[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"trauma-psychological\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:trauma-psychological":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,42,66,96,121,145,172,215,239,264,290,325],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100538044","enhancing-the-effectiveness-of-prolonged-exposure-among-suicidal-individuals-with-ptsd-100538044",false,"NCT06285708","Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD","Inclusion Criteria:\n\n* Current diagnosis of PTSD or subthreshold PTSD; ability to speak and understand the English language; and ability to complete the informed consent process.\n\nExclusion Criteria:\n\n* Substance use disorder requiring medical management; imminent suicide risk warranting inpatient hospitalization or suicide-focused treatment; and impaired mental status that precludes the ability to provide informed consent (e.g., intoxication, psychosis, mania).","ALL","18 Years",{"count":18,"type":19},100,"ESTIMATED","INTERVENTIONAL",[22],"NA","The long-term goal of this study is to reduce suicidal thoughts and behaviors among treatment-seeking individuals who also have posttraumatic stress disorder (PTSD). Prolonged exposure (PE) and crisis response plan (CRP) have demonstrated empirical support for reducing suicide attempts as compared to treatment as usual. However, no studies to date have assessed their effectiveness when used in combination. In light of this knowledge gap, the primary objective of this study will be to test the effectiveness of PE augmented with CRP as compared to PE with care as usual (self-guided treatment plan), an active comparator, for the reduction of suicide ideations and attempts for individuals with comorbid PTSD.",[25,26,27,28],"PTSD","Suicidal Ideation","Suicide, Attempted","Trauma, Psychological","RECRUITING","2026-06-24",{"date":32,"type":33},"2026-06-29","ACTUAL",{"date":35,"type":33},"2024-02-26",{"date":37,"type":19},"2027-06",{"name":39,"class":40},"Ohio State University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":15,"minAge":16,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":20,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":41},"100537942","interaction-between-early-trauma-and-odor-induced-dopamine-release-100537942","NCT06284382","Interaction Between Early Trauma and Odor-induced Dopamine Release","Consequence of Early Trauma on Odor Hedonics Appreciation and DOpamine Release","T-ODOR","Inclusion Criteria:\n\n* Aged 18 years or older\n* Have been selected based on the Childhood Trauma Questionnaire score\n* Non-smoker\n* Be able to speak and read French\n* Sign a consent form before intervention.\n\nExclusion Criteria:\n\n* A pre-existing condition that affects olfaction including congenital anosmia, upper respiratory tract infection, nasal and\u002For sinus disease,\n* Be on medication, with the exception of oral contraceptives\n* Pregnant or breast-feeding woman (check with urine pregnancy tests);\n* Contraindications to TMS or MRI (implanted medical devices or metallic foreign body in the head);\n* Psychiatric disorders\n* Use of psychotropic drugs\n* Have participated in a study involving the injection of a radiotracer during the year",true,"30 Years",{"count":53,"type":19},30,[22],"This prospective, double-blind, parallel-group controlled trial aims to investigate the consequence of early trauma on dopamine release evoked by positive valence odors.",[28],"2026-06-10",{"date":59,"type":33},"2026-06-12",{"date":61,"type":33},"2026-04-27",{"date":63,"type":19},"2028-12-01",{"name":65,"class":40},"Hôpital le Vinatier",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":50,"sex":73,"minAge":16,"maxAge":4,"enrollmentInfo":74,"targetDuration":4,"studyType":20,"phases":76,"briefSummary":77,"conditions":78,"keywords":85,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":41},"100602905","trauma-informed-care-for-smoking-cessation-for-pregnancy-100602905","NCT07129590","Trauma-Informed Care for Smoking Cessation for Pregnancy","TRauma-Informed Care in Smoking cEssation for Pregnancy (RISE Pregnancy)","Inclusion Criteria:\n\nClinician Eligibility Criteria (Aims 1 - 3):\n\nIn Aims 1-3, will be recruiting clinicians working in our clinic sites.\n\n1. Nurse practitioner, physician assistant, nurse-midwife, medical doctor, registered nurse, clinical pharmacist, behavioral health professional, social worker, or any other healthcare professional caring for pregnant patient-participants.