[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"total-occlusion-of-coronary-artery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:total-occlusion-of-coronary-artery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100537250","drug-coated-balloon-in-native-chronic-total-occlusion-percutaneous-coronary-intervention-100537250",false,"NCT06275386","Drug-Coated Balloon in Native Chronic Total Occlusion Percutaneous Coronary Intervention","Drug-Coated Balloon in Native Chronic Total Occlusion Percutaneous Coronary Intervention (IMAGINATION)","IMAGINATION","Inclusion Criteria:\n\n* clinical indication for CTO PCI as determined by the local heart team (presence of angina or equivalent symptoms and\u002For documented ischemia or viability)\n* native CTO lesion as defined by invasive coronary angiography\n* informed consent for participation in the study\n\nExclusion Criteria:\n\n* \\\u003C18 years of age\n* myocardial infarction\n* cardiogenic shock\n* severe valvular disease\n* estimated life expectancy \\\u003C1 year\n* contraindication to PCI\n* positive pregnancy test or breast-feeding\n* in-stent CTO\n* CTO recanalization using antegrade or retrograde dissection and re-entry techniques","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The IMAGINATION trial is an investigator-initiated, prospective, single-center study of symptomatic patients with a native chronic total occlusion (CTO) undergoing intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) with a drug-coated balloon (DCB). Post-PCI IVUS and fractional flow reserve (FFR) at baseline and at 6-months follow-up will be performed. In addition, patients included in the coronary computed tomography angiography (CCTA) substudy will undergo CCTA at 12-months follow-up. The aim of this study is to evaluate the efficacy and safety of DCB-only approach in native coronary CTO.",[27,28],"Coronary Artery Disease","Total Occlusion of Coronary Artery",[30,31,32],"chronic total occlusion","percutaneous coronary intervention","drug-coated balloon","RECRUITING","2025-12-29",{"date":36,"type":37},"2026-01-02","ACTUAL",{"date":39,"type":37},"2024-03-24",{"date":41,"type":21},"2026-05",{"name":43,"class":44},"National Institute of Cardiology, Warsaw, Poland","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":45},"100404710","computed-tomography-scan-in-complex-chronic-total-occlusion-percutaneous-coronary-intervention-100404710","NCT04549896","Computed Tomography Scan in Complex Chronic Total Occlusion Percutaneous Coronary Intervention;","Interest of Coronary CT Scan Before Complex Chronic Total Occlusion (CTO) Percutaneous Coronary Intervention (PCI).","CTS-C-CTOPCI","Inclusion Criteria:\n\n1. Male or female ≥ 18 years old and ≤ 90 years old,\n2. BMI ≤ 40 kg\u002Fm²,\n3. Dated and signed informed consent, before any study-related procedures\n4. Ability to understand and comply with the study procedures,\n5. Affiliate or recipient of a social security scheme,\n6. Coronary artery chronic total occlusion (TIMI 0 flow from \\> 3 months) associated with myocardial viability (intended like normokinetic\u002Fhypokinetic wall motion or instrumental data in favor of viability) associated with ≥ CCS2 angina or ≥ NHYA2 dyspnea or documented ischemia or ejection fraction \\\u003C50%.\n7. Coronary angiography J-CTO score ≥ 2 (complex cases)\n\nExclusion Criteria:\n\n1. Pregnant or breastfeeding woman,\n2. Adults patients protected by law,\n3. Very frequent and irregular cardiac rhythm (\\>100\u002Fmin.),\n4. More than one CTO to be treated by PCI,\n5. Coronary angiography J-CTO (Japan Chronic Total Occlusion) score 0\u002F1\n6. Hemodynamic instability,\n7. Anemia \\\u003C 9g\u002Fdl,\n8. Gastrointestinal bleeding,\n9. Thrombocytopenia with \\\u003C 50 000\u002Fmm3 platelets count,\n10. Severe valvular disease associated\n11. CT-Scan performed as part of the standard of care pathology diagnosis, before the inclusion","90 Years",{"count":56,"type":21},130,[24],"The chronic total occlusion of a coronary artery is the most frequent cardiac disease in the developped countries. The percutaneous coronary intervention is one of the existing treatments. This procedure is long, expensive and uses a lot of contrast medium and X ray. With this study, the investigators want to adress the impact of CT scan performed before the surgical procedure. A better knowledge of the patient's anatomy could lead to a better success rate of the operation, with a lower radiation, lower contrast injection, and a faster and more cost-efficient procedure.",[28],"2024-06-25",{"date":62,"type":37},"2024-06-26",{"date":64,"type":37},"2022-06-01",{"date":66,"type":21},"2025-12",{"name":68,"class":44},"Elsan"]