[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"trauma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:trauma":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,84,0,25,[9,49,87,119,142,164,192,221,242,267,298,325,353,378,402,427,452,478,501,528,550,572,590,604,620],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100572913","hospital-based-continuous-patient-monitoring-system-100572913",false,"NCT06739447","Hospital Based Continuous Patient Monitoring System","Implementing a Hospital-based Continuous Patient Monitoring System Using Consumer Wearable Devices in Ghana","Inclusion Criteria:\n\n* Pediatric patients presenting with traumatic injury\n* Pediatric patients postoperative status after an appendectomy\n\nExclusion Criteria:\n\n* Pediatric patients missing their upper limbs,\n* Pediatric patients who cannot wear a Fitbit on their wrist for known allergies to rubber or those with traumatic or medical conditions that prevent them from being able to comfortably wear a Fitbit on either hand","ALL","3 Years","18 Years",{"count":21,"type":22},250,"ESTIMATED","INTERVENTIONAL",[25],"NA","In Ghana, and many other low and middle income countries in Africa, manual vital signs monitoring is the prevalent mode of vital signs monitoring because continuous bedside monitors are non-functional. This lack of continuous vital signs monitoring may result in missed opportunities to catch physiologic deterioration.\n\nThe investigators propose to develop a dashboard that is based on the Garmin Venu 3, a consumer wearable device that reliably measures heart rate, SPO2, and respiratory rate, as an alternative to bedside monitors in hospitals in Ghana.",[28,29,30,31],"Trauma","Appendectomy","Pediatric ALL","Vital Signs Monitoring",[33,34,35,36],"Garmin Venu 3","pediatric appendectomy","trauma","vital sign monitoring","NOT_YET_RECRUITING","2026-06-30",{"date":40,"type":41},"2026-07-02","ACTUAL",{"date":43,"type":22},"2026-09-01",{"date":45,"type":22},"2030-01-30",{"name":47,"class":48},"University of Alabama at Birmingham","OTHER",{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":12,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100644863","preventing-harmful-alcohol-use-among-trauma-patients-in-cameroon-100644863","NCT07677449","Preventing Harmful Alcohol Use Among Trauma Patients in Cameroon","Implementation of a Culturally Adapted Alcohol Screening, Brief Intervention and Referral to Treatment (SBIRT) Program in Cameroon","Inclusion Criteria:\n\n* Adult trauma patients aged 18 years and older presenting to the Emergency Department of Limbe Regional Hospital.\n* Positive alcohol screening based on the Single Alcohol Screening Question (SASQ).\n* AUDIT-C score ≥4 for men or ≥3 for women.\n* Able to provide informed consent.\n* Resident within the study catchment area and available for follow-up.\n* Access to a telephone or another reliable means of contact for follow-up assessments.\n\nExclusion Criteria:\n\n* Severe cognitive impairment preventing participation in study procedures or - provision of informed consent.\n* Severe traumatic brain injury or other medical condition requiring immediate life-saving intervention that precludes participation.\n* Current psychosis or severe psychiatric illness preventing meaningful participation in the intervention.\n* In police custody or other circumstances limiting ability to participate in follow-up.\n* Planned relocation outside the study catchment area during the study follow-up period.\n* Previously enrolled in the study.",{"count":57,"type":22},690,[25],"\\*\\*Brief Summary\\*\\*\n\nAlcohol use is a major contributor to injury burden in Cameroon, particularly among trauma patients presenting to emergency departments. Despite the strong association between alcohol use and injury, structured alcohol screening and intervention programs are not routinely integrated into trauma care in Cameroon. This study aims to evaluate a Cameroon-adapted Screening, Brief Intervention, and Referral to Treatment (SBIRT) program for trauma patients at the Limbe Regional Hospital.\n\nThe study will be conducted in three phases: (1) training emergency department healthcare providers on a culturally adapted SBIRT program; (2) evaluating the feasibility, acceptability, and fidelity of SBIRT implementation in routine emergency care; and (3) assessing the effectiveness of SBIRT in reducing harmful alcohol use among trauma patients. Healthcare workers will be trained to deliver SBIRT, and eligible trauma patients screening positive for risky alcohol use will be enrolled in a randomized waitlist-controlled trial. Participants will undergo alcohol screening using validated tools and will be followed for six months. Outcomes will include alcohol use measured by the Alcohol Use Disorders Identification Test (AUDIT), phosphatidylethanol (PEth) biomarker levels, referral uptake, implementation outcomes, and patient well-being measures.\n\nThe study is expected to generate evidence on the feasibility and effectiveness of integrating alcohol interventions into trauma care in a low-resource setting and inform future scale-up of SBIRT programs in Cameroon and similar settings.",[61,62,28],"Alcohol Use Disorder","Alcohol-Related Injury",[64,65,62,66,67,68,69,70,71,72,73,74,75,76,77],"Alcohol Use Disorder (AUD)","Alcohol Screening","Screening, Brief Intervention, and Referral to Treatment (SBIRT)","Brief Intervention","Emergency Department","Trauma Care","AUDIT-C","Referral to Treatment","Substance Use Intervention","Emergency Medicine","Implementation Science","Injury Prevention","Road Traffic Injury","Trauma Patients","2026-06-27",{"date":38,"type":41},{"date":81,"type":22},"2027-03",{"date":83,"type":22},"2030-08",{"name":85,"class":48},"University of Buea",1,{"id":88,"slug":89,"hasResults":12,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":94,"sex":17,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":4,"studyType":23,"phases":99,"briefSummary":100,"conditions":101,"keywords":105,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":4},"100540003","exploring-ptsd-symptoms-barriers-and-facilitators-to-mindfulness-100540003","NCT06311188","Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness","Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness-based Stress Reduction for Justice-Involved Black\u002FAfrican American Female Adolescents and Parents\u002FCaregivers","Inclusion Criteria:\n\n* Black girls aged 14-18\n* Black girls with a misdemeanor and\u002For felony charge in their lifetime\n* Positive PTSD screen (PC-PTSD score of 2 or more; if more than one JI BAFA are from the same family, the investigators will recruit the girl with the highest PTSD score)\n* Black girls report juvenile justice involvement within 12 months prior\n* Black girls live with a P\u002FC (mothers, fathers, and other caregivers\u002Flegal guardians) who will also participate in the study\n* Parents\u002FCaregivers nominated by the girls to participate in the study who are between the ages of 18 and 90 years of age\n* Legal\u002F social services providers \u002F educators who work with the population.