[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"trauma-exposure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:trauma-exposure":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,76,110,153],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100634290","early-phase-1-predictors--mechanisms-of-adolescent-ptsd-100634290",false,"NCT07537764","Predictors & Mechanisms of Adolescent PTSD","Identifying Biobehavioral Predictors and Targeting Mechanisms of Intervention in Adolescent Posttraumatic Stress Disorder","Adolescent Inclusion Criteria:\n\n1. Adolescent of any sex, race, or ethnicity; between the ages of 14 and 18 years old.\n2. Accompaniment by a caregiver willing to participate. Note: Adolescents aged 18 years old are able to provide their own consent though still require caregiver participation to be eligible for study participation.\n3. Ability to comprehend English. Rationale: Public census data indicates that the overwhelming majority of youth in the local community are English-speaking (\\>98%), inclusive of multi-lingual households.\n4. Endorsement of exposure to one or more potentially traumatic event(s), as defined by DSM-5 Criterion A event, that the adolescent remembers and is able to verbalize.\n5. A total score ≥15 on the Child and Adolescent Trauma Screen (CATS) or report at least one clinically significant symptom on Intrusion\u002FRe-experiencing, Avoidance, and Hyperarousal symptom domains, as defined by DSM-5 PTSD criteria, and one area of impairment.\n\nAdolescent Exclusion Criteria:\n\n1. Previous diagnosis indicating intellectual disability or pervasive developmental disorder that would preclude participant from understanding study procedures.\n2. Active psychosis, bipolar disorder, or a comorbid condition that requires a higher level of immediate care (e.g., anorexia nervosa, alcohol withdrawal).\n3. Active suicide risk with ideation, plan and intent and\u002For recent (past 6 months) hospitalization for suicidality. These individuals will be referred directly for immediate services and treatment. All participants who endorse suicidal ideation will be engaged in safety planning as part of the study protocol.\n4. Individuals on psychotropic medications must be stabilized on the medication for at least four weeks prior to study start date.\n5. Individuals currently engaged in trauma-focused, exposure-based treatment.\n\nCaregiver Inclusion Criteria:\n\n1. Caregiver, parent, or legal guardian of an adolescent between the ages of 14 and 18 years old.\n2. Ability to comprehend English.\n\nCaregiver Exclusion Criteria:\n\n1\\. Previous diagnosis indicating intellectual disability or pervasive developmental disorder that would preclude participant from understanding study procedures.","ALL","14 Years","18 Years",{"count":20,"type":21},180,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","This study examines how adolescents with trauma-related symptoms respond to stress and strong emotions. The study assesses brain activity, physiological responses, and behavior during experimental tasks that involve responding to potential threats, regulating emotions, and repeatedly imagining details of a personally experienced stressful or traumatic event using a script-driven imagery task.\n\nThe study evaluates whether repeated imaginal exposure is associated with changes in anxiety and physiological responses across sessions, and whether baseline patterns of threat reactivity and emotion regulation are associated with individual differences in response to the exposure task. Outcomes include self-reported anxiety, subjective distress ratings, and psychophysiological indices such as heart rate, skin conductance, and electromyographic activity.\n\nThe goal of this research is to improve understanding of biobehavioral processes related to trauma exposure in adolescents and to identify potential predictors of response to exposure-based intervention components relevant to posttraumatic stress disorder (PTSD).",[27,28],"Posttraumatic Stress Disorder (PTSD)","Trauma Exposure",[30,28],"Adolescent PTSD","NOT_YET_RECRUITING","2026-05-07",{"date":34,"type":35},"2026-05-08","ACTUAL",{"date":37,"type":21},"2026-09",{"date":39,"type":21},"2031-03",{"name":41,"class":42},"Medical University of South Carolina","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":43},"100611062","game-intervention-for-resilience-100611062","NCT07235696","Game Intervention for Resilience","A Randomized Controlled Trial to Examine the Impact of a Game-based Intervention in Promoting Positive Affectivity and Enhancing Psychological Resilience","Inclusion Criteria:\n\n* fluency in oral and written Cantonese or Mandarin;\n* having experienced at least one major life stress in the recent 5 years (assessed by the Life Stress Index);\n* normal or corrected-to-normal vision and hearing.