[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"transfemoral-amputation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:transfemoral-amputation":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,53,83,120,148,173,197,217],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100644229","effectiveness-of-an-inpatient-rehabilitation-and-prosthetic-training-model-in-patients-with-vascular-and-metabolic-transfemoral-amputation-100644229",false,"NCT07665775","Effectiveness of an Inpatient Rehabilitation and Prosthetic Training Model in Patients With Vascular and Metabolic Transfemoral Amputation","Effectiveness of an Inpatient Multidisciplinary Rehabilitation and Prosthetic Training Model in Patients With Vascular and Metabolic Transfemoral Amputation Treated at a National Rehabilitation Center: An Ambispective Cohort Study","Inclusion Criteria:\n\n* Unilateral transfemoral amputation secondary to vascular disease or diabetes-related complications.\n* Participation in the INRLGII inpatient prosthetic rehabilitation program.\n* Availability of complete clinical records or willingness to participate in follow-up assessments .\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Current prosthesis user before admission to the INRLGII rehabilitation program.\n* Bilateral major lower-limb amputation.\n* Inability to complete follow-up assessments.\n\nWithdrawal Criteria\n\n* Incomplete or inconsistent clinical information.\n* Loss to follow-up during the 6-month observation period.\n* Participant withdrawal of consent.","ALL","18 Years",{"count":19,"type":20},54,"ESTIMATED","6 Months","OBSERVATIONAL","Patients with vascular and metabolic transfemoral amputations experience substantial functional limitations and high rates of prosthetic abandonment. Although multidisciplinary inpatient rehabilitation programs have been associated with improved outcomes, evidence regarding their effectiveness in low- and middle-income countries remains limited.\n\nThis study aims to evaluate the effectiveness of an inpatient rehabilitation and prosthetic training model implemented at the National Institute of Rehabilitation \"Luis Guillermo Ibarra Ibarra\" (INRLGII), Mexico. An ambispective cohort design will be used, including a retrospective review of patients treated between 2013 and 2025 and a prospective cohort enrolled between 2026 and 2029.\n\nThe primary objective is to determine the proportion of patients who achieve functional prosthesis use after hospital discharge. Secondary objectives include identifying clinical, metabolic, functional, and psychosocial factors associated with successful prosthetic use, adherence, and abandonment.",[25,26,27,28],"Diabetes Mellitus","Transfemoral Amputation","Peripheral Arterial Disease","Vascular Thrombosis",[26,30,25,31,32,33,34,35,36,37,38,39],"Vascular Amputation","Prosthetic Rehabilitation","Lower Limb Amputation","Prosthesis Use","Prosthetic Adherence","Prosthetic Abandonment","Functional Outcomes","Inpatient Rehabilitation","Multidisciplinary Care","Houghton Scale","NOT_YET_RECRUITING","2026-06-18",{"date":43,"type":44},"2026-06-24","ACTUAL",{"date":46,"type":20},"2026-06-19",{"date":48,"type":20},"2030-09",{"name":50,"class":51},"Instituto Nacional de Rehabilitacion","OTHER_GOV",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":68,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":52},"100608697","phase-1-towards-efficient-personalization-of-computerized-lower-limb-prostheses-via-reinforcement-learning-in-a-clinical-setup---group-1-100608697","NCT07204925","Towards Efficient Personalization of Computerized Lower Limb Prostheses Via Reinforcement Learning in a Clinical Setup - Group 1","Towards Efficient Personalization of Computerized Lower Limb Prostheses Via Reinforcement Learning in a Clinical Setup - Patient Study","Inclusion Criteria:\n\n* Unilateral transfemoral amputees between 18-75 with K level three or higher\n* More than one year after amputation\n* Using current prosthetic socket and leg for more than three months\n* No major skin issues on the residual limb for more than six months\n* Can walk for more than 4 minutes continuously without any other assistive devices\n\nExclusion Criteria:\n\n* Have very short residual thighs (the length of the residual limb is \\\u003C15% of the length of the unimpaired limb)\n* Are \\\u003C1.50m in height or \\>116Kg in weight (who would not fit our prosthesis or the PowerKnee)\n* Have cognitive, visual, audio impairments that would affect their ability to give informed consent or to follow simple Instructions during the experiments\n* Have any significant co-morbidity that interferes with the study (e.g. stroke, pacemaker placement, pain, etc.).","75 Years",{"count":62,"type":20},24,"INTERVENTIONAL",[65],"PHASE1","The goal of this clinical trial is to understand the feasibility and effectiveness of using reinforcement learning to personalize robotic prosthetic legs (an experimental prototype) for unilateral transfemoral amputees. The main questions it aims to answer are:\n\n* With the developed RL-based Recommendation Interfacing System (RISE), clinicians are able to personalize prosthetic legs faster compared with existing manual personalization procedures.