[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tracheal-stenosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tracheal-stenosis":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,76,96,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100607692","paclitaxel-coated-pulmonary-balloon-for-the-treatment-of-benign-central-airway-stenosis-100607692",false,"NCT07191860","Paclitaxel-Coated Pulmonary Balloon for the Treatment of Benign Central Airway Stenosis","A Randomized, Controlled, Multi-Center, Prospective Trial of Paclitaxel-Coated Pulmonary Balloon for the Treatment of Benign Airway Stenosis (OXYGEN-RCT Trial)","OXYGEN-RCT","Inclusion Criteria:\n\n1. Age ≥ 22 years.\n2. Symptomatic de-novo or restenotic benign central airway stenosis in the subglottis, trachea, or mainstem bronchi with at least 50% narrowing, as determined by CT or bronchoscopy.\n3. In the opinion of the investigator, subject can undergo laryngoscopy\u002Fbronchoscopy under general anesthesia and has a central airway stenosis amenable to balloon dilation.\n4. For idiopathic subglottic stenoses, either de-novo or a dilation interval equal to or less than 18 months.\n5. Target benign stenosis etiologies including:\n\n   1. Post-intubation stenosis,\n   2. Idiopathic subglottic stenosis,\n   3. Post-transplantation stenosis,\n   4. Non-malignant trachea-bronchial stenosis\n6. Willing and able to complete protocol required follow-up visits.\n7. Willing and able to provide written informed consent.\n\nExclusion Criteria:1. Two or more clinically significant (e.g. non-traversable) stenoses with total length \\>5cm or unable to be treated with a single balloon 2. Female subjects who are pregnant or breastfeeding or plan to become pregnant in next 12 months 3. Subject currently has a stent at target stenosis location or has had a stent at the target location within the past 90 days.\n\n4\\. Subject has existing tracheostomy or had a tracheostomy within past 90 days 5. Contraindication to laryngoscopy\u002Fbronchoscopy, anesthesia, or deep sedation 6. Planned tracheal resection in the next 90 days. 7. Dynamic etiology of benign stenosis such as excessive dynamic airway collapse, tracheobronchomalacia, or stenosis due to external compression, or past tracheostomy which requires stent placement or surgical referral 8. Inclusion of vocal cord in target stenosis 9. Known medically significant unresolved lower respiratory tract infection, such as pneumonia, fungus, tuberculosis, etc.unrelated to stenosis 10. Target stenosis is beyond the mainstem bronchi 11. Signs or suspicion of a malignant airway obstruction NOTE: If obstruction is suspicious for malignancy based on clinical or laryngoscopic\u002Fbronchoscopic presentation, malignancy must be excluded by biopsy prior to randomization 12. Severe coagulation disorders or current use of anticoagulant or antiplatelet medication that cannot be safely managed per recommended guidelines prior to the index procedure 13. Chronic steroid use exceeding more than 10 mg per day for any medical condition including immunosuppression post-lung transplant or autoimmune associated airway suppression.\n\n14\\. Received local steroid or chemotherapeutic treatments into target stenosis in the last 12 weeks or planned treatment during index or staged study procedure.\n\n15\\. Planned serial intralesional steroid injections (SILSIs) post index procedure.\n\n16\\. Stenosis not amenable to laryngoscopic\u002Fbronchoscopic dilation in the opinion of the investigator 17. Acute condition that requires emergent procedure prior to screening assessment 18. Concurrent medical condition that would affect the investigator's ability to evaluate the patient's condition or could compromise patient safety, such as recent myocardial infarction, severe pulmonary disease, bleeding diathesis, large thoracic aneurysm, pharyngeal or cervical deformity, ongoing infection, etc 19. Subject has known fistula between tracheobronchial tree and esophagus, mediastinum to pleural space.