\n\nExclusion Criteria:\n\n* formal diagnosis of any major psychiatric illnesses or history of suicidal behaviour;\n* major physical illness, neurological condition or traumatic brain injury;\n* Intake of medication within the previous 6 months that may affect emotion or cognitive functions;\n* pregnancy (for women);\n* prior experience with any commercial computer repair simulation game.","23 Years","35 Years",{"count":54,"type":21},60,[56],"NA","The goal of this clinical trial is to learn if a game-based intervention can enhance psychological resilience and promote positive affectivity in adults who have experienced major life stress.\n\nThe main questions it aims to answer are:\n\n* Does the game-based intervention improve positive affectivity and mental health compared to a waitlist control group immediately after the intervention and at 3-month follow-up?\n* Are the mental health benefits of the game-based intervention mediated by improvements in positive affectivity over time?\n\nResearchers will compare the game-based intervention to an active control group and a waitlist control group to see if the game leads to better emotional and mental health outcomes.\n\nParticipants will:\n\n* Be randomly assigned to the game-based intervention group, the psychoeducation intervention group (as active control group), or the waitlist control group\n* Engage with the assigned program for 10 days within two weeks\n* Complete psychological assessments before and after the intervention, and again at 3-month follow-up",[59,28,60,61],"Chronic Stress","Resilience, Psychological","Major Life Stress",[63,64,61,65],"Game-Based Intervention","Psychological Resilience","Positive Affectivity","RECRUITING","2026-04-27",{"date":69,"type":35},"2026-05-01",{"date":71,"type":21},"2026-07-15",{"date":73,"type":21},"2026-12-20",{"name":75,"class":42},"The University of Hong Kong",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":16,"minAge":85,"maxAge":18,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":89,"conditions":90,"keywords":95,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":4},"100635847","many-trauma-affected-youth-face-long-waits-for-therapy-worsening-stress-and-avoidance-ciss-a-90-minute-session-based-on-stanfords-cue-centered-therapy-offers-coping-tools-and-psychoeducation-during-this-gap-this-pilot-tests-cisss-feasibility-acceptability-and-impact-on-30-40-adolescents-100635847","NCT07558005","Many Trauma-affected Youth Face Long Waits for Therapy, Worsening Stress, and Avoidance. CISS, a 90-minute Session Based on Stanford's Cue-Centered Therapy, Offers Coping Tools and Psychoeducation During This Gap. This Pilot Tests CISS's Feasibility, Acceptability, and Impact on 30-40 Adolescents.","CISS: CCT-Informed Single Session Intervention","CISS","Inclusion Criteria:\n\n* Age: 13 to 18 years old (adolescents).\n\nTrauma Exposure: History of chronic or single-event trauma (e.g., interpersonal violence, serious accidents, natural disaster) as documented in Child and Adolescent Mental Health Services (CAMHS) intake records.\n\nService Status: Currently on a CAMHS waitlist for trauma-focused therapy, or self-referred but hesitant to begin multi-session treatment.\n\nCapacity and Consent: Ability to provide informed assent (ages 13-15 with parental permission) or informed consent (ages 16-18).\n\nExclusion Criteria:\n\nCurrent Trauma Treatment: Actively engaged in any form of trauma-focused psychotherapy (e.g., TF-CBT, EMDR, CCT) at the time of enrollment.\n\nSevere Cognitive Impairment: Intellectual disability or cognitive impairment (e.g., IQ \\\u003C 70) that precludes comprehension of psychoeducational material or completion of self-report questionnaires.\n\nAcute Suicidality: Endorsement of imminent self-harm or suicide risk (e.g., PHQ-9 item 9 ≥ 2) during screening that necessitates immediate crisis management rather than study participation.",true,"13 Years",{"count":87,"type":21},40,[56],"Many young people who have experienced traumatic events such as sexual assault, domestic violence, serious accidents, or natural disasters face long waits before they can begin full trauma-focused therapy. During this waiting period, symptoms such as avoidance, anxiety, and distress may worsen, and many youth lose motivation or confidence to start treatment. The Cue-Centered Therapy (CCT)-Informed Single Session Intervention (CISS) was designed to bridge this gap by offering a one-time, 90-minute session that teaches coping and self-understanding skills while youth are still on the waiting list.