[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"total-knee-replacement\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:total-knee-replacement":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,50,85,109,141,175,201,228,252,283,305,333,358,387,415,437,454,475,503,536,558],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100639644","digitally-supported-short-term-prehabilitation-before-total-knee-replacement-100639644",false,"NCT07621666","Digitally Supported Short-Term Prehabilitation Before Total Knee Replacement","Prehab2Rehab: Digitally Supported Short-Term Prehabilitation Before Total Knee Replacement - A Randomized Controlled Feasibility Trial","P2R-KneeTEP","Inclusion Criteria:\n\nEligibility will be determined during the outpatient consultations at the Medical\n\nCenter in Bad Vigaun. Patients will be screened against the following criteria:\n\n* Age ≥18 years at the time of enrolment.\n* Clinically diagnosed with advanced osteoarthritis and with a medical indication for elective TKR.\n* Either a scheduled surgery or a documented intention to undergo TKR within the recruitment period.\n* Elective surgery is scheduled for at least 14 days after enrolment to allow completion of the 10 to 14-day prehabilitation intervention.\n* Physical ability to safely perform the prescribed exercise program, as confirmed by the treating physician.\n* Willingness to participate in a digitally supported training intervention at either the center or home-based.\n* Sufficient digital literacy and access to internet-enabled devices (smartphone, tablet, or computer).\n* Adequate German language proficiency to follow exercise instructions and study procedures.\n\nExclusion Criteria:\n\nPatients will be excluded if any of the following apply:\n\n* Pregnancy at the time of enrolment.\n* Emergency, revisional, or non-elective surgery.\n* Surgery scheduled less than 14 days after enrolment.\n* Severe physical impairment or medical contraindication to exercise training (e.g., unstable cardiovascular disease, uncontrolled hypertension, acute musculoskeletal injury).\n* Patients with contraindications outlined in the Medizinisches Leistungsprofil (MLP) 2.0 that preclude rehabilitation and\u002For surgery.\n* Participation in another clinical study that could interfere with the intervention or study outcomes.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study evaluates the feasibility of a short-term, digitally supported prehabilitation program for patients scheduled for elective total knee replacement (TKR). Osteoarthritis is a leading cause of disability, and recovery following TKR remains heterogeneous, with a substantial proportion of patients experiencing delayed functional recovery. Prehabilitation may improve perioperative outcomes, but its implementation is often limited by short preoperative time windows.\n\nThe Prehab2Rehab-KneeTEP trial is a single-center, two-arm, randomized controlled feasibility study conducted in Austria. Patients will be randomized (1:1) to either a multimodal video-supported prehabilitation program or usual care. The intervention consists of a 10 to 14-day preoperative exercise program including strength, endurance, coordination, and gait training, supported by a digital application, and is complemented by a digitally supported transition phase after hospital discharge until the start of inpatient rehabilitation.\n\nThe primary objective is to assess feasibility in terms of recruitment, retention, adherence, fidelity, acceptability, and safety. Secondary exploratory outcomes include clinical recovery indicators, functional performance, and patient-reported outcomes assessed across the perioperative pathway.",[27,28],"Knee Osteoarthristis","Total Knee Replacement",[30,31,32,33,34,35,36],"Prehabilitation","Digital Health","Exercise Therapy","Perioperative Care","Rehabilitation Pathway","Randomised Controlled Trial","Tele-rehabilitation","NOT_YET_RECRUITING","2026-06-02",{"date":40,"type":41},"2026-06-04","ACTUAL",{"date":43,"type":21},"2026-05-20",{"date":45,"type":21},"2027-05-01",{"name":47,"class":48},"Ludwig Boltzmann Institute for Digital Health and Prevention","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":71,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":49},"100626579","binaural-beats-for-postoperative-pain-and-anxiety-reduction-100626579","NCT07437469","Binaural Beats for Postoperative Pain and Anxiety Reduction","Binaural Beats vs Music of Choice for Early Postoperative Pain After Ambulatory Total Knee and Total Hip Arthroplasty: A Randomized Controlled Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists Physical Status Classification System (ASA) 1-3\n* Spinal anesthesia\n* Patients receiving nerve-block in Post-Anesthesia Care Unit (PACU)\n* Primary total hip or total knee arthroplasty\n\nExclusion Criteria:\n\n* Moderate-severe hearing impairment or use of hearing aids\n* History of significant tinnitus, active delirium, chronic high-dose opioid therapy (\\>60 MME\u002Fday baseline)\n* Major psychiatric pathology\n* General anesthesia","99 Years",{"count":59,"type":21},50,[24],"To deliver a 30-minute binaural beats audio intervention in PACU and collect pain and anxiety outcomes immediately following surgery, and 4 hours following surgery completion in adults undergoing ambulatory total knee arthroplasty and total hip arthroplasty (TKA and THA).",[63,64,65,66,67,68,69,28,70],"TKA","THA","Anxiety","Binaural Beats","Music Exposure","Total Hip Arthroplasty (THA)","Total Knee Arthroplasty","Total Hip Replacement",[64,63,72,73,65,74,66,67],"Total hip arthroplasty","Total knee arthroplasty","Pain","RECRUITING","2026-04-29",{"date":78,"type":41},"2026-04-30",{"date":80,"type":41},"2026-03-09",{"date":82,"type":21},"2026-08-30",{"name":84,"class":48},"University of Miami",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":22,"phases":97,"briefSummary":98,"conditions":99,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":49},"100635693","effect-of-physical-therapy-rehabilitation-on-gait-and-plantar-pressure-in-patients-after-total-knee-replacement-100635693","NCT07556003","Effect of Physical Therapy Rehabilitation on Gait and Plantar Pressure in Patients After Total Knee Replacement","Effect of Physical Therapy Rehabilitation on Gait Temporospatial Parameters and Plantar Pressure Distribution in Patients Following Total Knee Replacement Surgery","Inclusion Criteria:\n\n* Female