\n\nExclusion Criteria:\n\n* Prisoners per the IRB definition\n* Black girls who are younger than 14 and older than 18\n* Severe cognitive delay so the youth cannot complete the assessment instruments, as measured using the Montreal Cognitive Assessment (MoCA)\n* Active psychosis requiring a greater level of care \\[Structured Clinical Interview for DSM Disorders (SCID)\\]. Screening for the study will take place prior to consent\u002Fassent of the study participants\n* Parents\u002FCaregivers who are not nominated by the girls to participate in the study who are not between the ages of 18 and 90 years of age\n* Legal\u002F social services providers \u002F educators who have been working with the population for less than three years.",true,"14 Years","90 Years",{"count":98,"type":22},90,[25],"The purpose of this study is to investigate justice-involved Black\u002FAfrican American female adolescents' (JI BAFAs; N=35) self-reported outcomes: stress, posttraumatic stress disorder (PTSD), recidivism, etc., as well as their parents\u002Fcaregivers' (P\u002FCs; N=35) stress and pre- and post- intervention results along with their views of an adapted intervention.",[102,28,103,104],"Stress","PTSD","HPA",[106,107,108,109],"Nonrandomized trial","Black girls","Legal system involvement","Cortisol Biomarker","2026-06-12",{"date":112,"type":41},"2026-06-16",{"date":114,"type":22},"2026-07-08",{"date":116,"type":22},"2027-01-31",{"name":118,"class":48},"University of Michigan",{"id":120,"slug":121,"hasResults":12,"nctId":122,"briefTitle":123,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":94,"sex":17,"minAge":19,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":23,"phases":128,"briefSummary":129,"conditions":130,"keywords":131,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":86},"100642529","litter-packaging-in-the-lateral-position-effects-of-position-and-vacuum-mattress-packaging-on-pulmonary-function-100642529","NCT07644793","Litter Packaging in the Lateral Position: Effects of Position and Vacuum Mattress Packaging on Pulmonary Function","Inclusion Criteria:\n\n* Subjects must be 18 to 65 years old. Per the harness manufacturer's recommendation, participants must weigh between 130 and 300 pounds and have a waist between 32 and 42 inches.\n\nExclusion Criteria:\n\n* Weight greater than 300 pounds or less than 130 pounds, pregnancy, any known heart condition or murmur or lower extremity edema or wheezing detected on pre-participation exam, or a waist size \\\u003C32\" or \\>42\". Prior to suspension, female participants of childbearing potential will self-administer an FDA approved urine pregnancy test supplied by the investigator. Results will be verified by the investigator.","65 Years",{"count":127,"type":22},24,[25],"This is a study to look at the effect on breathing of various ways to package a person in a rescue litter. We will measure lung function in a litter, lying down, lying down in a vacuum mattress, one the side in a vaccum mattress, and vertical in a vacuum mattress.",[28],[132,133,35],"pulmonary function","search and rescue","2026-06-08",{"date":110,"type":41},{"date":137,"type":22},"2026-08-15",{"date":139,"type":22},"2026-12-31",{"name":141,"class":48},"University of California, San Francisco",{"id":143,"slug":144,"hasResults":12,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":12,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":149,"targetDuration":151,"studyType":152,"phases":4,"briefSummary":153,"conditions":154,"keywords":4,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":86},"100630629","enteric-anastomoses-100630629","NCT07490158","Enteric Anastomoses","Enteric Anastomoses in Trauma","Inclusion Criteria:\n\n18 years old Included in the MDMC(Methodist Dallas Medical Center) Trauma Registry Any diagnosis code indicative of injury to the large and\u002For small bowel (S36.5 and\u002For S36.4)\n\nExclusion Criteria:\n\n\\\u003C18 years old Prisoners, pregnant persons, or other protected population.",{"count":150,"type":22},100,"5 Years","OBSERVATIONAL","This retrospective data repository will serve as a means to aggregate and analyze best practices as relative to traumatic colon injury outcomes.",[28],"RECRUITING",{"date":157,"type":41},"2026-06-10",{"date":159,"type":41},"2024-02-16",{"date":161,"type":22},"2028-01",{"name":163,"class":48},"Methodist Health System",{"id":165,"slug":166,"hasResults":12,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":12,"sex":17,"minAge":172,"maxAge":4,"enrollmentInfo":173,"targetDuration":4,"studyType":23,"phases":175,"briefSummary":177,"conditions":178,"keywords":181,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":4},"100643542","early-phase-1-clinical-evaluation-of-an-ai-risk-prediction-system-ai-trips-100643542","NCT07634185","Clinical Evaluation of an AI Risk Prediction System (AI-TRiPS)","Clinical Evaluation of an AI Risk Prediction and Decision Support System for Early Management of Injured Patients: a Stepped-wedge Cluster Randomised Trial","AI-TRiPS","Inclusion Criteria:\n\nClinician Participants\n\n* Senior clinical decision-maker involved in the initial trauma resuscitation (e.g. consultant or senior trainee in emergency medicine, anaesthesia, intensive care medicine, or surgery).\n* Based at one of the four participating Major Trauma Centres.\n* Able and willing to provide informed consent.\n* Completed the required study-specific training.\n\nTrauma Patients\n\n* Aged 16 years and above.\n* Treated and transported to a participating Major Trauma Centre by London's Air Ambulance.\n* Managed by one or more participating trauma clinicians during the resuscitation.\n\nExclusion Criteria:\n\nClinician Participants\n\n● Decline or withdraw informed consent at any stage.\n\nTrauma Patients\n\n* Aged under 16\n* Not treated by London's Air Ambulance.\n* Transported to a non-participating hospital.\n* Not managed by any participating clinicians.\n* Presenting with injuries resulting from burns, hangings, drownings, or isolated psychiatric emergencies.\n* Have registered a national NHS data opt-out or otherwise requested that their routine clinical data not be used for research.","16 Years",{"count":174,"type":22},1200,[176],"EARLY_PHASE1","The goal of this clinical study is to evaluate a software device and its impact on clinician behaviour during the initial management of trauma patients in a real-world clinical setting. Known as the AI-TRiPS Device this software uses real-time prehospital data and machine learning-based risk predictions which are displayed digitally for hospital trauma teams prior patient arrival.\n\nThe investigators will use a Stepped Wedge Cluster Randomised Controlled study design with an integrated process evaluation.\n\nThe Device will be deployed across the London Major Trauma System where the Major Trauma Centres will be the clusters. Each cluster will transition from control (standard care) to intervention at a pre-specified time (time of transition is randomised).\n\nPrimary Outcome: Clinician behaviour, assessed via the accuracy of risk prediction and clinician confidence.\n\nSecondary Outcome: Clinician acceptability, care process metrics, patient outcomes, and safety endpoints.\n\nPrimary study population: Hospital trauma clinicians, following initial resuscitation of each eligible trauma patient, who will complete electronic questionnaires.\n\nSecondary study population: Adult trauma patients, data will be collected for the duration of their index admission to hospital, to assess outcomes and enable comparison with clinician risk predictions.",[28,179,180],"Injury","Decision Support Systems, Clinical",[182,183],"Device trial, prediction tool, trauma","clinical decision support","2026-06-03",{"date":134,"type":41},{"date":187,"type":22},"2026-06-01",{"date":189,"type":22},"2027-12-01",{"name":191,"class":48},"Queen Mary University of London",{"id":193,"slug":194,"hasResults":12,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":12,"sex":17,"minAge":199,"maxAge":4,"enrollmentInfo":200,"targetDuration":4,"studyType":23,"phases":202,"briefSummary":203,"conditions":204,"keywords":209,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":220},"100573170","onyx-liquid-embolic-ide-clinical-study-100573170","NCT06742801","Onyx™ Liquid Embolic IDE Clinical Study","PELE IDE Clinical Study, Peripheral Onyx™ Liquid Embolic Safety and Effectiveness of The Onyx™ LES for Embolization of Arterial Hemorrhage in the Peripheral Vasculature","Inclusion Criteria:\n\n1. Patient is ≥ 22 years old.\n2. Active arterial bleeding in the peripheral vasculature confirmed by radiologic and\u002For endoscopic imaging and deemed suitable for embolization treatment by the investigator.\n\n   In this study, peripheral vasculature is defined as outside the brain and heart.\n3. Patient or legally authorized representative (LAR) is able to provide written consent to participate in the study.\n4. Life expectancy of \\>30 days, in the opinion of the investigator at the time of enrollment.\n5. Target treatment area is free from prior embolization treatment.\n\nExclusion Criteria:\n\n1. Pregnant or breastfeeding.\n2. Symptoms of active infection.\n3. Patient is known to be participating in the study of an investigational drug, biologic, or device.