[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"trismus\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:trismus":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,46,75,110,134,163,191,215,244,266],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100635613","phase-4-effect-of-preoperative-submucosal-dexamethasone-on-postoperative-discomfort-after-mandibular-third-molar-surgery-100635613",false,"NCT07554963","\"Effect of Preoperative Submucosal Dexamethasone on Postoperative Discomfort After Mandibular Third Molar Surgery\"","Effect of Preoperative 4 mg Submucosal Dexamethasone on Postoperative Discomfort After Impacted Mandibular Third Molar Surgery: A Randomized Controlled Trial","DEXA-M3M","Inclusion Criteria:\n\n* Adults aged 18 to 55 years\n* Patients requiring surgical extraction of impacted mandibular third molars\n* Patients willing to provide informed consent\n\nExclusion Criteria:\n\n* Patients with systemic diseases\n* Patients with periodontal disease\n* Pregnant or lactating women\n* Patients who have used antibiotics or anti-inflammatory drugs within the past 7 days\n* Patients with known hypersensitivity to dexamethasone","ALL","18 Years","55 Years",{"count":21,"type":22},268,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","This study aims to determine whether giving a single dose of dexamethasone before surgery can reduce pain and difficulty in opening the mouth after removal of an impacted lower wisdom tooth. Pain and limited mouth opening are common problems after this procedure and can affect eating, speaking, and daily activities.\n\nA total of 268 patients aged 18 to 55 years who require surgical removal of an impacted mandibular third molar will be included. Participants will be randomly assigned to one of two groups. One group will receive a 4 mg dexamethasone injection under the gum before surgery, while the other group will not receive this medication. All patients will undergo the same surgical procedure and receive standard postoperative care.\n\nPain will be measured using a visual analogue scale, and mouth opening will be assessed using a standard measuring method. These outcomes will be recorded on the second and seventh days after surgery.\n\nThe results of this study will help determine whether preoperative dexamethasone is an effective and simple method to reduce postoperative discomfort and improve recovery after third molar surgery.",[28,29,30],"Impacted Mandibular Third Molar","Postoperative Pain","Trismus",[32,33,34,29],"Dexamethasone","Third Molar Surgery","Impacted Tooth","NOT_YET_RECRUITING","2026-04-27",{"date":38,"type":39},"2026-05-01","ACTUAL",{"date":38,"type":22},{"date":42,"type":22},"2026-10-01",{"name":44,"class":45},"Hayat Abad Medical Complex, Peshawar","OTHER_GOV",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":74},"100556897","feasibility-of-prospective-surveillance-and-early-physical-therapy-for-trismus-100556897","NCT06531083","Feasibility of Prospective Surveillance and Early Physical Therapy for Trismus","Feasibility of PRospective Surveillance and Early PhysiCal Therapy for TrIsmuS in Individuals With Head and Neck CancEr: A Single-Group Feasibility Trial (PRECISE)","PRECISE","Inclusion Criteria:\n\n* Have a diagnosis of oral, oropharyngeal, or nasopharyngeal cancer\n* Be scheduled to undergo cancer treatment that includes radiation therapy\n* Be able to read and understand English\n* Be an Alberta resident.\n\nExclusion Criteria:\n\n* Previous surgery for the temporomandibular joint that is not related to the HNC diagnosis.\n* Local cancer recurrence or metastatic disease.\n* Unable to provide informed consent.",{"count":55,"type":22},30,[57],"NA","Trismus, or restricted jaw movement, can occur in individuals with head and neck cancer (HNC) undergoing surgery or radiation therapy. There is a paucity of research examining interventions for trismus. We aim to assess the feasibility of prospective surveillance and early intervention to mitigate trismus in individuals undergoing HNC treatment.\n\nMethod: The investigators will conduct a pilot single group feasibility study involving 30 individuals with HNC who will be undergoing radiation therapy. Participants will be identified at the HNC new patient clinic. Participants will be seen weekly during radiation therapy and will receive early intervention including manual therapy and a device-based jaw exercise regimen if presenting with 5% or greater reduction in jaw opening compared to pre-treatment.