participants aged between 40 and 70 years\n* Patients who have undergone unilateral total knee replacement (TKR) or have knee pathology without surgical intervention\n* Ability to walk independently with or without assistive devices\n* Medically stable and able to participate in a physical therapy rehabilitation program\n\nExclusion Criteria:\n\n* Neurological disorders affecting gait (e.g., stroke, Parkinson's disease)\n* Severe musculoskeletal disorders other than knee pathology\n* History of revision knee replacement surgery\n* Significant cognitive impairment affecting the ability to follow instructions\n* Any contraindications to physical therapy rehabilitation","FEMALE","40 Years","70 Years",{"count":96,"type":21},30,[24],"This study aims to investigate the effects of a structured physical therapy and rehabilitation program on gait temporospatial parameters and plantar pressure distribution in patients who have undergone total knee replacement surgery.\n\nPatients undergoing total knee replacement often experience alterations in gait patterns and weight distribution, which may affect functional mobility and recovery outcomes. This study will evaluate whether a targeted rehabilitation program can improve walking performance and restore more symmetrical plantar pressure distribution.\n\nParticipants will be assessed before and after the intervention using objective gait analysis and plantar pressure measurement tools. The findings of this study may help improve rehabilitation strategies and enhance functional recovery following knee replacement surgery.",[100,28],"Knee Osteoarthritis","2026-04-21",{"date":76,"type":41},{"date":104,"type":41},"2025-08-15",{"date":106,"type":21},"2027-12-30",{"name":108,"class":48},"Jouf University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":119,"phases":4,"briefSummary":120,"conditions":121,"keywords":122,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":140},"100629174","dressing-related-experiences-and-surgical-site-self-care-in-hip-and-knee-replacement-an-observational-cohort-study-100629174","NCT07471243","Dressing-related Experiences and Surgical Site Self-care in Hip and Knee Replacement: an Observational Cohort Study","Dressing-Related Experiences and Surgical Site Self-Care in Hip and Knee Replacement: an Observational Cohort Study (DRESS-X)","DRESS-X","Inclusion Criteria:\n\n* Adults (18+) undergoing primary total hip or knee replacement\n* Enrolled in an ERAS protocol\n* Willing and able to provide informed consent\n\nExclusion Criteria:\n\n* Requiring revision replacement\n* Unable to provide informed consent (cognitive disorder such as dementia, psychiatric illness)\n* Unable to understand written English",{"count":118,"type":21},100,"OBSERVATIONAL","The goal of this prospective observational cohort study is to investigate dressing-related experiences and surgical site self-care in patients who are undergoing a total hip or knee replacement. The main objectives of the study are:\n\n* To evaluate patient adherence to the ISWCAP self-care checklist after total hip or knee replacement within an ERAS pathway.\n* To explore patient-reported outcomes related to the performance and comfort of advanced dressings.\n* To assess the perceived adequacy and usefulness of post-discharge wound care education.\n* To identify the incidence and types of wound-related complications in the 12 weeks following surgery.\n\nParticipants will give informed consent before surgery and will start the study once the dressing has been applied following surgery. There will be follow up study visits at discharge, 7 days, 12 days, 6 weeks and 12 weeks post-surgery. Data relating to vital signs, medical history, surgery and medication will be taken from routine data.",[70,28],[123,124,125,126,127,128,129,130],"Hip arthroplasty","Hip replacement","Knee arthroplasty","Knee replacement","Musculoskeletal","Enhanced recovery after surgery","ERAS","Surgical wound","2026-03-10",{"date":133,"type":41},"2026-03-13",{"date":135,"type":21},"2026-04-01",{"date":137,"type":21},"2027-08-31",{"name":139,"class":48},"Bournemouth University",2,{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":148,"targetDuration":4,"studyType":22,"phases":150,"briefSummary":151,"conditions":152,"keywords":155,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":49},"100587552","mako-cementless-tka-vs-mako-cemented-tka-100587552","NCT06929871","Mako Cementless TKA vs Mako Cemented TKA","A Prospective Randomised Controlled Trial Comparing Cementless Mako Robotic-arm Assisted Total Knee Arthroplasty Versus Cemented Mako Robotic-arm Assisted Total Knee Arthroplasty.","Inclusion Criteria:\n\n1. Patient has symptomatic knee osteoarthritis requiring primary TKA\n2. Patient and surgeon are in agreement that TKA is the most appropriate treatment\n3. Patient is fit for surgical intervention following review by surgeon and anaesthetist\n4. Patient is over 18 years old at time of surgery\n5. Gender: male and female\n6. Patient must be capable of giving informed consent and agree to comply with the postoperative review program\n7. Patient must have sufficient postoperative mobility to attend follow-up clinics and allow for radiographs to be taken\n\nExclusion Criteria:\n\n1. Patient is not suitable for routine primary TKA e.g. patient has ligament deficiency that requires a constrained prosthesis\n2. Patient has bone loss that requires augmentation\n3. Patient is not medically fit for surgical intervention\n4. Patient requires revision surgery following previously failed correctional osteotomy or ipsilateral TKA\n5. Patient has a DEXA scan with T-score \\\u003C -2.5 at any point\n6. Patient is immobile or has another neurological condition affecting musculoskeletal function\n7. Patient is less than 18 years at time of surgery\n8. Patient is unable or unwilling to sign the informed consent form specific to this study\n9. Patient is unable to attend the follow-up programme\n10. Previous pathological fracture",{"count":149,"type":21},120,[24],"The overall aims of this prospective, randomised, single-blinded controlled trial are to compare functional, radiological and clinical outcomes in Mako robotic-arm assisted cementless Total Knee Arthroplasty (TKA) versus Mako robotic-arm assisted cemented TKA.",[28,153,69,154],"Total Knee Replacement Surgery","Osteoarthritis (OA) of the Knee",[156,157,158,159,160,161,162,163,164,165],"robotic surgery","cemented