[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"trauma-blunt\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:trauma-blunt":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100640690","the-healing-and-empowerment-actions-for-recovery-from-trauma-heart-trial-100640690",false,"NCT07584252","The Healing and Empowerment Actions for Recovery From Trauma (HEART) Trial","HEART","Patients:\n\nInclusion Criteria:\n\n1. Age \\>= 18 years\n2. Anticipated hospital length of stay \\> 72 hours\n3. Moderate to severe orthopaedic trauma treated surgically for 1 or more injuries\n4. GCS \\>= 13 at the time of enrollment\n5. Willing and able to meet with Evellere coach while hospitalized or via the telephone within 72 hours of discharge (intervention cohort only)\n\nExclusion Criteria:\n\n1. Non-english speaking (must be sufficiently fluent in English to consent and complete surveys without interpretive services)\n2. Prior to index hospitalization, patient must not be receiving home services or be independent in daily tasks\n3. Any penetrating brain injury\n4. Patients with significant burn injury\n5. Prior cognitive impairment\n6. Hospital death or imminent death\n7. Hospice care at time of trauma or selection for hospice during initial hospital admission or do not resuscitate or comfort care only before index visit\n8. Prisoner\u002F inmate or police\u002F security intervention during hospitalization\n9. No reliable internet access at baseline\n10. Psychosis\n11. Trauma presentation is a result of suicide attempt\u002F self-harm\n\nCare Partners\n\nInclusion criteria:\n\n1. Identified by the enrolled patient as a primary source of support during their recovery. A care partner can be in person or supporting remotely.\n2. Age \\>= 18 years\n3. Willing and able to meet with an Evellere coach during patient hospitalization or via telephone within 72 hours of discharge (intervention cohort only)\n\nExclusion criteria:\n\n1. Non-english speaking (must be sufficiently fluent in English to consent and complete surveys without interpretive services)\n2. Paid professionals or home healthcare providers whose support is provided as part of employment (e.g., nurses, aides, case managers)\n3. Already enrolled as a care partner for another participant in the HEART Trial\n4. Hospitalized at time of patient enrollment\n5. No reliable internet access at baseline\n\nHealthcare Workers\n\nInclusion criteria:\n\n1. Age \\> 18 years\n2. Currently employed (full-time, part-time) at a participating trauma center in a role type associated with trauma care (e.g., engaged in clinical care navigation, behavioral health, rehabilitation, recovery coordination, etc.)\n3. Provides or supports care for orthopedic trauma patients for ≥20% of their clinical time\n4. Expected to remain employed at the trauma center for \\>12 months after enrollment\n\nExclusion criteria:\n\n1. Are contracted staff or traveling temporary staff\n2. Are students or trainees\n3. No reliable internet access at baseline","ALL","18 Years",{"count":19,"type":20},804,"ESTIMATED","INTERVENTIONAL",[23],"NA","The HEART Trial aimed to determine if wrap-around psychosocial support for patients who sustain moderate to severe trauma requiring orthopedic surgery intervention improves outcomes for patients (Aim 1), care-partners (Aim 2), and healthcare workers (Aim 3) as well as explore implementation strategies to improve health systems' capabilities and capacity to integrate psychosocial support services. The comparators represent real healthcare options for patients, caregivers, and healthcare workers. The HEART Trial is a multicenter pragmatic, stepped-wedge cluster randomized, hybrid type I comparative effectiveness-implementation superiority trial. The study intervention (C-TRP) is a trauma-focused psychosocial intervention, with each site serving as its own control (TRP).",[26,27],"Trauma Blunt","Orthopedic",[29,30,31],"Healing and Empowerment Actions for Recovery from Trauma Trial (HEART)","Comprehensive trauma recovery programming (C-TRP)","Trauma recovery programming (TRP)","NOT_YET_RECRUITING","2026-05-07",{"date":35,"type":36},"2026-05-13","ACTUAL",{"date":38,"type":20},"2026-07-01",{"date":40,"type":20},"2032-03-01",{"name":42,"class":43},"Stephanie Di Stasi","OTHER",7,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100617116","5-minute-hot-trauma-ct-rates-of-detection-study-100617116","NCT07314437","5 Minute 'HOT' Trauma CT Rates Of Detection Study","Randomised Trial (With Integrated Pilot) Evaluating Whether a Standardised Approach, Educational Package (Including Checklist) Improve Recognition of Major Life-threatening Injuries in the Hot Reporting of Trauma Scans","Inclusion Criteria:\n\n* Medical professionals involved in trauma image review.