\n2. Age ≥ 18 years old.\n\nPatient-participant Eligibility Criteria (Aim 1):\n\nIn Aim 1, will be recruiting pregnant women (ages 18+) who:\n\n1. Currently smoking or report having smoked during a previous pregnancy\n2. Age ≥18 years old.\n3. Currently Pregnant.\n4. Identifies as a cisgender woman, or female at birth.\n5. Reports having experienced trauma aligned with Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) definition for traumatic exposure.\n6. Proficient in English or Spanish languages.\n\nPatient-Participant Eligibility Criteria (Aim 2):\n\nPatient-participants will be recruited to give feedback on our intervention using Evidence-Based Quality Improvement (EBQI) meetings.\n\nInclusion criteria:\n\n1. Current or former patient in the participating clinical sites.\n2. Age ≥18 years old.\n3. Proficient in English or Spanish languages.\n\nPatient-Participant Eligibility Criteria (Aim 3): In Aim 3, will be recruiting pregnant women who are actively smoking and have histories of trauma (ages 18+).\n\nInclusion criteria:\n\n1. Currently smoking (ever smoked 100 cigarettes in their lifetime, smoked in the past 7 days and at least 1 cigarette per day, verified by CO≥6ppm)\n2. ≥18 years old\n3. Currently Pregnant\n4. Identifies as a cisgender women, or female at birth\n5. Meets DSM-5 Criterion A for trauma exposure on the Brief Trauma Questionnaire (BTQ)\n6. English or Spanish Proficient\n\nExclusion Criteria:\n\nClinician- and Patient-participant Exclusion criteria (Aims 1 - 3):\n\n1\\. Any condition, including active mental health crises or cognitive impairment, that would interfere with the ability to provide informed consent or safely complete the study.","FEMALE",{"count":75,"type":19},20,[22],"Trauma-informed approaches have been shown to support recovery from other substance use disorders and involve four key elements: (1) Realizing the prevalence of trauma and pathways to recovery, (2) Recognizing symptoms of trauma, (3) Responding by embedding knowledge of trauma into practices and policies and (4) Resisting re-traumatization (the 4Rs). In close partnership with Breathe California and a public safety-net clinic in San Francisco that serves primarily racial and ethnic minoritized (REM) pregnant women, the 4Rs along with the Ask, Advise, Assess, Assist and Arrange (the 5As) evidence-based intervention for tobacco cessation that is delivered by health care professionals and is a US Public Health Services clinical practice guideline for treating tobacco will be used to create and implement a smoking cessation intervention for pregnant women with experiences of trauma.",[79,80,81,82,83,28,84],"Smoking Cessation","Tobacco Smoking","Tobacco Use Cessation","Smoking Reduction","Smoking, Cigarette","Trauma and Stressor Related Disorders",[86],"Pregnancy","2026-04-20",{"date":89,"type":33},"2026-04-23",{"date":91,"type":33},"2025-11-19",{"date":93,"type":19},"2026-07-31",{"name":95,"class":40},"University of California, San Francisco",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":15,"minAge":103,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":20,"phases":106,"briefSummary":107,"conditions":108,"keywords":109,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":41},"100588440","systematic-redesign-of-trauma-focused-cognitive-behavioral-therapy-tf-cbt-100588440","NCT06941428","Systematic Redesign of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT)","Systematic Redesign of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) to Enhance Usability, Engagement, Appropriateness, and Impact in Schools","INCLUSION CRITERIA\n\nDiscover, Design\u002FBuild Phase:\n\n* Providers. Providers will be included if they (a) deliver mental health treatment on school grounds; (b) English speaking.\n* Students. Youth participants will meet eligibility criteria for this study, including (a) be within the TF-CBT developmental range, ages 7-19; (b) are receiving, or have previously received, school mental health services; and (c) are English speaking.