[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"transtibial-amputation---unilateral\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:transtibial-amputation---unilateral":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100613235","phase-1-influence-of-prosthetic-foot-stiffness-on-transtibial-osseointegrated-bone-anchored-limb-outcomes-100613235",false,"NCT07263945","Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes","TBAL","Inclusion Criteria:\n\n* Unilateral transtibial amputation due to traumatic, congenital, or cancer-related causes\n* \\> 12-months bone-anchored limb implantation surgery (Bone Anchored Limb group)\n* \\> 12-months limb amputation (Socket Control group)\n* Non-vascular amputation etiology\n* Low profile prosthetic foot (nominal)\n* Can walk unassisted for 5-minutes\n* \\> 18 years old\n\nExclusion Criteria:\n\n* Major amputation on contralateral limb\n* Vascular amputation etiology\n* Neurologic pathology that impairs coordination\u002Fbalance\n* Regular assistive device use required for community ambulation\n* Inflammatory diseases or diabetes\n* Pregnancy or breastfeeding","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"PHASE1","A clinical trial utilizing cross-over study design in which individuals with transtibial amputation using either a bone-anchored limb or standard socket prosthesis will perform activities of daily living with varying prosthetic foot stiffness categories to complete the following 4 Specific Aims: 1) Determine the influence of prosthetic foot stiffness on dynamic bone-implant loading, 2) Determine how prosthetic foot stiffness influences function, pain, and multi-joint biomechanics outcomes, 3) Establish how prosthetic foot stiffness influences osseoperception and fall risk, and 4) Establish target ranges of optimal foot stiffness based on the sensitivity biomechanical outcomes to variability in foot stiffness.",[26,27,28,29],"Amputation","Transtibial Amputation - Unilateral","Bone Anchored Devices","Osseointegration",[31,32,33,34,35,36],"amputation","bone anchored limb","osseointegration","transtibial amputation","below knee amputation","prosthetics","RECRUITING","2026-04-20",{"date":40,"type":41},"2026-04-21","ACTUAL",{"date":43,"type":41},"2025-11-25",{"date":45,"type":20},"2030-05-31",{"name":47,"class":48},"University of Colorado, Denver","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":63,"conditions":64,"keywords":65,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":81,"leadSponsor":83,"locationsCount":49},"100633069","socket-leg-interface-movements-in-transtibial-amputees-100633069","NCT07521891","Socket-leg Interface Movements in Transtibial Amputees","Socket-leg Interface Movements as a Measure of Dynamic Prosthetic Fit for Transtibial Amputees: An Exploratory Study","SLMinTTA","Inclusion Criteria:\n\n* Age ≥16 years\n* Unilateral transtibial amputation\n* Activity level K2-K4\n* Actively using a prosthesis for ≥12 months\n* Ability to understand and communicate in Norwegian (oral and written)\n* Digital file of current socket model available (required for test socket fabrication)\n\nExclusion Criteria:\n\n* Use of a thigh corset attached to the prosthesis\n* Requirement of a walker for ambulation\n* Open wounds, skin ulcers, or blisters on the residual limb\n* No liner\n* Missing digital socket model file\n* Medical advice to avoid physical activity similar to study tasks\n* Other medical conditions that may worsen with activity and have not been cleared by a healthcare professional","16 Years",{"count":60,"type":20},20,[62],"NA","This exploratory interventional study investigates dynamic prosthetic fit in unilateral transtibial prosthesis users by objectively measuring socket-leg interface movements (SLMs) during functional activities. During one single study visit, participants complete standardized laboratory tasks using three different suspension systems (pin-lock, passive vacuum, and active vacuum) applied to a transparent replica of their current prosthetic socket. Motion capture, force measurements, and patient-reported outcomes are used to evaluate how suspension systems influence interface motion, rotation resistance, gait characteristics, and user comfort. The study aims to improve clinical understanding of prosthetic fit and support more informed prosthetic decision-making in routine care.",[27],[66,67,68,69,70,71,72,73,74,75],"Transtibial amputation","Lower-limb prosthesis","Prosthetic socket fit","3D motion capture","Prosthesis comfort","Prosthetic rotation resistance","Pistoning","Prosthetic suspension systems","Prosthetic alignment","gait","NOT_YET_RECRUITING","2026-04-07",{"date":79,"type":41},"2026-04-13",{"date":38,"type":20},{"date":82,"type":20},"2029-12-27",{"name":84,"class":48},"Norwegian University of Science and Technology"]