[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"trauma-and-stress-related-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:trauma-and-stress-related-disorders":93},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,50,79,116,145],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100641098","early-intervention-to-prevent-development-of-ptsd-in-burn-survivors-and-their-caregivers-100641098",false,"NCT07656545","Early Intervention to Prevent Development of PTSD in Burn Survivors and Their Caregivers","Inclusion Criteria:\n\n* Alert, oriented, \\& not withdrawing from substance at time of screening\n* Can read and write in English\n* Hospitalized within 10 days of burn injury\n* Anticipated discharge \\\u003C=4 weeks\n* Have an email, mailing address, and at least 1 smart device for telehealth sessions\n* PTSD risk score of 2 or greater (patient-only)\n* Willing to attend therapy sessions with a loved one\n\nExclusion Criteria:\n\n* Currently incarcerated or in police custody\n* \\> 10 days post-burn\n* Lifetime diagnosis of primary psychosis or intellectual disability\n* Ongoing reported domestic violence in the dyad\n* Unstable bipolar disorder, severe substance use disorder, or acute suicidality with imminent intent that does not remit within 10 days of burn-injury\n* Inflammation Confounds (patient-only) of BMI \\> 40, metabolic syndrome, admission A1C of \\>= 6.5%\n* Currently receiving couples therapy",true,"ALL","18 Years",{"count":19,"type":20},44,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this clinical trial is to adapt and test a brief patient-caregiver early intervention designed to reduce posttraumatic stress symptoms in hospitalized burn patients and their caregivers. This intervention is a brief, 4-session cognitive-behavioral intervention designed for burn patients and their loved one to complete together, during and after hospitalization. The intervention targets relational communication and functioning through reduction of invalidating, negative statements and avoidant coping by teaching patients and their loved ones to engage in adaptive natural disclosures, supportive responses, and approach coping after the burn trauma. The intervention uses evidence-based psychotherapy techniques, including psychoeducation, motivational interviewing, and skills coaching. The clinical trial will occur in two sequential phases. In the first phase of the study (case series), the intervention will be provided to two burn patient-caregiver dyads (four adults) to pilot test the intervention, seek patient and provider feedback, and refine the intervention. All four adults will receive the intervention. In the second phase of the study, the randomized controlled trial (RCT) phase, investigators will enroll 20 more burn patient-caregiver dyads (40 more adults) who will be randomly assigned (like the flip of a coin) at the dyad level to receive the intervention or a burn survivor-only minimally enhanced usual care psychoeducation control condition (mEUC). The goals of the RCT phase are to study whether the intervention is acceptable to patients, feasible to conduct, and whether the intervention improves burn survivor-caregiver healthy relationship communication about difficult events and treatment outcomes compared to mEUC.",[26,27,28,29,30,31,32,33,34,35,36],"Posttraumatic Stress Disorder","Burns","Traumatic Injury","Acute Stress Disorder","Trauma and Stressor Related Disorders","Trauma and Stress Related Disorders","Stress Disorder","Stress Disorders, Post-Traumatic","Stress Disorders, Traumatic","Stress Disorders, Traumatic, Acute","Relationship, Social","NOT_YET_RECRUITING","2026-06-14",{"date":40,"type":41},"2026-06-18","ACTUAL",{"date":43,"type":20},"2026-08-01",{"date":45,"type":20},"2029-02-28",{"name":47,"class":48},"University of Southern California","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100639797","psychosocial-effects-of-a-trauma-informed-artificial-intelligence-supported-chatbot-in-adults-newly-diagnosed-with-cancer-100639797","NCT07583069","Psychosocial Effects of a Trauma-Informed Artificial Intelligence-Supported Chatbot in Adults Newly Diagnosed With Cancer","Evaluation of the Psychosocial Effects of a Trauma-Informed Care-Based Artificial Intelligence-Supported Chatbot in Newly Diagnosed Cancer Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Over 18 years of age,\n* Able to speak and understand Turkish,\n* Without any cognitive, visual, or auditory impairments,\n* Diagnosed with cancer within the last month (Stage I, II, and III) (regardless of cancer type),\n* Have started active cancer treatment,\n* Have access to a digital device and the internet,\n* Volunteer to participate in the study will be included.\n\nExclusion Criteria:\n\n* Patients participating in another simultaneous psychosocial\u002Fdigital intervention study,\n* Patients diagnosed with advanced stage (Stage IV) cancer, in the terminal phase and with metastases,\n* Patients diagnosed with schizophrenia, bipolar disorder, substance abuse, depression and anxiety disorders will be excluded.",{"count":58,"type":20},62,[23],"The goal of this clinical trial is to evaluate whether a trauma-informed, artificial intelligence-supported chatbot can reduce psychological distress and unmet psychosocial needs in adults newly diagnosed with cancer.:\n\n* Does the chatbot reduce trauma-related distress and anxiety levels compared to standard care?