\n\nTest Phase:\n\n* Providers. Providers will be included if they (a) deliver mental health treatment on school grounds; (b) have not previously received formal training in TF-CBT; and (c) are English speaking\n* Students. Youth participants will meet eligibility criteria for this study, including (a) be within the TF-CBT developmental range, ages 7-19; (b) have traumatic event exposure (e.g., exposure to violence); (c) demonstrate significant post-traumatic stress symptoms (have a trauma history as defined as a score \\>31 on the Child PTSD Symptoms Scale for DSM-V \\[CPSS-V\\]); and (d) are English speaking.\n\nEXCLUSION CRITERIA\n\nDiscover, Design\u002FBuild Phase:\n\n\\- Students with intellectual impairments documented in education or mental health records.\n\nTest Phase:\n\n* Providers. Providers will be excluded if they participated in the redesign process for TF-CBT.\n* Students. Students will be excluded if they (a) have intellectual impairments documented in education or mental health records and (2) are not trauma exposed.","7 Years",{"count":105,"type":19},102,[22],"Trauma-focused cognitive behavior therapy (TF-CBT) has the strongest evidence of any clinical intervention for youth trauma but is rarely adopted in the education sector - the most common setting for youth mental healthcare. Use of TF-CBT in schools is limited by (1) problems with its usability (e.g., rigid structures, complicated patient identification workflows) and (2) provider perceptions that some core elements (e.g., exposure) are not contextually appropriate for schools; both of which hinder provider and student engagement with TF-CBT. Our preliminary studies identified that TF-CBT demonstrates \"below average\" usability, suggesting that many providers are likely to experience it as excessively onerous (e.g., due to lengthy sessions, low caregiver engagement). Without a systematic process for redesign, treatment adaptations made to improve intervention-setting fit can be reactive and risk omitting their core elements or functions. Locally driven, user focused redesign of TF-CBT for schools that maintains its core functions can enhance the accessibility and impact of evidence-based trauma treatment for youth. In light of the need for usable, contextually appropriate, and engaging interventions for youth trauma, the current project will iteratively adapt TF-CBT for use by school-based providers (e.g., school counselors, school social workers) via the University of Washington ALACRITY Center's (UWAC) Discover, Design\u002FBuild, Test (DDBT) approach and methods drawn from the field of human-centered design.",[28,84],[110,111],"School Mental Health","Trauma-Focused Cognitive Behavioral Therapy","2026-02-23",{"date":114,"type":33},"2026-02-27",{"date":116,"type":33},"2025-06-22",{"date":118,"type":19},"2027-03-01",{"name":120,"class":40},"University of Washington",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":50,"sex":73,"minAge":128,"maxAge":129,"enrollmentInfo":130,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":41},"100417287","early-life-stress-and-depression-molecular-and-functional-imaging-100417287","NCT04713722","Early Life Stress and Depression: Molecular and Functional Imaging","ELS","Inclusion Criteria:\n\n* Females of all races and ethnic origins\n* Ages from 20 to 32\n* Right-handed\n* Capable of providing written informed consent\n* Currently unmedicated. Note that this criterion applies at enrollment only, and subjects will be informed that they can continue to be in the study if they begin a new medication after enrollment.\n* Normal or corrected-to-normal vision and hearing\n* Fluency in written and spoken English\n* Absence of first-degree relatives with a history of a psychotic disorder or psychotic symptoms; (adopted individuals are eligible to participate but we will probe about family history in case such information is available to the adopted subject)\n\nExclusion Criteria:\n\n* Participants with suicidal ideation where continued study participation is deemed unsafe by the study clinician (these participants will be immediately referred to appropriate clinical treatment)\n* Pregnant women, or women of childbearing potential who have a positive result on a urine pregnancy test\n* Failure to meet MRI safety requirements including but not limited to any metal implants or prostheses that cannot be removed, or exposure to shrapnel\n* Claustrophobia or severe anxiety that might impact participation in neuroimaging\n* Injury or movement disorder that may make it difficult to lie still in the scanner\n* Any current recreational\u002Fillicit drug use as assessed by a urine drug test (covering cocaine, cannabinoids, opiates, amphetamines, methamphetamines, phencyclidine, MDMA, benzodiazepines, methadone, oxycodone, tricyclic antidepressants, and barbiturates)\n* Use of drug or herbal supplement for depression (e.g., St. John's Wort or SAMe) of those that could affect stress response\n* Use of any medication in the 24 hours prior to the Scanning procedure (including antibiotics, asthma inhalants, pain relievers, antihistamines, or over-the-counter medications).