[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"trauma-related-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:trauma-related-injuries":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100587458","stratifying-critically-ill-patients-for-novel-ferroptosis-or-pyroptosis-intervention-strategies-100587458",false,"NCT06928649","Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies","Innovative Cell Death Diagnostics Allowing Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies","ICU-FERRO","Inclusion Criteria:\n\n* Admitted to the ICU of UZA\n* Critically ill and predicted to be hospitalised in the ICU for \\> 48 hours (i.e. mostly patients admitted for sepsis, trauma, haemorrhagic shock, neurological catastrophe … which means at risk to develop mono-or multiple organ failure)\n* With arterial line in place (for blood sampling)\n\nExclusion Criteria:\n\n* Refusal of consent by patient or closest relative\n* Postoperative patients after major surgery in whom prolonged ICU stay is not foreseen (i.e. elective cardiac surgery","ALL","18 Years",{"count":20,"type":21},600,"ESTIMATED","INTERVENTIONAL",[24],"NA","In order to better determine which therapy is best for patiënts which present with organ falure during the course of their stay in the intesive care unit (ICU) , one has to determine which underlying mechanism is causing this organ falure. We will determine levels of so called \"biomarkers\" for ferroptosis (a mechan ism of iron-related cell death) in the peripheral blood and biological fluids of criticaly ill patients admitted to the ICU with a catastrrophy (severe infection, trauma ...) . Why ? If it turns out that this ferroptosis plays a role in the ocurrence of organ failure in the critially ill, this will lead to new therapies in the future as drugs become more and more available which can influene this biochemical \"pahway\". of iron-relatd death.",[27,28,29],"Sepsis","Trauma Related Injuries","Subarachnoid Haemorrhage (SAH)","RECRUITING","2025-04-07",{"date":33,"type":34},"2025-04-15","ACTUAL",{"date":36,"type":34},"2024-03-13",{"date":38,"type":21},"2026-08",{"name":40,"class":41},"University Hospital, Antwerp","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":51,"targetDuration":53,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":65,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":4},"100571890","the-nrc-dataset-developing-a-minimum-dataset-for-multidisciplinary-rehabilitation-a-modified-e-delphi-study-100571890","NCT06726135","The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study","The National Rehabilitation Centre Dataset. Development of a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study","Inclusion Criteria:\n\nThe panel will aim to include clinicians with a minimum of 5 years' experience from a variety of professional backgrounds within the following specialist areas:\n\n* Neuro Rehab\n* Trauma Rehab\n* Community Rehab\n* Outpatient Rehabilitation services\n* Defence medical services\n* Psychology services\n* Amputee Rehab\n* Speech and Language therapy\n* Emergency department\n* Critical Care\n* Trauma and Orthopaedics\n* Rehabilitation Medicine\n\nIt is expected that the expert panel will include:\n\n* Medical Doctors\n* Dietitians\n* Physiotherapists\n* Psychologists\n* Prosthetists\n* Occupational therapists\n* Speech and Language therapists\n* Data-base managers\n* Researchers\u002FAcademics\n* Commissioners\n* Local service managers\n* A department of work and pensions representative\n* An epidemiologist\u002Fdata-scientist with healthcare financial modelling experience\n\nExclusion Criteria:\n\nIndividuals will be excluded from the expert panel for any of the following reasons:\n\n1. They do not have 5 years' experience in their specialist field\n2. They do not have an understanding of various health indicators and the appropriate outcome measure instruments required to evaluate these health indicators.\n3. They have no understanding of how demographic and socio-economic variables impact health outcomes\n4. They have no understanding of how to evaluate clinical effectiveness and cost efficiency of inpatient rehabilitation services.\n5. Their professional background is not represented in the above noted specialist areas",true,{"count":52,"type":21},50,"6 Months","OBSERVATIONAL","Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated outcomes within a cohort of Major Trauma patients between 2015 and 2018 using data from two of these datasets. The NCASRI project outlined some of the shortcomings of the pre-existing datasets and highlighted the need for a single National Rehabilitation Dataset to provide long term evaluation of a variety of patient presentations.