[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"trauma-multiple\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:trauma-multiple":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,70,95,128,151],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":47,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":69},"100497203","assessing-symptom-and-mood-dynamics-in-pain-using-the-smartphone-application-soma-100497203",false,"NCT05754190","Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA","INCLUSION CRITERIA \\[General study\\]\n\n* Chronic pain group:\n\n  * Age above 18\n  * Access to a personal smartphone and a stable internet connection\n  * Average pain intensity score of greater than 3 in the past week or\n  * Average pain interference score of greater than 3 in the past week or\n  * Average pain distress score of greater than 3 in the past week\n  * Pain duration: greater than 6 months\n* Acute pain group:\n\n  * Age above 18\n  * Access to a personal smartphone and a stable internet connection\n  * Average pain intensity score of greater than 3 in the past week\n\n    ○ or\n  * Average pain interference score of greater than 3 in the past week\n\n    ○ or\n  * Average pain distress score of greater than 3 in the past week\n  * Pain duration: less than 3 months\n  * Pain cause: Due to recent surgery, injury, acute illness, or childbirth (within the past 3 months)\n* Healthy control group:\n\n  * Age above 18\n  * Access to a personal smartphone and a stable internet connection\n  * Average pain intensity score of less than 3 in the past week\n  * Average pain interference score of less than 3 in the past week\n  * Average pain distress score of less than 3 in the past week\n  * No surgery, injury, acute illness, or childbirth (within the past 3 months)\n* In person EEG testing \\[Sub-Study only\\]:\n\n  * Same as in General App Study Above and additionally:\n  * Current diagnosis of Fibromyalgia, Chronic Low Back Pain or Failed Back Surgery Syndrome OR\n  * No current or prior history of chronic pain\n  * If participant has chronic low back pain or failed back surgery syndrome: are they planning to have either a radio-frequency ablation, back surgery, or spinal cord stimulation implant in the next few months\n  * If participant has chronic low back pain or failed back surgery syndrome: have they received insurance approval for the procedure?\n  * Ok with EEC\u002FECG measures\n\nEXCLUSION CRITERIA \\[General study\\]\n\n* Chronic pain group:\n\n  * recent injury or surgery unrelated to the pain in the past 3 months\n  * difficulty participating for technical\u002Flogistical issues (e.g., no computer, incompatible smartphone, can't commit to 4 months study participation);\n  * Not fluent in English (difficulty understanding questions)\n  * Current primary or metastatic cancer (organic cause of pain)\n* Acute pain group:\n\n  * History of Chronic Pain (Pain lasting for more than 6 months)\n  * difficulty participating for technical\u002Flogistical issues (e.g., no computer, incompatible smartphone, can't commit to 4 months study participation);\n  * Not fluent in English (difficulty understanding questions)\n  * Current primary or metastatic cancer (organic cause of pain)\n* Healthy control group:\n\nHistory of Chronic Pain (Pain lasting for more than 6 months)\n\n* difficulty participating for technical\u002Flogistical issues (e.g., no computer, incompatible smartphone, can't commit to 4 months study participation);\n* Not fluent in English (difficulty understanding questions)\n\n  -In person EEG testing \\[Sub-study only\\]: \\[will interfere with EEG data collection safety or quality\\]:\n* Same as in General App Study Above and additionally:\n* Baldness\n* Pregnancy\n* Dreadlocks\n* Left-handedness\n* Use of a wheelchair\n* Heart failure diagnosis\n* Current or prior experience with acute psychosis or mania\n* implanted pacemaker, neurostimulator or any other head or heart implants\n* require a hearing aid to hear properly\n* claustrophobia\n* metal fragments in the body",true,"ALL","18 Years",{"count":19,"type":20},800,"ESTIMATED","OBSERVATIONAL","This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary goal of the study is to use fluctuations in daily self-reported symptoms to identify computational predictors of acute-chronic pain transition, pain recovery, and\u002For chronic pain maintenance or flareups. The general study will include anyone with current acute or chronic pain, while a smaller sub-study will use a subset of patients from the chronic pain group who have been diagnosed with chronic low back pain, failed back surgery syndrome, or fibromyalgia. These sub-study participants will first take part in one in-person EEG testing session while completing simple interoception and reinforcement learning tasks and then begin daily use of the SOMA app. Electrophysiologic and behavioral data from the EEG testing session will be used to determine predictors of treatment response in the sub-study.",[24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46],"Chronic Pain","Acute Pain","Post Operative Pain","Fibromyalgia, Primary","Fibromyalgia, Secondary","Fibromyalgia","Irritable Bowel Syndrome","Chronic Headache Disorder","Chronic Migraine","Chronic Pelvic Pain Syndrome","Temporomandibular Joint Disorders","Endometriosis-related Pain","Arthritis","Chronic Low-back Pain","Failed Back Surgery