\n4. Contrast allergy or other contraindication to angiography, CT, or catheterization, including contrast sensitivity that cannot be adequately treated prior to index procedure.\n5. Known allergy to components of Onyx™.\n6. Target vasculature unsuitable for the delivery of Onyx™ based upon physician assessment.\n7. More than 4 target lesions will require embolization, in the investigator's opinion after imaging-based assessment.","22 Years",{"count":201,"type":22},119,[25],"The purpose of this study is to evaluate the safety and effectiveness of Onyx™ LES in the treatment of subjects with active arterial bleeding in the peripheral vasculature outside of the heart and brain.",[205,28,206,207,208],"Peripheral Arterial Hemorrhage","GI Bleed","Ulcer","Hemorrhage",[205,210],"Embolization treatment","2026-06-02",{"date":184,"type":41},{"date":214,"type":41},"2025-05-09",{"date":216,"type":22},"2027-05",{"name":218,"class":219},"Medtronic Endovascular","INDUSTRY",18,{"id":222,"slug":223,"hasResults":12,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":4,"eligibilityCriteria":227,"healthyVolunteers":12,"sex":17,"minAge":228,"maxAge":4,"enrollmentInfo":229,"targetDuration":4,"studyType":23,"phases":231,"briefSummary":232,"conditions":233,"keywords":4,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":235,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":86},"100556130","optimizing-recovery-in-trauma-patients-by-integrating-enhanced-nutrition-delivery-100556130","NCT06521086","Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery","Optimizing Recovery in Trauma Patients: Integrating Enhanced Nutrition Delivery With Muscle Assessments, Functional Outcomes and Quality of Life","Inclusion Criteria:\n\n* Patients who are at least 45 years old and presented to the Emergency Department as a leveled trauma\n* Patients who have the ability to tolerate oral nutrition\n* Patients who have had a standard of care CT scan this admission\n\nExclusion Criteria:\n\n* Expected withdrawal of life-sustaining treatment within 48 hours\n* Traumatic Brain Injury\n* Presence of lower extremity fracture(s)\n* Mechanical Ventilation\n* Subjects for who the Investigator would recommend a different supplement based on their medical condition.\n* Prisoner\n* Pregnancy for women of child-bearing potential","45 Years",{"count":230,"type":22},60,[25],"This is a prospective, randomized, controlled trial designed to evaluate the impact of enhanced protein supplementation compared to a standard of care nutrition delivery in critically ill older adult trauma patients. Subjects will be randomized 1:1 to either enhanced nutrition or control arm. Subjects randomized to the enhanced nutrition arm will receive oral nutrition supplements (ONS) up to 3 times per day while in the hospital and for 4 weeks after discharge. Subjects in the standard of care arm will receive normal nutrition recommendations from their clinical providers. Participants in both groups will undergo non-invasive tests that measure how much energy (calories) they are using, body composition, and muscle mass.",[28,234],"Critical Illness",{"date":184,"type":41},{"date":237,"type":41},"2026-02-18",{"date":239,"type":22},"2028-05-30",{"name":241,"class":48},"Duke University",{"id":243,"slug":244,"hasResults":12,"nctId":245,"briefTitle":246,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":12,"sex":17,"minAge":19,"maxAge":96,"enrollmentInfo":249,"targetDuration":4,"studyType":23,"phases":251,"briefSummary":253,"conditions":254,"keywords":255,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":259,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":266},"100512891","phase-2-calcium-and-vasopressin-following-injury-early-resuscitation-cavalier-trial-100512891","NCT05958342","CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial","CAVALIER","Inclusion Criteria:\n\nPrehospital Phase:\n\nInjured patients at risk of hemorrhagic shock being transported from scene or referral hospital to a participating CAVALIER trial site who meet the following criteria:\n\n1A. Systolic blood pressure ≤ 90mmHg and tachycardia (HR ≥ 108) at scene, at outside hospital, or during anticipated transport to a participating CAVALIER trial site\n\nOR\n\n1B. Systolic blood pressure ≤ 70mmHg at scene, at outside hospital, or during anticipated transport to a participating CAVALIER trial site\n\nEarly In-Hospital Phase:\n\nInjured patients at a participating CAVALIER trial site at risk of hemorrhagic shock who meet the following criteria:\n\n1A. Systolic blood pressure ≤ 90mmHg and tachycardia (HR ≥ 108) at scene, at outside hospital, during transport, or in emergency department of a participating CAVALIER trial site\n\nOR\n\n1B. Systolic blood pressure ≤ 70mmHg at scene, at outside hospital, during transport, or in emergency department of a participating CAVALIER trial site\n\nAND\n\n2.Blood\u002Fblood component transfusion initiated in prehospital setting or deemed clinically indicated within 60 minutes of arrival at the enrolling trauma center\n\nAND 3. Clinical team deems Operating Room for major hemorrhage control procedure (e.g., laparotomy, thoracotomy, vascular exploration or extremity amputation) indicated within 60 minutes of arrival at the enrolling trauma center\n\nAND\n\n4\\. Anticipated admission to intensive care unit (ICU)\n\nExclusion Criteria:\n\nPrehospital Phase\n\n1. Wearing NO CAVALIER opt-out bracelet\n2. Age \\> 90 or \\\u003C 18 years of age\n3. Isolated fall from standing injury mechanism\n4. Known prisoner\n5. Known pregnancy\n6. Traumatic arrest with \\> 5 minutes of CPR without return of vital signs\n7. Brain matter exposed or penetrating brain injury\n8. Isolated drowning or hanging victims\n9. Objection to study voiced by subject or family member at the scene or at the trauma center\n10. Inability to obtain IV\u002FIO access\n\nEarly In-Hospital Phase:\n\n1. Wearing NO CAVALIER opt-out bracelet\n2. Age \\> 90 or \\\u003C 18 years of age\n3. Isolated fall from standing injury mechanism\n4. Known prisoner\n5. Known pregnancy\n6. Traumatic arrest with \\> 5 minutes of CPR without return of vital signs\n7. Brain matter exposed or penetrating brain injury\n8. Isolated drowning or hanging victims\n9. Objection to study voiced by subject or family member at the scene or at the trauma center\n10. Inability to obtain IV access",{"count":250,"type":22},1050,[252],"PHASE2","The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) Trial is a proposed 4 year, double-blind, mutli-center, prehospital and early in hospital phase randomized trial designed to determine the efficacy and safety of prehospital calcium and early in hospital vasopressin in patients at risk of hemorrhagic shock.",[28,208],[256,35,257,258],"hemorrhagic shock","calcium gluconate","vasopressin",{"date":184,"type":41},{"date":261,"type":41},"2024-06-30",{"date":263,"type":22},"2028-03",{"name":265,"class":48},"Jason Sperry",15,{"id":268,"slug":269,"hasResults":12,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":94,"sex":274,"minAge":19,"maxAge":275,"enrollmentInfo":276,"targetDuration":4,"studyType":23,"phases":278,"briefSummary":279,"conditions":280,"keywords":284,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":294,"leadSponsor":296,"locationsCount":86},"100640077","trauma-informed-yoga-intervention-in-young-women-100640077","NCT07589777","Trauma-Informed Yoga Intervention in Young Women","Trauma-Informed Yoga Intervention: A Randomized Controlled Trial on Psychological Trauma, Emotion Regulation, and Interoceptive Awareness in Young Adult Women","Inclusion Criteria:\n\n* Being a woman aged 18-25 years\n* Providing voluntary written informed consent after being informed about the study\n* Scoring within the highest 25th percentile on the Transmitted Psychological Trauma Scale based on the pre-screening assessment, indicating high levels of trauma-related symptoms\n* Having no physical limitations that would prevent participation in weekly sessions and being medically eligible to engage in yoga practices\n* Agreeing to comply with the study protocol, including attendance at intervention sessions and completion of all assessments\n\nExclusion Criteria:\n\n* Inability to provide reliable responses due to the