[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tracheotomy-patients\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tracheotomy-patients":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100595534","feasibility-and-safety-of-the-airway-exchange-broncholaryngoscope-aeblscope-100595534",false,"NCT07033702","Feasibility and Safety of the Airway Exchange Broncholaryngoscope (AEBLScope)","Pilot Study Assessing the Feasibility and Safety of the Airway Exchange Broncholaryngoscope (AEBLScope) During Routine Tracheostomy Tube Exchanges","Inclusion Criteria:\n\n* Age ≥18 years\n* Chronically (\\>1 month) tracheostomy-dependent outpatients\n* Currently not requiring ventilatory or supplemental oxygen support\n* Have undergone at least one prior tracheostomy tube exchange\n* Scheduled for routine in-office tracheostomy tube exchange\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Active respiratory infection\n* Patients with airway tubes having an inner diameter less than 6.0 mm\n* Patients with preexisting pulmonary conditions, including chronic obstructive pulmonary disease (COPD), restrictive lung disease, untreated pneumonia, or acute respiratory distress syndrome (ARDS)\n* Patients who are tracheostomy-dependent but cannot be orotracheally intubated.\n* Patients unable to provide informed consent and who have no legally authorized representative.","ALL","18 Years",{"count":19,"type":20},10,"ESTIMATED","INTERVENTIONAL",[23],"NA","This pilot study evaluates the safety and feasibility of a novel airway exchange broncholaryngoscope (AEBLScope) during routine tracheostomy tube exchanges in chronically tracheostomy-dependent adult outpatients.",[26,27,28],"Tracheotomy Patients","Airway Management","Airway Disease",[30,31,32,33,34],"tracheostomy","bronchoscope","airway exchange","feasibility","safety","NOT_YET_RECRUITING","2025-06-19",{"date":38,"type":39},"2025-06-24","ACTUAL",{"date":41,"type":20},"2025-09",{"date":43,"type":20},"2026-07",{"name":45,"class":46},"University of Southern California","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100594058","study-on-the-correlation-mechanism-and-application-of-genetic-susceptibility-hemoglobin-adaptation-changes-and-extubation-success-rate-in-stroke-patients-with-tracheotomy-at-different-altitudes-100594058","NCT07014501","Study on the Correlation Mechanism and Application of Genetic Susceptibility, Hemoglobin Adaptation Changes, and Extubation Success Rate in Stroke Patients With Tracheotomy at Different Altitudes","Inclusion Criteria:\n\n1. Age between 18 and 75 years.\n2. Hospitalized patients in the rehabilitation department with acute non-traumatic ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage requiring tracheostomy.\n3. Hemodynamic stability: Systolic blood pressure maintained between 90-160 mmHg, diastolic blood pressure between 60-100 mmHg, respiratory rate between 12-30 breaths\u002Fmin, heart rate between 60-120 beats\u002Fmin, body temperature between 36.5°C-38.5°C, and arterial oxygen saturation (SaO₂) consistently \\>90% at admission and prior to tracheostomy.\n4. Glasgow Coma Scale (GCS) score of 5-15 at assessment.\n5. Tracheostomy performed within 24-72 hours after stroke onset.\n6. Peripheral blood hemoglobin concentration at admission within specified ranges (male: 120-180 g\u002FL; female: 110-160 g\u002FL).\n7. Signed informed consent provided by the patient or legal guardian.\n\nExclusion Criteria:\n\n1. History of severe cardiopulmonary dysfunction (e.g., chronic obstructive pulmonary disease, cor pulmonale, coronary artery disease, cardiomyopathy) with New York Heart Association (NYHA) functional class III or IV, or recent (within 6 months) acute myocardial infarction or unstable angina.\n2. Diagnosis of advanced malignancy (life expectancy \\\u003C6 months) with ongoing chemotherapy, radiotherapy, or palliative care.\n3. Severe hepatic or renal insufficiency (e.g., decompensated cirrhosis, chronic renal failure requiring long-term dialysis).\n4. Uncontrolled endocrine disorders (e.g., thyrotoxic crisis, myxedema coma, diabetic ketoacidosis, hyperosmolar hyperglycemic state).