\n* Recent use (within 3 weeks) or any medication that affects blood flow or blood pressure, or which is vasodilating\u002Fvasoconstricting\n* Use of Melatonin within 5 days of the Scanning procedure\n* Metformin use in the past 6 months (for either clinical care or as part of research)\n* Serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine (hypothyroidism), neurologic, autoimmune disease (such as Lyme, Crohn's), or hematologic disease\n* Current infectious illness (either transient or chronic); Current episode of allergic reaction or asthma\n* Hemophilia; Diabetes with poor glucose control; History of chronic migraine (\\> 15 days\u002Fmo.); History or current diagnosis of dementia\n* History of seizure disorder\n* Any history of significant head injury or concussion\n* Past\u002Fcurrent DSM-5 diagnosis of: OCD, ADHD, schizophrenia, schizoaffective disorder, delusional disorder, psychotic disorders NOS, bipolar disorder, patients with mood congruent or mood incongruent psychotic features, autism or any other pervasive developmental disorder, organic mental disorder, anorexia, binge eating disorder or bulimia (however a history of bulimia or binge eating disorder is allowable if it has been in remission for at least two years)\n* History of moderate or severe substance or alcohol use disorder; or, mild substance or alcohol use disorder within the last 12 months (with the exception of cocaine or stimulant abuse, which will lead to automatic exclusion).\n* History of ECT\n* Patient is clinically unstable, in the judgment of the clinician","20 Years","32 Years",{"count":131,"type":19},160,"OBSERVATIONAL","Severe childhood adversity accounts for a large portion of psychiatric illness, and an increased risk for major depressive disorder (MDD). For some individuals, childhood adversity has negative psychological and medical consequences; others preserve mental and physical health despite such experiences (they are resilient). In spite of this, little is known about the neurobiological mechanisms related to childhood adversity, especially oxidative stress abnormalities in the brain. To fill this gap, this study combines functional, structural, and molecular imaging approaches to examine the role of oxidative stress abnormalities related to childhood adversity.",[135,28],"Depression","2025-12-04",{"date":138,"type":33},"2025-12-12",{"date":140,"type":33},"2021-02-01",{"date":142,"type":19},"2026-06-30",{"name":144,"class":40},"Mclean Hospital",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":50,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":20,"phases":154,"briefSummary":155,"conditions":156,"keywords":160,"overallStatus":162,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":4},"100612276","transparent-communication-to-improve-mental-wellbeing-and-attitude-towards-reintegration-100612276","NCT07251478","Transparent Communication to Improve Mental Wellbeing and Attitude Towards Reintegration","Transparent Communication to Improve Mental Wellbeing and Public Attitude Towards the Reintegration of Former Boko Haram Members in Nigeria: A Pilot Randomised Control Trial","Inclusion Criteria:\n\n* 18 years and above\n* Able to provide full consent for their participation.\n* A resident of the study areas\n\nExclusion Criteria:\n\n* Less than 18 years\n* Unable to consent\n* Currently undergoing severe mental health treatment\n* Unable to speak the English language fluently",{"count":153,"type":19},74,[22],"Reintegrating those once affiliated with proscribed terrorist groups constitutes significant global challenges due to public stigma, poor awareness of reintegration programmes and resentment towards incentives provided to rehabilitated former members of such groups. Of central concern is the anxiety, trauma and depression suffered alongside distrust for reintegration programmes, including the genuine repentance of former members of the proscribed group. The