\n\nThis study is a pilot feasibility trial conducted in partnership between Stanford University and the University of Auckland. The purpose of the study is to evaluate whether CISS is a practical, acceptable, and safe intervention for young people aged 13-18 who have been exposed to trauma and are currently waiting for or hesitant to begin full-length therapy within New Zealand Hapai Ora Clinics.\n\nYouth participants will meet once with a trained Hapai Ora clinician who will deliver the 90-minute CISS session. The session combines psychoeducation about trauma cues with skill-building strategies to improve coping, confidence, and readiness to engage in future treatment. Participants will complete short questionnaires before and after the session, and again at 3- and 6-month follow-ups. Measures will assess coping self-efficacy, treatment readiness, posttraumatic stress symptoms, and whether participants eventually begin full-length therapy.\n\nThe study will recruit approximately 30-40 adolescents across Hapai Ora clinical sites in Auckland, New Zealand. All clinicians providing the intervention are qualified mental-health professionals trained in both CISS and child-safety protocols. Participation involves minimal risk-similar to discussing difficult topics in a supportive therapy session.\n\nFindings from this pilot study will help researchers understand whether CISS can be feasibly and safely delivered within public mental-health services, and whether it shows promise in helping young people build coping skills, reduce avoidance, and increase readiness to start therapy. The results will guide future larger-scale trials and inform the development of single-session, early-intervention approaches for trauma-exposed youth worldwide.",[91,92,93,94,28],"Wellbeing","Mental Health","Psychological","Stress",[96,82,97,98,99,100],"Trauma Intervention","Cue Centered Therapy (CCT)","Single-Session Intervention","Chronic Trauma","Trauma","2026-04-22",{"date":103,"type":35},"2026-04-30",{"date":105,"type":21},"2026-06-01",{"date":107,"type":21},"2028-11-30",{"name":109,"class":42},"Stanford University",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":117,"maxAge":18,"enrollmentInfo":118,"targetDuration":4,"studyType":22,"phases":120,"briefSummary":121,"conditions":122,"keywords":132,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":43},"100630104","comparative-effectiveness-of-sparcs-and-unified-protocol-for-youth-with-chronic-medical-conditions-and-trauma-related-distress-100630104","NCT07483333","Comparative Effectiveness of SPARCS and Unified Protocol for Youth With Chronic Medical Conditions and Trauma-Related Distress","Supporting Purposeful Interventions & Resilience In Trauma (SPIRIT) Program: Implementing Trauma-Specific Screening and Stratified Interventions for Youth With a Chronic Medical Condition","Inclusion Criteria:\n\n* Youth (aged 8-18 years) who received a SPIRIT program psychological trauma screening and were deemed clinically appropriate for SPIRIT group therapy. Clinically appropriate means the youth can historically engage in a group setting (e.g., school, camp, therapy group) without significant disruption to the group process or other participants.\n* Youth and parent\u002Flegal guardian are willing and able to provide informed consent\u002Fassent for randomization.\n* Youth and parent\u002Flegal guardian are fluent in English or Spanish.\n* Youth is not currently engaged in individual therapy at the time of enrollment (per patient\u002Fparent report).\n\nExclusion Criteria:\n\n* Wards of the state or DCFS youth in care.\n* Youth with reported or observed symptoms that would significantly impair group therapy engagement, including but not limited to: intellectual disability, moderate-to-severe autism spectrum disorder, active suicidal ideation, uncontrolled psychosis, or other acute psychiatric symptoms that could disrupt the group process.\n* Regular use of alcohol or other substances that interfere with participation or disrupt the group process.