[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tracheobronchitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tracheobronchitis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100459703","ventilator-associated-tracheobronchitis-initiative-to-conduct-antibiotic-evaluation-100459703",false,"NCT05266066","Ventilator-associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation","Multicenter Randomized Clinical Trial of Antimicrobial Treatment in Ventilator-associated Tracheobronchitis","VATICAN","Inclusion Criteria:\n\n* Admission to one of the participating ICUs\n* Invasive Mechanical ventilation ≥ 48 hours\n* Available chest imaging of screening day\n* Clinical diagnosis of VAT, defined by the presence of:\n\n  1. Temperature \\>38.0°C or \\\u003C36°C OR leukocytes \\>12000\u002FmL or \\\u003C4000\u002FmL or presence \\>10% of immature forms, AND\n  2. Onset of purulent tracheal secretion, or change in characteristics of the secretion, or increase in the amount of respiratory secretion, or increased need for aspiration\n* Culture of tracheal secretion from the day of screening under analysis or collected for analysis\n\nExclusion Criteria:\n\n* Pregnant or lactating women\n* Indication of use of antibiotics or use of systemic antibiotics for any indications at the time of screening\n* Hemodynamic instability, defined as hypotension unresponsive to volume expansion or increase in vasopressor dose \\> 0.1mcg\u002Fkg\u002Fmin of noradrenaline or equivalent in the past 6 hours\n* Worsening of gas exchange, defined as an increase in the fraction of inspired oxygen ≥ 20% or an increase in positive end-expiratory pressure (PEEP) ≥ 3 cm of water after a stability period ≥ 2 days\n* Prolonged mechanical ventilation, defined by use of invasive mechanical ventilation for 21 days or more\n* Presence of pulmonary radiological image suggestive of new infectious infiltrate\n* Previous lung disease that makes radiological interpretation for the diagnosis of VAP difficult\n* Previous diagnosis of ventilator associates pneumonia (VAP) during hospitalization\n* Neutropenic patients (neutrophils \\\u003C1000\u002FmL)\n* Known severe immunosuppression\n* Tracheostomized patients at the time of screening\n* Inclusion in the study in the past 30 days\n* Expected limitation of care or early withdrawal of supportive therapies (\\\u003C 7 days)\n* Patients with a survival expectancy of less than 48 hours\n* Refusal of consent to participate in the study","ALL","18 Years",{"count":20,"type":21},590,"ESTIMATED","INTERVENTIONAL",[24],"NA","The Ventilator Associated tracheobronchitis Initiative to Conduct Antibiotic evaluation (VATICAN) trial is a national, multicenter, non-inferiority trial in ICU patients comparing antibiotic treatment for 7 days versus clinical observation without antibiotic treatment for patients with ventilator-associated tracheobronchitis.",[27,28],"Ventilator Associated Tracheobronchitis","Tracheobronchitis",[30,31,32,33],"Antibiotics","Ventilator associated Tracheobronchitis","Mechanical ventilation","Critically ill","RECRUITING","2025-06-16",{"date":37,"type":38},"2025-06-19","ACTUAL",{"date":40,"type":38},"2022-07-11",{"date":42,"type":21},"2026-12-01",{"name":44,"class":45},"Hospital Sirio-Libanes","OTHER",16,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":64,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100539984","mechanical-insufflation-exsufflation-and-hypertonic-saline-in-nosocomial-bacterial-respiratory-tract-infection-100539984","NCT06310941","Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection","Aspiration of Bronchial Secretions With Mechanical Insufflation-Exsufflation and Hypertonic Saline in Bacterial Nosocomial Tracheobronchitis and Pneumonia in Intubated Patients.","ABSENTA","Inclusion Criteria:\n\n* Signed informed consent\n* Nosocomial pneumonia (vHAP or VAP) or nosocomial tracheobronchitis\n* Intubated with a cuffed endotracheal tube or tracheostomy cannula.\n\nExclusion Criteria:\n\n* Ominous prognosis\n* Frank hemoptisis\n* Barotrauma (pneumothorax or pneumomediastinum)\n* Bronchospasm (patients on bronchodilators for previous bronchospasm may be included\n* Unstable thoracic cage\n* Suspected unmonitored intracraneal hypertension",{"count":56,"type":21},100,[24],"Multicenter, randomized open label clinical trial to evaluate IEM and HS as concomitant therapy for respiratory tract infection in patients under artificial ventilation in the ICU.\n\nLung infection is a serious complication that may occur during hospital stay and may need artificial respiration or even develop during artificial ventilation for other causes.\n\nCurrent specific treatment consists of intravenous antibiotics. The current study evaluated whether aspiration and drainage of infected sputum helps curing this severe complication and whether nebulized HS has additional benefits, like loosening of secretions, eradicating bacteria or reducing inflammation.",[60,61,28,62,63],"Nosocomial Infection","Nosocomial Pneumonia","Mechanical Ventilation Complication","Endotracheal Intubation",[65,66,67,68,69,70,71,72],"mechanical insufflation-exsufflation","cough assist device","hypertonic saline","nosocomial respiratory tract infection","hospital-acquired pneumonia","tracheobronchitis","ventilator-associated pneumonia","nebulization","NOT_YET_RECRUITING","2025-03-21",{"date":76,"type":38},"2025-03-26",{"date":78,"type":21},"2026-01-01",{"date":80,"type":21},"2027-12-30",{"name":82,"class":45},"Hospital San Carlos, Madrid",8]