[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"total-knee-replacement-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:total-knee-replacement-surgery":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,78,107,136],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100635107","phase-3-suzetrigine-for-treatment-and-reduction-of-intense-discomfort-after-knee-replacement-pain-100635107",false,"NCT07548385","Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN","STRIDE-PAIN","Inclusion Criteria:\n\nTo be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Adults 18-85 years old\n* Scheduled to undergo total knee replacement surgery\n* All genders\n\nExclusion Criteria:\n\nAny individual who meets any of the following criteria will be excluded from participation in this study:\n\n* American Society of Anesthesiology Physical Classification (ASA) Class V\n* Urgent or emergent surgery\n* Contraindications to administration of Suzetrigine:\n\n  * Patients who take moderate-to-severe CYP3A inhibitors (such as Ritonavir, Voriconazole, and Clarithromycin)\n  * Patients who take moderate-to-severe CYP3A inducers (such as Phenytoin, Carbamazapine, and Rifabutin)\n  * Patients with moderate to severe hepatic impairment\n* History of substance use disorder or chronic opioid use or alcohol abuse\n* Reoperation\n* Patient refusal or inability to consent\n* Pregnancy","ALL","18 Years","85 Years",{"count":20,"type":21},235,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","This is a prospective, randomized study. The purpose of this study is to evaluate if the addition of Suzetrigine, a new pain medication, to well established peri-operative pain regimen used for total knee replacement surgery will effect pain control.\n\n1. Does Suzetrigine given pre-operatively decrease the total opioid consumed after total knee replacement surgery?\n2. Dose Suzetrigine given pre-operatively decrease the visual analog pain scale pain scores after total knee replacement surgery? Study participants will be randomly assigned to receive either Suzetrigine medication or placebo medication.",[27,28],"Total Knee Replacement Surgery","Post-operative Pain","RECRUITING","2026-04-16",{"date":32,"type":33},"2026-04-23","ACTUAL",{"date":35,"type":21},"2026-04",{"date":37,"type":21},"2027-02-23",{"name":39,"class":40},"Icahn School of Medicine at Mount Sinai","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":41},"100587552","mako-cementless-tka-vs-mako-cemented-tka-100587552","NCT06929871","Mako Cementless TKA vs Mako Cemented TKA","A Prospective Randomised Controlled Trial Comparing Cementless Mako Robotic-arm Assisted Total Knee Arthroplasty Versus Cemented Mako Robotic-arm Assisted Total Knee Arthroplasty.","Inclusion Criteria:\n\n1. Patient has symptomatic knee osteoarthritis requiring primary TKA\n2. Patient and surgeon are in agreement that TKA is the most appropriate treatment\n3. Patient is fit for surgical intervention following review by surgeon and anaesthetist\n4. Patient is over 18 years old at time of surgery\n5. Gender: male and female\n6. Patient must be capable of giving informed consent and agree to comply with the postoperative review program\n7. Patient must have sufficient postoperative mobility to attend follow-up clinics and allow for radiographs to be taken\n\nExclusion Criteria:\n\n1. Patient is not suitable for routine primary TKA e.g. patient has ligament deficiency that requires a constrained prosthesis\n2. Patient has bone loss that requires augmentation\n3. Patient is not medically fit for surgical intervention\n4. Patient requires revision surgery following previously failed correctional osteotomy or ipsilateral TKA\n5. Patient has a DEXA scan with T-score \\\u003C -2.5 at any point\n6. Patient is immobile or has another neurological condition affecting musculoskeletal function\n7. Patient is less than 18 years at time of surgery\n8. Patient is unable or unwilling to sign the informed consent form specific to this study\n9. Patient is unable to attend the follow-up programme\n10. Previous pathological fracture",{"count":50,"type":21},120,[52],"NA","The overall aims of this prospective, randomised, single-blinded controlled trial are to compare functional, radiological and clinical outcomes in Mako robotic-arm assisted cementless Total Knee Arthroplasty (TKA) versus Mako robotic-arm assisted cemented TKA.",[55,27,56,57],"Total Knee Replacement","Total Knee Arthroplasty","Osteoarthritis (OA) of the Knee",[59,60,61,62,63,64,65,66,67,68],"robotic surgery","cemented implants","uncemented implants","makoplasty","functional outcomes","clinical outcomes","radiological outcomes","inflammatory marker","radiostereometric analysis","RSA","2026-02-17",{"date":71,"type":33},"2026-02-20",{"date":73,"type":33},"2025-09-29",{"date":75,"type":21},"2031-08-01",{"name":77,"class":40},"University College, London",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":4},"100600352","coupling-of-ipack-block-with-adductor-canal-block-versus-adductor-canal-block-alone-on-pain-functional-recovery-and-inflammatory-response-after-knee-replacement-100600352","NCT07096375","Coupling of IPACK Block With Adductor Canal Block Versus Adductor Canal Block Alone on Pain, Functional Recovery and Inflammatory Response After Knee Replacement","Competency of Coupling of IPACK Block With Adductor Canal Block Versus Adductor Canal Block Alone on Postoperative Pain, Functional Recovery and Inflammatory Response After Total Knee Replacement","Inclusion Criteria:\n\n* Patients undergoing total knee replacement.\n* ASA physical status I to III\n* Sex (males and females).\n* Age 20 - 70 years.\n\nExclusion Criteria:\n\n* Patients undergoing bilateral or revision total knee replacement.