presence of active psychotic disorder, bipolar disorder, or severe cognitive impairment\n* Being in an acute psychological crisis\n* Initiation of intensive psychotherapy targeting trauma symptoms (e.g., trauma-focused therapy) within the past 3 months or participation in a similar structured psychosocial intervention during the study period\n* Presence of serious musculoskeletal, cardiovascular, or neurological conditions or injuries that would prevent participation in yoga, or medical restriction of physical activity by a physician\n* Having an established regular practice of yoga or meditation","FEMALE","25 Years",{"count":277,"type":22},46,[25],"The aim of this study is to evaluate the effects of a trauma-informed yoga intervention on psychological trauma symptoms, difficulties in emotion regulation, and interoceptive awareness in young adult women.",[28,281,282,283],"Young Adult Females","Awareness","Emotional Regulation",[285,286,287,288,289],"trauma-informed yoga","emotion regulation","interoceptive awareness","psychological trauma","randomized controlled trial","2026-05-09",{"date":292,"type":41},"2026-05-15",{"date":187,"type":22},{"date":295,"type":22},"2026-11-30",{"name":297,"class":48},"Saglik Bilimleri Universitesi",{"id":299,"slug":300,"hasResults":12,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":4,"eligibilityCriteria":304,"healthyVolunteers":94,"sex":274,"minAge":19,"maxAge":4,"enrollmentInfo":305,"targetDuration":4,"studyType":23,"phases":306,"briefSummary":307,"conditions":308,"keywords":313,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":322,"leadSponsor":324,"locationsCount":86},"100637653","prenatal-yoga-intervention-in-pregnant-women-100637653","NCT07585916","Prenatal Yoga Intervention in Pregnant Women","Effects of a Prenatal Yoga Intervention on Traumatic Childbirth Perception, Self-Perception, and Delivery Preferences in Pregnant Women","Inclusion Criteria:\n\n* Being at or beyond the 16th week of gestation (second trimester or later)\n* Being aged 18 years or older\n* Having no diagnosis of high-risk pregnancy based on obstetric evaluation\n* Having no medical restriction on physical activity or yoga practice as determined by a physician\n* Providing written informed consent after being informed about the study\n\nExclusion Criteria:\n\n* Diagnosis of high-risk pregnancy (e.g., preeclampsia, placenta previa, premature rupture of membranes, risk of preterm birth, or other serious obstetric complications)\n* Physician-imposed restriction on physical activity\n* Presence of serious systemic conditions that would prevent participation in yoga practice\n* Inability to complete the questionnaires reliably due to psychiatric or cognitive conditions\n* Declining to participate or not providing informed consent",{"count":277,"type":22},[25],"The aim of this study is to determine the effects of a prenatal yoga intervention on traumatic childbirth perception, self-perception, and delivery preferences in pregnant women.",[309,310,28,311,312],"Pregnant Women","Prenatal Yoga","Body Image","Delivery",[314,315,316,317,318],"perception of traumatic childbirth","body image","preferred mode of delivery","pregnant women","prenatal yoga",{"date":320,"type":41},"2026-05-14",{"date":292,"type":22},{"date":323,"type":22},"2026-12-30",{"name":297,"class":48},{"id":326,"slug":327,"hasResults":12,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":331,"eligibilityCriteria":332,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":333,"targetDuration":4,"studyType":23,"phases":335,"briefSummary":336,"conditions":337,"keywords":338,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":86},"100638171","data-driven-lay-first-responder-program-in-cameroon-100638171","NCT07581327","Data-Driven Lay First Responder Program in Cameroon","Implementation of a Data-Driven Pre-Hospital Lay First Responder Program in Cameroon","K-LFR Project","Inclusion Criteria:\n\n\\- Trauma patients presenting to Limbe Regional Hospital and enrolled in the Cameroon Trauma Registry\n\nExclusion Criteria\n\n\\- Trauma patients not included in the Cameroon trauma registry at Limbe regional hospital.",{"count":334,"type":22},1812,[25],"Cameroon experiences a high burden of injury-related morbidity and mortality and currently lacks a formal pre-hospital care system. Lay First Responder (LFR) programs have been implemented in several low-and middle-income countries to improve early injury care by training non-medical community members with high exposure to injury, such as commercial drivers, in basic first aid and safe transport of injured patients.\n\nThe study aims to implement and evaluate a data-driven, context-adapted LFR program in Cameroon using an implementation science approach. Quantitative trauma registry data and qualitative stakeholder interviews will be used to adapt the LFR curriculum to local injury patterns and care gaps. LFR program implementation will be associated with increased chances of survival on presentation and improved trauma outcomes.\n\nThe study is an interrupted time series evaluation of an LFR intervention where prehospital care rates and clinical patterns in the Cameroon Trauma Registry (CTR) patients at Limbe Regional hospital will be compared between historical pre-implementation controls and post-implementation of a data-driven lay first responder training program (the intervention).",[28,179],[339,28,340,76,341,342,343],"Lay First Resposnder","Pre-Hospital care","By-stander response","Trauma systems","Emergency Care","2026-05-05",{"date":346,"type":41},"2026-05-12",{"date":348,"type":22},"2026-09",{"date":350,"type":22},"2028-09",{"name":352,"class":48},"Sabrinah Christie",{"id":354,"slug":355,"hasResults":12,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":359,"eligibilityCriteria":360,"healthyVolunteers":12,"sex":17,"minAge":172,"maxAge":4,"enrollmentInfo":361,"targetDuration":4,"studyType":23,"phases":362,"briefSummary":363,"conditions":364,"keywords":365,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":371,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":376,"locationsCount":86},"100554146","swift-canada-study-of-whole-blood-in-frontline-trauma-100554146","NCT06495294","SWiFT Canada (Study of Whole Blood in Frontline Trauma)","SWiFT Canada (Study of Whole Blood in Frontline Trauma): A Pilot Randomized Controlled Trial Assessing Prehospital Whole Blood Versus Component Therapy in Traumatic Hemorrhage","SWiFTCanada","Inclusion Criteria:\n\n* Patient who has suffered a traumatic injury\n* Attended by a participating Ornge AAS clinical team\n* Requires prehospital blood transfusion to treat major traumatic hemorrhage\n\nExclusion Criteria:\n\n* Pediatric (age \\\u003C16 or transported to pediatric trauma centre \\[if age unknown\\])\n* No intravenous or intraosseous access (should be assessed prior to opening box)\n* Knowledge that patient will object to being given blood transfusion for any reasons\n* Blood already administered on-scene, prior to arrival of the participating Ornge AAS",{"count":230,"type":22},[25],"Traumatic injuries affect people of all ages, races, and socioeconomic backgrounds. The Global Burden of Disease study showed that globally in 2019, there were more than 4.4 million deaths due to injury. Furthermore, unintentional injuries are the leading cause of death for people aged 5-29 years worldwide. Uncontrolled bleeding accounts for a significant proportion of these deaths, with approximately 20% occurring in the first 24 hours and 40% occurring within the first 30 days.\n\nBlood transfusion is a life-saving treatment in the management of bleeding patients until bleeding is controlled in hospital, typically delivered through different blood components (red blood cells, plasma and platelets). These components are derived from a whole blood donation and are stored in separate bags (units). There are challenges in carrying separate blood products, such as additional weight in kit bags, and transfusing multiple blood products at the scene can delay transport to hospital.\n\nIn Ontario, Ornge Air Ambulance carries red blood cells and plasma to transfuse prehospital. However, a prehospital transfusion strategy has not been established and practice varies across the Canadian setting, and more broadly across the world.