implants","uncemented implants","makoplasty","functional outcomes","clinical outcomes","radiological outcomes","inflammatory marker","radiostereometric analysis","RSA","2026-02-17",{"date":168,"type":41},"2026-02-20",{"date":170,"type":41},"2025-09-29",{"date":172,"type":21},"2031-08-01",{"name":174,"class":48},"University College, London",{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":22,"phases":184,"briefSummary":185,"conditions":186,"keywords":188,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":4},"100624983","cooling-of-the-knee-after-total-knee-arthroplasty-100624983","NCT07416721","Cooling of the Knee After Total Knee Arthroplasty","Effects of the Cooling of the Knee After Total Knee Replacement: Does It Help Compared With a Standard Protocol?","Inclusion Criteria:\n\n* • Adults undergoing primary total knee arthroplasty\n\n  * Use of a primary knee prosthesis of identical design in all patients\n  * Body mass index (BMI) \\\u003C 35 kg\u002Fm²\n  * Ability to understand the study protocol and comply with postoperative instructions\n  * Absence of diagnosed mental disease\n\nExclusion Criteria:\n\n* • Unregulated or poorly controlled diabetes mellitus\n\n  * Rheumatoid arthritis or other inflammatory arthropathies\n  * Presence of mental disease impairing cooperation or protocol adherence",{"count":183,"type":21},99,[24],"This study investigates whether cooling the knee after total knee replacement surgery can reduce pain and improve early recovery. After surgery, patients are randomly assigned to one of three groups: cooling with a liquid cooling bandage, cooling with an ice pack, or standard postoperative care without cooling. Cooling begins 24 hours after surgery and continues for two weeks. Pain levels, use of pain medication, blood values, knee swelling, knee movement, and length of hospital stay are recorded. The goal is to determine whether postoperative knee cooling provides additional benefits compared with standard care.",[187,28],"Osteoarthritis, Knee",[189,190,191],"knee osteoarthritis","postoperative cooling","total knee replacement","2026-02-13",{"date":194,"type":41},"2026-02-18",{"date":196,"type":21},"2026-03-01",{"date":198,"type":21},"2027-03-01",{"name":200,"class":48},"Clinical Center of Vojvodina",{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":209,"sex":17,"minAge":93,"maxAge":210,"enrollmentInfo":211,"targetDuration":4,"studyType":22,"phases":212,"briefSummary":215,"conditions":216,"keywords":217,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":49},"100618372","phase-1-analgesic-efficacy-of-pre-operative-dose-of-palmitoylethanolamide-in-patients-undergoing-total-knee-arthroplasty-100618372","NCT07330765","Analgesic Efficacy of Pre-Operative Dose of Palmitoylethanolamide in Patients Undergoing Total Knee Arthroplasty","Analgesic Efficacy of Pre-Operative Dose of Palmitoylethanolamide in Patients Undergoing Total Knee Arthroplasty, A Randomized Double-Blinded Controlled Trial.","Total knee","Inclusion Criteria:\n\nPatients Undergoing Total Knee Replacement from 40 years old to 80 years old\n\nExclusion Criteria\n\n* Rheumatoid Arthritis\n\n  * History of Renal impairment\n  * Any complications of surgery as( iatrogenic fractures -patient with low bone quality that needs long stem prosthesis -patient with depressed tibial plateau that needs graft )\n  * Patients refused to be enrolled in the study",true,"80 Years",{"count":49,"type":21},[213,214],"PHASE1","PHASE2","Analgesic Efficacy of Pre-Operative Dose of palmitoylethanolamide in Patients Undergoing total Knee Arthroplasty, A Randomized Double-Blinded Controlled Trial.",[28],[218],"Post operative pain","2026-01-05",{"date":221,"type":41},"2026-01-09",{"date":223,"type":21},"2026-01-13",{"date":225,"type":21},"2027-10-13",{"name":227,"class":48},"Abdelrahman Gaber Sayed Elkhateeb",{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":119,"phases":4,"briefSummary":238,"conditions":239,"keywords":240,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":49},"100614160","total-knee-replacement-under-spinal-anesthesia-comparison-of-postoperative-recovery-versus-general-anesthesia-100614160","NCT07275983","Total Knee Replacement Under Spinal Anesthesia, Comparison of Postoperative Recovery Versus General Anesthesia","Total Knee Replacement Under Spinal Anesthesia, Comparison of Postoperative Recovery Versus General Anesthesia: A Retrospective Single-Center Observational Comparative Superiority Study","PTG-RachiVsAG","Inclusion Criteria:\n\n* Male or female, 18 years of age or older (no upper age limit)\n* Underwent total knee replacement surgery between January 1, 2020 and June 30, 2023\n* Assessed using the QoR-15F score\n\nExclusion Criteria:\n\n* Subject (and\u002For their legal representative, if applicable) who expressed their opposition to the reuse of their data for scientific research purposes.\n* Revision, emergency, oncological, bilateral, or septic surgery",{"count":237,"type":21},500,"Intraoperative anesthetic management for total knee replacement (TKR) can be performed under general or spinal anesthesia. These two techniques have their own characteristics and may impact postoperative recovery differently. However, there are no studies in the literature analyzing postoperative functional recovery after TKR surgery according to the type of anesthesia. The objective of this study is to compare postoperative recovery, assessed by the QoR-15F score, in patients undergoing TKR under spinal anesthesia versus surgery under general anesthesia.",[28],[241,28,242],"knee","Spinal Anesthesia","2025-12-08",{"date":245,"type":41},"2025-12-10",{"date":247,"type":41},"2024-05-03",{"date":249,"type":21},"2025-12-03",{"name":251,"class":48},"University Hospital, Strasbourg, France",{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":11,"sex":92,"minAge":259,"maxAge":4,"enrollmentInfo":260,"targetDuration":4,"studyType":22,"phases":262,"briefSummary":263,"conditions":264,"keywords":267,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":49},"100488603","effects-of-fall-prevention-program-on-the-number-of-falls-among-elderly-following-total-knee-replacement-100488603","NCT05642260","Effects of Fall Prevention Program on the Number of Falls Among Elderly Following Total Knee Replacement","The Short- and Long-term Effects of Fall Prevention Program on the Number of Falls Among Elderly Following Total Knee Replacement: a Pragmatic Single-blinded Randomized Controlled Trial.","Inclusion Criteria:\n\n* Female gender.