implication is its risk in exacerbating reoffending. Yet, a gap exists to address this urgent problem. The proposed study seeks to test and pilot the feasibility and acceptability of a novel intervention called Prosociality, Empathy and Awareness Communication to aid rEintegration (PEACE) in improving mental well-being and public attitude towards reintegration. The intervention is a low-intensity intervention lasting approximately 3-5 minutes design to create awareness on the rationale behind reintegration programme, reduce anxiety, depression and foster positive attitude towards reintegration.",[135,157,158,159,28],"Anxiety","Trauma","Stress",[157,135,161,158],"Reintegration","NOT_YET_RECRUITING","2025-11-24",{"date":165,"type":33},"2025-11-26",{"date":167,"type":19},"2025-12-10",{"date":169,"type":19},"2026-09-30",{"name":171,"class":40},"Teesside University",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":180,"targetDuration":4,"studyType":20,"phases":182,"briefSummary":183,"conditions":184,"keywords":189,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":214},"100529540","heartgps-a-study-exploring-the-effects-of-a-psychological-intervention-for-parents-and-their-babies-after-prenatal-cardiac-diagnosis-100529540","NCT06175104","HeartGPS: A Study Exploring the Effects of a Psychological Intervention for Parents and Their Babies After Prenatal Cardiac Diagnosis","HeartGPS: A Longitudinal Randomized Controlled Trial Examining the Effects of a Prenatally-Delivered Psychological Intervention for Parents and Their Babies With Single Ventricle Congenital Heart Disease","HeartGPS","Inclusion Criteria\n\n1. Pregnant person carrying a fetus diagnosed with single ventricle congenital heart disease (CHD).\n2. Single ventricle CHD diagnosis between 16 and 30 weeks gestation.\n3. Singleton pregnancy.\n4. Pregnant person is planning to continue with the pregnancy.\n5. Pregnant person is able to participate and complete study assessments in English.\n\nExclusion Criteria\n\n1. Fetus with comorbid condition with a predictable adverse impact on neurodevelopment (e.g., DiGeorge Syndrome).\n2. Fetal or maternal medical condition determined by treating physician to be contraindicative to study participation.\n3. Parent with an untreated major psychiatric condition, substance use disorder, or other circumstances that would interfere with study engagement or safe participation in the trial.\n4. Parent with a moderate to severe intellectual disability.\n5. Parent age \\\u003C18 years.\n6. Surrogate for pregnancy.\n\nPrenatal administration of oral or intravenous corticosteroids for fetal lung maturation will be recorded but are not a reason for exclusion.",{"count":181,"type":19},50,[22],"Babies with single ventricle congenital heart disease (SVCHD) are often diagnosed during pregnancy. While prenatal diagnosis has important clinical benefits, it is often stressful and overwhelming for parents, and many express a need for psychological support. HeartGPS is a psychological intervention for parents who receive their baby's diagnosis of SVCHD during pregnancy. It includes 8 sessions with a psychologist, coupled with tailored educational resources, and a personalized care plan. The intervention focuses on fostering parent psychological adjustment and wellbeing, and supporting parents to bond with their baby in ways that feel right for them. Through this study, the investigators will learn if HeartGPS is useful and effective for parents and their babies when it is offered in addition to usual fetal cardiac care. The investigators will examine the effects of the HeartGPS intervention on parental anxiety, depression, and traumatic stress; fetal and infant brain development; parent-infant bonding; and infant neurobehavioral and neurodevelopmental outcomes. The investigators will also explore mechanisms associated with stress biology during pregnancy, infant brain development and neurodevelopmental outcomes, and parent and infant intervention effects.",[185,186,187,28,188],"Heart Defects, Congenital","Anxiety in Pregnancy","Depression, Postpartum","Neurodevelopmental Disorders",[190,191,192,193,194,195,196,197,198,199,200,201,202,203,204],"Congenital Heart Disease","Prenatal","Mental Health","Neurodevelopment","Neurobehavior","Fetal Cardiology","Psychological Intervention","Mother-Infant Attachment","Mother-Infant Bonding","Medical Traumatic