Syndrome","Post Herpetic Neuralgia","Neuropathic Pain","Painful Diabetic Neuropathy","Painful Bladder Syndrome","Trauma-related Wound","Trauma, Multiple","Chronic Pain Syndrome","Chronic Shoulder Pain",[48,49,50,51,52,53,54,55,56],"digital health","e-health","smartphone application","chronic pain","acute pain","symptom tracking","experience sampling methodology","ecological momentary assessment","pain self-management","RECRUITING","2025-09-16",{"date":60,"type":61},"2025-09-19","ACTUAL",{"date":63,"type":61},"2023-06-20",{"date":65,"type":20},"2026-05-30",{"name":67,"class":68},"Brown University","OTHER",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":79,"conditions":80,"keywords":81,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":69},"100570615","mortality-prediction-using-trauma-scores-100570615","NCT06709547","Mortality Prediction Using Trauma Scores","Which Trauma Severity Score (ISS, NISS, RTS, or TRISS) Best Predicts Mortality in Trauma Patients? A Prospective Observational Study","Inclusion Criteria:\n\n* Trauma patients admitted to the emergency room (ER).\n* Documented injury data sufficient to calculate both the New Injury Severity Score (NISS) and the Injury Severity Score (ISS).\n* Trauma scores (ISS, NISS, Revised Trauma Score \\[RTS\\], and Trauma and Injury Severity Score \\[TRISS\\]) calculated within 12 hour of arrival to ensure timely predictions.\n* Informed consent provided by the patient or a legal guardian in cases of incapacity.\n\nExclusion Criteria:\n\n* Under 18 years of age and pregnant women, due to differences in trauma management and scoring applicability.\n* Non-trauma cases, including patients with terminal illnesses or severe cognitive impairments, to maintain focus on trauma outcomes.\n* Incomplete trauma scoring, missing or incomplete medical records, and\n* patients not treated in the trauma or emergency department.\n* Patients who refuse participation or withdraw consent to ensure ethical participation.\n* Transferred patients and those enrolled in other research studies that could interfere with trauma scoring.",{"count":78,"type":20},150,"The goal of this prospective cohort study is to compare the predictive utility of the Injury Severity Score (ISS), New Injury Severity Score (NISS), Revised Trauma Score (RTS), and Trauma and Injury Severity Score (TRISS) in determining mortality outcomes among trauma patients admitted to the trauma and emergency department at Kadhimiya Educational Hospital in Baghdad.\n\nThe main questions it aims to answer are:\n\nWhich trauma scoring system provides the most accurate prediction of mortality? Are there specific trauma patient subgroups where one scoring system outperforms the others?\n\nParticipants will:\n\nBe assessed using all four trauma scoring systems (ISS, NISS, RTS, and TRISS) upon admission to the trauma and emergency department.\n\nHave their clinical outcomes, including mortality, length of hospital stay, ICU admission, and discharge status, monitored throughout their hospital stay to evaluate the accuracy and utility of each scoring system in predicting patient outcomes.",[44],[82,83,84,85],"ISS","NISS","RTS","TISS","2025-04-27",{"date":88,"type":61},"2025-04-30",{"date":90,"type":61},"2025-01-28",{"date":92,"type":20},"2025-12-15",{"name":94,"class":68},"Al-Nahrain University",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":105,"phases":106,"briefSummary":108,"conditions":109,"keywords":112,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":69},"100487976","phase-3-whole-blood-in-trauma-patients-with-hemorrhagic-shock-100487976","NCT05634109","Whole Blood in Trauma Patients With Hemorrhagic Shock","Whole Blood vs. Blood Components Therapy in the Hemostatic Resuscitation of Severe Trauma Patients: An Open-label, Randomized, Controlled Clinical Trial","WEBSTER","Inclusion Criteria:\n\n* Adult patients (\\> 18 years)\n* Activating institutional trauma code for trauma patients with hemorrhagic shock.\n* Candidate for massive transfusion (Patient with an Assessment Blood Consumption (ABC) Score ≥ 2 or at the discretion of the treating physician)\n* Concurrent availability of whole blood or blood component therapy\n\nExclusion Criteria:\n\n* More than 4 hours from trauma to hospital admission\n* More than 2 hours from hospital admission to randomization\n* Transfusion of more than one packed red blood cell unit prior to randomization.\n* Patients who have undergone surgery (laparotomy, thoracotomy, or sternotomy) before hospital admission.\n* In-extremis patients with devastating injuries (expected to die within 60 minutes).\n* Blood group other than to O or A and positive Rh factor\n* Severe traumatic brain injury in which neurosurgical intervention is futile (partial decapitation, massive intracranial hemorrhage, or transcranial gunshot wounds).\n* Burns over 20% of the total body surface area.\n* Suspected airway burn.\n* Cardiopulmonary resuscitation (CPR) before arrival at the ED.\n* CPR for more than 5 minutes before randomization.\n* Do not resuscitate order.\n* Incarcerated\u002Fprisoners.\n* Known pregnancy in the ED.