\n5. Coagulation disorders:\n\n   * Congenital or acquired coagulopathies (e.g., hemophilia, vitamin K deficiency, coagulation factor deficiency due to severe liver disease, antiphospholipid syndrome).\n   * Active anticoagulation therapy (e.g., warfarin with INR \\>3.0, heparin with APTT exceeding twice the upper limit of normal) unadjustable to a safe range within 72 hours.\n6. Major surgery within 3 months (e.g., cardiac, abdominal, or orthopedic surgery).\n7. Severe chest trauma (e.g., multiple rib fractures, pneumohemothorax) or abdominal trauma (e.g., liver\u002Fspleen rupture, intestinal perforation) within 1 month prior to stroke onset, with incomplete recovery.\n8. Active uncontrolled infection at admission (e.g., pneumonia, urinary tract infection, intracranial infection, sepsis) defined by:\n\n   * Temperature \\>38.5°C persisting \\>24 hours.\n   * Elevated white blood cell count, increased neutrophil percentage, and clinical signs of infection.\n   * Positive bacterial cultures (blood, sputum, urine).\n9. Recent (within 1 week) exposure to infectious diseases (e.g., travel to epidemic areas, contact with confirmed cases) with suspected latent or active infection.\n10. History of neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's disease) or motor neuron disorders (e.g., amyotrophic lateral sclerosis).\n11. Congenital neurological developmental abnormalities (e.g., hydrocephalus, cerebral palsy).\n12. Severe uncontrolled psychiatric disorders (e.g., schizophrenia, major depressive disorder, bipolar disorder) impairing daily function or treatment adherence.\n13. Cognitive impairment (e.g., dementia) with Mini-Mental State Examination (MMSE) score \\\u003C10.\n14. Pregnancy or lactation.\n15. Hypersensitivity or contraindications to study-related drugs or procedures (e.g., allergy to tracheostomy tube materials, antibiotic allergies without alternatives).\n16. Inability to complete follow-up or required tests (e.g., geographical barriers, unreliable contact information).\n17. Non-compliance of the patient or family members with the study protocol.\n18. Failure to obtain informed consent.\n19. Participation in other interventional clinical trials.","75 Years",{"count":56,"type":20},717,"OBSERVATIONAL","Patients with brain injuries caused by various reasons often need tracheotomy to improve breathing, but this procedure can cause the air to lose its nasal regulation, increase the risk of lung infections, and reduce their quality of life. Tracheal extubation is crucial for patient recovery. Environmental factors in high-altitude areas have a significant impact on human cardiovascular function, including changes in blood oxygen caused by low oxygen environments and cardiovascular adaptability of long-term residents. There is limited research on the impact of high altitude on the success rate of tracheal extubation in brain injury. The research team conducted a retrospective study on 501 patients who underwent tracheotomy at the Second Affiliated Hospital of Kunming Medical University and found that high GCS scores and hemoglobin concentrations were beneficial for extubation. The increase in hemoglobin concentration among high-altitude residents may be an adaptive response to hypoxia, and the research team speculates that this may become a protective factor for successful extubation. However, some argue that altitude sickness and adaptive genetic changes may counteract each other. Simonson's team found that the decline of hemoglobin concentration in Tibetans was related to specific gene expression, indicating that the genetic adaptability of high altitude residents had a unique relationship with hemoglobin concentration. Therefore, the research team speculates that people living in highlands for a long time are more adaptable to hypoxic environments than those living in lowlands. Under severe stress (hypoxia), people living in highlands for a long time may have lower sensitivity to pulmonary blood flow redistribution or oxygen delivery compared to those living in lowlands. This study is a multicenter observational