\n* With the developed RL-based Recommendation Interfacing System (RISE), clinicians are able to personalize prosthetic legs without detailed knowledge about how the prosthetic legs are controlled.\n* Patients perform better when the prosthetic legs are personalized with RISE system compared with the ones personalized manually Researchers will compare two arms (RISE guided personalization and manual personalization) to see if the tuning speed will increase and if patients can perform better.\n\nParticipants will go through the standard prosthetic fitting procedures, such as alignment adjustment, then they will experience repeated prosthesis personalization procedures conducted by tuning specialists without RISE, tuning specialists with RISE, and prosthetists (without tuning expertise) with RISE on different types of terrains. In the end, the participants will go through a testing trial, in which they will experience the prototype personalized through the three different approaches without knowing how the control parameters are decided. Their walking performance will be recorded. It is expected that the participants will visit the testing site 8 times, which including alignment (1 visit), three personalization procedures (twice for each), and one testing trial (1-2 visits).",[26],[69,70,71],"Powered prosthesis legs","control parameter personalization","reinforcement learning","RECRUITING","2026-05-18",{"date":75,"type":44},"2026-05-19",{"date":77,"type":44},"2025-08-01",{"date":79,"type":20},"2029-11-01",{"name":81,"class":82},"North Carolina State University","OTHER",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":16,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":63,"phases":95,"briefSummary":97,"conditions":98,"keywords":101,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":119},"100600923","effect-of-a-microprocessor-controlled-prosthetic-knee-joint-on-k2-level-ambulators-100600923","NCT07103798","Effect of a Microprocessor-controlled Prosthetic Knee Joint on K2 Level Ambulators","Does a Microprocessor-Controlled Prosthetic Knee Joint Improve Mobility and Quality of Life in K2-Level Veteran Ambulators?","MPK-K2","Inclusion Criteria:\n\n* Unilateral, transfemoral amputation (any etiology).\n* Age from 45-85 years.\n* Residual limb length classified as standard (i.e., medium) to long.\n* Prosthesis user for at least 1 year prior to enrolling in the study.\n* K2-level classification while using their NMPK.\n* Good sensation on their residual limb.\n* Good skin integrity upon visual inspection.\n* Presents with good socket fit based upon a standard assessment by the study prosthetist.\n\nExclusion Criteria:\n\n* Bilateral leg amputations.\n* Individuals with a knee disarticulation.","45 Years","85 Years",{"count":94,"type":20},20,[96],"NA","Microprocessor-controlled knees (MPKs) automatically adjust resistance or damping in the joint to improve swing- and\u002For stance-phase control as appropriate for the prosthesis user during gait. The purpose of this proposed investigation is to determine if there are substantial physical and psychological benefits to fitting lower functioning Veteran ambulators having transfemoral amputations with an MPK compared with a nonmicroprocessor-controlled knee (NMPK). Using a repeated-measures, cross-sectional experimental design, approximately 20 Veterans with unilateral, transfemoral amputations will be evaluated on two separate occasions at the Jesse Brown VA Medical Center or the Edward Hines, Jr. VA Hospital, first with their conventional NMPK and then again after a 2-month accommodation period with the College Park Icon MPK.",[26,99,100],"Limb Loss","Limb Absence",[102,103,104,105,106,107,108],"amputation","limb loss","limb deficiency","transfemoral","above-knee","prosthesis","knee joint","2026-05-07",{"date":111,"type":44},"2026-05-08",{"date":113,"type":20},"2026-07-01",{"date":115,"type":20},"2028-06-30",{"name":117,"class":118},"VA Office of Research and Development","FED",2,{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":128,"sex":16,"minAge":17,"maxAge":129,"enrollmentInfo":130,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":132,"conditions":133,"keywords":135,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":52},"100515264","improving-socket-fit-in-female-and-male-veterans-with-transtibial-and-transfemoral-amputation-100515264","NCT05989243","Improving Socket Fit in Female and Male Veterans With Transtibial and Transfemoral Amputation","Improving Socket Fit in Female and Male Veterans With Transtibial and TransfemoralAmputation","SocketFit","Inclusion Criteria:\n\n* The investigators will enroll up to 40 Veterans\n\n  * 20 with unilateral transtibial amputation\n  * 20 with unilateral transfemoral amputation who are at or above a K2 Medicare functional classification level (MFCL) and who are 18-65 years old\n* All participants will have no current problems with their prosthesis or residual limb, and be at least 6-months post-amputation\n* Participants will be at or above a K2 MFCL, defined as a person who has the ability or potential