\n\n20\\. Subject has vasculitis that is not well controlled in the opinion of the investigator.\n\n21\\. Diagnosed with a disease requiring chemotherapy (e.g. cancer). 22. Allergy to paclitaxel or structurally related compounds 23. Target stenosis is within a transplanted lung or transplant anastomosis, or a tracheal resection anastomosis, which has been transplanted or resected within the last 60 days.\n\n24\\. Target stenosis is related to radiation therapy 25. Subject has a life expectancy of less than 2 years. 26. Current participation in another pre-market drug or medical device clinical study that has not reached its primary endpoint.\n\n\\-","ALL","22 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","The OXYGEN-RCT trial is a randomized, controlled, double blinded, prospective, multi-center trial to demonstrate the safety and efficacy in adult benign central airway stenosis. Participates will be in a 1:1 allocation to treatment with the Airiver Pulmonary DCB or standard of care laryngoscopic\u002Fbronchoscopic balloon dilation, respectively.",[27,28,29,30,31,32],"Adult Subjects With Symptomatic Benign Airway Obstruction","Adult Benign Central Airway Stenosis","Adult Tracheobronchial Stenosis","Tracheal Stenosis","Central Airway Stenosis","Central Airway Obstruction","RECRUITING","2026-06-16",{"date":36,"type":37},"2026-06-18","ACTUAL",{"date":39,"type":37},"2026-02-24",{"date":41,"type":21},"2030-11-01",{"name":43,"class":44},"Airiver Medical, Inc.","INDUSTRY",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":45},"100628600","transcriptomic-profile-changes-in-benign-tracheal-stenosis-wedge-resection-vs-radial-incision-100628600","NCT07463742","Transcriptomic Profile Changes in Benign Tracheal Stenosis: Wedge Resection vs. Radial Incision","A Randomized Controlled Trial Comparing Transcriptomic Profile Changes Following Carbon Dioxide (CO2) Laser Wedge Resection Versus Radial Incision for Benign Tracheal Stenosis","Inclusion Criteria:\n\n* symptomatic tracheal stenosis\n* idiopathic subglottic stenosis\n* iatrogenic tracheal stenosis from intubation or tracheostomy\n\nExclusion Criteria:\n\n* positive ANA or ANCA\n* tracheal stenosis from infection, i.e. TB\n* tracheal stenosis with cartilage fracture\n* tracheal stenosis with malacia\n* tracheal stenosis from malignancy\n* tracheal stenosis from benign tumor\n* presence of glottic or supraglottic stenosis","18 Years","80 Years",{"count":56,"type":21},40,[24],"Some people develop a narrowing of their windpipe (trachea), called benign tracheal stenosis, which can make it hard to breathe. Doctors often treat this by using a bronchoscope-a thin, flexible tube with a camera-to open up the airway or remove scar tissue. While these procedures help patients breathe better, we do not fully understand why the narrowing occurs or how the tissue heals afterward.\n\nThe purpose of this study is to better understand the biological changes in the airway tissue before and after these standard medical procedures. During the procedure, small samples of tissue that would already be collected as part of normal care will be analyzed in the laboratory. The results may help doctors learn more about airway healing and could guide better treatments in the future.",[30],[61,62,63,64],"tracheal stenosis","bronchoscopy","wedge resection","CO2 laser","NOT_YET_RECRUITING","2026-03-12",{"date":68,"type":37},"2026-03-16",{"date":70,"type":21},"2026-05-01",{"date":72,"type":21},"2032-05-01",{"name":74,"class":75},"University of Maryland, Baltimore","OTHER",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":82,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":45},"100612838","rna-sequencing-of-discarded-tracheal-stenosis-tissue-to-characterize-cellular-and-molecular-pathogenesis-100612838","NCT07258784","RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis","Inclusion Criteria:\n\n* Patients with benign tracheal stenosis\n\nExclusion Criteria:\n\n* Malignancy. active infection",{"count":83,"type":21},10,"OBSERVATIONAL","Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring. It