\n* This includes clinicians who are emergency department doctors, radiologists and other specialties.\n* Non-radiologist clinicians will be participating completing the hot reports, radiologists will be evaluating their submissions and assessing their accuracy.\n\nExclusion Criteria:\n\n* Unable to review CT imaging due to lack of previous experience or disability that prevents them from doing so.\n* Under 18 years old.\n* Not a medical professional or clinician.",true,{"count":54,"type":20},300,[23],"Many injured patients receive urgent CT imaging to identify major injury. CT imaging of trauma patients is often time critical and the accurate detection of life-threatening findings on this CT is essential. Often following a scan a radiologist is not immediately available to review the imaging, however other members of the trauma team have access to the imaging and may be in a position to provide a \"hot\" report. In this study we aim to demonstrate if an educational intervention with a checklist improves accuracy of the hot report.",[58,59,26,60],"Trauma (Including Fractures)","Trauma Abdomen","Trauma Centers",[62,63,64,65,66],"Trauma","CT","Hot Report","Radiology","HOT-RODs","2026-01-08",{"date":69,"type":36},"2026-01-12",{"date":71,"type":20},"2026-01-30",{"date":73,"type":20},"2027-02-28",{"name":75,"class":43},"University Hospital Plymouth NHS Trust",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":96,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":4},"100607133","nucleosome-monitoring-relevance-for-outcome-prediction-in-critically-ill-patients-100607133","NCT07184593","Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients","Validation of a Point-of-care Device for Rapid Bedside Measurement of Circulating Nucleosome Levels in Critically Ill Patients and Study of Its Relevance to Prognostication","NuROPI","Inclusion Criteria:\n\n* Admission to the intensive care unit (ICU) within the past 24 hours.\n* Patient must meet one of the following conditions:\n\nSepsis, defined according to SEPSIS-3 criteria.\n\nSeptic shock, defined according to SEPSIS-3 criteria.\n\nCardiogenic shock, classified as Stage C according to the Society for Cardiovascular Angiography and Interventions (SCAI).\n\nSevere trauma requiring transfusion of four or more units of red blood cells within six hours.\n\nAcute brain injury requiring invasive neuromonitoring.\n\nPost-cardiac arrest with at least 15 minutes of no or low perfusion.\n\nSevere acute pancreatitis requiring ICU-level care.\n\n\\- Presence of an arterial or central venous catheter to allow blood sampling.\n\nExclusion Criteria\n\n* Patient who has expressed opposition to participate.\n* Age younger than 18 years.\n* Imminent death with an expected survival of less than 24 hours.\n* Presence of therapeutic limitations (e.g., no indication for intubation).\n* Active cancer.\n* Absence of the required vascular access.\n* ICU admission longer than 24 hours prior to screening.\n* Readmission of a previously enrolled patient.",{"count":86,"type":20},130,"OBSERVATIONAL","The goal of this observational study is to evaluate whether whole blood H3.1 nucleosome levels can predict 30-day mortality in adult critically ill patients admitted to the ICU with conditions such as sepsis, septic shock, cardiogenic shock, severe trauma, post-cardiac arrest, acute brain injury, or severe acute pancreatitis.\n\nThe main questions it aims to answer are:\n\nDo initial whole blood H3.1 nucleosome levels predict 30-day mortality in critically ill patients?\n\nAre whole blood nucleosome measurements using a novel point-of-care device correlated with traditional plasma chemiluminescence immunoassays (ChLIA)?\n\nIf there is a comparison group: Researchers will compare point-of-care whole blood nucleosome results with plasma ChLIA assays to see if the device provides reliable and feasible bedside measurements.\n\nParticipants will:\n\nProvide blood samples at admission, 6h, Day 1, Day 3, and Day 7 for nucleosome analysis.\n\nUndergo point-of-care H3.1 nucleosome measurement and parallel plasma storage for ChLIA testing.\n\n(If applicable, in acute brain injury patients with external ventricular drains) provide daily cerebrospinal fluid samples until Day 5, only if otherwise discarded.\n\nHave standard ICU data (SOFA, SAPS II, etc.) collected as part of routine care.",[90,91,92,93,94,26,95],"Sepsis","Septic Shock","Cardiac Arrest (CA)","Pancreatitis","Acute Brain Injury","Cardiogenic Shock",[97,98,99,100,101,62,102],"nucleosome","septic shock","Histones","Cardiac Arrest","Cardiogenic shock","Acute brain injury","2025-09-17",{"date":105,"type":36},"2025-09-22",{"date":107,"type":20},"2025-10-01",{"date":109,"type":20},"2027-09-30",{"name":111,"class":43},"Erasme University Hospital"]