\n\nThis trial aims to investigate if carrying and transfusing two units of whole blood instead of four units (two red blood cells and two plasma) is feasible and leads to better outcomes for patients.",[28],[366,367,368,369],"prehospital","major hemorrhage","transfusion","emergency medicine","2026-04-29",{"date":372,"type":41},"2026-05-06",{"date":374,"type":41},"2024-12-16",{"date":81,"type":22},{"name":377,"class":48},"Unity Health Toronto",{"id":379,"slug":380,"hasResults":12,"nctId":381,"briefTitle":382,"officialTitle":382,"acronym":383,"eligibilityCriteria":384,"healthyVolunteers":94,"sex":274,"minAge":19,"maxAge":4,"enrollmentInfo":385,"targetDuration":4,"studyType":23,"phases":387,"briefSummary":388,"conditions":389,"keywords":4,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":394,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":86},"100532729","women-focused-encounters-for-resilience-independence-strength-and-eudaimonia-100532729","NCT06216600","Women Focused Encounters for Resilience Independence Strength and Eudaimonia","WE RISE","Inclusion Criteria:\n\n1. Is a woman\n2. Able to read and understand English\n3. Able to participate in a low intensity exercise program\n4. HIV-seropositive\n5. At risk substance use (any illegal or unprescribed drug), tobacco, marijuana or alcohol use (four or more drinks in one day or 8 or more in one week).\n6. Reports missing more ART doses than previous months, or \\> 5 in a month, or has a detectable HIV viral load\n7. Experienced interpersonal violence\n8. Able and willing to provide informed consent\n\nExclusion Criteria:\n\n1. Unwilling to participate in video record sessions (used to evaluate the quality of the intervention)\n2. Enrolled in hospice\n3. Not willing or not able to comply with study advisory board group participation agreement.",{"count":386,"type":22},300,[25],"The goal of this combination Type 1 hybrid and observational study is to evaluate the impact of a peer delivered intervention of acceptance and commitment therapy (ACT) + exercise + social support to address the substance (ab)use, violence, and AIDS\u002FHIV (SAVA) to improve medication adherence for women living with HIV (WLWH). This intervention will be implemented by community based organizations that focus on WLWH across four counties. The main question it aims to answer are:\n\n* Will peer provision of ACT, exercise, and social support improve medication adherence for WLWH?\n* Will community based organizations be able to sustain the intervention after research is completed, and what changes will need to be made to sustain the intervention.",[390,391,28,392],"HIV Infections","Substance Use","Medication Adherence","2026-04-27",{"date":395,"type":41},"2026-05-01",{"date":397,"type":41},"2024-09-19",{"date":399,"type":22},"2028-05-31",{"name":401,"class":48},"University of California, San Diego",{"id":403,"slug":404,"hasResults":12,"nctId":405,"briefTitle":406,"officialTitle":406,"acronym":407,"eligibilityCriteria":408,"healthyVolunteers":12,"sex":17,"minAge":172,"maxAge":4,"enrollmentInfo":409,"targetDuration":4,"studyType":23,"phases":410,"briefSummary":411,"conditions":412,"keywords":415,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":419,"lastUpdatePostDateStruct":420,"startDateStruct":421,"completionDateStruct":423,"leadSponsor":425,"locationsCount":86},"100575764","boosting-refugee-integration-through-psychological-intervention-100575764","NCT06776523","Boosting Refugee Integration Through Psychological Intervention","BRIGHT","The inclusion criteria for participating in the study are:\n\n* refugees and asylum seekers (RAS) aged 16 or older;\n* residing in one of the participating local sites (Swiss municipalities, namely, Gemeinden, and transitional asylum centers, namely, Durchgangszentren) where PM+ is offered and which gave their consent for participation in the RCT;\n* speaking at least one of the following 12 languages: German, English, French, Arabic, Farsi, Kurdish, Tigrinya, Turkish, Ukrainian, Russian, Tamil, and Pashto;\n* obtaining a score of 20 or higher on the Kessler Psychological Distress Scale (K10; Kessler et al., 2002), a brief clinically validated screening questionnaire that assesses general psychological distress in the past 30 days. A score equal to or higher than 20 is used as an indication of moderate to high levels of psychological distress.\n\nThe exclusion criteria for participating in the study are:\n\n* significant cognitive or neurological impairment measured through specific tools developed by the WHO and integrated into the PM+ manual (impairment questionnaire);\n* acute medical conditions or severe mental disorders (e.g., psychotic or substance-abuse disorders) measured through specific tools developed by the WHO and integrated into the PM+ manual (impairment questionnaire);\n* acute risk of suicide as measured by the Suicidal Ideation Attribution Scale (SIDAS; van Spijker et al., 2014) and the Thoughts of Suicide Questionnaire (World Health Organization WHO, 2016).",{"count":174,"type":22},[25],"Refugees and asylum seekers (RAS) face numerous stressors and adversities which put them at risk for developing mental health problems. However, access to adequate mental health care in host countries is limited. To address this problem, the World Health Organization (WHO) introduced Problem Management Plus (PM+), a short, low-intensity psychological intervention administered by non-professionals, aiming to alleviate common mental disorders among crisis-affected communities.\n\nThe present study aims at expanding the existing PM+ intervention by providing additional booster sessions and homework reminders while evaluating its effectiveness and implementation in the public health system.",[413,103,28,414],"Psychological Distress","Common Mental Health Problems",[416,413,417,418],"Problem Management Plus","Mental Health Care","Refugees","2026-04-21",{"date":393,"type":41},{"date":422,"type":41},"2025-01-16",{"date":424,"type":22},"2027-09",{"name":426,"class":48},"University of Zurich",{"id":428,"slug":429,"hasResults":12,"nctId":430,"briefTitle":431,"officialTitle":432,"acronym":4,"eligibilityCriteria":433,"healthyVolunteers":12,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":434,"targetDuration":4,"studyType":152,"phases":4,"briefSummary":436,"conditions":437,"keywords":440,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":419,"lastUpdatePostDateStruct":444,"startDateStruct":446,"completionDateStruct":448,"leadSponsor":450,"locationsCount":86},"100571429","mg-osteocrete-post-treatment-outcomes-100571429","NCT06720142","Mg OSTEOCRETE Post-Treatment Outcomes","Clinical and Radiographic Outcomes of Patients Treated With Mg OSTEOCRETE","Inclusion Criteria:\n\n* 18 years of age and older on the day of surgery\n* has received or will receive Mg OSTEOCRETE as a component of their treatment at this institution in accordance with Instructions for Use for the implanted product\n* Mg OSTEOCRETE is indicated for one of the following reasons:\n\n  1. as a bone void filler following bone tumor resection, or;\n  2. as an augment for defects causing aseptic loosening of orthopaedic implants, or;\n  3. to help substitute bone for trauma-related conditions\n\nExclusion Criteria:\n\n* any contraindication as per Instructions for Use for Mg OSTEOCRETE",{"count":435,"type":22},10,"Mg OSTEOCRETE is a bone substitute used to fill a defect in bone caused by excision of a tumor, orthopaedic hardware that has become loosened, or a trauma-related condition. The aim of this study is to determine the amount of time it takes for bone to heal after treatment with Mg OSTEOCRETE, and to better understand the efficacy of this treatment through clinical and patient-reported outcomes.",[438,28,439],"Cancer of Bone","Aseptic Loosening of Orthopaedic Hardware",[441,442,443],"bone defect","bone substitute","osteocrete",{"date":445,"type":41},"2026-04-22",{"date":447,"type":41},"2025-03-17",{"date":449,"type":22},"2028-03-17",{"name":451,"class":48},"Santiago Lozano-Calderon",{"id":453,"slug":454,"hasResults":12,"nctId":455,"briefTitle":456,"officialTitle":457,"acronym":458,"eligibilityCriteria":459,"healthyVolunteers":12,"sex":17,"minAge":172,"maxAge":460,"enrollmentInfo":461,"targetDuration":4,"studyType":152,"phases":4,"briefSummary":463,"conditions":464,"keywords":466,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":469,"lastUpdatePostDateStruct":470,"startDateStruct":472,"completionDateStruct":474,"leadSponsor":476,"locationsCount":86},"100533025","blunt-adrenal-gland-injury-bad-guy-project-100533025","NCT06220448","Blunt ADrenal Gland injUrY (BAD GUY) Project","Exploring the Epidemiology and Burden of Blunt Adrenal Gland Injury in the Context of Major Trauma","BADGUY","Inclusion criteria:\n\n* Age \\> 16 years old\n* All patients with blunt thoraco-abdominal trauma\n\nExclusion criteria:\n\n* TBI with AIS \\> 3\n* Isolated TBI and Spinal cord injury\n* Patients died in emergency department","99 Years",{"count":462,"type":22},5000,"Type: retrospective observational multicenter trial. Population of interest: adult patients suffering from thoraco-abdominal trauma undergoing both non-operative and operative management.