[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"transcutaneous-spinal-stimulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:transcutaneous-spinal-stimulation":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,59],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100580737","cardiovascular-function-and-response-to-stimulation-within-the-first-year-after-spinal-cord-injury-100580737",false,"NCT06841198","Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury","Assessing Cardiovascular Effects: Is There a Time Too Early for Spinal Stimulation in Acute SCI? A Year-Long Evaluation of Autonomic Function Following Injury","For the main study:\n\nInclusion Criteria:\n\n* Individuals with a spinal cord injury undergoing inpatient rehabilitation at the Kessler Institute for Rehabilitation\n* Between 18-75 years old\n* 7-50 days after injury\n* Injury level ≥ T6 (a cervical or a high-level chest injury)\n* Individuals experiencing low blood pressure after the injury\n* American Spinal Injury Association Impairment Scale (AIS) A or B\n\nExclusion Criteria:\n\n* A ventilator is needed for breathing.\n* Devices such as brain\u002Fspine\u002Fnerve stimulators, a cardiac pacemaker\u002Fdefibrillator, or intra-cardiac lines are present in the body.\n* There is a significant disease affecting the blood vessels or signals in the heart, or a recent heart attack (myocardial infarction) has occurred.\n* A new medication has been prescribed to treat blood pressure or a heart problem within the last five days (excluding midodrine).\n* There is a known infection in the body (e.g., urinary tract infection) or a current illness (e.g., recent diagnosis of deep vein thrombosis (DVT) or other blood clotting issues, and\u002For a pressure injury that might interfere with the study).\n* There is a history of seizures.\n* Pregnancy.\n\nFor the spin-off study ice-water vs ice-wrap test (see description in study arms):\n\n\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\n\nInclusion:\n\nAge 18-75.\n\nInclusion for individuals with SCI:\n\n* Injury sustained more than 6 months ago\n* Injury level ≥ T6 (a cervical or a high-level chest injury)\n* American spinal injury association impairment scale (AIS) A - D\n\nExclusion:\n\nFoot lesions, uses a ventilator, devices such as brain\u002Fspine\u002Fnerve stimulators, significant or recent cardiovascular disease, known infection in the body",true,"ALL","18 Years","75 Years",{"count":21,"type":22},15,"ESTIMATED","INTERVENTIONAL",[25],"NA","The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect blood pressure.\n\nThe main questions are:\n\nHow does stimulation affect blood pressure over the year? What is the level of cardiovascular activation throughout the year?\n\nThe study will start during the inpatient stay at the Kessler Institute for Rehabilitation and continue after discharge as an outpatient, totaling about 20-29 sessions over the year.",[28,29,30,31],"Spinal Cord Injuries (SCI)","Orthostatic Hypotension, Dysautonomic","Cardiovascular","Transcutaneous Spinal Stimulation",[33,34,35,36,37,38,39,40,41,42,43,44,45],"Transcutaneous Spinal Cord Stimulation","spinal cord stimulation","orthostatic hypotension","blood pressure","cardiovascular","neuromodulation","acute spinal cord injury","chronic spinal cord injury","inpatient rehabilitation","tilt testing","cold pressor test","ambulatory blood pressure monitoring","autonomic dysfunction following spinal cord injury","RECRUITING","2026-06-26",{"date":49,"type":50},"2026-07-01","ACTUAL",{"date":52,"type":50},"2025-04-01",{"date":54,"type":22},"2026-11",{"name":56,"class":57},"Kessler Foundation","OTHER",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":16,"sex":17,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":4,"studyType":23,"phases":71,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":58},"100625783","rehab-and-mechanical-ventilation-100625783","NCT07427121","Rehab and Mechanical Ventilation","Rehabilitation-based Approaches to Prevent Mechanical Ventilation-induced Breathing Dysfunction","REHAB-MV","Inclusion Criteria:\n\nNon-smokers Sedentary or recreationally active Normal lung function No history of claustrophobia\n\nExclusion Criteria:\n\nCurrent smoking or vaping Obstructive lung disease Use of antibiotics or systemic corticosteroids to treat an acute condition History of sepsis or metastatic disease Post infectious conditions that affect breathing Diagnosed with a neurological or neuromuscular condition Any use of supplemental oxygen, continuous positive airway pressure (CPAP), or other positive pressure ventilation to treat sleep apnea Cardiac disease Orthopedic conditions that impair lung expansion Pregnancy Implanted metallic devices within 10 cm of the cervical spine","25 Years","80 Years",{"count":70,"type":22},16,[25],"The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness. High levels of MV support have been reported to alter the function of the diaphragm muscle, the primary breathing muscle, in people with compromised health. However, rehabilitation may have some potential to improve diaphragm function in advance of using MV. This study will test different rehabilitation interventions, including (1) inspiratory strength training (IST), (2) transcutaneous spinal cord stimulation (TSCS), or sham TSCS. Before and after MV, participants will complete breathing strength tests and responses to phrenic nerve stimulation.",[74,31,75],"Inspiratory Strength Training (IST)","Sham Spinal Stimulation",[77,78,79,80],"diaphragm","phrenic nerve","maximal inspiratory pressure","mechanical ventilation","2026-04-29",{"date":83,"type":50},"2026-05-05",{"date":85,"type":50},"2026-03-30",{"date":87,"type":22},"2027-12-31",{"name":89,"class":57},"University of Florida"]