\n* Youth requiring immediate higher-level psychiatric care (e.g., intensive outpatient programming, partial hospitalization, inpatient psychiatric admission, or residential treatment) at the time of first randomization.","8 Years",{"count":119,"type":21},400,[56],"The goal of this clinical trial is to compare the effectiveness of trauma-focused therapies for improving mental health symptoms and daily functioning in youth with chronic medical conditions who have experienced psychological trauma and trauma-related distress. The study evaluates two evidence-based cognitive-behavioral therapies - Structured Psychotherapy for Adolescents Responding to Chronic Stress (SPARCS) and the Unified Protocol (UP) - delivered in group and individual formats to determine which approach, or combination of approaches, best reduces trauma symptoms and supports coping and adjustment. The study will also help researchers understand how to best support youth who continue to experience distress after an initial round of therapy.\n\nThe main questions it aims to answer are:\n\n* Does SPARCS group therapy or UP group therapy lead to greater improvements in trauma symptoms and functional impairment?\n* For youth who do not show enough improvement after group therapy, does adding SPARCS or UP individual therapy lead to better outcomes?\n* Which sequence of group and individual therapies leads to the greatest improvements in trauma symptoms and functioning?\n\nResearchers will compare two evidence-based therapies currently offered at Ann \\& Robert H. Lurie Children's Hospital of Chicago. Youth will first be randomly assigned to receive either SPARCS or UP in a group format. After completing group therapy, youth who still need additional support will be randomly assigned again to receive individual or family therapy using SPARCS or UP. This stepwise approach will help identify which sequence of therapies leads to the best overall outcomes for youth.\n\nParticipants will:\n\n* Take part in group therapy sessions using either SPARCS or UP\n* For those needing additional support after group therapy, participate in individual SPARCS or UP therapy\n* Complete brief assessments of mental health and daily functioning at enrollment, and every 12 weeks thereafter for 48 weeks, as part of their regular care through Ann \\& Robert H. Lurie Children's Supporting Purposeful Interventions \\& Resilience in Trauma (SPIRIT) program",[28,100,123,124,125,126,127,128,129,130,131],"Trauma and Stressor Related Disorder","Mental Health Functioning","Chronic Medical Conditions","Chronic Medical Condition","Chronic Medical Illness","Posttraumatic Stress Disorder PTSD","Posttraumatic Stress Disorders","Posttraumatic Stress Symptoms","Posttraumatic Stress",[133,134,135,136,137,138,139,140,141,142,143],"pediatric trauma","posttraumatic stress disorder","chronic medical conditions","pediatrics","trauma symptoms","trauma and stressor related disorder","trauma informed care","Sequential, Multiple Assignment Randomized Trial","Supporting Purposeful Interventions and Resilience in Trauma","Unified Protocol","Structured Psychotherapy for Adolescents Responding to Chronic Stress","2026-03-16",{"date":146,"type":35},"2026-03-19",{"date":148,"type":21},"2026-07",{"date":150,"type":21},"2029-09-29",{"name":152,"class":42},"Anthony Vesco",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":22,"phases":162,"briefSummary":163,"conditions":164,"keywords":173,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":215},"100587056","effectiveness-implementation-and-cost-of-cognitive-processing-therapy-in-prisons-100587056","NCT06923423","Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons","STRIDES2","Inclusion Criteria:\n\n* 18 years of age or older\n* Able to understand and speak English\n* Able to give informed consent\n* All items listed in \"Inclusion criteria for all participants\"\n* Be currently incarcerated in one of the prisons that have partnered as study sites\n* Have met criteria for a drug use disorder in the year prior to their current incarceration (≥ 2 symptoms on a DSM-5 drug use disorder checklist)\n* Have used drugs in the 30 days prior to their current incarceration\n* Have a history of traumatic event exposure\n* Endorse clinically significant posttraumatic stress symptoms (score ≥ 4 on the Primary Care PTSD Screen for DSM-5; PC-PTSD-5)\n* Expect to be incarcerated for at least long enough to complete CPT-CJ as it is being implemented at the particular site (i.e., anticipated to be \\~3 months, but will depend on dates associated with next available intervention group)\n* Expect to be released from prison within 12 months following the end of