Stress","Neuroimaging","Brain Development","Fetal Neuroimaging","Perinatal Mental Health","Medical Psychology","2025-07-16",{"date":207,"type":33},"2025-07-20",{"date":209,"type":19},"2025-07-14",{"date":211,"type":19},"2027-12",{"name":213,"class":40},"Children's Hospital Medical Center, Cincinnati",4,{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":222,"enrollmentInfo":223,"targetDuration":4,"studyType":20,"phases":225,"briefSummary":226,"conditions":227,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":41},"100467217","development-of-a-culturally-grounded-trauma-informed-alcohol-intervention-with-a-reserve-dwelling-first-nation-group-100467217","NCT05363878","Development of a Culturally Grounded, Trauma-Informed Alcohol Intervention With a Reserve-Dwelling First Nation Group","NativeHEALTH","Inclusion Criteria:\n\n* At least 18 years of age\n* Used alcohol in the past week\n* Self-identify as a First Nation member\n* Reside within the partner community\n* Want to cut down or stop alcohol use\n\nExclusion Criteria:\n\n* Experiencing current psychotic symptoms\n* High scores (\\>10) on the Clinical Institute Withdrawal Assessment for Alcohol, Revised","90 Years",{"count":224,"type":19},60,[22],"The objective of this project is to develop and obtain preliminary data on a culturally grounded, trauma-informed alcohol intervention. The specific aims are to (1) use Community-Based Participatory Research methods to deepen partnerships with First Nation through capacity-building and knowledge sharing; (2) collect and apply qualitative data to develop a culturally grounded, trauma-informed alcohol intervention that is focused on historical trauma for use with a First Nation sample; and (3) conduct a pilot RCT study to examine acceptability, sustainability, and initial efficacy data of the intervention compared to waitlist control. This work is important, timely, and innovative. Addressing alcohol use has important implications for the health of Indigenous populations.",[228,28,229],"Alcohol Drinking","Historical Trauma","2025-04-21",{"date":232,"type":33},"2025-04-24",{"date":234,"type":33},"2025-01-13",{"date":236,"type":19},"2025-09-29",{"name":238,"class":40},"University of Rhode Island",{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":245,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":15,"minAge":247,"maxAge":248,"enrollmentInfo":249,"targetDuration":4,"studyType":20,"phases":250,"briefSummary":251,"conditions":252,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":41},"100471519","emdr-therapy-in-young-children-a-double-blinded-randomized-controlled-trial-100471519","NCT05419934","EMDR Therapy in Young Children, a Double-blinded Randomized Controlled Trial","Is Eye-Movement Desensitization and Reprocessing (EMDR) Therapy Effective in Children Aged 3 to 6 Years With Trauma-related Disorders or Stressors and Anxiety? A Double-blinded Randomized Controlled Trial.","EMDRJEER","Inclusion Criteria:\n\n* Child aged 3 to 6 at the time of inclusion;\n* Established diagnosis of one or more disorders related to a trauma or a stress factor, and\u002For an anxiety disorder, assessed by the Diagnostic Infant and Preschool Assessment (DIPA) diagnostic tool\n* Typical language\n\nExclusion Criteria:\n\n* Child taking a psychotropic treatment\n* Suicidal intentions or ideation of the main caregivers, or of the child, and self-harming behavior;\n* Parent(s) or care figure(s) with a substance use disorder;\n* Presence or diagnosis of specific pathological conditions in the child (neurodevelopmental disorders based on Diagnostic and Statistical Manual of Mental Disorders (DSM V) criteria, brain trauma, or neurological pathology);\n* Participation of the child in another biomedical research on the psychic care of disorders related to trauma or stress and anxiety factors","3 Years","6 Years",{"count":224,"type":19},[22],"This project aims to answer to the question of EMDR effectiveness in young children and to determine whether or not the therapy effectiveness is related to the level of cognitive functioning in young children. The study requires a total of 60 children, girls and boys, aged 3 to 6 years and presenting disorders related to stressors, anxiety and\u002For trauma. Participants will be randomly distributed in two groups: \"EMDR therapy\" (N=30) group or \"control therapy\" (N=30) group. The study will take place in four stages: 1\u002F Pre-treatment phase : An evaluation of child's various cognitive and executive functions, child's symptomatology and parental distress is planned in a pre-treatment phase. 