can be secondary to iatrogenic etiologies such as intubation or tracheostomy , as well as autoimmune diseases and being idiopathic. Patients typically undergoes endoscopic or surgical interventions to open up the airways. This project will analyze resected or biopsied tissue from patients with benign tracheal stenosis to define disease-specific RNA expression profiles.",[30,87],"Subglottic Stenosis","2025-11-20",{"date":90,"type":37},"2025-12-02",{"date":92,"type":37},"2025-09-11",{"date":94,"type":21},"2026-12-31",{"name":74,"class":75},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":22,"phases":104,"briefSummary":105,"conditions":106,"keywords":107,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":45},"100586580","slide-tracheoplasty-versus-tracheal-resection-anastomosis-in-acquired-tracheal-stenosis-100586580","NCT06917222","Slide Tracheoplasty Versus Tracheal Resection Anastomosis in Acquired Tracheal Stenosis","Inclusion Criteria:\n\n* All patients with grade III, IV acquired tracheal stenosis (e.g., due to trauma, prolonged intubation) regardless their age or sex.\n\n  * Patient with symptomatic high grade II acquired laryngotracheal stenosis after failure of endoscopic interventions.\n  * Clinical indications for surgical intervention (Symptoms of airway obstruction).\n  * Feasible for surgical intervention.\n\nExclusion Criteria:\n\n* congenital tracheal stenosis\n\n  * Malignant stenosis.\n  * Severe comorbidities that contraindicate the surgery.\n  * Patients refusing to sign the consent.",{"count":103,"type":21},30,[24],"Aim of the Work To compare the clinical outcomes between patients will undergo slide tracheoplasty and those will undergo tracheal resection anastomosis for acquired tracheal stenosis.",[30,87],[108,109],"Slide tracheoplasty","Tracheal resection anastomosis","2025-09-22",{"date":112,"type":37},"2025-09-25",{"date":114,"type":37},"2025-05-01",{"date":116,"type":21},"2026-08-01",{"name":118,"class":75},"Mansoura University Hospital",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":128,"conditions":129,"keywords":130,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":4},"100599610","ct-based-scoring-system-to-predict-surgical-need-in-tracheal-stenosis-tsmas-study-100599610","NCT07086729","CT-Based Scoring System to Predict Surgical Need in Tracheal Stenosis (TSMAS Study)","Development of a CT-Derived Risk Score to Guide Treatment Decision: Tracheal Stenosis Morphology and Attenuation Score (TSMAS)","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosed with tracheal stenosis\n* Underwent thoracic CT imaging at the time of diagnosis\n* CT scans available in adequate quality and in DICOM format\n* No prior surgical treatment for tracheal stenosis before CT imaging\n\nExclusion Criteria:\n\n* Tracheal stenosis due to malignancy, foreign body, or tracheobronchial tumors\n* History of tracheal surgery before CT imaging\n* Poor quality CT images (e.g., motion artifacts, incomplete tracheal segments)\n* Patients with a history of radiotherapy (RT) to the neck or mediastinum",{"count":127,"type":21},80,"This study aims to develop a CT-based scoring system to help predict whether patients with tracheal stenosis will require surgical treatment or can be managed with endoscopic procedures. Using retrospective data, researchers will evaluate CT scans of patients diagnosed with tracheal stenosis to measure features such as airway diameter, wall thickness, and tissue density (measured in Hounsfield Units). The goal is to create a non-invasive, reproducible, and objective tool-called the Tracheal Stenosis Morphology and Attenuation Score (TSMAS)-that can support clinical decision-making and improve treatment planning.",[30],[30,131,132,133,134],"Postintubation Stenosis","Hounsfield Unit","Morphologic Scoring","Computed Tomography","2025-07-18",{"date":137,"type":37},"2025-07-25",{"date":139,"type":21},"2025-09-01",{"date":141,"type":21},"2026-01-30",{"name":143,"class":75},"Ondokuz Mayıs University"]