[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"traumatic-brain-injury-tbi-concussion-initial-encounter\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:traumatic-brain-injury-tbi-concussion-initial-encounter":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,59,87],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":58},"100618010","safety-and-outcomes-of-muse-stem-cell-therapy-in-individuals-with-traumatic-brain-injury-100618010",false,"NCT07326059","Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury","An Observational Study on the Safety and Outcomes of MUSE Stem Cell Therapy in Participants With Traumatic Brain Injury Receiving International Clinical Treatment","MUSE-TBI-OBS","Inclusion Criteria:\n\nIndividuals aged 6 to 75 years at the time of enrollment.\n\nDocumented history of traumatic brain injury (TBI) occurring at least 6 months prior to enrollment (chronic phase).\n\nParticipant has independently elected to receive MUSE (Multilineage-differentiating Stress-Enduring) stem cell therapy at a licensed treatment facility outside the United States.\n\nAbility of the participant or legally authorized representative to provide informed consent for participation in an observational study.\n\nWillingness to participate in remote or in-person follow-up assessments for up to 12 months.\n\nAbility to provide medical records, laboratory reports, or treatment documentation when available.\n\nExclusion Criteria:\n\nIndividuals who have not received, and do not plan to receive, MUSE cell therapy as part of their independent medical care.\n\nInability or unwillingness to complete study assessments (e.g., severe communication barriers not manageable through caregiver assistance or technology).\n\nAny condition that, in the opinion of the study team, would make participation in an observational registry unsafe or infeasible (e.g., inability to provide minimal required data).\n\nPlanned participation in another research study that would prevent collection of observational outcomes for this registry.\n\nIndividuals currently incarcerated or in institutional settings where research participation is restricted.\n\n\\-","ALL","6 Years","75 Years",{"count":21,"type":22},10,"ESTIMATED","OBSERVATIONAL","This prospective observational study evaluates the safety profile and patient-reported outcomes associated with MUSE (Multilineage-differentiating Stress-Enduring) stem cell therapy in individuals aged 6 to 75 with chronic traumatic brain injury (TBI). Participants independently elect to receive MUSE cell treatment through international clinical programs, and this study aims to capture real-world evidence on the potential therapeutic effects and risks of this emerging regenerative approach.\n\nThe study does not administer any intervention. Instead, it follows participants who have received, or plan to receive, MUSE cell infusions outside the United States. Over a 12-month follow-up period, data will be collected on neurological functioning, quality of life, activities of daily living, and any reported adverse events or complications. Information will be gathered through remote interviews, structured digital surveys, and review of medical documentation when available.\n\nThis research is sponsored by Healing Hope International and is intended to contribute to the ethical and responsible advancement of novel cell-based therapies by generating real-world evidence that may guide future clinical trial development and inform patient care practices.",[26,27,28,29,30,31],"Traumatic Brain Injury","Traumatic Brain Injury (TBI) Patients","Traumatic Brain Injury (TBI); Concussion, Initial Encounter","Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter","Traumatic Brain Injury With Brief Loss of Consciousness","Traumatic Brain Injury With Persistent Cognitive Deficits",[33,34,35,26,36,37,38,39,40,41,42,43,44,45,46],"MUSE Cells","Stem Cell Therapy","Regenerative Medicine","Chronic Brain Injury","Acquired Brain Injury","Cell-Based Therapy","Neuroregeneration","Adult Neurorehabilitation","Medical Tourism","Observational Study","Real-World Evidence","Healing Hope International","Functional Recovery","Compassionate Use Registry","NOT_YET_RECRUITING","2026-03-08",{"date":50,"type":51},"2026-03-10","ACTUAL",{"date":53,"type":22},"2028-01",{"date":55,"type":22},"2036-06-30",{"name":44,"class":57},"OTHER",2,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":17,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":70,"conditions":71,"keywords":72,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":4},"100579924","acute-concussion-management-in-emergency-medicine-with-7t-mri-a-feasibility-study-100579924","NCT06830616","Acute Concussion Management in Emergency Medicine with 7T MRI: a Feasibility Study","ACME-7T","Inclusion Criteria:\n\n1. Isolated head trauma\n2. Initial review within 96h of injury\n3. No acute findings on CT head\n4. Aged 18-40 years\n\nExclusion Criteria:\n\n1. Patient unable to give informed consent\n2. Patient unable to speak and understand English\n3. Patients where alternative diagnosis cannot be excluded\n4. Polytrauma\n5. Contra-indication to MRI\n6. BMI \\>40 or unable to comfortably lie on MRI scanner\n7. Pregnant\n8. Major confounding neurological disease e.g Multiple sclerosis, Stroke, Parkinson's Disease.