\n* Patient or legal representative who refuse to participate in clinical research studies.",{"count":104,"type":20},220,"INTERVENTIONAL",[107],"PHASE3","This study aims to evaluate among trauma patients with hemorrhagic shock the clinical impact of hemostatic resuscitation between whole blood vs. blood components therapy in the following outcomes in a hierarchical analysis: mortality at 28 days and evolution of organ dysfunction.",[110,111,44],"Trauma","Trauma Injury",[113,114,115,116,117,118],"whole blood","Blood Transfusion","Blood Component Transfusion","Hemorrhage","Advanced Trauma Life Support Care","Hemostatic resuscitation","2025-02-24",{"date":121,"type":61},"2025-02-27",{"date":123,"type":61},"2023-01-14",{"date":125,"type":20},"2026-03",{"name":127,"class":68},"Fundacion Clinica Valle del Lili",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":16,"minAge":135,"maxAge":4,"enrollmentInfo":136,"targetDuration":138,"studyType":21,"phases":4,"briefSummary":139,"conditions":140,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":150},"100326130","swiss-trauma-registry-100326130","NCT03526029","Swiss Trauma Registry","Observational Retrospective and Prospective Registry With Standardized Data Collection on Trauma Treatment in Switzerland","Inclusion Criteria:\n\n* injury severity code \\> 16 and 7 or abbreviated injury scale \\>3 for region of skull and brain\n\nExclusion Criteria:\n\n* patients who will transferred in a burn unit\n* drowned patients","16 Years",{"count":137,"type":20},2000,"5 Years","The Swiss Conference of Cantonal Health Directors has transferred the planning of highly specialized medicine to a specialized body under the direction of the Swiss Academy of Sciences. This specialist body has defined the treatment of critically ill as part of highly specialized medicine and founded the Swiss Trauma Registry at 12 hospitals in Switzerland. The registry is designed to provide a consistent and standardized approach and treatment outcomes in the short and long term quality control and as a basis for planning highly specialized medicine.",[44,110],"2025-02-17",{"date":143,"type":61},"2025-02-19",{"date":145,"type":61},"2015-01-01",{"date":147,"type":20},"2040-12-31",{"name":149,"class":68},"University Hospital, Basel, Switzerland",12,{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":105,"phases":161,"briefSummary":163,"conditions":164,"keywords":166,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":69},"100539590","effectiveness-of-a-self-management-program-after-traumatic-injury-100539590","NCT06305819","Effectiveness of a Self-management Program After Traumatic Injury","Managing Symptoms and Disability in the Sub-acute Phase After Traumatic Injury - A Pragmatic Randomised Controlled Trial of a Self-management Support Program","SEMPO","Inclusion Criteria:\n\n* Adults residing in the southeast region of Norway who are aged between 18 and 72 years.\n* Admitted to OUH directly or after transfer from local hospitals within 72 hours of injury.\n* At least a two-day hospital stay.\n* Traumatic injury corresponding to a New Injury Severity Scale score (NISS) \\>9.\n* Patients reporting injury-related symptoms, functional impairments, and\u002For difficulties with daily activities at the discharge from OUH.\n\nExclusion Criteria:\n\n* Cognitive function corresponding to a Mini Mental Status score (MMS) \\\u003C 20 points.\n* Psychiatric diseases that require treatment.\n* Drug\u002Falcohol dependence that require treatment.\n* Complete spinal cord injury and isolated thoracic or abdominal injury\n* Insufficient command of Norwegian","72 Years",{"count":104,"type":20},[162],"NA","Traumatic injuries, defined as a physical injury with sudden onset, are a leading cause to disability and impaired health. Persons who sustain a traumatic injury often report problems in daily life activities and reduced quality of life, which may limit participation in work\u002Fstudies, leisure activities and family life. Consequently, complex rehabilitation and support is recommended in National Trauma guidelines due to the often long-lasting physical and psychological sequela of the injury.\n\nThe main goal of this study is to determine the effectiveness of a self-management support program delivered to persons with a moderate or severe traumatic injury in the sub-acute phase of recovery (i.e. 3-4 months after injury). The self-management program aims to enhance patients' self-efficacy by building skills and self-management strategies to cope with injury-related consequences. The program has a group-based format and consists of eight sessions comprising psychoeducation, skill mastery and sharing of experiences. The participants who will be included in the study must be between 18 and 70 years, be residing in the southeast region of Norway, be admitted to Oslo University hospital or transferred from local hospital within 72 hours after injury, have at least a two-day hospital stay, and be able to read and understand Norwegian language. Participants will be randomly assigned to either intervention or control group. A group of patients will also be able to self-select if they want to receive the self-management support program or be in the control group. The latter is an explorative part of the study to evaluate the influence of patients' treatment-preferences on the study outcomes. Participants in the control group will receive treatment as usual.",[111,44,165],"Polytrauma",[167,168,169],"Self-management program","Rehabilitation","Sub-acute phase","2024-04-10",{"date":172,"type":61},"2024-04-12",{"date":174,"type":61},"2024-01-01",{"date":176,"type":20},"2030-12-31",{"name":178,"class":68},"Oslo University Hospital"]