\n\nHypothesis: Adrenal gland injury is a rare finding after blunt thoracoabdominal trauma. Short-term outcomes of blunt adrenal gland injury (BAGI) described in literature are contradictory. Reports on the outcomes related to this injury are variable and consider heterogeneous populations of trauma patients Aim: This study aims to explore the burden related to BAGI in an homogeneous population of patients sustaining blunt thoraco-abdominal trauma treated in different institution",[28,465],"Adrenal Gland Injury",[28,467,468],"blunt adrenal gland trauma","major trauma","2026-04-13",{"date":471,"type":41},"2026-04-16",{"date":473,"type":41},"2024-01-01",{"date":475,"type":22},"2027-09-30",{"name":477,"class":48},"Niguarda Hospital",{"id":479,"slug":480,"hasResults":12,"nctId":481,"briefTitle":482,"officialTitle":483,"acronym":4,"eligibilityCriteria":484,"healthyVolunteers":12,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":485,"targetDuration":4,"studyType":152,"phases":4,"briefSummary":487,"conditions":488,"keywords":4,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":491,"lastUpdatePostDateStruct":492,"startDateStruct":494,"completionDateStruct":496,"leadSponsor":497,"locationsCount":500},"100615286","comparative-outcomes-of-pcc-and-recombinant-activated-factor-viia-in-trauma-associated-massive-transfusion-100615286","NCT07290634","Comparative Outcomes of PCC and Recombinant Activated Factor VIIa in Trauma-Associated Massive Transfusion","Comparative Outcomes of Prothrombin Complex Concentrate and Recombinant Activated Factor VIIa in Trauma-Associated Massive Transfusion: A Retrospective Cohort Study","Inclusion Criteria:\n\n* Adults ≥18 years\n* Trauma patients directly admitted from the scene with highest-level trauma activation: Injury -Severity Score (ISS) \\>15.\n* Requirement for massive transfusion, defined as ≥3 units packed red blood cells (PRBC) within the first hour or ≥10 PRBC within the first 24 hours\n\nExclusion Criteria:\n\n* Traumatic cardiac injury\n* Death anticipated within the first hour of admission: ISS score \\>49\n* Pre-injury anticoagulant therapy\n* Known pregnancy\n* Pre-injury terminal illness",{"count":486,"type":22},4,"This study aims to compare the incidence of thromboembolic complications among trauma patients receiving PCC, rFVIIa, both agents, or neither during massive transfusion. Secondary objectives include comparing mortality, transfusion requirements, intensive care unit (ICU) and hospital length of stay, ventilator-free days, and the incidence of transfusion-associated adverse events such as transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO). Subgroup analyses will evaluate outcomes in patients with and without laboratory-confirmed TIC (INR \\>1.2).",[489,490,28],"Thromboembolus","Massive Blood Transfusion; Thrombocytopenia","2026-04-11",{"date":493,"type":41},"2026-04-14",{"date":495,"type":22},"2026-04-30",{"date":38,"type":22},{"name":498,"class":499},"Zeliha Alicikus","OTHER_GOV",2,{"id":502,"slug":503,"hasResults":12,"nctId":504,"briefTitle":505,"officialTitle":506,"acronym":507,"eligibilityCriteria":508,"healthyVolunteers":12,"sex":17,"minAge":509,"maxAge":510,"enrollmentInfo":511,"targetDuration":4,"studyType":23,"phases":513,"briefSummary":514,"conditions":515,"keywords":516,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":519,"lastUpdatePostDateStruct":520,"startDateStruct":522,"completionDateStruct":524,"leadSponsor":526,"locationsCount":86},"100589620","multiphase-optimization-strategy-most-for-treating-pediatric-post-traumatic-stress-disorder-ptsd-100589620","NCT06956781","Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)","Optimizing Behavioral Health Services Following Pediatric Trauma Exposure","MOST for PTSD","Inclusion Criteria:\n\nA child between the ages of 8-17 exposed to at least one DSM-defined trauma\n\nChild assent for participation\n\nThe participation of a caregiver with custodial rights to provide parental permission\n\nWilling to participate in treatment delivery and respond to surveys\n\nMeet PTSD diagnostic criteria that is the result of exposure to at least one of the identified traumas\n\nAbility to read and understand English\n\nWillingness to be randomized to an experimental condition\n\nPlacement in a stable caregiving environment for two months without an impending transition\n\nChildren currently taking psychotropic medications must have taken the medicine without dose adjustment for two months prior to study entry.\n\nCaregiver or child with a smartphone capable of downloading a freely available software application.\n\nExclusion Criteria:\n\nPsychiatric concerns requiring a higher level of care (e.g. suicidal ideation with intent; current psychotic disorder)\n\nAn intelligence quotient (IQ) \\\u003C 70\n\nCurrently receiving a behavioral health intervention for concerns related to PTSD or pediatric trauma\n\nA participating caregiver who is a perpetrator of any identified trauma (e.g. sexual abuse)\n\nMRI contraindicators (e.g. presence of metal in the body)","8 Years","17 Years",{"count":512,"type":22},200,[25],"The goal of this clinical trial is to test the extent to which different treatment components work to improve pediatric post-traumatic stress disorder (PTSD). It will also provide evidence for how these components work. The main research questions are:\n\nWhat are the effects of different components used to treat PTSD? What do these components change to produce benefits in PTSD?\n\nResearchers will:\n\nCompare components to a psychological placebo to estimate their effects and measure how they work\n\nExamine how components work alone and in conjunction with other components\n\nParticipants will:\n\nReceive different combinations of components and placebo\n\nAttend weekly treatment sessions\n\nProvide information to evaluate changes in PTSD",[103,28,30],[103,28,517,518],"Pediatric","Multiphase Optimization Strategy","2026-04-07",{"date":521,"type":41},"2026-04-08",{"date":523,"type":41},"2026-03-15",{"date":525,"type":22},"2028-08",{"name":527,"class":48},"University of Rochester",{"id":529,"slug":530,"hasResults":12,"nctId":531,"briefTitle":532,"officialTitle":532,"acronym":4,"eligibilityCriteria":533,"healthyVolunteers":12,"sex":17,"minAge":19,"maxAge":534,"enrollmentInfo":535,"targetDuration":4,"studyType":23,"phases":537,"briefSummary":539,"conditions":540,"keywords":4,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":519,"lastUpdatePostDateStruct":543,"startDateStruct":544,"completionDateStruct":546,"leadSponsor":548,"locationsCount":86},"100524782","phase-4-nonopioid-pain-control-regimen-after-open-reduction-and-internal-fixation-of-traumatic-fractures-100524782","NCT06113211","Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures","Inclusion Criteria:\n\n* All adult patients over age eighteen and scheduled for primary open reduction internal fixation following a traumatic fracture at Henry Ford Hospital (Detroit, Michigan, United States), and Henry Ford West Bloomfield Hospital (West Bloomfield, Michigan, United States) will be eligible for inclusion in this study. All patients will be met in our abulatory orthopedic clinics. All surgeries will be performed by a fellowship trained truama surgeons.