[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tumor-pancreas\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tumor-pancreas":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100528404","upfront-eus-cgncpn-vs-conventional-step-up-approach-for-inoperable-painful-pancreatic-cancer-100528404",false,"NCT06160323","Upfront EUS CGN\u002FCPN vs Conventional Step up Approach for Inoperable Painful Pancreatic Cancer","Upfront Endoscopic Ultrasound-guided Celiac Ganglion Neurolysis Versus Conventional Step-up Approach for Patients With Painful, Inoperable Pancreatic Cancer","Inclusion Criteria:\n\n1. Age \\>= 18 years old\n2. Diagnosed to have inoperable pancreatic cancer\n3. Presence of tumor pain (centrally located, constant, with no other obvious cause) with a VAS \\>= 3\n4. Karnofsky performance status \\>= 60\n5. Planned for EUS examination and\u002For biopsy of the pancreatic tumor\n\nExclusion Criteria:\n\n1. Allergy to bupivacaine, or alcohol\n2. Potentially operable after neoadjuvant therapy\n3. Expected survival of less than 3 months\n4. Patient who is already on opioids for pain control\n5. Previous percutaneous or EUS-guided CGN\u002F CPN\n6. Recurrent pancreatic tumors after operation\n7. Uncorrectable coagulopathy\n8. Inability or unwillingness to provide informed consent","ALL","18 Years",{"count":19,"type":20},94,"ESTIMATED","INTERVENTIONAL",[23],"NA","Patients with unresectable pancreatic cancer are often demoralized by intractable, persistent and incapacitating pain. It must be managed aggressively and strong opioids are recommended as the mainstay of treatment. However, patients develop opioid-related adverse effects. EUS-guided celiac plexus neurolysis (CPN) and celiac ganglion neurolysis (CGN) has been shown to provide high efficacy for pain control. The optimal timing, however, is in debate.",[26,27,28],"Pancreatic Cancer Non-resectable","Tumor Pancreas","Pain Cancer",[26,30,31],"tumor pain","endoscopic ultrasound-guided celiac ganglion neurolysis","RECRUITING","2026-05-04",{"date":35,"type":36},"2026-05-06","ACTUAL",{"date":38,"type":36},"2023-11-10",{"date":40,"type":20},"2028-07-31",{"name":42,"class":43},"Chinese University of Hong Kong","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":44},"100552833","evaluate-the-safety-and-efficacy-of-bgt007h-cell-therapy-in-patients-with-relapsedrefractory-pancreatic-cancer-100552833","NCT06478225","Evaluate the Safety and Efficacy of BGT007H Cell Therapy in Patients With Relapsed\u002FRefractory Pancreatic Cancer","Clinical Study on the Safety and Preliminary Efficacy of BGT007H Cell Therapy in Patients With Recurrent\u002FRefractory Pancreatic Cancer","Inclusion Criteria:\n\n1. voluntarily sign an informed consent form in writing.\n2. Age ≥18 years and ≤75 years, both male and female are eligible.\n3. Expected survival ≥ 3 months.\n4. Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 or 1.\n5. Can provide pathological paraffin section detection targets (within 3 years prior to signing the informed consent form).\n6. According to the RECIST v1.1 criteria for the evaluation of solid tumors, there must be at least one measurable lesion, and the longest diameter of the lesions assessed by CT or MRI at baseline must be ≥ 10 mm (excluding lymph nodes, for which the short diameter must be ≥ 15 mm).\n7. Advanced pancreatic cancer confirmed by histology or cytology, with progression after second-line or later standard treatment, or intolerance to standard treatment, or no standard treatment available. The definition of intolerance: according to CTCAE v5.0, grade ≥IV hematological toxicity or grade ≥III non-hematological toxicity or grade ≥II damage to major organs such as heart, liver, and kidney occurred during treatment. The definition of treatment failure: disease progression (PD) during treatment or recurrence after treatment (including postoperative recurrence).\n8. Apheresis or venous blood collection venous access can be established, and there are no other contraindications to blood cell separation.\n9. Has adequate organ and bone marrow function, defined as follows: Blood routine: Neutrophil count (NEUT#) ≥1.0×10\\^9\u002FL Platelet count (PLT) ≥70×10\\^9\u002FL Hemoglobin concentration ≥80g\u002FL Liver function: For subjects without liver metastasis: Aspartate aminotransferase (AST) ≤2.5× upper limit of normal (ULN) Alanine aminotransferase (ALT) ≤2.5× ULN Total bilirubin (TBIL) ≤1.5× ULN For subjects with liver metastasis: AST ≤5× ULN ALT ≤5× ULN For subjects with liver metastasis or Gilbert's syndrome: Total bilirubin (TBIL) ≤2.5× ULN Renal function: Creatinine clearance rate (CCR) ≥50 mL\u002Fmin Coagulation function: International normalized ratio (INR) ≤1.5× ULN Activated partial thromboplastin time (APTT) ≤1.5× ULN Coagulation function in subjects with liver metastasis: INR ≤2× ULN APTT ≤2× ULN.\n10. During the study period and within 6 months after the end of dosing, subjects with childbearing potential (both male and female) must use effective medical contraception measures. Female subjects of childbearing potential must undergo a pregnancy test within 72 hours before the first dosing, and the result must be negative.\n\nExclusion Criteria:\n\n1. Has active central nervous system (CNS) metastasis (except for those treated and stable).\n2. HIV positive, HBsAg positive with positive Hepatitis B virus (HBV) DNA copy number (greater than the lower limit of detection), Hepatitis C virus (HCV) antibody positive and HCV RNA positive, syphilis non-treponemal antibody (RPR or TRUST) positive.\n3. Has a mental or psychological disorder that cannot cooperate with treatment and efficacy evaluation.\n4. Subjects with severe autoimmune diseases who have been long-term users of immunosuppressants.\n5. Within 14 days before enrollment, there is an active infection or uncontrollable infection that requires systemic treatment.\n6. Any unstable systemic diseases (including but not limited to): active infection (except for localized infection); unstable angina; cerebral ischemia or cerebral stroke (within 6 months of screening); myocardial infarction (within 6 months of screening); congestive heart failure (New York Heart Association (NYHA) class ≥ III); severe arrhythmia requiring medication treatment; heart disease requiring treatment or uncontrolled hypertension after treatment (blood pressure \\> 160 mmHg\u002F100 mmHg).\n7. Combined with dysfunction of important organs such as lungs, brain, and kidneys.\n8. Within 4 weeks before receiving cell therapy, the subject has undergone major surgery or serious trauma, or is expected to undergo major surgery during the study period.\n9. Within 1-2 weeks or 5 half-lives (whichever is shorter) before apheresis, the subject has received any systemic chemotherapy, immunotherapy, or small molecule targeted therapy.\n10. Received chimeric antigen receptor-modified T cell (CAR-T), T-cell receptor engineered T cells (TCR-T) therapy within the past 6 months.\n11. Severe allergies or a history of allergies.\n12. Subjects who require anticoagulant therapy.\n13. Pregnant or lactating women, or those who plan to become pregnant within six months (applicable to both men and women).\n14. The researcher believes that there are other reasons why the subject cannot be included in the treatment.","75 Years",{"count":54,"type":20},12,[23],"The primary objective of this study is to evaluate the safety and tolerability of BGT007H cell therapy in patients with recurrent\u002Frefractory pancreatic cancer.",[27],"2024-06-21",{"date":60,"type":36},"2024-06-27",{"date":62,"type":36},"2024-05-07",{"date":64,"type":20},"2027-08-31",{"name":66,"class":43},"RenJi Hospital"]