[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"transcranial-direct-current-stimulation-tdcs\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:transcranial-direct-current-stimulation-tdcs":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,43,75,93,118,142],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100583733","transcranial-direct-current-stimulation-in-children-with-autism-spectrum-disorder-100583733",false,"NCT06880159","Transcranial Direct Current Stimulation in Children With Autism Spectrum Disorder","Effects of Transcranial Direct Current Stimulation (tDCS) for Enhancing Cognitive Function in Children With Autism Spectrum Disorder","Inclusion Criteria:\n\n* being 8-12 years old\n* diagnosed with ASD given by registered psychiatrists or clinical psychologists according to the Diagnostic and Statistical Manual of Mental Disorders-5th Edition (DSM-5) criteria of ASD\n* IQ score above 60\n* able to communicate in Chinese\n\nExclusion Criteria:\n\n* with severe motor dysfunctions\n* history of other neurological and psychiatric disorders or head trauma","ALL","8 Years","12 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background: Transcranial Direct Current Stimulation (tDCS) is a form of non-invasive brain stimulation that has aroused increased interests in the past decade. Not only that it is transient with little side-effects, and can be well-tolerated by children, it is also affordable and readily accessible, making it an appealing treatment option for autism spectrum disorder (ASD).\n\nObjective: (1) To assess the therapeutic effects of tDCS when combined with cognitive training for 10 consecutive weekdays on improving cognitive processing in children with ASD, relative to control group receiving sham-stimulation, and (2) to evaluate the associated neural mechanisms underlying the treatment effect of tDCS on children with ASD.\n\nMethods: To assess the therapeutic effects of tDCS, 90 adolescents with ASD (age 6-12 years) will be randomly assigned to active- (n=45), or sham- (n=45) tDCS groups. Twenty-minute sessions of tDCS stimulation to the left dorsolateral prefrontal cortex (DLPRC) will be provided on 10 consecutive weekdays, in conjunction with cognitive training exercises. Participants with a head circumference of less than 53 cm will receive 1.0 mA of stimulation, while those with a circumference of 53 cm or greater will receive 1.5 mA. EEG, fNIRS and neuropsychological tests will be administered before, immediately after, and 2 months after the series of tDCS sessions.\n\nHypothesis: The investigators hypothesize that children with ASD who are randomly assigned to receive a montage of prefrontal tDCS, with cathode (inhibitory) placed over left DLPFC and anode (excitatory) over right supraorbital region) will evidence greater improvement in executive function (primary outcome) than children with ASD who are randomly assigned to receive sham-tDCS.\n\nIn addition to testing the primary clinical outcome, stated above, in planned exploratory analyses, the investigators will also examine the effects of tDCS on secondary outcome measures of cognitive function, including information processing speed, working memory, inhibitory control, and cognitive flexibility; and conduct exploratory mediation analyses to better understand the potential neurophysiological factors underlying the therapeutic effects of tDCS. This will include E\u002FI ratio as exploratory mediator variables. As these secondary analyses are exploratory, the investigators will report them as such in presentations and published papers, and the investigators will not draw definitive conclusions from them. Rather, they will be used to better understand the potential impact of tDCS and the mechanisms underlying impact, and to inform future research.",[27,28,29],"Autism Spectrum Disorder (ASD)","Transcranial Direct Current Stimulation (tDCS)","Electroencephalography","RECRUITING","2026-02-04",{"date":33,"type":34},"2026-02-06","ACTUAL",{"date":36,"type":34},"2025-09-01",{"date":38,"type":21},"2028-06",{"name":40,"class":41},"The Hong Kong Polytechnic University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":42},"100529855","evaluation-of-the-analgesic-effect-of-transcranial-direct-current-stimulation-tdcs-for-sedated-patients-in-intensive-care-unit-100529855","NCT06179199","Evaluation of the Analgesic Effect of Transcranial Direct Current Stimulation (tDCS) for Sedated Patients in Intensive Care Unit.","Evaluation of the Analgesic Effect of Transcranial Direct Current Stimulation (tDCS) for Sedated Patients in Intensive Care Unit.Randomized, Placebo-controlled, Double-blind Study.","REASTIM","Inclusion Criteria:\n\n* Age from 18 to 80 years,\n* Sedated patient requiring mechanical ventilation for at least 48 hours with administration of morphine.