study, with sub centers listed as follows: Jiangchuan District People's Hospital, Huaning County People's Hospital, Baoshan Second People's Hospital, Huize County People's Hospital, Mengla County People's Hospital, Tonghai County People's Hospital, Jinghong City First People's Hospital, Xuanwei City First People's Hospital, Qiubei County People's Hospital, Fengqing County People's Hospital, Weixin County People's Hospital, Yulong County People's Hospital, Yanshan County People's Hospital, Xundian County People's Hospital, Shizong County People's Hospital, Luxi County People's Hospital, Yunnan Province Northeast Yunnan Central Hospital, Luoping County People's Hospital, Xinping County General Hospital, Suijiang County People's Hospital, Nanhua County Hospital, Guangnan County People's Hospital County People's Hospital, Jianshui County People's Hospital, Simao District People's Hospital of Pu'er City, Funing County People's Hospital, Xinping County Traditional Chinese Medicine Hospital Xundian County First People's Hospital and Jingdong County People's Hospital.",[60,26],"Stroke","RECRUITING","2025-06-07",{"date":64,"type":39},"2025-06-11",{"date":66,"type":39},"2025-01-01",{"date":68,"type":20},"2028-05-29",{"name":70,"class":46},"The Second Affiliated Hospital of Kunming Medical University",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":4},"100576922","evaluating-the-effects-of-intermittent-oro-esophageal-in-tracheotomy-patients-with-neurogenic-dysphagia-100576922","NCT06791590","Evaluating the Effects of Intermittent Oro-esophageal in Tracheotomy Patients With Neurogenic Dysphagia","Evaluating the Effects of Intermittent Oro-esophageal in Tracheotomy Patients With Neurogenic Dysphagia: a Randomized Study","Inclusion Criteria:\n\n* Diagnosis of neurogenic dysphagia；\n* Acute phase has passed, weaning time \\> 48 hours, tracheotomy time \\>1 week; in accordance with the decannulation process of tracheotomy patients formulated by our center in 2018;\n* steady vital signs, without severe cognitive impairment or sensory aphasia, able to cooperate with the assessment；\n* Gastrointestinal motility is good, can tolerate more than 150ml\u002Fh feeding pump speed;\n* Willing to sign an informed consent form.\n\nExclusion Criteria:\n\n* Structural swallowing disorders, such as oral, pharyngeal, larynx, esophagus and other anatomical abnormalities caused by swallowing disorders;\n* The clinical condition was unstable, accompanied by heart, lung, brain and other important organ dysfunction;\n* Severe cognitive dysfunction, confusion, unable to cooperate.","92 Years",{"count":81,"type":20},140,[23],"Neurogenic dysphagia refers to swallowing disorders caused by the damage of swallowing central or peripheral nerves and muscles. According to statistics, about 50% of patients with neurological diseases will be complicated with neurogenic dysphagia. Common diseases include stroke, dementia, Parkinson's disease and neuromuscular diseases. Dysphagia has a great impact on the quality of life of patients, and is related to malnutrition, aspiration pneumonia and even death. In severe cases, tracheotomy is required to maintain airway patency and discharge secretions. The common nutritional support methods for patients with neurogenic dysphagia after tracheotomy are nasogastric or nasointestinal tube placement and percutaneous gastrostomy.\n\nintermittent oro-esophageal tube feeding (IOE) is a new nutrition method proposed by scholars in recent years. Studies have shown that it can improve the swallowing function of patients with dysphagia while meeting the nutritional needs of patients, so as to effectively improve the quality of life of patients. However, there are few studies on patients with dysphagia after tracheotomy. This study aims to compare the intervention effects of two kinds of tube feeding methods in patients with neurogenic dysphagia after tracheotomy.",[85,26],"Neurogenic Dysphagia","2025-01-19",{"date":88,"type":39},"2025-01-24",{"date":90,"type":20},"2025-01-28",{"date":92,"type":20},"2025-12-30",{"name":94,"class":46},"Capital Medical University"]