraindications to nerve block",{"count":627,"type":21},52,[129],"Total Knee Arthroplasty patients are among the orthopedic cases that experience severe postoperative pain. In these cases, pain must be controlled. If pain is not controlled, early mobilization cannot be achieved. This can result in delayed physical therapy, prolonged hospital stays, the development of nosocomial infections, and impaired cognitive function. All of these factors contribute to increased patient care costs. Multimodal analgesia methods are used to control this pain. One of these methods is peripheral nerve blocks. Peripheral nerve blocks provide pain control and reduce the likelihood of opioid use and related side effects such as nausea, vomiting, and constipation. Current studies recommend Adductor Canal Blocks and iPACK (space between the popliteal artery and the posterior knee capsule) blocks for Total Knee Arthroplasty patients. In addition, studies are also being conducted on the application of the Suprainguinal Fascia-Iliaca Block in Total Knee Arthroplasty patients. The differences in postoperative analgesic effects between these methods are a matter of interest. No study has been conducted comparing the effects of these two approaches, which are routinely applied in our clinic and comply with guidelines, on the postoperative stress response. Regional anesthesia provides adequate pain control and has a positive effect on the stress response. The investigators aim to see a similar effect in peripheral nerve blocks. Therefore, comparing the methods that mentioned will contribute to the literature. In this study, the effects of these two different approaches on postoperative stress response and analgesic efficacy will be compared in terms of patients' postoperative opioid consumption, pain at rest and with movement, time to first analgesic need and development of motor block. IL-6 and CRP values will be examined pre-operatively and post-operatively to measure the effects on the stress response.",[28,631,378],"Ultrasound Guided Supra-inguinal Fascia Iliaca Block",{"date":633,"type":46},"2026-04-06",{"date":635,"type":46},"2025-08-04",{"date":637,"type":21},"2026-07",{"name":639,"class":53},"SB Istanbul Education and Research Hospital",{"id":641,"slug":642,"hasResults":12,"nctId":643,"briefTitle":644,"officialTitle":645,"acronym":646,"eligibilityCriteria":647,"healthyVolunteers":12,"sex":17,"minAge":63,"maxAge":4,"enrollmentInfo":648,"targetDuration":4,"studyType":66,"phases":650,"briefSummary":651,"conditions":652,"keywords":653,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":657,"lastUpdatePostDateStruct":658,"startDateStruct":659,"completionDateStruct":661,"leadSponsor":662,"locationsCount":54},"100632296","rest-knee-a-pilot-rct-of-72-hour-knee-immobilization-and-pain-outcomes-100632296","NCT07511842","REST-Knee: A Pilot RCT of 72-Hour Knee Immobilization and Pain Outcomes","Effect of 72-Hour Extension Splint Immobilization on Pain After Total Knee Arthroplasty: A Pilot Randomized Clinical Trial","REST-Knee","Inclusion Criteria:\n\n* Person undergoing primary unilateral TKA for knee osteoarthritis at CHUS\n\nExclusion Criteria:\n\n* Known thrombophilia or bleeding disorders\n* History of thromboembolic events\n* Contraindications to brace use (e.g., material allergy)\n* Revision or constrained knee prostheses\n* Use of continuous postoperative nerve block infusion",{"count":649,"type":21},106,[129],"Postoperative pain following total knee arthroplasty (TKA) is often difficult to manage, particularly with the increasing use of outpatient surgery where patients recover at home. This study aims to evaluate whether wearing a knee extension brace for the first 72 hours after surgery can reduce pain and improve recovery.\n\nThis pilot randomized controlled trial will compare two groups of patients undergoing primary unilateral TKA: one group will wear an extension brace continuously for 72 hours after surgery, while the control group will follow standard care with early mobilization. Participants will be followed for up to 12 months.\n\nThe primary objective of this pilot study is to assess the feasibility of conducting a larger trial, including recruitment rates, adherence to the intervention, follow-up completion, safety, and acceptability. Clinical outcomes will also be explored, including pain at 2 and 6 weeks after surgery (measured using a visual analog scale), knee function, range of motion, opioid consumption, complications, healthcare use, and quality of life.\n\nThe study hypothesizes that short-term immobilization of the knee in full extension will reduce postoperative pain and may improve early recovery outcomes. Findings from this pilot study will inform the design of a larger definitive trial and may contribute to improving postoperative care and pain management after knee replacement surgery.",[28],[133,134,654,655,656],"postoperative pain","Knee immobilization","Extension brace","2026-03-30",{"date":633,"type":46},{"date":660,"type":46},"2026-03-03",{"date":314,"type":21},{"name":663,"class":53},"Université de Sherbrooke"]