treatment (i.e., within \\~15 months of the pre-treatment assessment)\n* Willing to consent to randomization to treatment condition\n\nExclusion criteria for prisoners (additional requirements assessed during pre-treatment assessments or indicated by prison staff; will result in being withdrawn from the study prior to randomization by the PI):\n\n* Unable to provide any locator information for post-release assessments\n* Determined to be releasing sooner than would allow the individual to complete CPT-CJ\n* Determined to have an unavoidable scheduling conflict or facility restriction (e.g., disciplinary, medical) that would prevent participation in CPT-CJ. Of note, if the scheduling conflict or facility restriction is expected to resolve following the next round of randomization at the study site, the participant may be put on \"hold for next round\" status rather than withdrawn unless other exclusionary criteria would be met by that time (e.g., release).",{"count":161,"type":21},640,[56],"Addiction and trauma exposure are common among the 5.5 million people (1 in 47 adults) in the U.S. who are in prison or under supervision. About 85% of people in prison have a substance use disorder or are there for a drug-related crime, and many have experienced serious trauma before being incarcerated. Posttraumatic stress symptoms (PTSS) are often a result of trauma and are linked to more severe drug use, higher rates of relapse, and increased crime. PTSS and substance use disorder (SUD) each raise the chances of new arrests for people who are justice-involved, showing that addressing trauma and addiction could help reduce repeat offenses and the costs of incarceration. However, treatments for PTSS are rarely available in prisons, and there is little research on whether providing therapy for PTSS in prison can lower drug use, PTSS, or crime after release.\n\nThe goal of this clinical trial is to see if trauma-focused group therapy (CPT) provided while in prison, can help people after release from prison. The therapy has been adapted for use in prisons (CPT-CJ) and will be compared to trauma focused therapy delivered via a self-help workbook\n\nThis study will:\n\n* test whether a trauma-focused group therapy (CPT-CJ) can reduce post-incarceration drug and alcohol use, mental health issues, and drug-related crime, compared to trauma-focused self-help,\n* evaluate a strategy called implementation facilitation, which helps support the use of this therapy in prisons, and\n* measure the cost of the therapies and support strategies to help plan for future expansion.\n\nIncarcerated participants (N = 640; 50% female) will be enrolled from \\~10 prisons in \\~5 states, ensuring variability in population and setting characteristics. They will:\n\n* take surveys and answer questions up to 5 times (before starting treatment, right after getting treatment, right before leaving prison, 3 months after leaving prison and 6 months after leaving prison)\n* complete CPT group therapy or self-help therapy\n* provide urine samples 3 months and 6 months after leaving prison\n\nPrison stakeholders (e.g., prison staff, prison leadership, governmental officials; N = \\~15 per site) who will be purposively sampled based on their role in CPT-CJ implementation will also participate in some surveys.",[165,166,167,168,169,92,100,28,170,171,172],"PTSD - Post Traumatic Stress Disorder","PTSD and Alcohol Use Disorder","PTSD and Trauma-related Symptoms","Substance Use Disorder (SUD)","Depression","Traumatic Stress Disorder","Traumatic Stress","Post Traumatic Stress Symptoms",[174,175,176,177,178,179,180,181,182,183,184,185,186,100,169,187,188,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204,205],"Post traumatic Stress Disorder","Post traumatic Stress Symptoms","Substance Use","Substance Use Disorder","Cognitive Processing Therapy","Cognitive Processing Therapy for Criminal Justice Setting","Trauma focused self help","Facilitation","Implementation Facilitation","Implementation","Cost Estimation and Offsets","Drug Use Disorder","Alcohol Use Disorder","Adult","Incarcerated","Prison","Imprisonment","Intervention","Treatment Comparison","Acceptability","Feasibility","Budget Impact","Cost Estimate","Implementation Evaluation","Recidivism","Self Help","Workbook","Criminal Justice","Effectiveness","Evidence Based Intervention","CPT","CPT-CJ","2026-01-20",{"date":208,"type":35},"2026-01-21",{"date":210,"type":35},"2025-07-07",{"date":212,"type":21},"2028-12",{"name":214,"class":42},"University of Arkansas",6]