2\u002F Treatment phase : An EMDR therapy or a routine care is administered to the child between 6 to 10 weeks. 3\u002F Post-treatment phase : A reassessment of child's and parent's symptoms is planned at the end of treatment. 4\u002F Continuation of treatment: Children who have received control therapy and without symptomatic improvement will be proposed EMDR treatment. These children will receive the same symptomatic assessments at the end of EMDR treatment.\n\nA significant reduction in disorders related to trauma or stress and anxiety factors and their symptomatology, as well as comorbid disorders and their symptomatology, is expected in children who received EMDR therapy compared to the group who received a control therapy. These results are expected to be robust over a period of at least 3 months. The positive effects of EMDR on child symptomatology are also expected to be more pronounced in children showing higher levels of cognitive functioning",[28,253,254],"Stress, Psychological","Anxiety Disorders","2025-03-26",{"date":257,"type":33},"2025-04-01",{"date":259,"type":33},"2022-09-27",{"date":261,"type":19},"2025-12",{"name":263,"class":40},"Fondation Lenval",{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":271,"targetDuration":4,"studyType":20,"phases":272,"briefSummary":273,"conditions":274,"keywords":276,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":41},"100584452","lighthouse-parenting-nanai-a-mentalization-based-group-therapy-for-caregivers-with-history-of-trauma-100584452","NCT06889519","Lighthouse Parenting Nanai: a Mentalization-based Group Therapy for Caregivers with History of Trauma","A Mentalization-based Intervention to Enhance the Quality of Caregiver-child Interaction and Reduce the Risk of Child Maltreatment: a Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n1. Biological parents of children (0-36 months old) with custody of their child.\n2. Parents who have gone through adverse childhood experiences, have a history of parental substance abuse or incarceration, have current exposure to relationship violence, or social isolation, or have lost custody of a child in the past.\n3. Parents must be over the age of 18.\n\nExclusion Criteria:\n\n1. Parents who are unable to provide informed consent due to mental or cognitive impairment,\n2. Parents not fluent in Spanish.\n3. Child's diagnosis of autistic spectrum disorder or severe cognitive delay.",{"count":224,"type":19},[22],"The goal of this feasibility randomized controlled trial is to evaluate the effectiveness and acceptability of the Lighthouse Mentalization-Based Treatment Parenting Program (Lighthouse MBT-P) as an intervention for parents at risk of maltreating their children. The study focuses on parents with a history of childhood trauma, aiming to improve parent-child relationships, reduce parenting stress, and ultimately decrease the risk of child maltreatment.\n\nThe goal of this study is to test how well the Lighthouse Mentalization-Based Treatment Parenting Program (Lighthouse MBT-P) works for parents who may be at risk of harming their children. The program aims to help parents understand and manage their own and their children's emotions better. By improving these skills, the program hopes to reduce stress in parenting and lower the chances of child abuse or neglect.\n\nThe main questions this study will answer are:\n\n* Can parents follow and complete the Lighthouse MBT-P program?\n* Does the program help lower stress in parenting and improve relationships between parents and their children?\n\nParticipants in this study will:\n\n* Attend weekly group sessions for 12 weeks. These sessions will teach them how to better understand and manage emotions.\n* Take part in discussions led by trained psychologists.