\n* Aged 60 years and older.\n* Diagnosed with primary osteoarthritis of the knee.\n* Underwent unilateral TKR.\n\nExclusion Criteria:\n\n* revision TKR surgery\n* history of systemic inflammatory conditions (i.e., rheumatoid arthritis, Lupus erythematosus),\n* neurological disorders (i.e., multiple sclerosis, Parkinson's disease, stroke)\n* lower limb surgery\u002Ftrauma in the past 12 months\n* have cognitive and\u002For vision impairments\n* post-surgical complications (e.g., infection, intraoperative fracture)\n* any health condition that may preclude them from undertaking physiotherapy.","60 Years",{"count":261,"type":21},90,[24],"the aim of the proposed research is to investigate the short and long-term effects of integrating a comprehensive fall prevention programme into conventional physiotherapy on the number of falls, balance, and functional ability among elderly following TKR. the investigator hypothesize that conventional physiotherapy integrated with a fall prevention program is more effective than conventional physiotherapy alone in improving balance and functional ability and preventing the occurrence of falls among elderly following TKR.\n\nStudy type: The proposed study is a parallel group prospective (24 weeks) randomised single-blinded pragmatic controlled trial.\n\nParticipants: Older adults operated for TKR at Al-Razi orthopedic hospital, who met the inclusion criteria.",[265,266,28],"Fall","Osteo Arthritis Knee",[268,269,270,271,272],"fall","older people","fall prevention","TKR","rehabilitation","2025-12-02",{"date":275,"type":41},"2025-12-09",{"date":277,"type":41},"2023-01-08",{"date":279,"type":21},"2026-09-08",{"name":281,"class":282},"Ministry of Health, Kuwait","OTHER_GOV",{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":290,"targetDuration":4,"studyType":22,"phases":291,"briefSummary":292,"conditions":293,"keywords":294,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":49},"100609803","the-feasibility-of-a-nurse-initiated-weighted-blanket-in-orthopedic-surgical-patients-undergoing-total-knee-arthroplasty-100609803","NCT07219329","The Feasibility of a Nurse-Initiated Weighted Blanket in Orthopedic Surgical Patients Undergoing Total Knee Arthroplasty","The Feasibility of a Nurse-Initiated Weighted Blanket in Orthopedic Surgical Patients Undergoing Total Knee Arthroplasty: A Pilot Study","Inclusion Criteria:\n\n1. Adults aged 18 years and older\n2. Adults undergoing elective total knee arthroplasty at NYU Langone Orthopedic Hospital.\n3. Adults who are scheduled to receive spinal anesthesia.\n4. Subjects with a planned same day discharge to home from the PACU\n\nExclusion Criteria:\n\n1. cognitive disability that would interfere with their ability to complete the study's pre and post assessments (e.g. dementia, non-verbal)\n2. subject disclosed history of pre-existing anxiety disorder, claustrophobia, epilepsy, respiratory conditions (e.g. obstructive sleep apnea (OSA), asthma), skin conditions (e.g. pressure injury), which are contradictions for weighted blanket.",{"count":96,"type":21},[24],"The purpose of this study is to explore the acceptability and feasibility of weighted blankets in total knee replacement (TKR) patients. The study also aims to measure the difference in anxiety of adult orthopedic patients in need of total knee arthroplasty surgery who receive weighted blanket before and after surgery compared to those who receive a non-weighted blanket.",[28],[295],"anxiety","2025-10-20",{"date":298,"type":41},"2025-10-21",{"date":300,"type":21},"2025-11",{"date":302,"type":21},"2026-06",{"name":304,"class":48},"NYU Langone Health",{"id":306,"slug":307,"hasResults":11,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":311,"eligibilityCriteria":312,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":313,"targetDuration":4,"studyType":22,"phases":315,"briefSummary":316,"conditions":317,"keywords":319,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":49},"100552522","comparison-of-the-effects-of-apixaban-on-thrombin-generation-in-patients-with-de-novo-multiple-myeloma-100552522","NCT06474182","Comparison of the Effects of Apixaban on Thrombin Generation in Patients With de Novo Multiple Myeloma","Comparison of the Effects of Prophylactic Administration of Apixaban on Thrombin Generation in Patients With de Novo Multiple Myeloma and Patients Undergoing a Surgery for Total Knee Replacement","ProApix","Inclusion Criteria:\n\n* Age ≥ 18 years old,\n* Signed informed consent,\n* Patient covered by a social security scheme.\n* Group 1 : patient with a diagnosis of de novo multiple myeloma, with an indication of thromboprophylaxis with Apixaban,\n* Group 2 : patient requiring a surgery for total knee replacement, , with an indication of thromboprophylaxis with Apixaban.\n\nExclusion Criteria:\n\n* Curative doses of anticoagulation treatment,\n* Contra-indication to Apixaban,\n* Pregnant or breastfeeding woman,\n* Refusal to sign consent,\n* Patient under legal protection.",{"count":314,"type":21},32,[24],"Patients with multiple myeloma (MM) are at high risk of venous thromboembolism (VTE) and these patients require adequate thromboprophylaxis. Following the publication of the AVERT clinical study, Apixaban is strongly recommended as a prophylactic treatment option for patients with cancer, based on high quality of evidence and a favorable efficacy\u002Fsafety profile. A multicenter and ancillary study - APIXABOR - that measured the plasmatic concentration of Apixaban in patients with MM and treated with preventive dose has been conducted. The peak drug concentration was superior in MM plasma, as compared to non-myeloma patients under prophylaxis. Therefore, the present study evaluated whether differences in pharmacokinetics have an impact on pharmacodynamics (i.e. decrease in coagulability in MM patients as compared to non-MM patients undergoing a surgery for total knee replacement who also have VTE prophylaxis). In fine, this study may inform to better manage thromboprophylaxis in MM patients.",[318,28],"Multiple Myeloma",[320,321,322,323],"Multiple myeloma","thromboprophylaxis","pharmacodynamics","coagulability","2025-09-24",{"date":326,"type":41},"2025-09-25",{"date":328,"type":41},"2025-09-15",{"date":330,"type":21},"2027-09",{"name":332,"class":48},"Centre Hospitalier Universitaire de Saint Etienne",{"id":334,"slug":335,"hasResults":11,"nctId":336,"briefTitle":337,"officialTitle":337,"acronym":4,"eligibilityCriteria":338,"healthyVolunteers":11,"sex":17,"minAge":339,"maxAge":210,"enrollmentInfo":340,"targetDuration":4,"studyType":119,"phases":4,"briefSummary":342,"conditions":343,"keywords":344,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":49},"100602183","an-open-label-data-collection-study-of-my-connect-post-op-a-post-operative-communication-tool-100602183","NCT07120191","An Open Label Data Collection Study of My Connect Post-Op, a Post-Operative Communication Tool","Inclusion Criteria:\n\nOrthopedic patients scheduled for elective joint arthroplasty (single or double knee, or single or double hip replacement surgery).