\n\nThe investigators will assess recruitment and completion rates, intervention acceptability, and data collection procedures. Descriptive statistics will summarize feasibility metrics and participant demographics. Findings will inform the design of a larger multicentre trial.",[60,30],"Head and Neck Cancer",[62],"Physical Therapy","RECRUITING","2026-04-03",{"date":66,"type":39},"2026-04-06",{"date":68,"type":39},"2025-03-01",{"date":70,"type":22},"2026-08-31",{"name":72,"class":73},"University of Alberta","OTHER",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":17,"minAge":18,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":74},"100611703","aescin-based-herbal-extract-reparil-for-postoperative-sequelae-after-mandibular-third-molar-surgery-100611703","NCT07244029","Aescin-Based Herbal Extract (Reparil) for Postoperative Sequelae After Mandibular Third Molar Surgery","Evaluation of Aescin-Based Herbal Extracts for Managing Postoperative Sequelae Following Impacted Mandibular Third Molar Surgery: A Randomized, Single-Blind, Controlled Trial","Reparil","Inclusion Criteria:\n\n* Patients indicated for surgical removal of impacted mandibular third molars according to National Institute for Health and Care Excellence (NICE) guidelines.\n\nAge between 18 and 40 years.\n\nImpacted mandibular third molars with similar anatomical position and difficulty level as classified by Pell and Gregory and Pederson scoring.\n\nHealthy individuals (ASA I-II) with no significant systemic illness.\n\nWilling to provide written informed consent and attend all follow-up visits (Day 2 and Day 7 post-surgery).\n\nExclusion Criteria:\n\n* Recent use (within three weeks preoperatively) of anti-inflammatories, corticosteroids, or antibiotics.\n\nKnown allergies or hypersensitivity to Aescin, Ibuprofen, rescue medications, or local anesthetics.\n\nPregnant or lactating women.\n\nPatients with contraindications to NSAIDs (e.g., asthma, bleeding disorders, chronic kidney disease, active peptic ulcer, or cardiovascular disease).\n\nRecent use of substances that may affect surgery or interact with study drugs (e.g., contraceptives, alcohol, or tobacco).\n\nSurgical time exceeding 30 minutes or cases with intraoperative complications requiring non-study medications.",true,"40 Years",{"count":86,"type":22},100,[57],"This randomized, single-blind, controlled clinical trial aims to evaluate the efficacy and safety of Aescin-based herbal extract (Reparil®) compared with Ibuprofen in managing postoperative sequelae following surgical removal of impacted mandibular third molars. A total of 100 participants aged 18-40 years will be enrolled at the Dental Center, Medical City Hospital for Military and Security Services (MCMSS), Al Khoud, Oman. Participants will be randomly assigned to receive either Reparil® (Aescin 20 mg, three times daily for five days) or Ibuprofen (400 mg, three times daily for five days) following standardized third molar extraction procedures. Postoperative outcomes including pain (VAS), facial swelling (3D facial scanner), and mouth opening (digital caliper) will be assessed preoperatively, on day 2, and day 7 post-surgery. The study aims to determine whether Aescin offers comparable analgesic and anti-edematous effects to Ibuprofen with fewer adverse events.",[29,90,30],"Facial Swelling",[92,93,81,94,95,96,97,98,99,100],"Aescin","Escin","Ibuprofen","Herbal anti-inflammatory","Postoperative sequelae","Third molar extraction","Oral surgery","Phytotherapeutic agents","Pain management","2026-01-13",{"date":103,"type":39},"2026-01-15",{"date":105,"type":39},"2026-01-01",{"date":107,"type":22},"2026-09-30",{"name":109,"class":45},"Oman Medical Speciality Board",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":83,"sex":17,"minAge":4,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":121,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":74},"100618141","comparison-of-two-different-suture-knot-techniques-on-post-operative-trismus-and-swelling-after-impacted-third-molar-surgery-100618141","NCT07327762","Comparison of Two Different Suture Knot Techniques on Post-Operative Trismus and Swelling After Impacted Third Molar Surgery","COMPARISON OF TWO DIFFERENT SUTURE KNOT TECHNIQUES ON POST-OPERATIVE TRISMUS AND SWELLING AFTER IMPACTED THIRD MOLAR SURGERY","Impacted molar","Inclusion Criteria:\n\n* • Healthy individuals\n\n  * Gender: male and female\n  * Age: 18-45 years\n  * Mandibular third molar impaction all positions\n  * Mandibular third molar impaction all classes\n\nExclusion Criteria:\n\n* • Patients with ASA status III and above\n\n  * Patients requiring multiple extractions in same appointment\n  * Patients allergic to Lignocaine\n  * Patients in whom adrenaline is contraindicated\n  * Medically compromised individual such as those with poorly controlled diabetes, hypertension and pregnancy, etc.","45 Years",{"count":120,"type":22},60,[57],"To compare the two different suture knot techniques, locked and unlocked, in terms of mean on postoperative