[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"trauma-wounds\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:trauma-wounds":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":34,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100610154","phase-3-efficacy-of-carbonlife-amniotic-tissue-product-in-the-treatment-of-chronic-wounds-100610154",false,"NCT07223892","Efficacy of Carbonlife Amniotic Tissue Product in the Treatment of Chronic Wounds","A Prospective Controlled Trial Evaluating the Efficacy of Carbonlife Amniotic Tissue Product in the Treatment of Chronic Wounds: A Stratified Analysis by Wound Etiology and Care Setting","Inclusion Criteria:\n\n* Facilities and centers with the capacity to follow strict treatment and care guidelines for patients.\n* Adults aged 18 years or older.\n* Presence of a chronic wound (defined as a wound that has not shown significant improvement in 4 weeks) of any of the following etiologies: Diabetic foot ulcers, Venous leg ulcers, Arterial ulcers, Pressure ulcers, Burns, Trauma, Surgical\n* Wound size greater than 1 cm²\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Presence of active osteomyelitis\n* Untreated malignancy in the wound area\n* Known allergy to components of ATPs\n* Pregnant or breastfeeding women\n* Patients receiving immunosuppressive therapy\n* Patients with a life expectancy of less than 12 weeks","ALL","18 Years",{"count":19,"type":20},600,"ESTIMATED","INTERVENTIONAL",[23],"PHASE3","Chronic wounds constitute a significant global health burden, affecting millions of individuals and contributing to increased morbidity, diminished quality of life, and rising healthcare costs. These wounds are characterized by delayed healing and are often associated with complex etiologies and prolonged treatment courses. This study aims to evaluate the clinical efficacy and cost-effectiveness of Carbonlife amniotic tissue products (ATPs) compared to standard wound care in the management of chronic wounds. A prospective, controlled clinical trial will be conducted across diverse care settings and patient populations with varying wound etiologies. Participants will be stratified by wound type and treatment environment to enable subgroup analyses. The primary endpoint will assess wound healing outcomes, while secondary endpoints will include quality-of-life measures and healthcare resource utilization. The study is designed to generate high-quality evidence regarding the therapeutic value of ATPs in chronic wound management. Stratified analyses will provide insights into the differential effectiveness of ATPs across clinical contexts. Findings are anticipated to have implications for clinical practice guidelines and healthcare policy, with the goal of improving patient outcomes and optimizing resource allocation in wound care.",[26,27,28,29,30,31,32,33],"Chronic Wounds","Venous Leg Ulcers (VLUs)","Diabetic Foot Ulcers (DFUs)","Arterial Ulcers","Pressure Ulcers","Burn Wounds","Trauma Wounds","Surgical Wounds",[35],"chronic wounds","NOT_YET_RECRUITING","2025-11-04",{"date":39,"type":40},"2025-11-06","ACTUAL",{"date":42,"type":20},"2026-01-01",{"date":44,"type":20},"2028-03",{"name":46,"class":47},"Bardia Anvar","INDUSTRY",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":78},"100591295","comparative-efficacy-of-adm-hydrogel-vs-alginate-dressings-in-chronic-trauma-wounds-100591295","NCT06978569","Comparative Efficacy of ADM Hydrogel vs. Alginate Dressings in Chronic Trauma Wounds","A Randomized, Outcome Assessor-Blinded Clinical Trial Comparing the Efficacy of Acellular Dermal Matrix (ADM) Hydrogel Versus Alginate Dressings in the Treatment of Chronic Traumatic Wounds","Inclusion Criteria:\n\n* Chronic trauma wounds persisting ≥3 weeks.\n* Wound size between 4 and 20 cm² and depth ≤9 mm on the lower limbs.\n* Willingness and ability to provide informed consent.\n* Wounds without uncontrolled infection\n\nExclusion Criteria:\n\n* Wounds with exposed bone.\n* Current use of immunomodulators, corticosteroids, immunosuppressive or cytotoxic drugs.\n* Pregnant individuals.\n* Significant reduction (≥30%) of wound size during a 2-week run-in phase.\n* Concurrent participation in another clinical trial involving drugs.\n* Wounds with uncontrolled infection\n* Allergy or hypersensitivity to components of ADM gel or alginate","65 Years",{"count":57,"type":20},130,[59],"NA","The goal of this clinical trial is to find out whether a wound treatment made from acellular dermal matrix (ADM) gel can help heal chronic traumatic wounds more effectively than standard alginate dressings in adults aged 18 and older with wounds that have lasted more than 3 weeks.\n\nThe main questions it aims to answer are:\n\nDoes ADM gel reduce the size of chronic wounds more than alginate dressings after 12 weeks?\n\nDoes ADM gel help wounds heal faster and improve quality of life for patients?\n\nResearchers will compare ADM gel to alginate dressings to see if the ADM gel leads to better healing results and fewer complications.\n\nParticipants will:\n\nBe randomly assigned to receive either ADM gel or alginate dressing.\n\nHave the treatment applied directly to their cleaned wound.\n\nAttend weekly visits for up to 12 weeks for wound checks, measurements, and dressing changes.",[32],[63,64,65,66,67],"chronic wound","acellular dermal matrix","ADM","wound size","alginate","2025-05-11",{"date":70,"type":40},"2025-05-18",{"date":72,"type":20},"2025-07",{"date":74,"type":20},"2026-09",{"name":76,"class":77},"Isfahan University of Medical Sciences","OTHER",1]