\n\nExclusion Criteria:\n\n* patients with a medical history of known allergies or intolerance to allergies or intolerance to Motrin, Lyrica, Tylenol, tramadol, Zanaflex\n* substantial alcohol or drug abuse\n* pregnancy\n* history of narcotics within 6 months of surgery\n* renal impairment, peptic ulcer disease, GI bleeding.","80 Years",{"count":536,"type":22},75,[538],"PHASE4","An open reduction and internal fixation is a painful procedure requiring intensive postoperative pain management. Traditionally, opioid analgesia has been the gold standard for postoperative pain control. However, given the harmful side effect profile and opioid epidemic in the United States, it is advantageous to use alternate forms of analgesia. Multimodal pain control captures the effectiveness of different analgesic modalities and maximizes analgesia while minimizing side effects. The theory behind their use is that agents with different mechanisms of action work synergistically in preventing acute pain.\n\nObjective: To measure postoperative pain control in patients in two treatment arms of ORIF of the clavicle: a treatment group given a nonopioid pain control regimen, and a standard of care control group given standard opioid pain control regimen.\n\nStudy Design: A randomized single blinded standard of care controlled clinical trial comparing pain management interventions. All adult patients scheduled for an ORIF following a traumatic fracture by fellowship trained Trauma surgeons will be eligible for inclusion. Patients will be excluded if their medical history presents known allergies or intolerance to Motrin, Lyrica, Tylenol, Zanaflex, substantial alcohol or drug abuse, and pregnancy, history of narcotics within 6 months of surgery, renal impairment, peptic ulcer disease, GI bleeding.\n\nOn the day of surgery, patients will be randomized to receive a nonopioid pain control regimen or an opioid regimen using a computer-generated sequence.\n\nIf pain is uncontrolled, patients will also be sent home with a prescription with 10 pills of 5 mg of Oxycodone for breakthrough pain. The amount of oxycodone taken will be recorded. Patients can call the resident on call, available 24-hours per day, if additional pain control is needed.\n\nTreatment: All patients will undergo previously scheduled ORIF of the clavicle in standard fashion and be randomized to the non-narcotic pain regimen vs the narcotic pain regimen.",[541,542,28],"Opioid Use","Fractures, Bone",{"date":469,"type":41},{"date":545,"type":41},"2024-10-01",{"date":547,"type":22},"2026-09-15",{"name":549,"class":48},"Henry Ford Health System",{"id":551,"slug":552,"hasResults":12,"nctId":553,"briefTitle":554,"officialTitle":555,"acronym":4,"eligibilityCriteria":556,"healthyVolunteers":12,"sex":274,"minAge":19,"maxAge":557,"enrollmentInfo":558,"targetDuration":4,"studyType":23,"phases":560,"briefSummary":561,"conditions":562,"keywords":4,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":564,"lastUpdatePostDateStruct":565,"startDateStruct":567,"completionDateStruct":568,"leadSponsor":570,"locationsCount":86},"100630250","nitric-oxide-no-and-endothelial-dysfunction-in-women-with-ptsd-100630250","NCT07485231","Nitric Oxide (NO) and Endothelial Dysfunction in Women With PTSD","Role of Nitric Oxide (NO) in Endothelial Dysfunction in Premenopausal Women With Posttraumatic Stress Disorder (PTSD)","Inclusion Criteria:\n\n* Women ages 18-40 (female as defined biologically)\n* Premenopausal as indicated by self-report of menstrual cycles.\n* Trauma-exposed with or without PTSD. Diagnostic Criteria for both trauma exposure and PTSD will be obtained via clinical interview, medical records, and self-report.\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Diagnosis of major depression (MD).\n* Comorbid Psychiatric Conditions: Participants with other anxiety disorders, and bipolar disorder without psychotic features, mild to moderate traumatic brain injury, and borderline personality disorder will be included.\n* Medical records will also assist in the detection of current and lifetime comorbid psychiatric conditions.\n* Any over-the-counter medications must be held for 24 hours before each testing visit.\n\nThe PTSD groups must meet DSM-5 diagnostic criteria for PTSD assessed via the CAPS 5 (at least 6 symptoms: 1 B, 1 C, 2 D, and 2 E), with a total severity score of ≥25:\n\nWe will enroll participants as long as they are stable on meds (no changes within the past 3 months). Many participants are often on psychiatric meds, but still have PTSD symptoms. It really isn't that this is an untreated sample. It is more than that it includes people actively symptomatic, regardless of current treatment. Participants will not be required to stop any psychiatric medications.\n\nExclusion Criteria:\n\n* Non-biologically female people who may otherwise identify as women\n* Individuals who are taking hormone replacement therapy.\n* Pregnant, breastfeeding, or planning to become pregnant during the duration of the study\n* Individuals taking any types of hormonal contraceptives.\n* Self-reported Medical conditions: hypertension, diabetes, heart disease, vascular disease, ongoing illicit drug use, excessive alcohol use (\\>2 drinks per day), hyperlipidemia, autonomic dysfunction, any serious systemic disease, gastrointestinal disorders\n* Medications for PTSD or other cardiovascular diseases or any medication known to affect vascular function and central sympathetic output, such as antihypertensive medications (beta blockers, calcium channel blockers, angiotensin receptor blockers, angiotensin receptor inhibitors), corticosteroids, direct-acting vasodilators like nitrates and hydralazine, thyroid medications such as carbimazole, thyroxin.\n* Psychiatric Comorbidities: Ongoing substance abuse will be excluded because of the sympathoexcitatory effect of illicit drugs such as cocaine and methamphetamines that exert a powerful pressor and direct sympathoexcitatory effect. A report of a minimum of 6 months of non-drug use (recovery) will be required for those who have a history of illicit drug use\n* Psychotic and dissociative disorders will be excluded due to concerns regarding comprehension and adherence.\n* The inability or unwillingness to abstain from nicotine use for at least 12 hours prior to physiologic studies (visits 1 and 2), to eliminate sympathoexcitatory effects of nicotine (half-life of 2 hours).\n\nAny gastrointestinal complications, such as irritable bowel syndrome, and diseases such as celiac disease, irritable bowel syndrome. Any food allergy related to dietary nitrates. Any food allergy to nitrate-containing foods.","40 Years",{"count":559,"type":22},30,[25],"This research study is conducted to better understand why women with post-traumatic stress disorder (PTSD) have higher risk of cardiovascular disease as they get older. This study looks at how trauma and PTSD affect blood vessels in young women by testing whether the dietary supplement beetroot juice might help improve the function of blood vessels in women suffering from PTSD.",[563,28],"Post Traumatic Stress Disorder","2026-04-02",{"date":566,"type":41},"2026-04-03",{"date":237,"type":41},{"date":569,"type":22},"2028-05-01",{"name":571,"class":48},"University of Minnesota",{"id":573,"slug":574,"hasResults":12,"nctId":575,"briefTitle":576,"officialTitle":577,"acronym":4,"eligibilityCriteria":578,"healthyVolunteers":12,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":579,"targetDuration":151,"studyType":152,"phases":4,"briefSummary":580,"conditions":581,"keywords":4,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":582,"lastUpdatePostDateStruct":583,"startDateStruct":585,"completionDateStruct":587,"leadSponsor":589,"locationsCount":86},"100630630","traumatic-cardiac-arrest-100630630","NCT07490171","Traumatic Cardiac Arrest","Traumatic Cardiac Arrest Registry","Inclusion Criteria:\n\n≥18 years old Included in the MDMC Trauma Registry Cardiac arrest in pre-hospital setting or trauma bay\n\nExclusion Criteria:\n\n\\\u003C18 years old Prisoners, pregnant persons, or other protected population",{"count":150,"type":22},"This