trismus and swelling after impacted mandibular third molar surgery.",[30,124],"Swelling","2025-12-25",{"date":127,"type":39},"2026-01-08",{"date":129,"type":22},"2026-07-01",{"date":131,"type":22},"2027-01-31",{"name":133,"class":73},"Watim Medical & Dental College",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":83,"sex":17,"minAge":18,"maxAge":141,"enrollmentInfo":142,"targetDuration":4,"studyType":23,"phases":144,"briefSummary":145,"conditions":146,"keywords":149,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":74},"100606818","evaluation-of-the-effect-of-tea-tree-and-chlorhexidine-mouthwashes-on-healing-after-third-molar-extraction-100606818","NCT07180498","Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar Extraction","The Evaluation of the Effects of Chlorhexidine and Tea Tree Oil Mouthwash on Postoperative Complications and Periodontal Healing After the Extraction of Impacted Third Molars","Inclusion Criteria:\n\n* Individuals undergoing extraction of Class 2, Class B mandibular third molars impacted in the lower jaw (Pell \\& Gregory).\n* Individuals aged 18-65.\n* Individuals must be in stable general health (e.g., free of serious cardiovascular or kidney disease).\n* Individuals willing to use tea tree extract or other treatments.\n\nExclusion Criteria:\n\n* Individuals with a known allergy or hypersensitivity to tea tree extract.\n* Individuals with serious illnesses such as heart failure or kidney disease. Patients with bleeding disorders.\n* Individuals during pregnancy and breastfeeding.\n* Individuals taking medications that may interact with tea tree extract (e.g., blood thinners or antihypertensives)\n* Individuals previously treated for edema.\n* Individuals with chronic edema.","65 Years",{"count":143,"type":22},54,[57],"The purpose of this clinical study is to compare the effects of mouthwashes containing Chlorhexidine and tea tree oil on edema, pain, and trismus after the extraction of impacted third molars. Additionally, the effects on periodontal health will be examined by comparing the gum healing processes of patients using both mouthwashes.The main questions it aims to answer are:\n\n1. Tea tree oil, said to have anti-inflammatory and antibacterial effects, could be an alternative to chlorhexidine in reducing postoperative complications after impacted tooth extraction.\n2. Does tea tree oil, which has antimicrobial effects, have as positive an impact on periodontal health as chlorhexidine?Researchers will compare tea tree oil to chlorhexidine (routinely prescribed after the extraction of an impacted wisdom tooth) to see if tea tree oil works to decrease postoperative complications.\n\nParticipants will:\n\nFor 7 days after the operation, they will gargle with chlorhexidine mouthwash or mouthwash containing tea tree oil 3 times a day. They will come to the clinic for check-ups and measurements on the 2nd and 7th days after the operation. They will record their pain levels and the number of painkillers they take daily.",[29,147,30,148],"Postoperative Complications","Periodontal Health",[150,151,152,153],"tea tree oil","third molar surgery","postoperative complications","chlorhexidine digluconate","2025-09-15",{"date":156,"type":39},"2025-09-18",{"date":158,"type":39},"2025-04-15",{"date":160,"type":22},"2025-12-30",{"name":162,"class":73},"Harran University",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":23,"phases":173,"briefSummary":174,"conditions":175,"keywords":178,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":74},"100593451","hilotherapy-vs-kinesio-taping-in-orthognathic-surgery-recovery-100593451","NCT07006610","Hilotherapy vs. Kinesio Taping in Orthognathic Surgery Recovery","Comparison of the Effects of Hilotherapy and Kinesio Taping on Edema, Pain, and Trismus After Orthognathic Surgery","Inclusion Criteria:\n\n* Patients scheduled to undergo bimaxillary orthognathic surgery (Le Fort I + BSSRO)\n* Age between 18 and 50 years\n* No systemic disease\n* Voluntary participation with signed informed consent\n\nExclusion Criteria:\n\n* Presence of systemic disease or immunosuppressive medication\n* Known allergy to kinesio tape\n* Inability to attend follow-up appointments\n* Facial anatomical deformities preventing measurement","50 Years",{"count":172,"type":22},36,[57],"This prospective randomized controlled trial aims to compare the effects of kinesio taping and hilotherapy on postoperative edema, pain, and trismus in patients undergoing bimaxillary orthognathic surgery.",[176,29,30,177],"Postoperative Edema","Orthognathic Surgery",[179,180,177,147,181],"Hilotherapy","Kinesio Taping","Postoperative Recovery","2025-05-27",{"date":184,"type":39},"2025-06-05",{"date":186,"type":39},"2024-09-15",{"date":188,"type":22},"2025-07-15",{"name":190,"class":73},"Medipol