\n\nResearchers will compare the results of parents who take part in the Lighthouse MBT-P program with those who receive standard parenting support to see which approach works better.",[275,28],"Child Maltreatment",[277,278,279,280],"mentalization-based treatments",", cultural adaptation","child maltreatment","caregiving relationship","2025-03-16",{"date":283,"type":33},"2025-03-21",{"date":285,"type":33},"2024-08-17",{"date":287,"type":19},"2025-10-31",{"name":289,"class":40},"University Diego Portales",{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":296,"eligibilityCriteria":297,"healthyVolunteers":11,"sex":15,"minAge":298,"maxAge":16,"enrollmentInfo":299,"targetDuration":301,"studyType":132,"phases":4,"briefSummary":302,"conditions":303,"keywords":308,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":324},"100311328","youth-experiences-and-health-study-100311328","NCT03332966","Youth Experiences and Health Study","Youth Experiences and Health (YEAH) Study - Psychological Symptoms and Resources As Predictors of Mental Health Among Treatment-seeking Adolescents","YEAH","Inclusion Criteria:\n\nStart of care in adolescent mental health clinic\n\nExclusion Criteria:\n\nPrevious diagnosis of psychotic disorder","15 Years",{"count":300,"type":19},1000,"5 Years","This study aims to identify unusual experiences and psychiatric symptoms that indicate a heightened risk for severe mental disorders - especially psychoses. It is important to develop reliable questionnaire methods that are cost-effective in first-stage screening, leading to in-depth assessments and targeted care. However, existing psychosis-risk questionnaires are limited in content, intended for adults, and have been insufficiently tested for actual predictive value. Therefore we will collect a new, large dataset from an unselected group of adolescents entering psychiatric care in three major urban areas of Finland. Comprehensive national health care registers will be used to assess how well the selected experiences and symptoms predict the participants' mental health over the following few years.",[304,305,306,307,28],"Psychotic Disorders","Psychiatric Hospitalization","Prodromal Symptoms","Cannabis Use",[309,310,311,312,313],"adolescent","outpatients","questionnaire","psychotic-like symptoms","psychosis risk","2024-09-23",{"date":316,"type":33},"2024-09-25",{"date":318,"type":33},"2019-12-01",{"date":320,"type":19},"2024-12-31",{"name":322,"class":323},"Finnish Institute for Health and Welfare","OTHER_GOV",3,{"id":326,"slug":327,"hasResults":11,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":331,"eligibilityCriteria":332,"healthyVolunteers":11,"sex":73,"minAge":16,"maxAge":333,"enrollmentInfo":334,"targetDuration":4,"studyType":20,"phases":336,"briefSummary":337,"conditions":338,"keywords":339,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":348,"locationsCount":350},"100395625","emdr-pre-treatment-yoga-for-complex-trauma-100395625","NCT04431531","EMDR Pre-treatment Yoga for Complex Trauma","EMDR Pre-treatment Yoga for Complex Trauma Randomized Controlled Comparative Study","YOGA-EMDR","Inclusion Criteria:\n\n. Women\n\n* Meets diagnostic criteria for Complex Post-traumatic Stress Disorder according to ICD-11 criteria, related to childhood sexual abuse\n* PCL-5 must be at least 45\n* Age between 18 and 70.\n* Free, informed and signed consent.\n\nExclusion Criteria:\n\nNeurological disorders\n\n* Pregnant women\n* Severe and\u002For unstable somatic diseases\n* Diseases resulting in serious motor disorders (e.g. people paralyzed)\n* Patient not affiliated with social security, State Medical Aid (AME)\n* Patient hospitalized under stress in psychiatric care at the decision of the state representative or in psychiatric care at the request of a third party,\n* Patient under guardianship, curatorship and protection of justice\n* Patient participating in parallel biomedical research\n* French language not mastered\n* Persons unable to give consent","70 Years",{"count":335,"type":19},66,[22],"yoga is a technique of hope. Indeed, it is a practice that specifically combines postures, breathing technique and a state meditative. The combination of these elements produces multiple effects that are exposed to detailed in the publications of Bessel Van der Kolk (Price et al., 2017; Rhodes, Spinazzola, \\& van der Kolk, 2016; Van der Kolk, 2014; Van Der Kolk et al., 2014) and whose four main effects are summarized here:\n\n* A regulation of the level of vigilance\n* An improvement in self-awareness\n* An increased sense of self-efficacy\n* Improved metacognition, awareness and regulation emotional",[28],[340],"Yogatherapy-EMDR-psychiatry","2024-03-03",{"date":343,"type":33},"2024-03-06",{"date":345,"type":33},"2016-09-20",{"date":347,"type":19},"2026-09-06",{"name":349,"class":40},"Dominique JANUEL",2]