\n* Does the chatbot decrease unmet psychosocial needs in patients following a new cancer diagnosis? Researchers will compare the chatbot intervention to standard care to determine whether the chatbot provides additional psychosocial benefit.\n\nParticipants will:\n\n* Be randomly assigned to either the chatbot intervention group or the standard care group\n* Use the chatbot freely for 12 weeks (intervention group only)\n* Complete questionnaires at baseline, 1 month, and 3 months\n* Be monitored for any psychological risk indicators during the study period",[62,63,31,64],"Cancer","Psychosocial Distress","Anxiety",[66,67,68,69],"cancer diagnosis","unmet psychosocial needs","trauma-informed care","AI-powered chatbot","2026-05-07",{"date":72,"type":41},"2026-05-13",{"date":74,"type":20},"2026-07-01",{"date":76,"type":20},"2027-01-01",{"name":78,"class":48},"Koç University",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":21,"phases":90,"briefSummary":91,"conditions":92,"keywords":99,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":111,"leadSponsor":113,"locationsCount":115},"100625814","misapsy-childhood-maltreatment-food-insecurity-psychological-distress-and-professional-integration-among-socioeconomically-disadvantaged-young-adults-100625814","NCT07427524","MISAPSY: Childhood Maltreatment, Food Insecurity, Psychological Distress and Professional Integration Among Socioeconomically Disadvantaged Young Adults","Psychosocial Intervention With Precarious Young People: a Comparative Longitudinal Study on Psychological Distress and Food Insecurity","PRESPA","Inclusion Criteria:\n\n* Be aged 18 to 25 years\n* Be supported by a Mission Locale in Paris as part of a social and\u002For professional integration program\n* Voluntarily participate in the study after receiving clear information and signing an informed consent form\n* Experiencing severe food insecurity (positive response to item 8 of the FIES)\n* Experiencing significant psychological distress, defined by: PHQ-9 score \\> 15; GAD-7 score \\> 10\n* Have been exposed to at least one adverse childhood experience, identified via the CTQ-SF (Childhood Trauma Questionnaire - Short Form).\n\nExclusion Criteria:\n\n* Being unable to provide informed consent due to impaired comprehension or communication skills\n* Currently receiving psychiatric care for an acute or chronic mental illness requiring regular specialized treatment\n* Experiencing a social or medical emergency incompatible with the study (e.g., unstable emergency housing, acute suicidal crisis, ongoing hospitalization)\n* Being incarcerated, under guardianship or curatorship without specific legal authorization to participate in research\n* Having previously participated in a similar study or currently being engaged in a structured psychological intervention protocol\n* Having insufficient command of the French language, preventing comprehension of instructions, questionnaires, or interviews.","25 Years",{"count":89,"type":20},70,[23],"The MISAPSY study (Childhood Maltreatment, Food Insecurity, Psychological Distress and Professional Integration Among Socioeconomically Disadvantaged Young Adults) aims to model the complex interrelations between child maltreatment, trauma exposure, food insecurity, and psychological distress among precarious young adults enrolled in French youth employment and social integration services (Mission Locale).\n\nAdopting a methodology structured around three complementary components, this study consists of: (1) a cross-sectional survey to identify key associations ; (2) a qualitative study based on semi-structured interviews exploring psychologists' subjective experiences, and (3) a longitudinal comparative interventional study involving two different support programs to assess and compare the impact of these interventions on participants' food insecurity and psychological well-being.\n\nUsing a multi-phase design, MISAPSY seeks to move beyond linear risk-factor models by adopting a systemic and network-based approach to mental health and social vulnerability. The study integrates quantitative analyses, including network analyses, qualitative exploration of professional practices, and comparative longitudinal intervention to inform more holistic, equitable, and transferable models of care for vulnerable young adults.",[93,94,95,96,97,98],"Trauma and Stress-related Disorders","Food Insecurity","Child Maltreatment","Psychological Distress","Depression Symptoms","Anxiety Symptoms",[94,100,101,102,103,104,105,106],"Mental health","young adults","trauma","adverse childhood experience","psychological distress","precarity","mixed-methods","2026-04-28",{"date":109,"type":41},"2026-05-05",{"date":74,"type":20},{"date":112,"type":20},"2027-06",{"name":114,"class":48},"University