[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tourniquet-hypertension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tourniquet-hypertension":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100635121","a-long-axis-approach-to-the-femoral-artery-block-fab-for-managing-tourniquet-pain-and-hypertension-in-below-the-knee-fracture-surgery-100635121",false,"NCT07548567","A Long Axis Approach to the Femoral Artery Block (FAB) for Managing Tourniquet Pain and Hypertension in Below-the-Knee Fracture Surgery","Turning the Probe, Changing the View: A Novel Long Axis Approach to the Femoral Artery Block (FAB) for Managing Tourniquet Pain and Hypertension in Below-the-Knee Fracture Surgery: A Prospective, Randomized, Double-Blind Controlled Trial","FAB","Inclusion Criteria:\n\n* Age \\>18 years\n* Physical status ASA I-III\n* Fluent in Greek or English\n* Scheduled surgery: below-knee fractures\n* Tourniquet duration ≥45 minutes\n\nExclusion Criteria:\n\n* Refusal to participate\n* Local inflammation at block site\n* Known allergy to study drugs\n* Morbid obesity (BMI \\>40)\n* Communication inability\n* Systemic neurological disease affecting peripheral nerves\n* Chronic pain therapy\n* Diabetic neuropathy\n* Uncontrolled hypertension","ALL","18 Years",{"count":20,"type":21},84,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a prospective, randomized, double-blind controlled trial evaluating an ultrasound-guided femoral artery block (FAB) using a long-axis in-plane approach compared with a short-axis approach and a control group.\n\nThe study will include adult patients (ASA I-III) undergoing below-the-knee fracture surgery with tourniquet application. All patients will receive standardized anesthesia including sciatic nerve block and total intravenous anesthesia.\n\nParticipants will be randomized into three groups: short-axis FAB, long-axis FAB, or control (saline injection). The primary aim is to assess the effectiveness of the long-axis FAB in reducing tourniquet-induced hypertension. Secondary outcomes include hemodynamic stability, analgesic requirements, pain scores, block characteristics, and procedural performance metrics.",[27],"Tourniquet Hypertension",[29,30,31,32,33,34,35,36],"FAB block","Tourniquet-induced hypertension","Tourniquet pain","Below-knee fracture surgery","Sympathetic blockade","intraoperative hypertension","sciatic nerve block","randomized controlled trial","NOT_YET_RECRUITING","2026-04-29",{"date":40,"type":41},"2026-04-30","ACTUAL",{"date":43,"type":21},"2026-05",{"date":45,"type":21},"2028-02",{"name":47,"class":48},"National and Kapodistrian University of Athens","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100397367","phase-4-femoral-peri-arterial-local-anesthetic-injection-via-peri-arterial-perineural-catheter-reverses-tourniquet-associated-ischemic-hypertension-100397367","NCT04454203","Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension","Inclusion Criteria:\n\nPatients that will be included in the study are English speaking 18-75 year old ASA 1-3 patients undergoing total ankle arthroplasty.\n\nExclusion Criteria:\n\n1. ASA 4 or 5\n2. Diagnosis of chronic pain\n3. Daily chronic opioid use (over 3 months of continuous opioid use).\n4. Inability to communicate pain scores or need for analgesia.\n5. Infection at the site of block placement\n6. Age under 18 years old or greater than 75 years old\n7. Pregnant women (as determined by standard of care day-of surgery urine bHCG)\n8. Intolerance\u002Fallergy to local anesthetics\n9. Weight \\\u003C50 kg\n10. Suspected, or known addiction to or abuse of illicit drug(s), prescription medicine(s), or alcohol within the past 2 years.\n11. Uncontrolled anxiety, schizophrenia, or other psychiatric disorder that, in the opinion of the investigator, may interfere with study assessments or compliance.\n12. Current or historical evidence of any clinically significant disease or condition that, in the opinion of the investigator, may increase the risk of surgery or complicate the subject's postoperative course",true,"75 Years",{"count":58,"type":21},40,[60],"PHASE4","The goal of this prospective randomized double-blind study is to determine if an ultrasound guided peri-arterial injection of local anesthetic (LA) superomedially the femoral artery via peripheral nerve catheter reverses ischemic hypertension associated with prolonged lower extremity tourniquet time.",[27,63,64,65],"Intraoperative Hypertension","Total Ankle Arthroplasty","Ankle Fusion",[67,68,69,27],"Perifemoral","Tourniquet","Mepivacaine","RECRUITING","2026-03-20",{"date":73,"type":41},"2026-03-23",{"date":75,"type":41},"2021-02-05",{"date":77,"type":21},"2027-02-03",{"name":79,"class":48},"Duke University",1]