\n\nThe proposed study will seek to develop such a dataset by means of an E-delphi study. This study will seek consensus from a panel of experts on the data items required to measure the effectiveness and socio-economic impact of multidisciplinary inpatient rehabilitation. Providing commissioners, researchers and clinicians with the data required to improve patient care, conduct research and develop rehabilitation services.\n\nThere are three potential phases to this study:\n\n* Phase one involves the establishment of a core domain set, outlining what information (data) should be included in the NRC core dataset.\n* Phase one will consist of at least 2 rounds of voting, with successive rounds of voting undertaken until an a-priori consensus of 70% is reached for all core data items marked as mandatory\u002Fcritical data in fitting OMERACT guidelines.\n* After 2 rounds, any data item that have reached consensus will be included in the final dataset. These core domain (data items) will then be excluded from subsequent rounds of voting.\n* A maximum of 4 rounds will be allowed in Phase 1. At which point the highest-ranking data items remaining with a consensus above 60% from each of the pre-identified categories will be included in the final dataset.\n* Phase two will explore what tools should be used to collect the core domains (outcome measure instruments) for each category outlined in phase 1.\n* Phase 2 will follow the same protocol for including outcome measure instruments into the core outcome set as were required to include core data items from phase 1.\n* If a consensus of equal or greater than 60% cannot be reached using an E-Delphi method in either phase 1 or phase 2 then a virtual meeting will be held amongst all expert panel members to reach consensus using a nominal group technique (phase 3).",[57,58,59,60,61,62,63,64,28],"Pain","Traumatic Brain Injury","Major Trauma","Multiple Sclerosis","Amputees \u002F Rehabilitation","Spinal Cord Injuries (SCI)","Functional Neurological Disorder","Intensive Care Unit (ICU) Acquired Weakness (ICU - AW)",[66,67,68,69,70,71,72,73,74],"E-delphi","Delphi","Multidisciplinary","Rehabilitation","Core outcome set","Dataset","national rehabilitation centre","outcome measure instruments","inpatient","NOT_YET_RECRUITING","2024-12-15",{"date":78,"type":34},"2024-12-19",{"date":80,"type":21},"2025-01",{"date":82,"type":21},"2025-06",{"name":84,"class":41},"ThomasCorbett",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":108,"leadSponsor":110,"locationsCount":4},"100566982","phase-2-anti-xa-guided-dosing-of-low-molecular-weight-heparin-for-prevention-of-venous-thromboembolism-following-traumatic-injury-a-multicentre-pilot-randomized-trial-100566982","NCT06662253","Anti-Xa Guided Dosing of Low Molecular Weight Heparin for Prevention of Venous Thromboembolism Following Traumatic Injury: a Multicentre Pilot Randomized Trial","PrOVE iT","Inclusion Criteria:\n\n* Patients 18 years of age or older admitted to a hospital ward or intensive care unit following a traumatic injury involving two or more body systems (head, chest, abdomen, pelvis, extremity) and meeting at least one of the following high-risk criteria previously identified in a recent systematic review (1): age ≥ 65, body mass index ≥ 30 kg\u002Fm2, injury severity score ≥ 16, pelvic injury with activity restrictions, lower extremity injury with activity restrictions, or surgery during the index hospitalization.\n\nTo be eligible, patients must be deemed appropriate for pharmacologic prophylaxis by the most responsible physician and randomized with the intention to receive prophylaxis within 48 hours of admission. Prior to randomization, there is no restriction on whether or not patients have previously received pharmacologic or mechanical prophylaxis.\n\nExclusion Criteria:\n\n1. Greater than 7 days since time of injury.\n2. Requirement for therapeutic anticoagulation or dual-antiplatelet therapy\n3. Unable or unwilling to receive pharmacologic prophylaxis within 48 hours of admission.\n4. History of allergic reaction or sensitivity to LMWH.\n5. Thrombocytopenia with platelets \\< 30.\n6. Expected discharge or transfer from hospital within 72 hours.",{"count":93,"type":21},150,[95,96],"PHASE2","PHASE3","This multicentre pilot trial will assess the feasibility of a full-scale, randomized trial to determine whether bloodwork guided dosing of blood thinners reduces the risk of clotting in high-risk trauma patients. Patients will receive either standard of care dosing or dosing with adjustments based on bloodwork to achieve a minimum therapeutic threshold.",[99,28],"Venous Thromboembolism (VTE)",[101,102,103],"trauma","venous thromboembolism","prophylaxis","2024-10-24",{"date":106,"type":34},"2024-10-28",{"date":80,"type":21},{"date":109,"type":21},"2026-09",{"name":111,"class":41},"Alexandre Tran"]