University",{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":23,"phases":201,"briefSummary":202,"conditions":203,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":214},"100527462","manual-therapy-on-oral-opening-swallow-function-and-upper-quarter-mobility-on-head-and-neck-cancer-survivors-100527462","NCT06148077","Manual Therapy on Oral Opening, Swallow Function and Upper Quarter Mobility on Head and Neck Cancer Survivors","Effects of Manual Therapy on Oral Opening, Swallow Function, and Upper Quarter Mobility in Chilean Survivors of Head and Neck Cancer: A Study Protocol for a Controlled, Randomized Study (MATEO Study, MAnual ThErapy for Oral Opening).","MaTeO","Inclusion Criteria:\n\n* individuals with HNC\n* individuals over 18 years of age\n* individuals who have undergone oncological surgery of the head and neck and\u002For radiotherapy\n* having finished oncological medical treatment between 3 and 36 months before inclusion\n* having a medical diagnosis of trismus and\u002For TMD and\u002For cervical or shoulder dysfunction\n* Spanish native speakers\n\nExclusion Criteria:\n\n* sequelae of previous stroke\n* structural instability and\u002For osteoporosis of the cervical spine, spondylosis, cervical herniated discs\n* active osteoradionecrosis or open wounds (fistulas, soft tissue necrosis) in the anatomical treatment area\n* tracheostomized individuals\n* metastasis or active cancer\n* refuse to participate.",{"count":200,"type":22},70,[57],"Trismus has been reported as the second most common comorbidity in survivors of head and neck cancer (HNC). It is mainly associated with post-radiotherapy subcutaneous fibrosis, muscular atrophy, damage to neurological structures in the neck, or a combination of all, affecting masticatory musculature. In addition to this, the loss of flexibility and strength in the shoulder has also been shown to be related to deficits in the function and quality of life of these patients.\n\nThe goal of this clinical trial is to determinate the effectiveness and safety of Manual Therapy (MT) on Oral Opening, Swallow Function, as well as the mobility of the upper quarter, the strength of cervical musculature, pain, functionality, and the perception of quality of life in head and neck cancer survivors.\n\nParticipants will be assigned randomly to the study groups: a) manual therapy program and control motor exercises and b) motor control exercises (usual care).\n\nThe assessment refers to a baseline form (at the beginning of the study), at 6 weeks and at 6 weeks of patient follow-up.",[60,30,204],"Dysfunction","2025-05-23",{"date":207,"type":39},"2025-05-30",{"date":209,"type":39},"2024-09-25",{"date":211,"type":22},"2025-10-01",{"name":213,"class":73},"Universidad de La Frontera",2,{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":141,"enrollmentInfo":222,"targetDuration":4,"studyType":23,"phases":224,"briefSummary":225,"conditions":226,"keywords":228,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":74},"100589363","phase-4-the-effect-of-dexamethasone-submucosal-injection-after-surgical-extraction-of-lower-impacted-third-molars-on-trismus-and-edema-100589363","NCT06953440","The Effect of Dexamethasone Submucosal Injection After Surgical Extraction of Lower Impacted Third Molars on Trismus and Edema","The Effect of Dexamethasone Submucosal Injection After Third Molar Surgery on Trismus and Edema","Inclusion Criteria:\n\n* Patients with impacted lower third molars requiring surgical extraction.\n* Adults over the age of 18 years old.\n* American Society of Anaesthesiologists (ASA) 1, and ASA 2\n\nExclusion Criteria:\n\n* Patients with preoperative intraoral or extraoral swelling.\n* Patients requiring simple extraction (Class I group A according to Pell and ---Gregory classification).\n* Patients with uncontrolled systemic disease such as uncontrolled diabetic - patients.\n* Patients who are allergic to corticosteroids.\n* Patients who are contraindicated to use corticosteroids such as uncontrolled diabetic patients, and osteoporotic patients.\n* Patients who require extraction of additional teeth at the same visit.",{"count":223,"type":22},66,[25],"This clinical trial aims to investigate whether dexamethasone decreases edema and trismus in adults undergoing lower third molar surgical extraction.\n\nThe main question it aims to answer is:\n\nDoes dexamethasone submucosal injection have a positive impact on trismus and edema after third molar surgery compared to conventional postoperative prescription?\n\nParticipants will:\n\n* Be administered with dexamethasone submucosal injection or a placebo after the surgery.