\n\nAge 22-80 years. Owns a smart phone. Speaks and understands written and spoken English. Ability to give written informed consent.\n\nExclusion Criteria:\n\nKnown diagnosis of a psychiatric disorder. Known opioid dependence in the Investigator's opinion that may complicate participation.\n\nParticipation in another clinical trial investigating a drug, medical device, or a medical procedure in the 30 days preceding trial inclusion and throughout the duration of the trial.\n\nAny condition that in the Investigator's opinion may complicate or preclude the subject from participating in this trial, such as physical impairment or noncooperation","22 Years",{"count":341,"type":21},200,"This open label, multi-center study will collect data from the participant's use of My Connect Post-Op Software as a post-operative communication solution in supporting patient recovery through Technology-Assisted Conversation (TAC). The application will be tested by patients who have undergone total joint replacement as a post-op communication tool. Data will be collected on how effectively the product guides patients through their recovery, identifying potential complications, and providing appropriate recommendations based on structured question pairs.",[70,28],[345,346,347,348],"Total joint replacement","post op communication","AI assisted conversation","artificial intelligence","2025-08-12",{"date":104,"type":41},{"date":352,"type":41},"2025-05-01",{"date":354,"type":21},"2025-11-30",{"name":356,"class":357},"Concentra AI, inc","INDUSTRY",{"id":359,"slug":360,"hasResults":11,"nctId":361,"briefTitle":362,"officialTitle":363,"acronym":4,"eligibilityCriteria":364,"healthyVolunteers":11,"sex":17,"minAge":365,"maxAge":366,"enrollmentInfo":367,"targetDuration":4,"studyType":22,"phases":369,"briefSummary":371,"conditions":372,"keywords":373,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":49},"100395662","phase-4-a-study-to-compare-different-ways-of-steroid-administration-after-total-knee-implantation-100395662","NCT04432012","A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation","Comparison of Perioperative Intravenous vs Periarticular Dexamethasone vs no Steroid Supplementation in Terms of Post-operative Pain, Function, Nausea, Hospitalization Length, and Risk of Complications in Patients Undergoing Primary Total Knee Arthroplasty for Knee Osteoarthritis - A Randomized Controlled Trial Clinical Study Protocol","Inclusion Criteria:\n\n* Patients undergoing unilateral primary TKA at the Ospedale Regionale di Lugano.\n* Patients with a BMI \\>18.5 and \\\u003C35.\n* Patients able to provide informed consent and follow all the study procedures as indicated by the protocol.\n* Informed Consent as documented by signature (Appendix Informed Consent Form).\n\nExclusion Criteria:\n\n* Contraindications to steroids.\n* Revision TKA.\n* Active steroid therapy.\n* Women who are pregnant or breast feeding.\n* Presence of other clinically significant concomitant disease states (ASA IV).\n* Uncontrolled diabetes mellitus\n* Known or suspected non-compliance, drug or alcohol abuse.\n* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant.\n* Participation in another study with investigational drug within the 30 days preceding and during the present study.\n* Previous enrolment into the current study.\n* Enrolment of the investigator, his\u002Fher family members, employees and other dependent persons.","50 Years","85 Years",{"count":368,"type":21},159,[370],"PHASE4","We are going to evaluate the difference between perioperative intravenous steroid supplementation, perioperative periarticular steroid supplementation, and standard anaesthesia protocols. We'll evaluate the outcome of patients with knee osteoarthritis who are undergoing Total Knee Arthroplasty to understand which of the three treatments give more benefits to the patient.",[28],[374,375,376,377],"Knee","surgery","replacement","arthroplasty","2025-08-05",{"date":380,"type":41},"2025-08-06",{"date":382,"type":41},"2020-07-01",{"date":384,"type":21},"2033-04-30",{"name":386,"class":48},"Christian Candrian",{"id":388,"slug":389,"hasResults":11,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":393,"eligibilityCriteria":394,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":395,"targetDuration":4,"studyType":22,"phases":397,"briefSummary":398,"conditions":399,"keywords":401,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":49},"100414537","trabecular-metal-economic-and-clinical-knee-trial-100414537","NCT04677907","TRabecular Metal Economic and Clinical Knee Trial","Health Economic and Clinical Comparison of Trabecular Metal Uncemented and Cemented Modular Total Knee Replacements - A Double Blinded Randomised Controlled Trial","TRECK","Inclusion Criteria:\n\n* Male or female subjects may be recruited to the evaluation.\n* Age - there are no restrictions relating to age of the patient.\n* Subjects who are able to give voluntary, written informed consent to participate in this investigation and from whom consent has been obtained.\n* Subjects who in the opinion of the Investigator, are able to understand this investigation, co-operate with the investigation procedures and are willing to return to the hospital for all the required post-operative follow-ups.\n* Subjects with uni-lateral osteoarthritis of the knee or subjects with bi-lateral osteoarthritis of the knee, who have a well functioning and pain free knee replacement in the contralateral knee.\n* Subjects who require a TKR for surgical management of osteoarthritis\n\nExclusion Criteria:\n\n* Patients who, in the opinion of the Investigator, have an existing condition that would compromise their participation and follow-up in the study.