for ambulation with the ability to traverse low level environmental barriers such as curbs, stairs, or uneven surfaces, typical of the limited community ambulator\n\nExclusion Criteria:\n\n* Cardiovascular, pulmonary, or neurological disease or disorder or requirement for an assistive device for their unaffected leg (i.e. orthosis, cane)",true,"65 Years",{"count":131,"type":20},40,"The investigators do not yet know how a prosthetic socket with adjustable panels affects the performance of people with a lower limb amputation compared to a conventional prosthetic socket. The primary objective of this study is to compare an adjustable and conventional prosthetic socket and use this information to determine the optimal socket that would improve rehabilitation and function in people with lower limb amputation.",[134,26],"Transtibial Amputation",[136,137,138,139],"Biomechanics","Kinematics","Walking","Prostheses","2026-04-20",{"date":142,"type":44},"2026-04-23",{"date":144,"type":44},"2022-01-31",{"date":146,"type":20},"2027-03-31",{"name":117,"class":118},{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":60,"enrollmentInfo":154,"targetDuration":4,"studyType":63,"phases":156,"briefSummary":157,"conditions":158,"keywords":159,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":52},"100503164","metabolic-cost-of-walking-with-passive-vs-powered-prosthetic-knees-among-persons-with-limb-loss-100503164","NCT05831696","Metabolic Cost of Walking With Passive vs. Powered Prosthetic Knees Among Persons With Limb Loss","Inclusion Criteria:\n\n* Males and Females with unilateral knee disarticulation or transfemoral (KD\u002FTF) amputation.\n* a body mass greater than 49Kg and less than 117Kg\n* 18-75 years of age\n* Have an ambulation potential of K3 or K4\n* Use a prosthesis daily for walking or sports activities\n* No less than six months of experience with a prosthesis\n* No socket issues or changes in the last six weeks\n* No residual limb pain affecting functional ability.\n\nExclusion Criteria:\n\n* Cannot walk at different speeds (MCFL K0-K2)\n* Limb-loss below the knee or through the hip\n* More than one amputation.\n* Uses an assistive device for walking\n* Uncontrolled edema in leg compartments\n* Compromised skin of the residual limb or contralateral foot\n* Are 180 days or less post-amputation\n* Pregnant (self-reported)",{"count":155,"type":20},12,[96],"The purpose of this industry-initiated research study is to test that a powered microprocessor controlled knee improves metabolic function during walking in level and sloped conditions as compared to the subject's physician prescribed prosthesis.",[26],[160,161,162,163],"Power Knee","Amputation","Metabolic Costs","Heart Rate","2026-02-02",{"date":166,"type":44},"2026-02-04",{"date":168,"type":44},"2023-02-27",{"date":170,"type":20},"2026-12",{"name":172,"class":82},"Loma Linda University",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":63,"phases":182,"briefSummary":183,"conditions":184,"keywords":185,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":52},"100608696","evaluation-of-a-neural-controlled-powered-prosthesis-across-diverse-real-world-tasks-100608696","NCT07204912","Evaluation of a Neural-Controlled Powered Prosthesis Across Diverse Real-World Tasks","Inclusion Criteria:\n\n* Male or Female age 18-70.\n* The patient must have a unilateral transfemoral amputation .\n* The patient must have the ability to ambulate at variable cadence (an expected lower extremity prosthesis functional level of K3 or above).\n* The patient must have adequate socket to support the device.\n\nExclusion Criteria:\n\n* Women who are pregnant.\n* Severe co morbidity, atypical skeletal anatomy, or poor general physical\u002Fmental health that, in the opinion of the Investigator, will not allow the subject to be a good study candidate (i.e. other disease processes, mental capacity, substance abuse, shortened life expectancy, vulnerable patient population, BMI \\>40, etc.).","70 Years",{"count":181,"type":20},10,[96],"The purpose of this study is to evaluate the performance and adaptability of a neural-controlled powered knee or ankle prosthesis across diverse real-world mobility tasks. This research aims to assess how compare the sense of embodiment with the device, symmetry, and stability of a person with an lower-extremity amputation walking with a bionic prosthesis and their prescribed prosthesis. Findings from this study will inform future developments in bionic prosthesis design with optimal integration with the human body, with the goal of improving prosthetic integration into daily life.",[26],[26,186,187],"Bionic Prosthesis","Knee Prosthesis","2025-09-24",{"date":190,"type":44},"2025-10-02",{"date":192,"type":44},"2025-05-31",{"date":194,"type":20},"2028-05-31",{"name":196,"class":82},"Massachusetts Institute of Technology",{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":203,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":16,"minAge":91,"maxAge":60,"enrollmentInfo":205,"targetDuration":4,"studyType":63,"phases":206,"briefSummary":207,"conditions":208,"keywords":209,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":216,"locationsCount":52},"100532855","a-biomechanical-evaluation-of-the-ossur-power-knee-in-persons-with-transfemoral-amputation-100532855","NCT06218238","A Biomechanical Evaluation of the Ossur Power Knee in Persons With Transfemoral Amputation","Do Transfemoral Prostheses With Powered Prosthetic Knee Flexion and Extension Improve Mobility? A Biomechanical Evaluation of the Ossur Power Knee","OPKTFA","Inclusion Criteria:\n\n* Unilateral, transfemoral amputation (any etiology).