\n9. Patient participation in other research studies concurrently","18 Years","40 Years",{"count":69,"type":22},20,"The goal of this observational study is to learn about the brain imaging changes associated with concussion using a very detailed (7T) MRI scanner.\n\nTo do this, the investigators will study 7T MRI brain imaging in patients aged 18-40 who present to the Emergency Department within 96 hours of a head injury. Patients will be eligible if they have had a normal CT brain as part of their usual care.\n\nThe investigators will compare brain imaging from patients who have completely recovered from an episode of concussion to patients who still have significant symptoms at approximately 28 days after a head injury.\n\nThe study attempts to answer the following questions:\n\n1. Do patients with ongoing symptoms after concussion show greater 7T MRI brain imaging evidence of changes to the blood vessels at approximately 28 days after their injury in comparison to patients who have recovered fully?\n2. Do patients with ongoing symptoms after concussion show greater 7T MRI brain imaging evidence of changes in brain signaling pathways at approximately 28 days after their injury, in comparison to patients who have recovered fully?",[28],[73,74,75,76,77],"concussion","7T MRI","head injury","mildTBI","MRI brain","2025-02-18",{"date":80,"type":51},"2025-02-20",{"date":82,"type":22},"2025-02",{"date":84,"type":22},"2025-11",{"name":86,"class":57},"NHS Greater Glasgow and Clyde",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":66,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":97,"conditions":98,"keywords":99,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":114},"100576875","wearable-device-based-analysis-of-the-relationship-between-sleep-patterns-and-clinical-prognosis-in-patients-with-traumatic-brain-injury-100576875","NCT06790979","Wearable Device-Based Analysis of the Relationship Between Sleep Patterns and Clinical Prognosis in Patients With Traumatic Brain Injury","Wearable Device-Based Analysis of the Relationship Between Sleep Patterns and Clinical Prognosis in Patients With Mild to Moderate Traumatic Brain Injury","Inclusion Criteria:\n\n1. 18\\~60 years old.\n2. The patient had no sleep disturbance problems prior to traumatic brain injury.\n3. The patient has a definite diagnosis of traumatic brain injury and the Glasgow score is \\>8.\n4. The patient had abnormal imaging scans.\n5. It has complete preclinical data.\n\nExclusion Criteria:\n\n1. Patients with a previous history of traumatic brain injury, mental illness, alcohol abuse or sleep disorders.\n2. Patients admitted for surgical intervention.\n3. Patients with a combination of other heavy visceral injuries.\n4. Women during pregnancy and lactation.\n5. The patents' use of medications that interfere with sleep","60 Years",{"count":96,"type":22},50,"In patients with traumatic brain injury, post-traumatic sleep patterns have the potential to impact clinical prognosis. While some progress has been made in the study of sleep and prognosis in patients with traumatic brain injury, there is still lack of research on the relationship between sleep and clinical prognosis in post-traumatic patients due to differences in study design, patient age, severity of trauma, and definitions of sleep disorders. Additionally, the primary data collection methods employed in most studies have been self-reported sleep assessments, which are subject to potential biases and inaccuracies. Therefore, explore the impact of sleep patterns on clinical prognosis in post-traumatic patients, with potential to advance our comprehension of recovery outcomes in this patient group.",[28],[100,101,102,103],"Traumatic brain injury","Sleep","Prognosis of trauma","Wearable devices","RECRUITING","2025-01-18",{"date":107,"type":51},"2025-01-24",{"date":109,"type":51},"2024-10-01",{"date":111,"type":22},"2025-10-30",{"name":113,"class":57},"General Hospital of Ningxia Medical University",1]