\n* Patients with bi-lateral disease that significantly impacts on their current function and pain.\n* Patients who require revision knee arthroplasty surgery.\n* Disorders of the feet, ankles, hips or spine causing significant abnormal gait or significant pain.\n* Neurological conditions affecting movement.\n* Patients with a pathology, which, in the opinion of the Chief Investigator, will adversely affect healing.\n* Patients with other disorders which, in the opinion of the Chief Investigator, will\u002Fcould impair rehabilitation.\n* Subjects who in the opinion of the study investigator are unlikely to comply with the study follow-up protocol",{"count":396,"type":21},144,[24],"To compare the differences, if any, in clinical outcome, patient satisfaction and survivorship between cemented and uncemented Total Knee Replacements (TKR)? To investigate if there are health economic implications of using uncemented TKRs in the NHS?",[28,400],"Orthopedics",[402,400,403,404,405],"Total Knee Replacements","Orthopedic devices","Arthroplasty","Uncemented","2025-06-20",{"date":408,"type":41},"2025-06-25",{"date":410,"type":41},"2022-05-10",{"date":412,"type":21},"2035-06-30",{"name":414,"class":48},"NHS Greater Glasgow and Clyde",{"id":416,"slug":417,"hasResults":11,"nctId":418,"briefTitle":419,"officialTitle":419,"acronym":420,"eligibilityCriteria":421,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":422,"targetDuration":4,"studyType":22,"phases":424,"briefSummary":425,"conditions":426,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":140},"100495849","phase-2-yale-steroid-enhanced-versus-exparel-nerveblock-tka-part-2-100495849","NCT05736549","Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2","Yale SEVEN","Inclusion Criteria:\n\n* American Society of Anesthesiologists status I, II and III, elective, primary, bilateral TKA planned for spinal anesthesia with plain 0.5% bupivacaine.\n\nExclusion Criteria:\n\n* Refusal of consent\n* Pregnancy\n* Conditions making the patient unable to fill out questionnaire online, through email or over the phone including with cognitive dysfunction, psychiatric disorder, or non-English speaking patients, or lack of internet access which would prevent post discharge follow-up electronically\n* Coagulopathy\n* Allergy to or for any other reasons cannot use Acetaminophen, Celebrex, local anesthetic bupivacaine, DEX, MPA or LB\n* Patients on any amounts of opioids within one month of the surgery date, any substance abuse such as regular marijuana user (more frequent than once per month)\n* Insulin dependent or uncontrolled diabetes defined as, day of surgery finger stick glucose \\>200mg\u002Fdl, or HbA1C \\> 8.0%\n* Peripheral Nerve Block site or systemic infection\n* Immune compromise (e.g., HIV, chronic glucocorticoid use)\n* Severe pre-existing neuropathy\n* TKA for indications other than osteoarthritis such as post-traumatic injury or rheumatoid arthritis, history of surgery in the ipsilateral knee joint, revision TKA or bilateral TKA\n* Severe hepatic or renal dysfunction (GFR \\\u003C50 ml\u002Fmin)\n* Actual body weight \\\u003C60 kg\n* Patients with active or latent peptic ulcers, diverticulitis, fresh intestinal anastomoses, and non-specific ulcerative colitis",{"count":423,"type":21},66,[214],"The objective of this study is to investigate the efficacy of Dexamethasone sodium phosphate plus Methylprednisolone acetate in combination with plain bupivacaine ((B-DEX-MPA) compared with Liposomal Bupivacaine in combination with plain bupivacaine (B-LB) on post-surgical pain control among patients undergoing bilateral total knee arthroplasty (TKA) to asses if perineural B-DEX-MPA will result in superior analgesia efficacy as compared to B-LB.\n\nThis study will also assess if perineural B-DEX-MPA results in improved quality of postoperative recovery as compared to B-LB.",[28,427],"Knee Arthroplasty","2025-05-13",{"date":430,"type":41},"2025-05-14",{"date":432,"type":41},"2023-02-07",{"date":434,"type":21},"2028-03",{"name":436,"class":48},"Yale University",{"id":438,"slug":439,"hasResults":11,"nctId":440,"briefTitle":441,"officialTitle":442,"acronym":420,"eligibilityCriteria":443,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":444,"targetDuration":4,"studyType":22,"phases":446,"briefSummary":447,"conditions":448,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":449,"startDateStruct":450,"completionDateStruct":452,"leadSponsor":453,"locationsCount":140},"100460704","phase-2-yale-steroid-enhanced-versus-exparel-nerveblock-tka-rct-study-100460704","NCT05279092","Yale Steroid Enhanced Versus Exparel Nerveblock TKA RCT Study","Yale Steroid Enhanced Versus Exparel Nerveblock TKA Randomized Controlled Trial (RCT) Study","Inclusion Criteria:\n\n* American Society of Anesthesiologists status I, II and III, elective, primary, unilateral TKA planned for spinal anesthesia with plain 0.5% bupivacaine.\n\nExclusion Criteria:\n\n* Refusal of consent\n* Pregnancy\n* Conditions making the patient unable to fill out questionnaire online, through email or over the phone including with cognitive dysfunction, psychiatric disorder, or non-English speaking patients, or lack of internet access which would prevent post discharge follow-up electronically\n* Coagulopathy\n* Allergy to or for any other reasons cannot use Acetaminophen, Celebrex, local anesthetic bupivacaine, DEX, MPA or LB\n* Patients on any amounts of opioids within one month of the surgery date, any substance abuse such as regular marijuana user (more frequent than once per month)\n* Insulin dependent or uncontrolled diabetes defined as, day of surgery finger stick glucose \\>200mg\u002Fdl, or HbA1C \\> 8.0%\n* Peripheral Nerve Block site or systemic infection\n* Immune compromise (e.g., HIV, chronic glucocorticoid use)\n* Severe pre-existing neuropathy\n* TKA for indications other than osteoarthritis such as post-traumatic injury or rheumatoid arthritis, history of surgery in the ipsilateral knee joint, revision TKA or bilateral TKA\n* Severe hepatic or renal dysfunction (GFR \\\u003C50 ml\u002Fmin)\n* Actual body weight \\\u003C60 kg\n* Patients with active or latent peptic ulcers, diverticulitis, fresh intestinal anastomoses, and non-specific ulcerative colitis",{"count":445,"type":21},250,[214],"The objective of this phase 2 study is to investigate the efficacy of Dexamethasone sodium phosphate (DEX) plus Methylprednisolone acetate (MPA) in combination with plain bupivacaine (B) compared with Liposomal Bupivacaine (LB) in combination with plain bupivacaine on post-surgical pain control among patients undergoing unilateral total knee arthroplasty (TKA) to asses if perineural B-DEX-MPA will result in superior analgesia efficacy as compared to B-LB.