\n* Age from 45-75 years.\n* Residual limb length classified as standard (i.e., medium) to long.\n* Prosthesis user for at least 1 year prior to enrolling in the study.\n* K3 or K4 level ambulator.\n* Good sensation on their residual limb(s) (upon routine clinical examination).\n* Good skin integrity upon visual inspection.\n* Does not require the use of assistive devices to walk for short distances.\n* Not currently taking medications that are known to affect balance or gait.\n* Presents with good socket fit based upon a standard assessment by the study prosthetist.\n\nExclusion Criteria:\n\n* Bilateral amputations\n* Individuals with a knee disarticulation",{"count":94,"type":20},[96],"Microprocessor-controlled knees (MPKs) do not typically utilize motors to power joint rotation, but they automatically adjust resistance or damping in the joint to improve swing- and\u002For stance-phase control as appropriate for the prosthesis user during gait. The Ossur Power Knee is the only commercially-available MPK that uses a motor to provide active power generation during walking and other activities. The purpose of this proposed investigation is to perform and compare biomechanical evaluations of the Power Knee and Ossur Rheo XC, a passive MPK, during walking and other activities by prosthesis users. Furthermore, mobility between male and female subjects will be compared to determine if there are differences in prosthetic knee usage on the basis of sex.",[26,99,100],[102,103,104,105,106,107,108],"2025-09-08",{"date":212,"type":44},"2025-09-09",{"date":214,"type":44},"2024-04-01",{"date":146,"type":20},{"name":117,"class":118},{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":224,"enrollmentInfo":225,"targetDuration":227,"studyType":22,"phases":4,"briefSummary":228,"conditions":229,"keywords":230,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":4},"100595421","assessment-of-strength-balance-and-function-in-above-knee-amputees-in-relation-to-residual-limb-length-100595421","NCT07032233","Assessment of Strength, Balance, and Function in Above-Knee Amputees in Relation to Residual Limb Length","Assessment of Lower Extremity Muscle Strength, Balance, and Functional Capacity in Individuals With Transfemoral Amputation and Investigation of the Relationship With the Length of the Lost Extremity","Inclusion Criteria:\n\nIndividuals will be included in the study if they:\n\nAre between 18 and 50 years of age\n\nAre literate\n\nHave unilateral transfemoral amputation\n\nHave no cardiovascular, orthopedic, cognitive, or neurological conditions that could negatively affect balance, gait, or muscle strength\n\nAre able to ambulate independently with a prosthesis\n\nHave been walking for at least 6 months\n\nVoluntarily agree to participate in the study\n\nExclusion Criteria:\n\nParticipants will be excluded from the study if:\n\nThey develop complications such as pain (rated 3 or higher on the Visual Analog Scale) or stump irritation during the course of the study\n\nTheir residual limb length is less than 25 cm from the greater trochanter, which exceeds the limitations of the isokinetic dynamometer attachments used in the study\n\nThey voluntarily withdraw from the study - in such cases, their data will be removed from the records","50 Years",{"count":226,"type":20},15,"5 Days","The goal of this observational study is to learn how muscle strength, balance, and functional ability are affected in people with above-knee (transfemoral) amputations. The main questions it aims to answer are:\n\nHow does the length of the lost part of the leg, compared to the intact leg, affect muscle strength, balance, and functional capacity?\n\nIs muscle strength at specific lower limb joints related to balance and performance ?\n\nParticipants will:\n\nHave muscle strength measured at all intact lower limb joints using an isokinetic dynamometer\n\nComplete balance assessments using force platform technology that measures weight distribution and evaluates both static and dynamic balance\n\nPerform a six-minute walk test to evaluate endurance and functional capacity\n\nThe study will help improve understanding of how limb length and joint-specific muscle strength impact mobility, supporting the development of better rehabilitation programs for amputees.",[26],[26,231,232,233,234,235,236,237,238,239,240],"Muscle Strength","Isokinetic Dynamometry","Balance Assessment","Functional Capacity","Residual Limb Length","Prosthetics","Postural Control","Gait","Six-Minute Walk Test","Mobility","2025-06-13",{"date":243,"type":44},"2025-06-22",{"date":245,"type":20},"2025-06",{"date":247,"type":20},"2026-09",{"name":249,"class":82},"Ceren Kuzu"]