\n* Person affiliated to the social security system or beneficiary of an assimilated regime.\n* RASS ≤ -2\n* Close consent or emergency inclusion\n\nExclusion Criteria:\n\n* History of epilepsy.\n* Severe brain injury (head trauma, stroke, neuromeningeal infection, status epilepticus).\n* Presence of intracranial ferromagnetic material.\n* Presence of electronic stimulators or implants (e.g. pacemaker, spinal cord or intracranial stimulator).\n* Facial trauma preventing eye opening.\n* Patients who are blind and\u002For have eye damage.\n* Protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, persons under legal protection.\n* Subjects excluded from another study.","18 Years","80 Years",{"count":54,"type":21},40,[24],"Pain management for sedated ICU patients is complex, partly because of the difficulty of assessing pain in non-communicative patients, and partly because of the side effects associated with excessive use of morphine.\n\nIn this context, the use of another non-pharmacological approach, transcranial direct current stimulation (tDCS), could be of interest. With tDCS, neuronal activity is modulated by inducing a weak electric current through the cerebral cortex between two electrodes applied to the surface of the scalp. Although the mechanisms of action of tDCS are not yet fully understood, the medium-term effects are thought to be linked to the activation of N-methyl-D-aspartate receptors, glutamate-activated receptors involved in cellular memory. The use of tDCS as an analgesic therapy for chronic pain has produced encouraging results in patients suffering from fibromyalgia, migraine and central pain following spinal cord injury, Its use in sedated intensive care patients is unknown. To assess the possible analgesic effect of tDCS in these patients, we will use quantitative pupillometry, a technique already used in routine intensive care, to quantify nociception during a standardized nociceptive simulation.",[28],[59,60,61,62,63,64],"Pain management","Transcranial direct current stimulation (tDCS)","Analgesic therapy","Chronic pain","Sedated patient","Intensive care unit","NOT_YET_RECRUITING","2025-12-11",{"date":68,"type":34},"2025-12-12",{"date":70,"type":21},"2026-01",{"date":72,"type":21},"2026-12",{"name":74,"class":41},"University Hospital, Grenoble",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":90,"leadSponsor":92,"locationsCount":42},"100583592","resting-state-functional-connectivity-as-a-predictor-of-tdcs-effects-in-adolescents-with-autism-spectrum-disorder-100583592","NCT06878326","Resting-State Functional Connectivity as a Predictor of tDCS Effects in Adolescents With Autism Spectrum Disorder","Inclusion Criteria:\n\n* being 12-22 years old\n* diagnosed with ASD given by registered psychiatrists or clinical psychologists according to the Diagnostic and Statistical Manual of Mental Disorders-5th Edition (DSM-5) criteria of ASD\n* able to communicate in Chinese\n\nExclusion Criteria:\n\n* without a confirmed diagnosis from the clinical psychologist\n* history of other neurological and psychiatric disorders and head trauma\n* on psychiatric medication","22 Years",{"count":20,"type":21},[24],"Background: Transcranial Direct Current Stimulation (tDCS) is a form of non-invasive brain stimulation that has aroused increased interests in the past decade. Not only that it is transient with little side-effects, and can be well-tolerated by children, it is also affordable and readily accessible, making it an appealing treatment option for autism spectrum disorder (ASD).\n\nObjective: (1) To evaluate the therapeutic effects of tDCS on improving cognitive function in patients with ASD, (2) to better understand the neural mechanisms underlying the neuromodulation effects of tDCS in patients with ASD, and (3) to determine whether resting-state functional connectivity measures can predict the therapeutic effects of active tDCS in individuals with ASD.\n\nMethods: To assess the therapeutic effects and neural mechanisms of tDCS, 90 adolescents with ASD (age 12-22 years) will receive three stimulation conditions: cathodal tDCS of the left DLPFC, anodal tDCS of the left DLPFC and sham-tDCS with at least a week apart each time. During the active tDCS or sham-tDCS condition, the participants will be administered a computerized test battery (Cambridge Neuropsychological Test Automated Battery, CANTAB®) to evaluate their cognitive function. EEG before and after the tDCS to evaluate the tDCS-induced alteration in their neural activity and functional connectivity.