retrospective data repository will serve as a means to aggregate and analyze order of pre-hospital care (intubation, medication, etc) as it relates to Traumatic cardiac arrest.",[28],"2026-03-18",{"date":584,"type":41},"2026-03-24",{"date":586,"type":22},"2026-02",{"date":588,"type":22},"2028-02",{"name":163,"class":48},{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":595,"acronym":4,"eligibilityCriteria":596,"healthyVolunteers":12,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":597,"targetDuration":4,"studyType":152,"phases":4,"briefSummary":598,"conditions":599,"keywords":4,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":582,"lastUpdatePostDateStruct":600,"startDateStruct":601,"completionDateStruct":602,"leadSponsor":603,"locationsCount":86},"100630632","acute-subdural-hematoma-100630632","NCT07490197","Acute Subdural Hematoma","Acute Subdural Hematoma Registry","Inclusion Criteria:\n\n* ≥18 years old\n* Included in the Methodist Dallas Medical Center Trauma Registry\n* Acute subdural hematoma identified on computed tomography scan or magnetic resonance imaging of the brain in the trauma bay within 72 hours of a traumatic event\n\nExclusion Criteria:\n\n* \\\u003C18 years old\n* Prisoners, pregnant persons, or other protected population",{"count":150,"type":22},"This retrospective data repository will serve as a means to aggregate and analyze standard surgical interventions and Middle Meningeal Arteryembolization as suitable treatment options for Acute Subdural Hematoma.",[28],{"date":584,"type":41},{"date":586,"type":22},{"date":588,"type":22},{"name":163,"class":48},{"id":605,"slug":606,"hasResults":12,"nctId":607,"briefTitle":608,"officialTitle":609,"acronym":4,"eligibilityCriteria":610,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":611,"targetDuration":4,"studyType":152,"phases":4,"briefSummary":612,"conditions":613,"keywords":4,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":582,"lastUpdatePostDateStruct":614,"startDateStruct":615,"completionDateStruct":617,"leadSponsor":619,"locationsCount":86},"100630628","trauma-activation-criteria-100630628","NCT07490145","Trauma Activation Criteria","Trauma Activation Criteria Refinement","Inclusion Criteria:\n\nPatient is included in the Methodist Dallas Medical Center trauma registry. Trauma patients who recieved care at Methodist Dallas Medical Center between November 24, 2023 and November 25, 2025.\n\nExclusion Criteria:\n\nPatient does not meet registry inclusion criteria.",{"count":462,"type":22},"To quantify the over- and under-triage rates as relative to trauma activation criteria reform.",[28],{"date":584,"type":41},{"date":616,"type":41},"2024-11-24",{"date":618,"type":22},"2028-11",{"name":163,"class":48},{"id":621,"slug":622,"hasResults":12,"nctId":623,"briefTitle":624,"officialTitle":625,"acronym":4,"eligibilityCriteria":626,"healthyVolunteers":12,"sex":17,"minAge":509,"maxAge":19,"enrollmentInfo":627,"targetDuration":4,"studyType":23,"phases":629,"briefSummary":630,"conditions":631,"keywords":642,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":654,"lastUpdatePostDateStruct":655,"startDateStruct":657,"completionDateStruct":659,"leadSponsor":661,"locationsCount":86},"100630104","comparative-effectiveness-of-sparcs-and-unified-protocol-for-youth-with-chronic-medical-conditions-and-trauma-related-distress-100630104","NCT07483333","Comparative Effectiveness of SPARCS and Unified Protocol for Youth With Chronic Medical Conditions and Trauma-Related Distress","Supporting Purposeful Interventions & Resilience In Trauma (SPIRIT) Program: Implementing Trauma-Specific Screening and Stratified Interventions for Youth With a Chronic Medical Condition","Inclusion Criteria:\n\n* Youth (aged 8-18 years) who received a SPIRIT program psychological trauma screening and were deemed clinically appropriate for SPIRIT group therapy. Clinically appropriate means the youth can historically engage in a group setting (e.g., school, camp, therapy group) without significant disruption to the group process or other participants.\n* Youth and parent\u002Flegal guardian are willing and able to provide informed consent\u002Fassent for randomization.\n* Youth and parent\u002Flegal guardian are fluent in English or Spanish.\n* Youth is not currently engaged in individual therapy at the time of enrollment (per patient\u002Fparent report).\n\nExclusion Criteria:\n\n* Wards of the state or DCFS youth in care.\n* Youth with reported or observed symptoms that would significantly impair group therapy engagement, including but not limited to: intellectual disability, moderate-to-severe autism spectrum disorder, active suicidal ideation, uncontrolled psychosis, or other acute psychiatric symptoms that could disrupt the group process.\n* Regular use of alcohol or other substances that interfere with participation or disrupt the group process.\n* Youth requiring immediate higher-level psychiatric care (e.g., intensive outpatient programming, partial hospitalization, inpatient psychiatric admission, or residential treatment) at the time of first randomization.",{"count":628,"type":22},400,[25],"The goal of this clinical trial is to compare the effectiveness of trauma-focused therapies for improving mental health symptoms and daily functioning in youth with chronic medical conditions who have experienced psychological trauma and trauma-related distress. The study evaluates two evidence-based cognitive-behavioral therapies - Structured Psychotherapy for Adolescents Responding to Chronic Stress (SPARCS) and the Unified Protocol (UP) - delivered in group and individual formats to determine which approach, or combination of approaches, best reduces trauma symptoms and supports coping and adjustment. The study will also help researchers understand how to best support youth who continue to experience distress after an initial round of therapy.\n\nThe main questions it aims to answer are:\n\n* Does SPARCS group therapy or UP group therapy lead to greater improvements in trauma symptoms and functional impairment?\n* For youth who do not show enough improvement after group therapy, does adding SPARCS or UP individual therapy lead to better outcomes?\n* Which sequence of group and individual therapies leads to the greatest improvements in trauma symptoms and functioning?\n\nResearchers will compare two evidence-based therapies currently offered at Ann \\& Robert H. Lurie Children's Hospital of Chicago. Youth will first be randomly assigned to receive either SPARCS or UP in a group format. After completing group therapy, youth who still need additional support will be randomly assigned again to receive individual or family therapy using SPARCS or UP. This stepwise approach will help identify which sequence of therapies leads to the best overall outcomes for youth.\n\nParticipants will:\n\n* Take part in group therapy sessions using either SPARCS or UP\n* For those needing additional support after group therapy, participate in individual SPARCS or UP therapy\n* Complete brief assessments of mental health and daily functioning at enrollment, and every 12 weeks thereafter for 48 weeks, as part of their regular care through Ann \\& Robert H. Lurie Children's Supporting Purposeful Interventions \\& Resilience in Trauma (SPIRIT) program",[632,28,633,634,635,636,637,638,639,640,641],"Trauma Exposure","Trauma and Stressor Related Disorder","Mental Health Functioning","Chronic Medical Conditions","Chronic Medical Condition","Chronic Medical Illness","Posttraumatic Stress Disorder PTSD","Posttraumatic Stress Disorders","Posttraumatic Stress Symptoms","Posttraumatic Stress",[643,644,645,646,647,648,649,650,651,652,653],"pediatric trauma","posttraumatic stress disorder","chronic medical conditions","pediatrics","trauma symptoms","trauma and stressor related disorder","trauma informed care","Sequential, Multiple Assignment Randomized Trial","Supporting Purposeful Interventions and Resilience in Trauma","Unified Protocol","Structured Psychotherapy for Adolescents Responding to Chronic Stress","2026-03-16",{"date":656,"type":41},"2026-03-19",{"date":658,"type":22},"2026-07",{"date":660,"type":22},"2029-09-29",{"name":662,"class":48},"Anthony Vesco"]