\n* Visit the clinic three times the week after the extraction for follow-up.",[227,30],"Swelling\u002F Edema",[229,230,231,232,233,234],"Extraction","third molar","wisdom teeth","dexamethasone","steroids","submucosal","2025-04-23",{"date":237,"type":39},"2025-05-01",{"date":239,"type":39},"2024-02-01",{"date":241,"type":22},"2025-06-30",{"name":243,"class":73},"King Abdulaziz University",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":23,"phases":252,"briefSummary":253,"conditions":254,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":74},"100572540","phase-4-efficacy-of-botox-injection-of-the-masticatory-muscles-in-head-neck-cancer-patients-with-trismus-after-radiotherapy-100572540","NCT06734598","Efficacy of Botox Injection of the Masticatory Muscles in Head &Neck Cancer Patients with Trismus After Radiotherapy","Inclusion Criteria:\n\n1. Aged over 18 years old;\n2. Head and neck cancer patients must have completed radiotherapy for at least 3 months;\n3. Those whose mouth-opening distance is less than or equal to 3.5 cm (the functional cut-off point of trismus) and who have tightness or pain in the masticatory muscles;\n4. Medical condition is stable;\n\nExclusion Criteria:\n\n1. Those who have undergone surgery on their masticatory muscles;\n2. Patients with obvious muscle atrophy or complete fibrosis of masticatory muscles ;\n3. Those with tumor recurrence at the time of admission;\n4. Those whose vital signs are unstable due to acute illness.",{"count":251,"type":22},120,[25],"Trismus is a common side effect in head and neck cancer patients after radiation therapy. This project aims to explore the therapeutic effect of Botulinum toxin (Botox) injection to the masticatory muscles in the above-mentioned patients.\n\nIn this project, Botulinum toxin will be injected into the masticatory muscles (medial pterygoid and masticatory muscles), combined with oral rehabilitation exercises, to reduce the patient's masticatory muscle tension and spasm. Patient's mouth opening range, quality of life, trismus condition and pain will be evaluated to understand its efficacy.",[30,60,255,256],"Radiation Therapy Recipient","BOTOX","2024-12-12",{"date":259,"type":39},"2024-12-16",{"date":261,"type":39},"2024-12-01",{"date":263,"type":22},"2026-02-01",{"name":265,"class":73},"National Taiwan University Hospital",{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":4,"eligibilityCriteria":272,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":273,"enrollmentInfo":274,"targetDuration":4,"studyType":23,"phases":276,"briefSummary":277,"conditions":278,"keywords":283,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":74},"100551314","effects-of-the-application-of-a-hyper-oxygenated-gel-after-oral-surgery-100551314","NCT06458478","Effects of the Application of a Hyper-oxygenated Gel After Oral Surgery","Effects of the Application of a Hyper-oxygenated Gel After Extraction of Impacted Lower Third Molars: Randomized Controlled Study","Inclusion Criteria:\n\n* good systemic and local health conditions of the patient;\n* age between 18 and 35 years;\n* understanding of the Italian language,\n* indications for the extraction of impacted bilateral lower third molars (38 and 48) according to the criteria reported in the classifications of Winter and that of Pell and Gregory;\n* the root of the impacted third molars is completely formed.\n\nExclusion Criteria:\n\n* diabetes mellitus;\n* systemic arterial hypertension;\n* hyperthyroidism;\n* osteoporosis;\n* immunosuppressed;\n* osteonecrosis of the jaws;\n* pregnancy;\n* patients with mandibular third molars in position C according to \"the Pell \\& Gregory Classification\" on the radiological measurements (angles and positions) for which third molar extraction surgery is required.;\n* local alterations such as pericoronitis, odontogenic cysts and tumors in relation to the third molars;\n* allergies;\n* ordinary use of analgesics or antibiotics by the patient.","35 Years",{"count":275,"type":22},72,[57],"The goal of this clinical trial is to evaluate whether the topical application of Novox® Drop on surgical wounds after the extraction of lower third molars can have a clinical advantage.\n\nThe primary objective of the study is to evaluate the possible reduction of masseteric trismus (masticatory muscle spasm - primary outcome) and of post-operative pain and facial edema (swelling - secondary outcomes) after the extraction of impacted third molars compared to those who do not use it (placebo=glycerin-based gel).",[279,280,281,282,30],"Molar, Fourth","Extracting Own Teeth","Edema Face","Pain",[284,230,285,286,287,288],"dysodontiasis","oral surgery","edema","trismus","pain","2024-06-12",{"date":291,"type":39},"2024-06-13",{"date":293,"type":22},"2024-07-01",{"date":295,"type":22},"2025-02-01",{"name":297,"class":73},"Azienda Ospedaliera di Perugia"]