[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"transplant-associated-microangiopathy-tam\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:transplant-associated-microangiopathy-tam":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100622252","assessing-the-incidence-of-transplant-associated-thrombotic-microangiopathy-ta-tma-in-adult-patients-undergoing-allogeneic-stem-cell-transplant-sct-100622252",false,"NCT07381205","Assessing the Incidence of Transplant Associated Thrombotic Microangiopathy (TA-TMA) in Adult Patients Undergoing Allogeneic Stem Cell Transplant (SCT)","Prospective Evaluation of Transplant Associated Thrombotic Microangiopathy (TA-TMA) Markers in a High-risk Cohort of Adults Undergoing Allogeneic Stem Cell Transplantation (SCT)","Inclusion Criteria:\n\n* Inclusion Criteria\n\n  1. Adult male or female, age ≥18\n  2. Undergoing allogeneic SCT at UAB for any indication and any donor source.\n  3. For patients in cohort 1: Patients deemed high-risk for developing high-risk TA-TMA as stated by any of the following criteria\\*:\n\n     1. BMI \\> 35\\[42\\]\n     2. Mismatched donor (either Haploidentical or Mismatched Unrelated donor)\\[18, 29\\]\n     3. Non-Malignant Transplant Indication (Severe Aplastic Anemia or Sickle Cell Disease)\\[18, 43\\]\n     4. Acute Lymphoblastic Leukemia (any kind)\\[18, 31\\]\n     5. African American, Hispanic, Asian or Native American Ethnicity \\[44\\]\n     6. Myeloablative Conditioning Regimen\\[18\\]\n     7. Pre-Existing Renal Disease\\*\\* (defined as any of the following: 24 Hr Creatinine Clearance \\\u003C60, baseline serum creatinine \\> 1.2, 24 hr proteinuria \\>150mg or random spot urine Protein Creatinine ratio \\> 150mg\u002Fg)\\[20, 45\\]\n     8. TBI-containing conditioning regimen \\>400cGy \\[46\\]\n     9. Prior Autologous or Allogeneic SCT\\[45\\]\n\n        * \\*Some of these criteria have been adapted from pediatric literature due to a higher number of publications in that setting and in cases where the adult data is lacking or contradictory.\n        * \\*\\*Proteinuria thresholds are obtained from KDIGO guidelines and include moderate and severe levels of proteinuria\\[47\\].\n  4. Females of childbearing potential must have a negative urine or serum pregnancy test prior to enrollment.\n  5. For patients in cohort 2: Patients who develop GVHD with any of the following characteristics and were not included in cohort 1\n\n     1. Grade III-IV aGVHD, or SR-aGVHD of any grade, whichever occurs first\n     2. Moderate to Severe cGVHD or SR-cGVHD of any grade, whichever occurs first\n  6. For patients in cohort 3: Patients included in either cohort 1 or 2 who are diagnosed with TA-TMA and receive eculizumab\n\nExclusion Criteria:\n\n* Exclusion Criteria\n\n  1. Any other active malignancy requiring treatment or with expected survival ≤1 year.\n  2. Patients with psychiatric illness or social situations that would limit compliance with the study requirements.","ALL","18 Years",{"count":19,"type":20},85,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about the incidence of Transplant Associated Thrombotich Microangiopathy (TA-TMA), which is a known but underreported complication of Allogeneic Stem Cell Transplant (SCT). The main question it aims to answer is:\n\nWhat is the incidence of TA-TMA in adults undergoing SCT? How does TA-TMA diagnosis impact survival and other outcomes? Patients undergoing SCT will be eligible for this study, which will consist of collection of biological samples and standard clinical follow up.",[24,25],"Transplant Associated Microangiopathy TAM","Transplant Complication",[27,28],"Transplant Associated Thrombotic Microangiopathy","Allogeneic Stem Cell Transplant","NOT_YET_RECRUITING","2026-03-09",{"date":32,"type":33},"2026-03-11","ACTUAL",{"date":35,"type":20},"2026-07-01",{"date":37,"type":20},"2028-10",{"name":39,"class":40},"Manuel Ricardo Espinoza-Gutarra","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":50,"conditions":51,"keywords":56,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":5},"100571038","cell-free-dna-profiling-as-a-tool-to-monitor-clinically-relevant-events-in-allogeneic-hematopoietic-stem-cell-transplantation-100571038","NCT06715046","Cell Free DNA Profiling As a Tool to Monitor Clinically-Relevant Events in Allogeneic Hematopoietic Stem Cell Transplantation","Inclusion Criteria:\n\n* Patient must be affected by an hematological malignancy requiring hematopoietic stem cell transplantation (HSCT).\n\nExclusion Criteria:\n\n* Patients can not be 17 years old or yunger",{"count":49,"type":20},30,"Allogeneic hematopoietic stem cell transplantation (HSCT) is a life-saving treatment for people with severe blood-related diseases. However, it comes with serious risks, including a condition called graft-versus-host disease (GVHD), where the transplanted cells attack the patient's body. GVHD can occur in about 50% of patients acutely and 35% in a chronic form, potentially affecting organs like the skin, liver, and gastrointestinal system. Currently, doctors diagnose GVHD based on symptoms, as there are no easy tests available.\n\nInfections can also be a problem after HSCT, as dormant viruses may reactivate. These infections are monitored using specialized tests. Additionally, doctors use advanced methods, like analyzing minimal residual disease (MRD) and chimerism, to check for the risk of the original disease coming back. MRD is tracked by looking for specific genetic markers of the disease in the patient's blood or bone marrow.\n\nAnother emerging tool involves analyzing cell-free DNA (cfDNA)-tiny fragments of DNA found in bodily fluids that come from dying cells. This technique, called liquid biopsy, has been revolutionary in areas like cancer detection, pregnancy testing, and organ transplants. For example, in organ transplants, cfDNA can indicate early signs of rejection, helping reduce the need for invasive biopsies.\n\nIn HSCT, the use of cfDNA to monitor complications like GVHD or relapse has not been fully explored. This pilot study aims to investigate whether analyzing cfDNA using a technique called epigenomic profiling can help detect acute GVHD, as well as other post-transplant issues like infections, disease relapse, and chronic GVHD. The goal is to compare cfDNA analysis to current testing methods to see if it offers better or earlier detection of complications.\n\nThis research could pave the way for improved, less invasive monitoring of HSCT patients, potentially leading to better outcomes and fewer complications.",[52,53,24,54,55],"GVHD - Graft-Versus-Host Disease","Infections After HSCT","Sinusoidal Obstruction Syndrome (SOS)","HSCT Engraftment",[57,58,59,60,61],"cfDNA","methylation","epigenetic profile","HSCT","liquid biopsy","RECRUITING","2024-11-27",{"date":65,"type":33},"2024-12-04",{"date":67,"type":33},"2024-01-31",{"date":69,"type":20},"2026-12-31",{"name":71,"class":40},"University of Turin, Italy"]