of Lorraine",6,{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":87,"enrollmentInfo":124,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":127,"conditions":128,"keywords":131,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":144},"100587002","protocol-study-on-addiction-trauma-and-immigration-among-vulnerable-young-adults-in-grand-est-100587002","NCT06922721","Protocol Study on Addiction, Trauma and Immigration Among Vulnerable Young Adults in Grand Est","ATICC: A Mixed-Methods Study on Addiction, Trauma, and Immigration Among Vulnerable Young Adults in the Grand Est Youth Network","ATICC","Inclusion Criteria:\n\n* Resident in a Housing center, speak and read french, adult participants who are not under guardianship or curatorship, any cultural background.\n\nExclusion Criteria:\n\n* minors, don't speak and read french, adults under guardianship and curatorship.",{"count":125,"type":20},182,"OBSERVATIONAL","The ATICC study (Addiction, Trauma, and Immigration, Prevention and Cross-Cultural Support for Care) investigates the complex relationships between trauma, substance use, migration experiences, and mental health perceptions among vulnerable young adults in Transitional Housing (Foyers de Jeunes Travailleurs) in France. Using a tripartite methodology, the study includes: (1) a cross-sectional survey to identify risk factors, (2) qualitative interviews to explore individual experiences, and (3) a longitudinal intervention using focus groups to assess psychological well-being and attitudes toward care. The findings will contribute to developing culturally adapted prevention and support programs.",[93,129,130],"Substance Use Disorder (SUD)","Substance Use Risk",[132,102,133,100,101,134],"addiction","Immigration","Substance use","RECRUITING","2025-04-03",{"date":138,"type":41},"2025-04-10",{"date":140,"type":41},"2025-01-06",{"date":142,"type":20},"2025-12",{"name":114,"class":48},7,{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":15,"sex":16,"minAge":151,"maxAge":152,"enrollmentInfo":153,"targetDuration":4,"studyType":21,"phases":155,"briefSummary":156,"conditions":157,"keywords":4,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":49},"100479786","risk-and-resiliency-factors-in-the-rcmp-a-prospective-investigation-100479786","NCT05527509","Risk and Resiliency Factors in the RCMP: A Prospective Investigation","Inclusion Criteria:\n\n* Cadets starting the RCMP Cadet Training Program\n\nExclusion Criteria:\n\n* Anyone other than cadets starting the RCMP Cadet Training Program","19 Years","57 Years",{"count":154,"type":20},960,[23],"The Royal Canadian Mounted Police (RCMP), like all public safety personnel (PSP), are frequently exposed to potentially psychologically traumatic events that contribute to posttraumatic stress injuries (PTSI). Addressing PTSI is impeded by the limited available research. The RCMP are working to build evidence-based solutions to PTSI and other mental health challenges facing their members, which by extension will help all PSP, as part of the Canadian Government Federal Framework on Posttraumatic Stress Disorder. A key element is the \"Longitudinal Study of Operational Stress Injuries \u002F Étude longitudinale sur les traumatismes liés au stress opérationnel\", a study which has been renamed \"Risk and Resiliency Factors in the RCMP: A Prospective Investigation\", and is referred to as the \"RCMP Study\" for short. The RCMP Study has been detailed online (www.rcmpstudy.ca) and in a recently published peer-reviewed protocol paper, \"The Royal Canadian Mounted Police (RCMP) Study: protocol for a prospective investigation of mental health risk and resilience factors\" (https:\u002F\u002Fdoi.org\u002F10.24095\u002Fhpcdp.42.8.02). The RCMP Study, part of the concerted efforts by the RCMP to reduce PTSI by improving access to evidence-based assessments, treatments, and training as well as participant recruitment and RCMP Study developments to date. The RCMP Study has been designed to (1) develop, deploy and assess the impact of a system for ongoing annual, monthly and daily evidence-based assessments; (2) evaluate associations between demographic variables and PTSI; (3) longitudinally assess individual differences associated with PTSI; (4) augment the RCMP Cadet Training Program with skills to proactively mitigate PTSI; and (5) assess the impact of the augmented training condition (ATC) versus the standard training condition (STC). Participants in the STC (n = 480) and ATC (n = 480) are assessed before and after training and annually for 5 years on their deployment date; they also complete brief monthly and daily surveys. The RCMP Study results are expected to benefit the mental health of all participants, RCMP and PSP by reducing PTSI among all who serve.",[26,158,159,160,161,162,31,163],"Major Depressive Disorder","Panic Disorder","Generalized Anxiety Disorder","Trauma","Traumatic Stress Disorder","Vicarious Trauma","2023-11-27",{"date":166,"type":41},"2023-11-28",{"date":168,"type":41},"2019-04-22",{"date":170,"type":20},"2029-12",{"name":172,"class":48},"University of Regina"]