\n\nThis study will also assess if perineural B-DEX-MPA results in improved quality of postoperative recovery as compared to B-LB.",[28,427],{"date":430,"type":41},{"date":451,"type":41},"2022-09-08",{"date":434,"type":21},{"name":436,"class":48},{"id":455,"slug":456,"hasResults":11,"nctId":457,"briefTitle":458,"officialTitle":459,"acronym":460,"eligibilityCriteria":461,"healthyVolunteers":209,"sex":17,"minAge":93,"maxAge":366,"enrollmentInfo":462,"targetDuration":4,"studyType":119,"phases":4,"briefSummary":464,"conditions":465,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":466,"lastUpdatePostDateStruct":467,"startDateStruct":469,"completionDateStruct":471,"leadSponsor":473,"locationsCount":49},"100579833","movement-dynamics-of-knee-osteoarthritis-and-total-knee-replacement-100579833","NCT06829433","Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement","Quantifying the Movement Dynamics of Adults Living With Total Knee Arthroplasty and Knee Osteoarthritis","MDOA&TKR","Inclusion Criteria:\n\n* Diagnosed symptomatic bilateral or unilateral knee osteoarthritis, self-reported ability to walk without an aid for 10 minutes and to ascend and descend stairs, no neurological conditions or other musculoskeletal pathology\u002Finjury which would impact walking gait.\n\nExclusion Criteria:\n\n* Unable to walk at 0.8 m\u002Fs, exclusion based on IMO screening, non-English speaking, lacking ability to consent.",{"count":463,"type":21},36,"This research aims to explore differences in walking and functional movement mechanics, exercise response, and physical activity between people with osteoarthritis (OA), those who have undergone total joint replacement, and healthy individuals.",[100,28],"2025-02-19",{"date":468,"type":41},"2025-02-21",{"date":470,"type":41},"2024-05-07",{"date":472,"type":21},"2026-09",{"name":474,"class":48},"University of Portsmouth",{"id":476,"slug":477,"hasResults":11,"nctId":478,"briefTitle":479,"officialTitle":479,"acronym":480,"eligibilityCriteria":481,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":482,"enrollmentInfo":483,"targetDuration":4,"studyType":22,"phases":484,"briefSummary":485,"conditions":486,"keywords":489,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":494,"lastUpdatePostDateStruct":495,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":501,"locationsCount":49},"100568051","comparison-of-pivotal-medial-polyethylene-versus-ultra-congruent-in-total-knee-arthroplasty-100568051","NCT06676189","Comparison of Pivotal Medial Polyethylene Versus Ultra-congruent in Total Knee Arthroplasty","MEPCAT","Inclusion criteria :\n\n* Subjects 18 to 90 years of age, eligible for a primary total knee replacement for gonarthrosis\n* Competent subjects able to give informed consent to participate in the research\n* Affiliation to the social security system\n\nExclusion criteria :\n\n* Infection history of the knee to be replaced\n* Deformity greater than 15 degrees\n* Any surgical and\u002For anesthetic contraindication, or any condition deemed by the investigator to be incompatible with the research.\n* Any contraindication mentioned in the instructions for use of the medical device\n* Pregnant or breastfeeding women\n* Recent infection history of the surgical site\n* Adults who are subject to a legal protection measure or who are unable to express their constent (Article L1121-8 of the French Public Health Code) and subjects under judicial protection (article L. 1122-2 FPHC)\n* Subjects who refuse to participate","90 Years",{"count":261,"type":21},[24],"The aim of this study is to compare the forgotten joint score for the medial pivot polyethylene and ultra-congruent polyethylene which are used in total prosthetic replacement of the knee",[28,487,488],"Primary Knee Replacement","Gonarthrosis",[490,491,492,493],"prospective","randomized study","parallel groups","forgotten joint score","2025-01-16",{"date":496,"type":41},"2025-01-17",{"date":498,"type":41},"2024-06-04",{"date":500,"type":21},"2027-03",{"name":502,"class":48},"University Hospital, Clermont-Ferrand",{"id":504,"slug":505,"hasResults":11,"nctId":506,"briefTitle":507,"officialTitle":507,"acronym":508,"eligibilityCriteria":509,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":510,"targetDuration":4,"studyType":22,"phases":511,"briefSummary":512,"conditions":513,"keywords":518,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":528,"lastUpdatePostDateStruct":529,"startDateStruct":531,"completionDateStruct":532,"leadSponsor":534,"locationsCount":49},"100565604","remote-multichannel-monitoring-of-patients-with-chronic-diseases-using-speech-technologies-based-on-artificial-intelligence-100565604","NCT06644339","Remote Multichannel Monitoring of Patients With Chronic DIseAses Using Speech technoLogies Based On Artificial intelliGence","DIALOG","Inclusion Criteria:\n\n* Disease diagnosed according to the latest Clinical practice guidelines\n* Stable condition at the time of discharge from the hospital\n* Written informed consent to participate in the study\n\nNon-inclusion criteria:\n\n* Diagnosed dementia or severe cognitive impairment\n* The inability to use automatic devices to register blood pressure at home, a blood glucose meter\n* Alcohol or drug abuse\n* Inability to contact a voice assistant and other study requirements, due to major co-morbidities, social or financial issues, or a history of noncompliance with medical regimens, that might compromise the patient's ability to understand and\u002For comply with the protocol instructions or follow-up procedures\n\nExclusion Criteria:\n\n* Unwillingness of the patient to continue participating in the study\n* The development of conditions related to the criteria of non-inclusion",{"count":237,"type":21},[24],"DIALOG is a study to assess the efficacy and safety of remote patient monitoring using virtual operator voice technologies and a business intelligence (BI) system for timely detection, prevention of early complications, worsening of the condition, and other adverse events in patients who have been discharged from the hospital.",[514,515,516,517,28],"Heart Failure","Diabetes