\n\nHypothesis: Drawing together the different evidence linking ASD with cortical hyper-excitability and disordered neural connectivity, as reviewed previously, the investigators hypothesize that, relative to a sham-tDCS condition, active cathodal (inhibitory) and anodal (excitatory) tDCS over the left DLPRC will induce stimulation-linked facilitation of learning and resultant improvement of cognitive functioning in patients with ASD.\n\nIn addition to the therapeutic effects of tDCS, enhanced neural connectivity, as indexed by altered level EEG theta coherence in patients with ASD, will mediate the beneficial effects of tDCS, relative to sham tDCS, on improvements in cognitive function. Moreover, resting-state functional connectivity will moderate the beneficial effects of active tDCS on cognitive function, relative to sham tDCS, such that participants with greater pre-treatment resting state functional connectively will evidence greater\u002Fless response to tDCS, relative to participants receiving sham tDCS.",[27,28,29],"2025-09-18",{"date":88,"type":34},"2025-09-24",{"date":36,"type":34},{"date":91,"type":21},"2027-04",{"name":40,"class":41},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":99,"sex":16,"minAge":51,"maxAge":100,"enrollmentInfo":101,"targetDuration":4,"studyType":22,"phases":103,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":42},"100601254","interactions-between-placebo-effects-and-mindful-awareness-state-100601254","NCT07108101","Interactions Between Placebo Effects and Mindful Awareness State","* No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis\n* No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis that can cause cognitive impairment\n* No self-reported current chronic pain, or acute pain within three months of the study period\n* No current migraine disorder (i.e., 15 headache days or more in 1 month)\n* No use of central nervous system-effective medication or other medication for neurological\u002Fpsychiatric treatment\n* No self-reported substance abuse within the last six months\n* No contraindication to MRI or tDCS (e.g., pregnancy, claustrophobia, pacemakers, ear\u002Fcochlear implants, shrapnel injuries, clips, or other ferromagnetic\u002Felectrical objects\u002Fdevices, diagnosed brain abnormality such as tumor, or skin lesions on the scalp.)\n* No contraindications for induced pain (e.g., no heart disease, high blood pressure, heart surgery, heart problems of any kind, severe asthma, respiratory problems of any kind, fibromyalgia, Raynaud's Syndrome or Disease, chronic pain, diabetes)\n* Participants must be capable of performing experimental tasks (e.g., are able to read), are fluent or native speakers of English\n* Participants must be able to tolerate the maximum level of thermal pain stimuli (for thermal stimuli)",true,"55 Years",{"count":102,"type":21},120,[24],"In this experiment,the investigators study the effects of interpersonally induced placebo effects and a mindful awareness induction on negative affect. Specifically, it will be examining the effects of interpersonally induced placebo effects (sham tDCS vs. control) and a mindful awareness induction (mindful state vs. control), as well as their interaction. Each group will undergo fMRI scanning and physiological recording will performing the Multimodal Negative Affect Task (MNAT).",[106,107,108,28],"Placebo Effect","Mindfulness","Pain","2025-07-31",{"date":111,"type":34},"2025-08-06",{"date":113,"type":21},"2026-06-01",{"date":115,"type":21},"2028-11-30",{"name":117,"class":41},"Trustees of Dartmouth College",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":99,"sex":16,"minAge":51,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":127,"briefSummary":128,"conditions":129,"keywords":130,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":138,"leadSponsor":140,"locationsCount":4},"100599790","intensity-dependent-effects-of-4-week-transcranial-direct-current-stimulation-on-motor-learning-in-healthy-young-adults-100599790","NCT07089069","Intensity-Dependent Effects of 4-week Transcranial Direct Current Stimulation on Motor Learning in Healthy Young Adults","Inclusion Criteria:\n\n1. age between 18 and 25 years; (2) normal or corrected-to-normal vision; (3) no history of pregnancy, cardiovascular disease, other physical impairments or illnesses, and no personal or family history of mental illness; (4) no implantation of any internal or external medical devices; and (5) right-handedness.