\n* ASA physical status more than III\n* Age less than 20 or older than 70\n* severe renal insufficiency ( Estimated Glomerular filtration rate eGFR \\\u003C 15 mL\u002Fmin\u002F1.73 m2 ).\n* history of arrhythmia or seizures.\n* Hypersensitivity to local anesthetics.\n* Preexisting peripheral neuropathy and prior vascular surgery on femoral vessels on operated site.\n* Infection near site of injection e.g. osteomyelitis, septic knee joint, etc.\n* Patient refusal or with difficulties in comprehending numeric pain rating scale (NRS) pain scores\n* Any contraindications for spinal anesthesia. (eg.: refusal of patients, coagulopathy, use of anticoagulants or antiplatelets...)","20 Years","70 Years",{"count":88,"type":21},50,[52],"The aim of this study is to compare the Competency of coupling of IPACK Block with Adductor Canal Block versus Adductor Canal Block Alone on Postoperative Pain after total knee replacement as well as Functional Recovery and Inflammatory Response and range of motion postoperatively.",[92,27,93],"Adductor Canal Block","Functional Recovery",[95,92,96],"IPACK block","Inflammatory Response","NOT_YET_RECRUITING","2025-07-24",{"date":100,"type":33},"2025-07-31",{"date":102,"type":21},"2025-09-20",{"date":104,"type":21},"2026-09-28",{"name":106,"class":40},"Ain Shams University",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":118,"conditions":119,"keywords":122,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":41},"100584627","comparison-of-image-based-robotic-total-knee-arthroplasty-vs-imageless-augmented-reality-assisted-total-knee-arthroplasty-100584627","NCT06891807","Comparison of Image Based Robotic Total Knee Arthroplasty vs Imageless Augmented Reality Assisted Total Knee Arthroplasty","RobAR Study: Comparison of Image Based Robotic TKA vs Imageless Augmented Reality-Assisted TKA","RobAR","Inclusion Criteria:\n\n* Subjects from 18 years up to 85 years old\n* Patients eligible and planned for a primary Total Knee Arthroplasty\n* Patients willing to sign the informed consent form (ICF) for participating in this study\n* Indication of surgery is primary osteoarthritis\n\nExclusion Criteria:\n\n* Revision knee surgery\n* Other medical conditions contributing to the rehabilitation process of the TKA according to the surgeon, such as Parkinson's Disease, dementia, multiple sclerosis and cerebral vascular accident\n* The patient received a TKA within the last three months or has a TKA planned in the next three months, for the contralateral knee\n* Patient is participating in another clinical trial\n* Patient is not able to understand Dutch, French or English\n* Patients who did not meet all of the inclusion criteria",{"count":116,"type":21},250,[52],"This study compares the accuracy of two different techniques in placing a total knee replacement. In one technique, accurate instrument placement is facilitated by a robot, and in the other technique, augmented reality is used for correct instrument placement. Both surgical techniques are already commonly used. During both the robotic technique and the augmented reality technique, the additional information (angles - axes) obtained during the operation is used to optimize the placement of the various prosthesis components.\n\nPatients that were recently diagnosed with advanced osteoarthritis of the knee can participate in this study. This means that the cartilage of the knee is affected by wear and tear. This causes pain, stiffness and swelling resulting in reduced mobility. When non-operative treatments are insufficient in treating the osteoarthritis, surgery is proposed wherein a knee arthroplasty is performed.\n\nThe goal of this study is to further optimize and personalize patient care. Additionally, the aim of the study is to investigate whether both techniques are equivalent in optimally placing the prosthesis and whether both techniques lead to comparable results.",[120,121,27],"Knee Osteoarthritis","Total Knee Arthroplasty\\(TKA\\)",[123,120,124,125,126],"Total Knee Arthroplasty (TKA)","Assistive Technologies","Robotics","Augmented Reality","2025-03-17",{"date":129,"type":33},"2025-03-24",{"date":131,"type":33},"2024-07-18",{"date":133,"type":21},"2027-10-01",{"name":135,"class":40},"Medisch Centrum Latem",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":22,"phases":145,"briefSummary":146,"conditions":147,"keywords":150,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":41},"100568052","progressive-relaxation-exercises-on-anxiety-levels-100568052","NCT06676202","Progressive Relaxation Exercises on Anxiety Levels","The Effect of Progressive Relaxation Exercises on Anxiety Levels in Patients Undergoing Total Knee Replacement Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Being 18 years old and above\n* Speaking and understanding Turkish\n* Having total knee replacement surgery\n* Staying in the ward for approximately 96 hours after surgery\n* Volunteering to participate in the study\n* Not having a psychiatric diagnosis\n\nExclusion Criteria:\n\n* Being under 18 years old\n* Having speech and comprehension problems\n* Not having total knee replacement surgery\n* Early discharge after surgery\n* Having complications after surgery\n* Not volunteering to participate in the study\n* Having a psychiatric diagnosis",{"count":144,"type":21},66,[52],"The research will be conducted to determine the effect of progressive relaxation exercises on the anxiety level of patients who have had total knee replacement surgery.",[148,149,27],"Anxiety","Exercises Therapy",[148,151,27],"Exercises","2024-11-04",{"date":154,"type":33},"2024-11-06",{"date":156,"type":21},"2024-11-30",{"date":158,"type":21},"2025-05-30",{"name":160,"class":40},"Erzincan Binali Yildirim Universitesi"]