Mellitus","Arterial Hypertension","Lymphoproliferative Disease",[519,520,521,522,523,524,525,526,527],"heart failure","diabetes mellitus","arterial hypertension","lymphoproliferative diseases","knee replacement","remote monitoring","mHealth","telemedicine","voice assistant","2024-10-15",{"date":530,"type":41},"2024-10-16",{"date":528,"type":21},{"date":533,"type":21},"2025-04-30",{"name":535,"class":48},"I.M. Sechenov First Moscow State Medical University",{"id":537,"slug":538,"hasResults":11,"nctId":539,"briefTitle":540,"officialTitle":540,"acronym":4,"eligibilityCriteria":541,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":542,"targetDuration":4,"studyType":119,"phases":4,"briefSummary":544,"conditions":545,"keywords":546,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":549,"lastUpdatePostDateStruct":550,"startDateStruct":552,"completionDateStruct":554,"leadSponsor":556,"locationsCount":140},"100485968","a-post-market-observational-origin-cr-clinical-study-100485968","NCT05607966","A Post-market Observational ORIGIN® CR Clinical Study","Inclusion Criteria:\n\n* Male and female over 18 years of age\n* Each patient who is willing to give informed consent.\n* Clinically indicated for a total knee replacement\n* Females who are not pregnant and not planning to become pregnant ≤ 12 months. A pregnancy test should be performed for women of childbearing age\n* Geographically stable and willing to return to the implanting site for all follow-up visits at 1 year and 2 years.\n\nExclusion Criteria:\n\n* Acute or chronic, local or systemic infection\n* Muscular, ligamental, neurological, psychological or vascular deficits\n* Bone destruction or poor bone quality likely to affect implant stability (requiring a femoral and\u002For a tibial stem and\u002For a thick insert)\n* Any concomitant condition likely to affect implant integration or function\n* Allergy or hypersensitivity to any of the materials used\n* For devices in CoCrMo (ISO 5832\u002F4): renal and hepatic impairment\n* Hip Knee Ankle (HKA) angle \\\u003C 165° or \\> 195°\n* Severe collateral ligaments deficiency (requiring a more constrained prosthesis)\n* Posterior cruciate ligament deficiency\n* Major anatomical deformities\n* Severe flexion contracture or severe recurvatum\n* Revision of a partial or total knee prosthesis\n* Non-extractible material (e.g. screws, plate, intramedullary nail, osteosynthesis material…) which can create a conflict with any component of the prosthesis\n* Distal and\u002For posterior and\u002For anterior femoral bone loss which exceeds the femoral component thickness\n* Proximal tibial bone loss which exceeds the tibial component thickness (tibial tray + tibial insert)\n* Bone degradation requiring an anchoring stem for femoral component",{"count":543,"type":21},199,"The study objective is to evaluate safety and performance of the ORIGIN® CR (cruciate retaining) devices and associated instruments, more precisely to evaluate safety by the proportion of patients requiring a revision (i.e. revision rate) at 1-year post procedure and to evaluate performance by means of a Knee Society Score (KSS) Knee Score at 1 year post procedure and by means of a KSS Function Score also at 1 year post procedure.\n\nThe hypothesis raised for this study, regarding the scoring, is that patients will experience a marked improvement in the natural feel of the prosthesis during the first year after the surgery, and slightly significant improvement at the following interval of 2 years. The overall patient satisfaction is expected to be improved after 2 years follow-up with ORIGIN® CR.",[28],[547,63,548],"ORIGIN","Prosthesis","2024-10-03",{"date":551,"type":41},"2024-10-08",{"date":553,"type":41},"2024-07-10",{"date":555,"type":21},"2028-02",{"name":557,"class":357},"Symbios Orthopedie SA",{"id":559,"slug":560,"hasResults":11,"nctId":561,"briefTitle":562,"officialTitle":562,"acronym":563,"eligibilityCriteria":564,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":565,"targetDuration":4,"studyType":22,"phases":567,"briefSummary":568,"conditions":569,"keywords":570,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":582,"locationsCount":140},"100560575","the-effect-of-abdominal-massage-and-warm-application-on-excretory-activity-in-patients-undergoing-total-knee-replacement-with-spinal-anesthesia-100560575","NCT06578936","The Effect of Abdominal Massage and Warm Application on Excretory Activity in Patients Undergoing Total Knee Replacement With Spinal Anesthesia","Abdominal","Inclusion Criteria:\n\n* Written and verbal permission was obtained to participate in the study,\n* 18 years of age or older,\n* Conscious, oriented and cooperative,\n* Speaks and understands Turkish,\n* Total knee replacement with spinal anesthesia planned,\n* No condition in which abdominal massage is contraindicated (inflammatory bowel disease, presence of abdominal tumors, surgical intervention or radiotherapy to the abdominal area, presence or suspicion of ileus, and pregnancy),\n* No physician-diagnosed chronic constipation,\n* Mobilized,\n* Patients who do not have problems with transition to oral feeding and can be fed orally will be included.\n\nExclusion Criteria:\n\n* Written and verbal permission to participate in the research could not be obtained,\n* Under 18 years of age,\n* Unconscious, disoriented and uncooperative,\n* Can speak Turkish but cannot understand it,\n* Total knee replacement with general anesthesia planned,\n* Any condition in which abdominal massage is contraindicated (inflammatory bowel disease, presence of abdominal tumors, surgical intervention or radiotherapy to the abdominal area, presence or suspicion of ileus, and pregnancy),\n* Physician-diagnosed chronic constipation,\n* Non-mobilized,\n* Patients who have problems with transition to oral feeding and who cannot be fed orally will not be included.",{"count":566,"type":21},84,[24],"The aim of this study was to determine the effect of abdominal massage and warm application on the excretory activity (time of first bowel sounds, defecation time and the amount of laxative used until discharge) after total knee replacement surgery performed with spinal anesthesia.",[28],[571,572,573,574],"heat application","constipation","intestinal motility","spinal anesthesia","2024-08-28",{"date":577,"type":41},"2024-08-30",{"date":579,"type":41},"2024-08-05",{"date":581,"type":21},"2025-06-30",{"name":583,"class":48},"Ayşe Demirtaş"]