\n\nExclusion Criteria:\n\n\\-","25 Years",{"count":126,"type":21},44,[24],"The goal of this clinical trial is to investigate the effects of different intensities of transcranial direct current stimulationover primary motor cortex on motor learning in healthy adults. The main question it aims to answer is:\n\nWhich intensity of tDCS can best improve motor learning? Researchers will compare 1 mA, 2 mA, and 3 mA tDCS to sham tDCS to see which intensity of tDCS is most effective in improving the ability of motor learning.\n\nParticipants will be randomly divided into four groups and receive 4 different intensities of tDCS(1 mA, 2 mA, 3 mA and sham tDCS),and will be blinded to the type of tDCS they received. We hypothesized that anodal tDCS at 2 mA would produce the most substantial improvement in motor learning.",[28],[131,132,133],"Transcranial Direct Current Stimulation","motor learning","Healthy young adults","2025-07-20",{"date":136,"type":34},"2025-07-28",{"date":134,"type":21},{"date":139,"type":21},"2025-10-01",{"name":141,"class":41},"Beijing Sport University",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":99,"sex":16,"minAge":149,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":22,"phases":152,"briefSummary":153,"conditions":154,"keywords":158,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":4},"100592310","investigating-the-effectiveness-of-a-2-week-novel-non-invasive-brain-stimulation-technique-on-cognitive-outcomes-in-healthy-adults-100592310","NCT06991764","Investigating the Effectiveness of a 2-week Novel Non-invasive Brain Stimulation Technique on Cognitive Outcomes in Healthy Adults","Investigating the Effectiveness of a 2-week High-frequency Transcranial Pulsed-current Stimulation on Cognitive Outcomes in Healthy Adults: A Randomised, Double Blinded, Sham-controlled Study","Inclusion Criteria:\n\n* Male and female young (21 to 30 years) and older adults (60 to 75 years)\n* Right-handed\n* Must be a native English speaker\n* No clinical diagnosis of neurodevelopmental, mood, neurological or neurodegenerative disorders\n* Adults with cardiometabolic or cardiovascular conditions may participate if their condition is controlled and stable with medication and \u002F or lifestyle interventions\n\nExclusion Criteria:\n\n* Currently on long-term medication for pain or migraines \u002F headaches\n* Adults with metallic implants in the chest or head region\n* Adults with epilepsy, or known seizure or immediate family members that have had a seizure before\n* Had a recent head injury that resulted in a temporary loss of consciousness or of memory in the last 12 months\n* Had prior head surgery\n* Prone to fainting\n* Sensitive skin or prone to skin allergies","21 Years","75 Years",{"count":102,"type":21},[24],"The goal of this randomised controlled trial is to investigate the effects of a 2-week high-frequency transcranial pulsed current stimulation (tPCS) on cognitive outcomes in older and healthy adults. The main questions it aims to answer are:\n\n1. Would a single session of anodal tPCS over the left prefrontal cortex improve working memory, task inhibition, and task switching in healthy young and older adults, compared to anodal transcranial direct current stimulation (tDCS) and sham-tPCS?\n2. Would repeated session of anodal-tPCS (2-weeks) lead to improvements in working memory, task inhibition, and task switching in healthy young and older adults, compared to tDCS and sham-tPCS?\n3. Will tPCS be better tolerated among healthy adults, compared to tDCS?\n\nResearchers will compare tPCS \u002F tDCS \u002F sham-tPCS to see if there are any differences in cognitive outcomes after 1 session and after repeated sessions, as well as to compare the tolerance of tPCS against tDCS and sham-tPCS.\n\nParticipants will be requested to:\n\n* Undergo 1 of 3 of the following conditions: tDCS \u002F tPCS \u002F sham-tPCS\n* Complete three sessions of cognitive tasks testing working memory, inhibition and task switching at baseline (pre-stimulation), after day 1 of brain stimulation and after 10 sessions of brain stimulation (post- repeated stimulation)\n* Undergo fNIRS-EEG brain measurements concurrently with the cognitive tasks",[28,155,156,157],"Ageing","Executive Functioning","Transcranial Electric Stimulation",[159,160,156,131,161,162,155],"Randomised Controlled Trial","Non-Invasive Brain Stimulation","Transcranial Pulsed Current Stimulation","Healthy Adults","2025-05-18",{"date":165,"type":34},"2025-05-28",{"date":167,"type":21},"2025-06-01",{"date":169,"type":21},"2027-04-30",{"name":171,"class":41},"Nanyang Technological University"]